E. Maguen - Academia.edu (original) (raw)

Papers by E. Maguen

The Western journal of medicine, 1988

Ophthalmology, 1984

ABSTRACT Six eyes of four patients with Thygeson's superficial punctate keratitis were tr... more ABSTRACT Six eyes of four patients with Thygeson's superficial punctate keratitis were treated with trifluridine 1% drops. Five of the six treated eyes responded favorably to topical trifluridine therapy. Symptoms and later the signs of the disease disappeared, but more slowly than observed following topical corticosteroid therapy. One patient with an 11-year history of topical corticosteroid dependence for clearing of lesions was treated successfully with trifluridine, and his eyes have remained clear for over one year without therapy. Mild irritation and transient limbal follicle formation were the only recognized side effects. Trifluridine is thus an effective and safe alternative to corticosteroids in the treatment of this condition and may offer a means of treating the steroid-dependent patient.

Investigative Ophthalmology & Visual Science, 2007

To assess the relative impact of antibodies specific for HSV-1 glycoproteins on eye disease in re... more To assess the relative impact of antibodies specific for HSV-1 glycoproteins on eye disease in response to HSV-1 infection, the composition of antibodies specific for 10 of the viral glycoproteins, and the effect of anti-glycoprotein (g)D and anti-gK antibodies on antibody-dependent enhancement (ADE). In a prospective case-control study, sera from patients with a history of herpes stromal keratitis (HSK) were compared with sera from nonocular HSV-1-seropositive and HSV-seronegative control subjects. HSV-1 neutralizing antibody titer and type-specific IgG and IgM were measured. In addition, the presence of anti-HSV-1 gD and gK antibodies in the sera of all patients also was determined by ELISA using gD and gK antigens. Finally, the role of anti-gD- and gK-specific antibodies to ADE was investigated. Average neutralizing antibody titers and levels of HSV-1 IgG were similar between HSK- and non-HSK-seropositive patients. However, the contribution of gD to the neutralizing antibody titer in HSK sera was significantly lower than that in non-HSK-seropositive patients, despite higher anti-gD ELISA titers. Overall, sera from patients with HSK had higher anti-gK antibody titers and induced ADE in vitro compared with non-HSK or seronegative sera. The ADE response in HSK sera was attributed to anti-gK antibody. These results suggest that sera from HSK patients had higher anti-gD and -gK antibody titers than sera from seropositive patients who had no history of HSK despite similar levels of neutralizing antibody titers and HSV-1 IgG, that HSK sera induced ADE whereas sera from non-HSK patients did not induce ADE, and that anti-gD antibody in sera of HSK patients contributed less to the HSV-1 neutralization antibody titer than did sera from non-HSK patients.

International Ophthalmology Clinics, 1981

Cornea, 1985

A multifocal progressive infiltration of a corneal graft, which simulated a mycotic keratitis but... more A multifocal progressive infiltration of a corneal graft, which simulated a mycotic keratitis but was repeatedly negative on culture and unresponsive to antibacterial and antifungal therapy, was found upon regrafting to consist primarily of Gram-positive cocci. This bacterial colonization of the corneal graft was associated with epithelialized suture tracks and minimal inflammatory response. The immunosuppressive and bacteriostatic effects of chronic postsurgery low dose steroid and antimicrobial therapy may have played a role in the development of this atypical bacterial infiltrate.

Cornea, 1986

... Cornea: Editorial: PDF Only. Extraction of Soluble Proteins Reduces Rejection in Rabbit Porci... more ... Cornea: Editorial: PDF Only. Extraction of Soluble Proteins Reduces Rejection in Rabbit Porcine Corneal Xenografts. Maguen, Ezra; Isitt, John; Pinhas, Simon; Nesburn, Anthony B. Collapse Box Abstract. Lathed lyophilized porcine ...

