Edoardo De Benedetti - Academia.edu (original) (raw)
Papers by Edoardo De Benedetti
New England Journal of Medicine, 2000
Revue Medicale Suisse, Nov 16, 2011
The role of the sympathetic nervous system (SNS) in the control of blood pressure and the occurre... more The role of the sympathetic nervous system (SNS) in the control of blood pressure and the occurrence of hypertension has been established both in animal models and in clinical practice. Patients resistant to treatment are common in clinical practice and require a new approach to optimize blood pressure control. The development of a catheter-based technique to denervate the kidneys for the treatment of high blood pressure was introduced recently. The concept was based on old data of surgical renal denervation which was effective but associated with important morbidity. Recent data shows that catheter-based renal denervation is feasible and safe in humans and preliminary clinical studies are very promising. These data need confirmation in larger randomised controlled trials with longer-term follow-up.
Revue médicale suisse, Jan 14, 2007
The use of drug-eluting stents has brought considerable change to the treatment of coronary arter... more The use of drug-eluting stents has brought considerable change to the treatment of coronary artery disease. However, recent reports have suggested that they may be associated with an increase risk of late thrombosis. A current analysis of the available data suggests that the risk of late thrombosis is indeed probably higher with drug-eluting stents than with bare metal stents. However, this risk appears low, and does not justify withholding the device from the patients who would benefit from their use, especially when they suffer from complex disease (long lesions, small vessels, diabetes, etc) with a known higher risk of recurrent stenosis. Based on the information available to us today, appropriate patient selection, meticulous implantation technique and uninterrupted dual antiplatelet therapy (aspirin and clopidogrel) for six to twelve months after angioplasty appear to be the main ingredients for a successful and uncomplicated procedure.
Thrombosis Research, 1992
Abnormalities in local coagulation may explain alveolar fibrin deposition which often accompanies... more Abnormalities in local coagulation may explain alveolar fibrin deposition which often accompanies human lung injuries. The purpose of this study was to investigate the generation of procoagulant activity (PCA) and tissue factor pathway inhibitor (TFPI) in selected bronchoalveolar lavage fluids (BAL) from controls (n = 7) and from patients with interstitial lung diseases (n = 9), Pneumocystis carinii (PCP) pneumonia (n = 11) and bacterial pneumonia (n = 8). As compared with controls a significant increase of PCA was observed in the three groups with lung diseases. PCA in BAL from patients with untreated interstitial lung diseases (PC Units mean of 162 +/- 48) was significantly higher than PCA of treated patients (PC Units 36 +/- 10; p less than 0.05). Increases of PCA paralleled protein levels in BAL and the protein/albumin ratios were comparable in the four groups. TFPI was significantly increased in PCP (p less than 0.02) and bacterial pneumonia (p less than 0.03), but only marginally increased in interstitial lung diseases when compared with controls. No correlation was found between TFPI and PCA in any of the four groups. These data indicate that increased procoagulant activity observed in various lung diseases is not counterbalanced by TFPI.
The Lancet, 2007
We declare that we have no confl ict of interest.
Coronary Artery Disease, 2000
Wall shear stress (WSS) is closely associated with arteriosclerosis. WSS values for various vesse... more Wall shear stress (WSS) is closely associated with arteriosclerosis. WSS values for various vessels and species are available, but fully in-vivo measurements in human coronary arteries have not yet been reported. To measure WSS in undiseased coronary arteries of adult patients at rest. We recorded the temporal average value (APV) of the instantaneous maximal blood velocity in the three vessel segments of angiographically normal coronary artery bifurcations in 21 patients undergoing cardiac catheterization to treat various diseases by means of a 0.036 cm Doppler wire (FloWire). In total, 36 bifurcations were examined. The 36 x 3 cross-sectional areas (CSA) were determined by means of a three-dimensional angiographic technique. The three flows, Q1 (inflow), Q2, and Q3 of each bifurcation were calculated according to Q=0.5 x APV x CSA. For each segment, WSS was calculated as WSS=32 eta Q/(pi D3) (where blood viscosity eta=3.5 mPa s and D is vessel diameter). Only the 54 WSS values obtained from the 18 flow triplets which satisfied the equation Q1/(Q2+Q3)=1 better than did the 18 other ones were retained. The 54 WSS values ranged from 0.33 to 1.24 Pa (mean 0.68 Pa, SEM, 0.027 Pa). They did not depend significantly on Q (r=0.07; P=0.60) and the CSA (r=0.24, P=0.08) but the second relationship approached significance. The obtained mean WSS value (0.68 Pa) is half the value predicted for coronary arteries from optimality principles. It is also smaller than many values reported for human carotid, renal, and femoral arteries.
