E. Padlan - Academia.edu (original) (raw)

Papers by E. Padlan

Research paper thumbnail of The B-cell binding site on human immunoglobulin E

Research paper thumbnail of Grafting of "Abbreviated" Complementarity-Determining Regions Containing Specificity-Determining Residues Essential for Ligand Contact to Engineer a Less Immunogenic Humanized Monoclonal Antibody

The Journal of Immunology, 2002

Research paper thumbnail of Development of More Efficacious Antibodies for Medical Therapy and Diagnosis

Progress in Nucleic Acid Research and Molecular Biology, 1998

Two procedures for improving the efficacy of medically important antibodies are described. The fi... more Two procedures for improving the efficacy of medically important antibodies are described. The first procedure is designed to reduce the immunogenicity of nonhuman antibodies to the barest minimum--the "humanization" is accomplished by transplanting only the specificity-determining residues of the nonhuman antibody onto a human antibody template. The second procedure is designed to permit the easy production of multispecific/multivalent antibodies via heterodimer formation of electrostatically complementary Fc regions.

Research paper thumbnail of The B-cell binding site on human immunoglobulin E

Research paper thumbnail of Grafting of "Abbreviated" Complementarity-Determining Regions Containing Specificity-Determining Residues Essential for Ligand Contact to Engineer a Less Immunogenic Humanized Monoclonal Antibody

The Journal of Immunology, 2002

Research paper thumbnail of Development of More Efficacious Antibodies for Medical Therapy and Diagnosis

Progress in Nucleic Acid Research and Molecular Biology, 1998

Two procedures for improving the efficacy of medically important antibodies are described. The fi... more Two procedures for improving the efficacy of medically important antibodies are described. The first procedure is designed to reduce the immunogenicity of nonhuman antibodies to the barest minimum--the "humanization" is accomplished by transplanting only the specificity-determining residues of the nonhuman antibody onto a human antibody template. The second procedure is designed to permit the easy production of multispecific/multivalent antibodies via heterodimer formation of electrostatically complementary Fc regions.