Archives of Ophthalmology, 1982

ABSTRACT A method of prelathing lyophilized corneal tissue at room temperature for refractive ker... more ABSTRACT A method of prelathing lyophilized corneal tissue at room temperature for refractive keratoplasty is described. A solution was developed that preserves corneal transparency and allows adhesion of corneal tissue to modified plastic bases during lyophilization and lathing. Intracorneal implantation and keratophakia with lyophilized corneal tissue in two series of cats were performed. Transparent grafts and technically satisfactory results were obtained. This procedure could greatly simplify and render more accurate refractive keratoplasty procedures requiring lathed donor corneas.

Acta Ophthalmologica, 2009

Six subjects who never wore contact lenses underwent six determinations of corneal cell density u... more Six subjects who never wore contact lenses underwent six determinations of corneal cell density using each of two measurement modes: Mode A: the eye was applanated once and pairs of photographs were taken; Mode B: the eye was applanated and a single photograph was taken. For each measurement mode data were collected on two separate sessions (Test, Retest). Chi-square analyses revealed a significantly larger proportion of uncountable photographs from the first measurement session, and analysis of variance revealed that Mode A was less reliable than Mode B upon retesting. It was concluded that Mode B was the preferred measurement mode, and that many more than six determinations be made on the initial session in order to obtain six readable photographs. Finally, estimates of inter and intra-session variation, intra-pair variation, and inter and intra-observer variation are given.

The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc

ABSTRACT A three-year study was conducted to establish whether Polycon® contact lenses can be use... more ABSTRACT A three-year study was conducted to establish whether Polycon® contact lenses can be used as a long-term means of optically correcting keratoconus in patients in whom PMMA and CAB lenses have failed. Twelve (21 eyes) out of 17 patients (31 eyes) were available for evaluation after the third year of the study. The average length of wear was 33.25 months (range 27-41 months) and visual acuity was 20/40 or better in 81.8% of the eyes and 20/50 to 20/80 in the remaining eyes. Additional data is supplied, including hours of daily wear, corneal edema staining, and touch. The Polycon lens may serve as a long-term means of optically correcting keratoconus.

Ophthalmic surgery, 1984

A new technique which allows the use of a guarded trephine in penetrating keratoplasty for cornea... more A new technique which allows the use of a guarded trephine in penetrating keratoplasty for corneal perforation is described. It involves the combined use of cyanoacrylate adhesive and sodium hyaluronate and allows a normotensive eye to be obtained prior to trephination. Five cases in which this technique was used are described. A better tectonic result can be obtained and visual rehabilitation may be more readily achieved without performing a secondary procedure.

Investigative ophthalmology & visual science, 1979

Four subjects who had never worn contact lenses underwent measurement of their corneal thickness ... more Four subjects who had never worn contact lenses underwent measurement of their corneal thickness by each of three measurement methods: Haag-Streit pachometer with/and without Mishima-Hedby attachment and the Syber specular microscope. Data were collected on three separate sessions, and at each session triplicate measurement trials were made for each method. The resulting 108 measurements were analyzed statistically. Significant differences were found among the measurement methods. Two of the methods were found to be consistent from session to session. In addition, the specular microscope was found to be the most precise method within a session. It was concluded that the specular microscope, which highly trained technicians can utilize to make the measurements, offers a valuable alternative to the measurement of corneal thickness in long-term prospective studies.

Cornea, 1997

To report the association of keratoconus and Turner's syndrome in three patients and to r... more To report the association of keratoconus and Turner's syndrome in three patients and to review the ophthalmic manifestations of Turner's syndrome. Three patients with keratoconus and Turner's syndrome were identified and reported in a retrospective review. These three cases represent the first series of patients with keratoconus and Turner's syndrome. All three patients underwent penetrating keratoplasty with good visual rehabilitation. None of the patients had other ocular features associated with Turner's syndrome. Turner's syndrome is commonly associated with ocular problems. In this series we identify an association of keratoconus with Turner's syndrome. Clearly, a careful ocular examination in this condition with attention to ocular features of Turner's syndrome is important.

