E. Jarocka-cyrta - Academia.edu (original) (raw)
Papers by E. Jarocka-cyrta
Przyczyny bezdechu sennego u niemowl±t z zespo³em ALTE Wstep. Zespo³ ALTE niemowl±t ( apparent li... more Przyczyny bezdechu sennego u niemowl±t z zespo³em ALTE Wstep. Zespo³ ALTE niemowl±t ( apparent life-threatening event ), ktory rozpoznaje sie w przypadku wyst±pienia bezdechu z towarzysz±cymi objawami zagro?enia ?ycia, ma zro?nicowan± etiopatogeneze, miedzy innymi neurologiczn±, gastrologiczn±, kardiologiczn±, metaboliczn±. Wiekszo¶ae niemowl±t w chwili przyjecia do szpitala nie demonstruje ju? ?adnych objawow klinicznych. Na podstawie wywiadu i badan dodatkowych udaje sie okre¶liae przyczyny objawow zagro?enia ?ycia u oko³o 50-75% dzieci. W pracy przedstawiono potencjalne przyczyny ALTE u niemowl±t hospitalizowanych w klinice w latach 2004-2006. Materia³ i metody. Badaniem prospektywnym objeto 55 niemowl±t ALTE (24 ch³opcow, 31 dziewczynek; ¶r. wieku - 3,2 m?.; mediana wieku ci±?owego - 40 hbd, mediana urodzeniowej masy cia³a - 3240 g). Protoko³ diagnostyczny zespo³u ALTE na podstawie kryteriow rekomendowanych przez European Society for the Study and Prevention of Infant Death (ESP...
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American Journal of Physiology-Gastrointestinal and Liver Physiology, 1998
This study was undertaken to test the hypothesis that a change in the mother’s diet at the time o... more This study was undertaken to test the hypothesis that a change in the mother’s diet at the time of birth and continued during suckling modifies the intestinal transport of nutrients in the suckling offspring. Pregnant rat dams were fed one of four semisynthetic diets during pregnancy [high or low n-6/n-3 diet or a diet enriched with arachidonic acid (AA) or docosahexaenoic acid (DHA)] and were fed the same diet at the time of birth or switched to another diet. The greatest body weight gain was in the suckling rats (15–16 days of age) fed a low n-6/n-3 diet. Switching from this diet caused weight loss, and the observed weight gain with the low n-6/n-3 diet was prevented by previous exposure of the mother to the high n-6/n-3 diet or the AA- or DHA-containing diet. Although continuous feeding of a high n-6/n-3 diet to the mother during pregnancy and lactation was associated with the lowest in vitro rates of fructose uptake, switching the mother to another diet during lactation did not ...
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American Journal of Physiology-Gastrointestinal and Liver Physiology, 1997
Alterations in dietary lipids of the nursing mother result in variations in the lipid content of ... more Alterations in dietary lipids of the nursing mother result in variations in the lipid content of her milk. Maternal rats, weanlings, and 10-wk-old animals were fed chow or a semisynthetic isocaloric diet enriched with either saturated fatty acids (S) or polyunsaturated fatty acids (P). The jejunal and ileal in vitro uptake of varying concentrations (4-64 mM) of D-glucose and D-fructose or single concentrations of medium- and long-chain fatty acids and cholesterol were assessed in 18- to 21-day-old suckling rats, in 5-wk-old weanling animals, and in 12-wk-old young adults. The rate of uptake of D-glucose and D-fructose was unaffected in suckling rats by changing the lipid content of the diet of the nursing dams, whereas sugar uptake was greater in weanlings or adults fed S compared with P. The jejunal uptake of long-chain fatty acids was not influenced in suckling by changing the mother's diet, whereas in weanlings the uptake of 18:0 and 18:3 was higher with feeding S vs. P. In summary, jejunal uptake of cholesterol was greater in sucklings than in weanlings fed S vs. P. In suckling animals there are different adaptive patterns between the jejunum and the ileum and varying patterns of adaptation in response to alterations in the lipids in the diet when comparing suckling vs. weanling rats. These differences in nutrient uptake could not be explained by age- or diet-associated alterations in villus height. It is concluded that the age of the rat influences the intestinal adaptation of nutrient transport, which occurs in response to changes in dietary lipids, and dietary lipids fed to nursing dams and their offspring are important in the development of the intestine.