Leukemia Lymphoma, 2007
The genomic profile of mantle cell lymphoma (MCL) has been reported to be significantly different... more The genomic profile of mantle cell lymphoma (MCL) has been reported to be significantly different from that of other indolent lymphoproliferative disorders, Topoisomerase IIα, glutathione-s-transferaseπ (GSTπ) and ABCG2 (BCRP) chemoresistance genes being ...
Background-Intimal hyperplasia is the principal mechanism of in-stent restenosis. Matrix metallop... more Background-Intimal hyperplasia is the principal mechanism of in-stent restenosis. Matrix metalloproteinases (MMPs) play a key role in intimal growth after balloon angioplasty (BA). Little is known, however, about MMP expression after stent implantation (ST). We investigated whether MMP9 and MMP2 are differentially expressed after ST and BA. Methods and Results-Hypercholesterolemic rabbits underwent ST and BA in the right and left iliac arteries, respectively.
The Journal of Invasive Cardiology, 2003
At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Neverth... more At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Nevertheless, edge restenosis often related to geographical miss has been identified as a major limitation of the technique. The non-slippery cutting balloon has the potential to limit vascular barotraumas, which, together with low-dose irradiation at both ends of the radioactive source, are the prerequisite for geographical miss. This prospective study aimed to examine the efficacy of combining cutting balloon angioplasty and brachytherapy for in-stent restenosis. The Radiation in Europe NOvoste (RENO) registry prospectively tracked all patients who had been treated by coronary ß-radiation with the Beta-Cath ™ System (Novoste Corporation, Brussels, Belgium) but were not included in a randomized radiation trial. A subgroup of patients with in-stent restenosis treated by cutting balloon angioplasty and coronary ß-radiation (group 1, n = 166) was prospectively defined, and clinical outcomes of patients at 6 months were compared with those of patients treated by conventional angioplasty and coronary ß-radiation (group 2, n = 712). At 6-month follow-up, there was a significant difference between groups 1 and 2 in target vessel revascularization (10.2% versus 16.6% respectively; p = 0.04) and in the incidence of major adverse clinical events (MACE) including death, myocardial infarction, and revascularization (10.8% versus 19.2%; p = 0.01). This observation was confirmed by a multivariate analysis indicating a lower risk for MACE at 6 months (odds ratio: 0.49; confidence intervals: 0.27-0.88; p = 0.02). Compared to conventional angioplasty, cutting balloon angioplasty prior to coronary beta-radiation with the Beta-Cath ™ System seems to improve the 6-month clinical outcome in patients with instent restenosis. J INVAS CARDIOL 2003;15:5xx-5xx
International Surgery, 1998
MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of ... more MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis. A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis. He was successfully transplanted.
The Journal of invasive cardiology, 2003
At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Neverth... more At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Nevertheless, edge restenosis often related to geographical miss has been identified as a major limitation of the technique. The non-slippery cutting balloon has the potential to limit vascular barotraumas, which, together with low-dose irradiation at both ends of the radioactive source, are the prerequisite for geographical miss. This prospective study aimed to examine the efficacy of combining cutting balloon angioplasty and brachytherapy for in-stent restenosis. The Radiation in Europe NOvoste (RENO) registry prospectively tracked all patients who had been treated by coronary beta-radiation with the Beta-Cath System (Novoste Corporation, Brussels, Belgium) but were not included in a randomized radiation trial. A subgroup of patients with in-stent restenosis treated by cutting balloon angioplasty and coronary beta-radiation (group 1, n = 166) was prospectively defined, and clinical outcomes o...
Human hair has been examined by means of FT-IR microspectroscopy (FT-IR-M) using a high-pressure ... more Human hair has been examined by means of FT-IR microspectroscopy (FT-IR-M) using a high-pressure diamond cell. Microareas of the order of one hundred microns in diameter were analyzed, proceeding from bulb to shaft, for hairs in anagen, catagen, and telogen phases. The trends of the ratio values of integrated areas of the bands at 1080 and 1540 cm-• and at 1080 and 1238 cm-• in the three different phases showed remarkable differences in the bulb region near the root, probably due to a major DNA content with respect to proteinic components. Less evident spectral differences were observed in the suprabulbar region and in the shaft. The spectra of the shaft did not give rise to any spectral differences in the three hair phases. These findings offer a better insight into the structural changes of hairs submitted to exogenous and endogenous stresses.