Investigative ophthalmology & visual science, 1996

To uncover abnormalities of extracellular matrix (ECM) distribution in human corneas with pseudop... more To uncover abnormalities of extracellular matrix (ECM) distribution in human corneas with pseudophakic and aphakic bullous keratopathy (PBK/ABK). Indirect immunofluorescence with antibodies to 27 ECM components was used on frozen sections of 14 normal and 20 PBK/ABK corneas. Fibrillar deposits of an antiadhesive glycoprotein tenascin in the anterior and posterior stroma, epithelial basement membrane (BM), bullae and subepithelial fibrosis (SEF) areas, and posterior collagenous layer (PCL) were revealed in disease corneas. Tenascin in midstroma, which was observed in some cases, correlated with decreased visual acuity. In normal central corneas, tenascin was never found. Other major ECM abnormalities in PBK/ABK corneas compared to normals included: discontinuous epithelial BM straining for laminin-1 (alpha 1 beta 1 gamma 1), entactin/nidogen and fibronectin; accumulation of fibronectin and alpha 1-alpha 2 type IV collagen on the endothelial face of the Descemet's membrane; and ab...

Journal of refractive surgery (Thorofare, N.J. : 1995)

Patients with corneal shape abnormalities should be identified prior to photorefractive keratecto... more Patients with corneal shape abnormalities should be identified prior to photorefractive keratectomy (PRK). We used videokeratography screening to detect subclinical corneal abnormalities, including keratoconus, which might have been missed by conventional clinical evaluation. One hundred forty-six apparently normal myopic eyes (-1.00 to -7.00 diopters [D] with less than 1.50 D of cylinder) of 91 consecutive patients who were candidates for PRK were screened by videokeratography. In 6 of 91 patients (7 of 146 eyes), unsuspected corneal shape abnormalities were detected by videokeratography. Two patients had definite keratoconus and three were classified as keratoconus suspects by inferior corneal steepening (Rabinowitz I-S index ranging from 1.62 to 6.20 D). One patient had early pellucid marginal degeneration. Keratoconus suspects and contact lens-induced changes resembling keratoconus are present in the "normal" myopic population that presents for refractive surgery. Vide...

Journal of refractive and corneal surgery

Excimer laser (VISX) photorefractive keratectomy was performed using nitrogen flowing through the... more Excimer laser (VISX) photorefractive keratectomy was performed using nitrogen flowing through the ocular fixation ring. It was felt that eliminating nitrogen flow may provide faster early visual rehabilitation. Two groups of 50 consecutive eyes underwent photorefractive keratectomy with (N2 flow) and without (no N2 flow) nitrogen flow, and were evaluated at 1 month postoperatively. There were more under- or overcorrections exceeding 1.00 diopter (D) in the N2 flow than in the no N2 flow groups. Eighteen eyes in the N2 flow and 11 in no N2 flow groups saw 20/50 or less, without correction. Fourteen eyes in the N2 flow and nine eyes in the no N2 flow groups lost two or more lines of best spectacle-corrected visual acuity. Four eyes in the N2 flow and none in the no N2 flow groups increased more than 1.00 D of astigmatism. The elimination of nitrogen flow in photorefractive keratectomy performed with the VISX laser appears to improve visual results in the early postoperative period.

Ophthalmic surgery, 1982

A study was carried out to evaluate effects of various sources of variation on the accuracy and r... more A study was carried out to evaluate effects of various sources of variation on the accuracy and reproducibility of the modified artificial chamber in obtaining lamellar sections from rabbit cornea. Sources of variation included a) measurement error, inter-cornea and inter-session variation, b) length of storage time M-K medium, and c) choice of preselected values of thickness and diameter. The findings indicated tha a) measurement error, inter-cornea, and inter-session variations were of nominal magnitude; b) the length of storage time up to 10 days did not effect the precision of the procedure; c) the precision of diameter determinations did not depend on the preselected value of the diameter; d) the precision of thickness determinations did depend on preselected parameter values; and e) parameter values tended to be underestimated. Regression equations therefore are provided to adjust for the underestimation of thickness and diameter. Based on these findings, it was concluded that...