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Journal of Crohn's and Colitis, 2017
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Canadian Journal of Gastroenterology, 1997
The small bowel has undergone intense study. Part II of this review of the small bowel summarizes... more The small bowel has undergone intense study. Part II of this review of the small bowel summarizes the current knowledge about the permeability of the gastrointestinal epithelium; the brush border membrane; motility; carbohydrates; diabetes; ethanol; diet; and diagnostic procedures.
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Canadian Journal of Gastroenterology, 1997
The small bowel has undergone intense study. Part I of this two-part review of the small bowel fo... more The small bowel has undergone intense study. Part I of this two-part review of the small bowel focuses on gastrointestinal peptides; intestinal infections and human immunodeficiency virus; drugs; intestinal growth - mucosal proliferation and differentiation; nucleic acids, nucleotides and nucleosides; vitamins and minerals; Whipple's disease; radiation; and early development.
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Gastroenterology Review, 2016
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Methods in Enzymology, 1997
A reduction in fat intake may be achieved by making educated choices to reduce total calorie inta... more A reduction in fat intake may be achieved by making educated choices to reduce total calorie intake, to consume a lower quantity of total fats, or to modify the ratio of saturated-to-polyunsaturated lipids. Leptin agonists or NPY or CCK antagonists may prove to be useful to diminish appetite and thereby reduce the total intake of food. But eating has such
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![Research paper thumbnail of Bleeding Barrett's ulcer as a complication of GERD [corrected] in physically and intellectually disabled children--report of two cases](https://attachments.academia-assets.com/91430300/thumbnails/1.jpg)
](Advances in medical sciences, 2007
Gastroesophageal reflux disease (GERD) is a problem frequently occurring among physically and int... more Gastroesophageal reflux disease (GERD) is a problem frequently occurring among physically and intellectually disabled individuals. In this group of patients GERD is often overlooked, since the symptoms are usually non-specific. We present two cases of disabled children, who developed complications of GERD in the form of Barrett's esophagus, Barrett's ulceration and bleeding, the life-threatening events which were not preceded by typical GERD complaints.
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Advances in medical sciences, 2007
Hypersomnia is a significant problem in about 5% of the general population. We discussed clinical... more Hypersomnia is a significant problem in about 5% of the general population. We discussed clinical aspects in 3 patients with hypersomnia diagnosed in our sleep laboratory. All of the patients, both obese and non-obese, presented abnormal oral glucose tolerance test (OGTT) and plasma insulin level. (1) A 17-year-old girl (BMI = 20.3) with a two-year history of daytime sleep attacks (e.g. on the bus, in a classroom, while reading or eating), followed by refreshed feeling. The first symptoms appeared 2 years after spine injury (L2-L3). Total sleep time was > 98 perc. The diagnosis of narcolepsy was confirmed by sleep-onset REM periods in 3 of 4 daytime naps (positive Multiple Sleep Latency Tests) and HLA-DQB1 (alleles *0201, *0602). (2) A 16-year-old girl (BMI = 32.4) with a history of increased sleepiness (Epworth Sleepiness Scale score = 13), not refreshing naps, along with BMI increase, since the age of 13. The metabolic syndrome was diagnosed based on the presence of obesity, hy...
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Patologia polska, 1991
Benign dysplasia is a pathological process in the female breast associated with hypertrophy of in... more Benign dysplasia is a pathological process in the female breast associated with hypertrophy of interlobular and periductal connective tissue. It leads to disappearance of the lobular structure of this organ. It was found that the mammary tumours contain more collagen in comparison to the normal breast. In the normal breast collagen type I and type III constitute 70% and 25% of the total collagen content, respectively. The investigated tumors contain mainly a complex of collagen type I and type III which cannot be dissociated by the methods used for collagen preparation.
