Grafting of "Abbreviated" Complementarity-Determining Regions Containing Specificity-Determining Residues Essential for Ligand Contact to Engineer a Less Immunogenic Humanized Monoclonal Antibody (original) (raw)

Humanisation and characterisation of PR1A3, a monoclonal antibody specific for cell-bound carcinoembryonic antigen

Susan Young

Cancer Immunology, Immunotherapy, 1999

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Tumor localization of CEA-containing human tumors in nude mice by means of monoclonal anti-CEA antibodies

Sten Hammarström

International Journal of Cancer, 1982

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Comprehensive screening for antigens overexpressed on carcinomas via isolation of human mAbs that may be therapeutic

Hiroyuki Tsuda

Proceedings of the National Academy of Sciences, 2008

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Monoclonal antibody CIBCHTB1 defining an epitope on carcinoembryonic antigen (CEA)

SHUNMUGA KUMAR

Human Antibodies, 2000

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Evaluation of a complementarity-determining region-grafted (humanized) anti-carcinoembryonic antigen monoclonal antibody in preclinical and clinical studies

Malik Juweid

Cancer Research, 1995

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Potent Control of Tumor Growth by CEA/CD3-bispecific Single-chain Antibody Constructs That Are Not Competitively Inhibited by Soluble CEA

Susanne Mangold

Journal of Immunotherapy, 2009

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Human carcinoembryonic antigen cDNA expressed in rat carcinoma cells can function as target antigen for tumor localization of antibodies in nude rats and as rejection antigen in syngeneic rats

André Pèlegrin, Yves Chalandon

International Journal of Cancer, 1992

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Specificity and affinity of monoclonal antibodies against Carcinoembryonic antigen

Marius Nap

Cancer Research

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Cloning, isolation and characterization of human tumor in situ monoclonal antibodies

Jeffry Watkins

Cancer Immunol Immunother, 2002

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A multivalent recombinant antibody fragment specific for carcinoembryonic antigen

Lourdes Roque

Biotechnology and Applied Biochemistry, 2006

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Specificities and binding properties of eight monoclonal antibodies against carcinoembryonic antigen

Sten Hammarström

Molecular Immunology, 1982

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Serologic mapping and biochemical characterization of the carcinoembryonic antigen epitopes using fourteen distinct monoclonal antibodies

Fiorella Guadagni

International Journal of Cancer, 1989

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Generation of a recombinant mouse-human chimaeric monoclonal antibody directed against human carcinoembryonic antigen

Lee Gill

International Journal of Cancer, 1989

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Tumor-associated antigens recognized by human monoclonal antibodies

Helena Chang

Annals of Surgical Oncology, 1994

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Specificity and Affinity of Monoclonal Antibodies against Carcinoembryonic Antigen1

Marius Nap, Abraham Fuks

2000

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Immunohistochemical localization and molecular characteristics of three monoclonal antibody-defined epitopes detectable on carcinoembryonic antigen (CEA)

Klaus Kayser

International Journal of Cancer, 1985

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Application of Genetically-Engineered Anti-CEA Antibodies for Potential Immunotherapy of Colorectal Cancer

Gerd Pluschke

The International Journal of Biological Markers, 1992

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Complementation of anti-CEA and anti-TAG-72 monoclonal antibodies in reactivity to human gastric adenocarcinomas

David Colcher

International Journal of Cancer, 1987

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Practical applications of monoclonal antibodies against carcinoembryonic antigen (CEA)

Roberto Accolla

1981

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Effective production of carcinoembryonic antigen by conversion of the membrane-bound into a recombinant secretory protein by site-specific mutagenesis

abbas pakdel

Pathology & Oncology Research, 2005

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The structure, metabolism and function of the carcinoembryonic antigen gene family

Kuldeep Saini

Biochimica Et Biophysica Acta-reviews on Cancer, 1990

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Experimental Pretargeting Studies of Cancer with a Humanized anti-CEA × Murine anti-[In-DTPA] Bispecific Antibody Construct and a 99m Tc-/ 188 Re-Labeled Peptide

Jacques Barbet

Bioconjugate Chemistry, 2000

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Anti-idiotypic monoclonal antibody AB3, reacting with the primary antigen (CEA), can localize in human colon-carcinoma xenografts as efficiently as AB1

Jane de Moraes

International Journal of Cancer, 1994

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The potential for enhanced tumour localisation by poly(ethylene glycol) modification of anti-CEA antibody

adrian haines

British journal of cancer, 1994

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Purification and Analysis of an 80-kDa Carcinoembryonic Antigen-Binding Protein from Kupffer Cells

Peter Thomas

Archives of Biochemistry and Biophysics, 1996

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Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein

Fiorella Petronzelli

BMC Cancer, 2006

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Purification of the Carcinoembryonic Antigen (CEA) with Immunoadsorbents

Matti Vuento

Scandinavian Journal of Immunology, 1976

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Characterization of a mouse-human chimeric antibody to a cancer-associated antigen

Augusto Barbera

International Journal of Cancer, 1992

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Monoclonal antibodies for the therapy of cancer

Andrew Simpson

BMC Proceedings, 2014

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Zhou H, Stanners CP, Fuks A.. Specificity of anti-carcinoembryonic antigen monoclonal antibodies and their effects on CEA-mediated adhesion. Cancer Res 53: 3817-3822

Abraham Fuks

Cancer Research

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Epitope specificity and cross-reactivity pattern of a large series of monoclonal antibodies to carcinoembryonic antigen

Fairouz Zoubir

Molecular Immunology, 1986

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