American journal of ophthalmology, 1980

We devised a modified artificial anterior chamber that enables Barraquer microkeratome keratectom... more We devised a modified artificial anterior chamber that enables Barraquer microkeratome keratectomies on corneas preserved in McCarey-Kaufman medium. It consists of a hydraulic system, which creates a positive pressure of 60 mm Hg or more. An added rotating ring serves as a base to the microkeratome's tracks and varying diameters of lamellar sections can be obtained. This device allows the surgeon to use readily available corneas with scleral rims preserved in McCarey-Kaufman medium rather than whole eyes to obtain precise lamellar sections.

The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc

Ophthalmic surgery, 1983

A modified method of prelathing lyophilized corneal tissue at room temperature for refractive ker... more A modified method of prelathing lyophilized corneal tissue at room temperature for refractive keratoplasty is described. This method allows perfect centration of a lyophilized corneal button on the plastic base and thus more accurate lathing. Keratophakia was performed with lenticules prepared in this fashion on a series of eight cats which were followed for 30 weeks postoperatively. All lenticules were clear ten weeks following surgery and the final optical correction obtained varied +/- 2.5 D from the intended correction.

The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc, 1991

We studied Saturn II contact lenses in keratoconus patients who were intolerant to other availabl... more We studied Saturn II contact lenses in keratoconus patients who were intolerant to other available contact lenses. A total of 24 patients, who were followed for up to 15 months, participated in the study. Visual acuities improved significantly following fitting with the Saturn II contact lens; whereas only one eye in the series was correctable to 20/20 before fitting, eight eyes were corrected to 20/20 following fitting. A great number of lenses had to be replaced during the study because of deposit formation and tearing at the interface (rate of replacement: 0.52 lenses per eye per month). A variety of complications occurred during lens wear, resulting in only six eyes wearing the Saturn II lens at the close of the study (out of 46 eyes that had started wearing the lens). Discomfort due to tightness of the peripheral segment was the most common cause of lens discontinuation. We conclude that the Saturn II lens was inadequate for fitting patients with advanced keratoconus.

The Western journal of medicine, 1988

Ophthalmology, 1984

ABSTRACT Six eyes of four patients with Thygeson's superficial punctate keratitis were tr... more ABSTRACT Six eyes of four patients with Thygeson's superficial punctate keratitis were treated with trifluridine 1% drops. Five of the six treated eyes responded favorably to topical trifluridine therapy. Symptoms and later the signs of the disease disappeared, but more slowly than observed following topical corticosteroid therapy. One patient with an 11-year history of topical corticosteroid dependence for clearing of lesions was treated successfully with trifluridine, and his eyes have remained clear for over one year without therapy. Mild irritation and transient limbal follicle formation were the only recognized side effects. Trifluridine is thus an effective and safe alternative to corticosteroids in the treatment of this condition and may offer a means of treating the steroid-dependent patient.

Investigative Ophthalmology & Visual Science, 2007

To assess the relative impact of antibodies specific for HSV-1 glycoproteins on eye disease in re... more To assess the relative impact of antibodies specific for HSV-1 glycoproteins on eye disease in response to HSV-1 infection, the composition of antibodies specific for 10 of the viral glycoproteins, and the effect of anti-glycoprotein (g)D and anti-gK antibodies on antibody-dependent enhancement (ADE). In a prospective case-control study, sera from patients with a history of herpes stromal keratitis (HSK) were compared with sera from nonocular HSV-1-seropositive and HSV-seronegative control subjects. HSV-1 neutralizing antibody titer and type-specific IgG and IgM were measured. In addition, the presence of anti-HSV-1 gD and gK antibodies in the sera of all patients also was determined by ELISA using gD and gK antigens. Finally, the role of anti-gD- and gK-specific antibodies to ADE was investigated. Average neutralizing antibody titers and levels of HSV-1 IgG were similar between HSK- and non-HSK-seropositive patients. However, the contribution of gD to the neutralizing antibody titer in HSK sera was significantly lower than that in non-HSK-seropositive patients, despite higher anti-gD ELISA titers. Overall, sera from patients with HSK had higher anti-gK antibody titers and induced ADE in vitro compared with non-HSK or seronegative sera. The ADE response in HSK sera was attributed to anti-gK antibody. These results suggest that sera from HSK patients had higher anti-gD and -gK antibody titers than sera from seropositive patients who had no history of HSK despite similar levels of neutralizing antibody titers and HSV-1 IgG, that HSK sera induced ADE whereas sera from non-HSK patients did not induce ADE, and that anti-gD antibody in sera of HSK patients contributed less to the HSV-1 neutralization antibody titer than did sera from non-HSK patients.