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Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2009
The autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by socially a... more The autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by socially aloof behavior and impairment of language and social interaction. This paper is a review of literature on gastrointestinal problems in children with ASD. Gastrointestinal symptoms are described in 9-54% of autistic children, among which most common are: constipation, diarrhea and abdominal distension. The gastro-intestinal abnormalities reported in autism include: inflammation (esophagitis, gastritis, duodenitis, enterocolitis) with or without autoimmunity, lymphoid nodular hyperplasia, increased intestinal permeability, low activities of disaccharidase enzymes, impairment of detoxification (e.g. defective sulfation of ingested phenolic amines), dysbiosis with bacterial overgrowth, food intolerance or exorphin intoxication (by opioid derived from casein and gluten). A beneficial effect of dietary intervention on behavior and cognition of some autistic children indicates a functional relat...
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Pediatria, 2007
... RYCINA 1. Równowaga mikrobiologiczna i zjawisko dysbiozy (16) FIGURE 1. Microbial balance and... more ... RYCINA 1. Równowaga mikrobiologiczna i zjawisko dysbiozy (16) FIGURE 1. Microbial balance and dysbio-sis (16) Page 3. Kaczmarski M., Jarocka-Cyrta E., Uścinowicz M., Semeniuk J. Probiotics in inflammatory bowel disease Pediatr. Współcz. Gastroenterol. ... Broda i wsp. ...
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termedia.pl
Hypersensitivity to consumed food or group of foods, in infants, children and adolescents as well... more Hypersensitivity to consumed food or group of foods, in infants, children and adolescents as well as adults, is becoming an increasingly common cause of many individually different, recurrent or chronic clinical symptoms. This global health problem, which is becoming ...
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Journal of Pediatric Gastroenterology & Nutrition, 1999
Varying lipid content of the diet of pregnant and nursing dams results in alterations in sugar an... more Varying lipid content of the diet of pregnant and nursing dams results in alterations in sugar and lipid uptake into the intestine of their suckling offspring. In this study, we wished to determine whether the same alterations in dietary lipid result in adaptation of intestinal transport in postweaning rats. During nursing, the dams were fed the same diet that their offspring were fed for 3 more weeks after weaning. These semipurified diets contained: 1) 15.8% of total fatty acids (w/w) as 18:2n-6 and an n6/n3 ratio of 7.3:1; 2) a diet with 17.6% of total fatty acids as 18:2n-6 and an n6/n3 ratio of 4:1; 3) a diet with 16.2% of total fatty acids as 18:2n-6 and 1.2% arachidonic acid (AA); 4) a diet with 16.8% of total fatty acids at 18:2n-6, 1.2% AA and 0.7% docosahexaenoic acid (DHA); and 5) a diet with 16.0% of total fatty acids as 18:2n-6 and 0.7% as DHA. The in vitro uptake of D-glucose, D-fructose, medium- or long-chain fatty acids and cholesterol was assessed in 6-week-old rats. Feeding AA increased the Vmax for jejunal and ileal uptake of glucose, compared with the high n6/n3 diet. This effect was prevented by adding DHA to the AA diet. The low n6/n3 fatty acid ratio diet decreased uptake of fructose as compared with the high n6/n3 diet, and the increased uptake of fructose with DHA was prevented by adding AA. The incremental change in free energy associated with uptake of medium chain-length fatty acids was lower in the jejunum of animals fed AA plus DHA as compared with the other diet groups. Jejunal uptake of 18:0 was lower for animals fed DHA or AA plus DHA, as compared with AA alone; ileal rate of uptake of long-chain fatty acids was unaffected by diet. The intestine of young rats modifies its intestinal morphology and adapts its nutrient transport in response to variations in dietary lipids. In postweaning rats, the potentially undesirable effect of one fatty acid on nutrient uptake may be countered by adding a select second fatty acid to the diet.