International Ophthalmology Clinics, 1981

Cornea, 1985

A multifocal progressive infiltration of a corneal graft, which simulated a mycotic keratitis but... more A multifocal progressive infiltration of a corneal graft, which simulated a mycotic keratitis but was repeatedly negative on culture and unresponsive to antibacterial and antifungal therapy, was found upon regrafting to consist primarily of Gram-positive cocci. This bacterial colonization of the corneal graft was associated with epithelialized suture tracks and minimal inflammatory response. The immunosuppressive and bacteriostatic effects of chronic postsurgery low dose steroid and antimicrobial therapy may have played a role in the development of this atypical bacterial infiltrate.

Cornea, 1986

... Cornea: Editorial: PDF Only. Extraction of Soluble Proteins Reduces Rejection in Rabbit Porci... more ... Cornea: Editorial: PDF Only. Extraction of Soluble Proteins Reduces Rejection in Rabbit Porcine Corneal Xenografts. Maguen, Ezra; Isitt, John; Pinhas, Simon; Nesburn, Anthony B. Collapse Box Abstract. Lathed lyophilized porcine ...

Archives of Ophthalmology, 1982

ABSTRACT A method of prelathing lyophilized corneal tissue at room temperature for refractive ker... more ABSTRACT A method of prelathing lyophilized corneal tissue at room temperature for refractive keratoplasty is described. A solution was developed that preserves corneal transparency and allows adhesion of corneal tissue to modified plastic bases during lyophilization and lathing. Intracorneal implantation and keratophakia with lyophilized corneal tissue in two series of cats were performed. Transparent grafts and technically satisfactory results were obtained. This procedure could greatly simplify and render more accurate refractive keratoplasty procedures requiring lathed donor corneas.

Acta Ophthalmologica, 2009

Six subjects who never wore contact lenses underwent six determinations of corneal cell density u... more Six subjects who never wore contact lenses underwent six determinations of corneal cell density using each of two measurement modes: Mode A: the eye was applanated once and pairs of photographs were taken; Mode B: the eye was applanated and a single photograph was taken. For each measurement mode data were collected on two separate sessions (Test, Retest). Chi-square analyses revealed a significantly larger proportion of uncountable photographs from the first measurement session, and analysis of variance revealed that Mode A was less reliable than Mode B upon retesting. It was concluded that Mode B was the preferred measurement mode, and that many more than six determinations be made on the initial session in order to obtain six readable photographs. Finally, estimates of inter and intra-session variation, intra-pair variation, and inter and intra-observer variation are given.

The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc

ABSTRACT A three-year study was conducted to establish whether Polycon® contact lenses can be use... more ABSTRACT A three-year study was conducted to establish whether Polycon® contact lenses can be used as a long-term means of optically correcting keratoconus in patients in whom PMMA and CAB lenses have failed. Twelve (21 eyes) out of 17 patients (31 eyes) were available for evaluation after the third year of the study. The average length of wear was 33.25 months (range 27-41 months) and visual acuity was 20/40 or better in 81.8% of the eyes and 20/50 to 20/80 in the remaining eyes. Additional data is supplied, including hours of daily wear, corneal edema staining, and touch. The Polycon lens may serve as a long-term means of optically correcting keratoconus.

Ophthalmic surgery, 1984

A new technique which allows the use of a guarded trephine in penetrating keratoplasty for cornea... more A new technique which allows the use of a guarded trephine in penetrating keratoplasty for corneal perforation is described. It involves the combined use of cyanoacrylate adhesive and sodium hyaluronate and allows a normotensive eye to be obtained prior to trephination. Five cases in which this technique was used are described. A better tectonic result can be obtained and visual rehabilitation may be more readily achieved without performing a secondary procedure.

Investigative ophthalmology & visual science, 1979

Four subjects who had never worn contact lenses underwent measurement of their corneal thickness ... more Four subjects who had never worn contact lenses underwent measurement of their corneal thickness by each of three measurement methods: Haag-Streit pachometer with/and without Mishima-Hedby attachment and the Syber specular microscope. Data were collected on three separate sessions, and at each session triplicate measurement trials were made for each method. The resulting 108 measurements were analyzed statistically. Significant differences were found among the measurement methods. Two of the methods were found to be consistent from session to session. In addition, the specular microscope was found to be the most precise method within a session. It was concluded that the specular microscope, which highly trained technicians can utilize to make the measurements, offers a valuable alternative to the measurement of corneal thickness in long-term prospective studies.

Cornea, 1997

To report the association of keratoconus and Turner's syndrome in three patients and to r... more To report the association of keratoconus and Turner's syndrome in three patients and to review the ophthalmic manifestations of Turner's syndrome. Three patients with keratoconus and Turner's syndrome were identified and reported in a retrospective review. These three cases represent the first series of patients with keratoconus and Turner's syndrome. All three patients underwent penetrating keratoplasty with good visual rehabilitation. None of the patients had other ocular features associated with Turner's syndrome. Turner's syndrome is commonly associated with ocular problems. In this series we identify an association of keratoconus with Turner's syndrome. Clearly, a careful ocular examination in this condition with attention to ocular features of Turner's syndrome is important.

Investigative ophthalmology & visual science, 1996

To uncover abnormalities of extracellular matrix (ECM) distribution in human corneas with pseudop... more To uncover abnormalities of extracellular matrix (ECM) distribution in human corneas with pseudophakic and aphakic bullous keratopathy (PBK/ABK). Indirect immunofluorescence with antibodies to 27 ECM components was used on frozen sections of 14 normal and 20 PBK/ABK corneas. Fibrillar deposits of an antiadhesive glycoprotein tenascin in the anterior and posterior stroma, epithelial basement membrane (BM), bullae and subepithelial fibrosis (SEF) areas, and posterior collagenous layer (PCL) were revealed in disease corneas. Tenascin in midstroma, which was observed in some cases, correlated with decreased visual acuity. In normal central corneas, tenascin was never found. Other major ECM abnormalities in PBK/ABK corneas compared to normals included: discontinuous epithelial BM straining for laminin-1 (alpha 1 beta 1 gamma 1), entactin/nidogen and fibronectin; accumulation of fibronectin and alpha 1-alpha 2 type IV collagen on the endothelial face of the Descemet's membrane; and ab...

Journal of refractive surgery (Thorofare, N.J. : 1995)

Patients with corneal shape abnormalities should be identified prior to photorefractive keratecto... more Patients with corneal shape abnormalities should be identified prior to photorefractive keratectomy (PRK). We used videokeratography screening to detect subclinical corneal abnormalities, including keratoconus, which might have been missed by conventional clinical evaluation. One hundred forty-six apparently normal myopic eyes (-1.00 to -7.00 diopters [D] with less than 1.50 D of cylinder) of 91 consecutive patients who were candidates for PRK were screened by videokeratography. In 6 of 91 patients (7 of 146 eyes), unsuspected corneal shape abnormalities were detected by videokeratography. Two patients had definite keratoconus and three were classified as keratoconus suspects by inferior corneal steepening (Rabinowitz I-S index ranging from 1.62 to 6.20 D). One patient had early pellucid marginal degeneration. Keratoconus suspects and contact lens-induced changes resembling keratoconus are present in the "normal" myopic population that presents for refractive surgery. Vide...