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Journal of Pediatric Gastroenterology and Nutrition, 2001
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Journal of Pediatric Gastroenterology and Nutrition, 2005
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Journal of Pediatric Gastroenterology and Nutrition, 2005
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Journal of Endocrinological Investigation, 2009
Ghrelin is predominately produced in the stomach, but new findings indicate that the intestinal w... more Ghrelin is predominately produced in the stomach, but new findings indicate that the intestinal wall is an important source of the hormone. In patients with shortbowel syndrome, reduction in the intestinal tissue resulted in a decrease in the circulating ghrelin levels. Since in celiac disease (CD) intestinal mucosa atrophy is the main finding, alterations in duodenal ghrelin-positive cell population can be expected. The aim of the study was to evaluate the density of ghrelin-positive cells in the duodenum of CD children and its relationship with body mass index (BMI) and clinical presentation. The study included 31 consecutive patients with newly diagnosed CD [BMI SD scores (BMISDS) -0.926+/-1.496]. The control group consisted of 21 children (BMISDS -0.517+/-1.186], diagnosed with growth retardation, anemia or abdominal pain. All the patients underwent endoscopy with biopsy samples taken from distal duodenum. Immunohistochemistry was performed using rabbit anti- ghrelin (human) antiserum. The number of ghrelin-positive cells in the duodenum was significantly higher in children with CD than in controls (14.82+/-11.12 vs 5.69+/-5.02, p<0.0013). The density of ghrelin-positive cells in the duodenum did not correlate with age, pubertal status, BMISDS or clinical presentation. In the duodenum of CD children, the number of ghrelin-positive cells is increased compared with the control patients. The population of ghrelin-positive cells in the duodenum does not simply reflect an altered mucosal morphology or failure to thrive but is under the influence of other conditions.
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Journal of Crohn's and Colitis, 2013
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Przyczyny bezdechu sennego u niemowl±t z zespo³em ALTE Wstep. Zespo³ ALTE niemowl±t ( apparent li... more Przyczyny bezdechu sennego u niemowl±t z zespo³em ALTE Wstep. Zespo³ ALTE niemowl±t ( apparent life-threatening event ), ktory rozpoznaje sie w przypadku wyst±pienia bezdechu z towarzysz±cymi objawami zagro?enia ?ycia, ma zro?nicowan± etiopatogeneze, miedzy innymi neurologiczn±, gastrologiczn±, kardiologiczn±, metaboliczn±. Wiekszo¶ae niemowl±t w chwili przyjecia do szpitala nie demonstruje ju? ?adnych objawow klinicznych. Na podstawie wywiadu i badan dodatkowych udaje sie okre¶liae przyczyny objawow zagro?enia ?ycia u oko³o 50-75% dzieci. W pracy przedstawiono potencjalne przyczyny ALTE u niemowl±t hospitalizowanych w klinice w latach 2004-2006. Materia³ i metody. Badaniem prospektywnym objeto 55 niemowl±t ALTE (24 ch³opcow, 31 dziewczynek; ¶r. wieku - 3,2 m?.; mediana wieku ci±?owego - 40 hbd, mediana urodzeniowej masy cia³a - 3240 g). Protoko³ diagnostyczny zespo³u ALTE na podstawie kryteriow rekomendowanych przez European Society for the Study and Prevention of Infant Death (ESP...
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American Journal of Physiology-Gastrointestinal and Liver Physiology, 1998
This study was undertaken to test the hypothesis that a change in the mother’s diet at the time o... more This study was undertaken to test the hypothesis that a change in the mother’s diet at the time of birth and continued during suckling modifies the intestinal transport of nutrients in the suckling offspring. Pregnant rat dams were fed one of four semisynthetic diets during pregnancy [high or low n-6/n-3 diet or a diet enriched with arachidonic acid (AA) or docosahexaenoic acid (DHA)] and were fed the same diet at the time of birth or switched to another diet. The greatest body weight gain was in the suckling rats (15–16 days of age) fed a low n-6/n-3 diet. Switching from this diet caused weight loss, and the observed weight gain with the low n-6/n-3 diet was prevented by previous exposure of the mother to the high n-6/n-3 diet or the AA- or DHA-containing diet. Although continuous feeding of a high n-6/n-3 diet to the mother during pregnancy and lactation was associated with the lowest in vitro rates of fructose uptake, switching the mother to another diet during lactation did not ...