Journal of refractive and corneal surgery

Excimer laser (VISX) photorefractive keratectomy was performed using nitrogen flowing through the... more Excimer laser (VISX) photorefractive keratectomy was performed using nitrogen flowing through the ocular fixation ring. It was felt that eliminating nitrogen flow may provide faster early visual rehabilitation. Two groups of 50 consecutive eyes underwent photorefractive keratectomy with (N2 flow) and without (no N2 flow) nitrogen flow, and were evaluated at 1 month postoperatively. There were more under- or overcorrections exceeding 1.00 diopter (D) in the N2 flow than in the no N2 flow groups. Eighteen eyes in the N2 flow and 11 in no N2 flow groups saw 20/50 or less, without correction. Fourteen eyes in the N2 flow and nine eyes in the no N2 flow groups lost two or more lines of best spectacle-corrected visual acuity. Four eyes in the N2 flow and none in the no N2 flow groups increased more than 1.00 D of astigmatism. The elimination of nitrogen flow in photorefractive keratectomy performed with the VISX laser appears to improve visual results in the early postoperative period.

Ophthalmic surgery, 1982

A study was carried out to evaluate effects of various sources of variation on the accuracy and r... more A study was carried out to evaluate effects of various sources of variation on the accuracy and reproducibility of the modified artificial chamber in obtaining lamellar sections from rabbit cornea. Sources of variation included a) measurement error, inter-cornea and inter-session variation, b) length of storage time M-K medium, and c) choice of preselected values of thickness and diameter. The findings indicated tha a) measurement error, inter-cornea, and inter-session variations were of nominal magnitude; b) the length of storage time up to 10 days did not effect the precision of the procedure; c) the precision of diameter determinations did not depend on the preselected value of the diameter; d) the precision of thickness determinations did depend on preselected parameter values; and e) parameter values tended to be underestimated. Regression equations therefore are provided to adjust for the underestimation of thickness and diameter. Based on these findings, it was concluded that...

American journal of ophthalmology, 1980

We devised a modified artificial anterior chamber that enables Barraquer microkeratome keratectom... more We devised a modified artificial anterior chamber that enables Barraquer microkeratome keratectomies on corneas preserved in McCarey-Kaufman medium. It consists of a hydraulic system, which creates a positive pressure of 60 mm Hg or more. An added rotating ring serves as a base to the microkeratome's tracks and varying diameters of lamellar sections can be obtained. This device allows the surgeon to use readily available corneas with scleral rims preserved in McCarey-Kaufman medium rather than whole eyes to obtain precise lamellar sections.

The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc

Ophthalmic surgery, 1983

A modified method of prelathing lyophilized corneal tissue at room temperature for refractive ker... more A modified method of prelathing lyophilized corneal tissue at room temperature for refractive keratoplasty is described. This method allows perfect centration of a lyophilized corneal button on the plastic base and thus more accurate lathing. Keratophakia was performed with lenticules prepared in this fashion on a series of eight cats which were followed for 30 weeks postoperatively. All lenticules were clear ten weeks following surgery and the final optical correction obtained varied +/- 2.5 D from the intended correction.

The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc, 1991

We studied Saturn II contact lenses in keratoconus patients who were intolerant to other availabl... more We studied Saturn II contact lenses in keratoconus patients who were intolerant to other available contact lenses. A total of 24 patients, who were followed for up to 15 months, participated in the study. Visual acuities improved significantly following fitting with the Saturn II contact lens; whereas only one eye in the series was correctable to 20/20 before fitting, eight eyes were corrected to 20/20 following fitting. A great number of lenses had to be replaced during the study because of deposit formation and tearing at the interface (rate of replacement: 0.52 lenses per eye per month). A variety of complications occurred during lens wear, resulting in only six eyes wearing the Saturn II lens at the close of the study (out of 46 eyes that had started wearing the lens). Discomfort due to tightness of the peripheral segment was the most common cause of lens discontinuation. We conclude that the Saturn II lens was inadequate for fitting patients with advanced keratoconus.