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American Journal of Physiology-Gastrointestinal and Liver Physiology, 1997
Alterations in dietary lipids of the nursing mother result in variations in the lipid content of ... more Alterations in dietary lipids of the nursing mother result in variations in the lipid content of her milk. Maternal rats, weanlings, and 10-wk-old animals were fed chow or a semisynthetic isocaloric diet enriched with either saturated fatty acids (S) or polyunsaturated fatty acids (P). The jejunal and ileal in vitro uptake of varying concentrations (4-64 mM) of D-glucose and D-fructose or single concentrations of medium- and long-chain fatty acids and cholesterol were assessed in 18- to 21-day-old suckling rats, in 5-wk-old weanling animals, and in 12-wk-old young adults. The rate of uptake of D-glucose and D-fructose was unaffected in suckling rats by changing the lipid content of the diet of the nursing dams, whereas sugar uptake was greater in weanlings or adults fed S compared with P. The jejunal uptake of long-chain fatty acids was not influenced in suckling by changing the mother's diet, whereas in weanlings the uptake of 18:0 and 18:3 was higher with feeding S vs. P. In summary, jejunal uptake of cholesterol was greater in sucklings than in weanlings fed S vs. P. In suckling animals there are different adaptive patterns between the jejunum and the ileum and varying patterns of adaptation in response to alterations in the lipids in the diet when comparing suckling vs. weanling rats. These differences in nutrient uptake could not be explained by age- or diet-associated alterations in villus height. It is concluded that the age of the rat influences the intestinal adaptation of nutrient transport, which occurs in response to changes in dietary lipids, and dietary lipids fed to nursing dams and their offspring are important in the development of the intestine.
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Journal of Crohn's and Colitis, 2017
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Canadian Journal of Gastroenterology, 1997
The small bowel has undergone intense study. Part II of this review of the small bowel summarizes... more The small bowel has undergone intense study. Part II of this review of the small bowel summarizes the current knowledge about the permeability of the gastrointestinal epithelium; the brush border membrane; motility; carbohydrates; diabetes; ethanol; diet; and diagnostic procedures.
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Canadian Journal of Gastroenterology, 1997
The small bowel has undergone intense study. Part I of this two-part review of the small bowel fo... more The small bowel has undergone intense study. Part I of this two-part review of the small bowel focuses on gastrointestinal peptides; intestinal infections and human immunodeficiency virus; drugs; intestinal growth - mucosal proliferation and differentiation; nucleic acids, nucleotides and nucleosides; vitamins and minerals; Whipple's disease; radiation; and early development.
Bookmarks Related papers MentionsView impact
Gastroenterology Review, 2016
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Methods in Enzymology, 1997
A reduction in fat intake may be achieved by making educated choices to reduce total calorie inta... more A reduction in fat intake may be achieved by making educated choices to reduce total calorie intake, to consume a lower quantity of total fats, or to modify the ratio of saturated-to-polyunsaturated lipids. Leptin agonists or NPY or CCK antagonists may prove to be useful to diminish appetite and thereby reduce the total intake of food. But eating has such
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Advances in medical sciences, 2007
Gastroesophageal reflux disease (GERD) is a problem frequently occurring among physically and int... more Gastroesophageal reflux disease (GERD) is a problem frequently occurring among physically and intellectually disabled individuals. In this group of patients GERD is often overlooked, since the symptoms are usually non-specific. We present two cases of disabled children, who developed complications of GERD in the form of Barrett's esophagus, Barrett's ulceration and bleeding, the life-threatening events which were not preceded by typical GERD complaints.
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Advances in medical sciences, 2007
Hypersomnia is a significant problem in about 5% of the general population. We discussed clinical... more Hypersomnia is a significant problem in about 5% of the general population. We discussed clinical aspects in 3 patients with hypersomnia diagnosed in our sleep laboratory. All of the patients, both obese and non-obese, presented abnormal oral glucose tolerance test (OGTT) and plasma insulin level. (1) A 17-year-old girl (BMI = 20.3) with a two-year history of daytime sleep attacks (e.g. on the bus, in a classroom, while reading or eating), followed by refreshed feeling. The first symptoms appeared 2 years after spine injury (L2-L3). Total sleep time was > 98 perc. The diagnosis of narcolepsy was confirmed by sleep-onset REM periods in 3 of 4 daytime naps (positive Multiple Sleep Latency Tests) and HLA-DQB1 (alleles *0201, *0602). (2) A 16-year-old girl (BMI = 32.4) with a history of increased sleepiness (Epworth Sleepiness Scale score = 13), not refreshing naps, along with BMI increase, since the age of 13. The metabolic syndrome was diagnosed based on the presence of obesity, hy...
Bookmarks Related papers MentionsView impact
Patologia polska, 1991
Benign dysplasia is a pathological process in the female breast associated with hypertrophy of in... more Benign dysplasia is a pathological process in the female breast associated with hypertrophy of interlobular and periductal connective tissue. It leads to disappearance of the lobular structure of this organ. It was found that the mammary tumours contain more collagen in comparison to the normal breast. In the normal breast collagen type I and type III constitute 70% and 25% of the total collagen content, respectively. The investigated tumors contain mainly a complex of collagen type I and type III which cannot be dissociated by the methods used for collagen preparation.
Bookmarks Related papers MentionsView impact
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2009
The autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by socially a... more The autistic spectrum disorder (ASD) is a neurodevelopmental disorder characterized by socially aloof behavior and impairment of language and social interaction. This paper is a review of literature on gastrointestinal problems in children with ASD. Gastrointestinal symptoms are described in 9-54% of autistic children, among which most common are: constipation, diarrhea and abdominal distension. The gastro-intestinal abnormalities reported in autism include: inflammation (esophagitis, gastritis, duodenitis, enterocolitis) with or without autoimmunity, lymphoid nodular hyperplasia, increased intestinal permeability, low activities of disaccharidase enzymes, impairment of detoxification (e.g. defective sulfation of ingested phenolic amines), dysbiosis with bacterial overgrowth, food intolerance or exorphin intoxication (by opioid derived from casein and gluten). A beneficial effect of dietary intervention on behavior and cognition of some autistic children indicates a functional relat...
Bookmarks Related papers MentionsView impact
Pediatria, 2007
... RYCINA 1. Równowaga mikrobiologiczna i zjawisko dysbiozy (16) FIGURE 1. Microbial balance and... more ... RYCINA 1. Równowaga mikrobiologiczna i zjawisko dysbiozy (16) FIGURE 1. Microbial balance and dysbio-sis (16) Page 3. Kaczmarski M., Jarocka-Cyrta E., Uścinowicz M., Semeniuk J. Probiotics in inflammatory bowel disease Pediatr. Współcz. Gastroenterol. ... Broda i wsp. ...
Bookmarks Related papers MentionsView impact
termedia.pl
Hypersensitivity to consumed food or group of foods, in infants, children and adolescents as well... more Hypersensitivity to consumed food or group of foods, in infants, children and adolescents as well as adults, is becoming an increasingly common cause of many individually different, recurrent or chronic clinical symptoms. This global health problem, which is becoming ...
Bookmarks Related papers MentionsView impact
Journal of Pediatric Gastroenterology & Nutrition, 1999
Varying lipid content of the diet of pregnant and nursing dams results in alterations in sugar an... more Varying lipid content of the diet of pregnant and nursing dams results in alterations in sugar and lipid uptake into the intestine of their suckling offspring. In this study, we wished to determine whether the same alterations in dietary lipid result in adaptation of intestinal transport in postweaning rats. During nursing, the dams were fed the same diet that their offspring were fed for 3 more weeks after weaning. These semipurified diets contained: 1) 15.8% of total fatty acids (w/w) as 18:2n-6 and an n6/n3 ratio of 7.3:1; 2) a diet with 17.6% of total fatty acids as 18:2n-6 and an n6/n3 ratio of 4:1; 3) a diet with 16.2% of total fatty acids as 18:2n-6 and 1.2% arachidonic acid (AA); 4) a diet with 16.8% of total fatty acids at 18:2n-6, 1.2% AA and 0.7% docosahexaenoic acid (DHA); and 5) a diet with 16.0% of total fatty acids as 18:2n-6 and 0.7% as DHA. The in vitro uptake of D-glucose, D-fructose, medium- or long-chain fatty acids and cholesterol was assessed in 6-week-old rats. Feeding AA increased the Vmax for jejunal and ileal uptake of glucose, compared with the high n6/n3 diet. This effect was prevented by adding DHA to the AA diet. The low n6/n3 fatty acid ratio diet decreased uptake of fructose as compared with the high n6/n3 diet, and the increased uptake of fructose with DHA was prevented by adding AA. The incremental change in free energy associated with uptake of medium chain-length fatty acids was lower in the jejunum of animals fed AA plus DHA as compared with the other diet groups. Jejunal uptake of 18:0 was lower for animals fed DHA or AA plus DHA, as compared with AA alone; ileal rate of uptake of long-chain fatty acids was unaffected by diet. The intestine of young rats modifies its intestinal morphology and adapts its nutrient transport in response to variations in dietary lipids. In postweaning rats, the potentially undesirable effect of one fatty acid on nutrient uptake may be countered by adding a select second fatty acid to the diet.
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Journal of Pediatric Gastroenterology and Nutrition, 2001
Bookmarks Related papers MentionsView impact
Journal of Pediatric Gastroenterology and Nutrition, 2005
Bookmarks Related papers MentionsView impact
Journal of Pediatric Gastroenterology and Nutrition, 2005
Bookmarks Related papers MentionsView impact
Journal of Endocrinological Investigation, 2009
Ghrelin is predominately produced in the stomach, but new findings indicate that the intestinal w... more Ghrelin is predominately produced in the stomach, but new findings indicate that the intestinal wall is an important source of the hormone. In patients with shortbowel syndrome, reduction in the intestinal tissue resulted in a decrease in the circulating ghrelin levels. Since in celiac disease (CD) intestinal mucosa atrophy is the main finding, alterations in duodenal ghrelin-positive cell population can be expected. The aim of the study was to evaluate the density of ghrelin-positive cells in the duodenum of CD children and its relationship with body mass index (BMI) and clinical presentation. The study included 31 consecutive patients with newly diagnosed CD [BMI SD scores (BMISDS) -0.926+/-1.496]. The control group consisted of 21 children (BMISDS -0.517+/-1.186], diagnosed with growth retardation, anemia or abdominal pain. All the patients underwent endoscopy with biopsy samples taken from distal duodenum. Immunohistochemistry was performed using rabbit anti- ghrelin (human) antiserum. The number of ghrelin-positive cells in the duodenum was significantly higher in children with CD than in controls (14.82+/-11.12 vs 5.69+/-5.02, p<0.0013). The density of ghrelin-positive cells in the duodenum did not correlate with age, pubertal status, BMISDS or clinical presentation. In the duodenum of CD children, the number of ghrelin-positive cells is increased compared with the control patients. The population of ghrelin-positive cells in the duodenum does not simply reflect an altered mucosal morphology or failure to thrive but is under the influence of other conditions.
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Journal of Crohn's and Colitis, 2013
Bookmarks Related papers MentionsView impact