The technique for the generation of ultrafast pulses of extreme-ultraviolet (XUV) radiation is pr... more The technique for the generation of ultrafast pulses of extreme-ultraviolet (XUV) radiation is presented here as a tool for time-resolved interaction of radiation in the single-photon ionization regime. The intrinsic synchronization of the XUV with an IR pulse fosters to devise its application in a pump-probe scheme in this very interesting spectral region.
Leukemia & Lymphoma, 2007
Swiss Medical Weekly, 2012
Origins of Life and Evolution of the Biosphere, 1996
New England Journal of Medicine, 2000
Revue Medicale Suisse, Nov 16, 2011
The role of the sympathetic nervous system (SNS) in the control of blood pressure and the occurre... more The role of the sympathetic nervous system (SNS) in the control of blood pressure and the occurrence of hypertension has been established both in animal models and in clinical practice. Patients resistant to treatment are common in clinical practice and require a new approach to optimize blood pressure control. The development of a catheter-based technique to denervate the kidneys for the treatment of high blood pressure was introduced recently. The concept was based on old data of surgical renal denervation which was effective but associated with important morbidity. Recent data shows that catheter-based renal denervation is feasible and safe in humans and preliminary clinical studies are very promising. These data need confirmation in larger randomised controlled trials with longer-term follow-up.
Revue médicale suisse, Jan 14, 2007
The use of drug-eluting stents has brought considerable change to the treatment of coronary arter... more The use of drug-eluting stents has brought considerable change to the treatment of coronary artery disease. However, recent reports have suggested that they may be associated with an increase risk of late thrombosis. A current analysis of the available data suggests that the risk of late thrombosis is indeed probably higher with drug-eluting stents than with bare metal stents. However, this risk appears low, and does not justify withholding the device from the patients who would benefit from their use, especially when they suffer from complex disease (long lesions, small vessels, diabetes, etc) with a known higher risk of recurrent stenosis. Based on the information available to us today, appropriate patient selection, meticulous implantation technique and uninterrupted dual antiplatelet therapy (aspirin and clopidogrel) for six to twelve months after angioplasty appear to be the main ingredients for a successful and uncomplicated procedure.
Thrombosis Research, 1992
Abnormalities in local coagulation may explain alveolar fibrin deposition which often accompanies... more Abnormalities in local coagulation may explain alveolar fibrin deposition which often accompanies human lung injuries. The purpose of this study was to investigate the generation of procoagulant activity (PCA) and tissue factor pathway inhibitor (TFPI) in selected bronchoalveolar lavage fluids (BAL) from controls (n = 7) and from patients with interstitial lung diseases (n = 9), Pneumocystis carinii (PCP) pneumonia (n = 11) and bacterial pneumonia (n = 8). As compared with controls a significant increase of PCA was observed in the three groups with lung diseases. PCA in BAL from patients with untreated interstitial lung diseases (PC Units mean of 162 +/- 48) was significantly higher than PCA of treated patients (PC Units 36 +/- 10; p less than 0.05). Increases of PCA paralleled protein levels in BAL and the protein/albumin ratios were comparable in the four groups. TFPI was significantly increased in PCP (p less than 0.02) and bacterial pneumonia (p less than 0.03), but only marginally increased in interstitial lung diseases when compared with controls. No correlation was found between TFPI and PCA in any of the four groups. These data indicate that increased procoagulant activity observed in various lung diseases is not counterbalanced by TFPI.
The Lancet, 2007
We declare that we have no confl ict of interest.
Coronary Artery Disease, 2000
Wall shear stress (WSS) is closely associated with arteriosclerosis. WSS values for various vesse... more Wall shear stress (WSS) is closely associated with arteriosclerosis. WSS values for various vessels and species are available, but fully in-vivo measurements in human coronary arteries have not yet been reported. To measure WSS in undiseased coronary arteries of adult patients at rest. We recorded the temporal average value (APV) of the instantaneous maximal blood velocity in the three vessel segments of angiographically normal coronary artery bifurcations in 21 patients undergoing cardiac catheterization to treat various diseases by means of a 0.036 cm Doppler wire (FloWire). In total, 36 bifurcations were examined. The 36 x 3 cross-sectional areas (CSA) were determined by means of a three-dimensional angiographic technique. The three flows, Q1 (inflow), Q2, and Q3 of each bifurcation were calculated according to Q=0.5 x APV x CSA. For each segment, WSS was calculated as WSS=32 eta Q/(pi D3) (where blood viscosity eta=3.5 mPa s and D is vessel diameter). Only the 54 WSS values obtained from the 18 flow triplets which satisfied the equation Q1/(Q2+Q3)=1 better than did the 18 other ones were retained. The 54 WSS values ranged from 0.33 to 1.24 Pa (mean 0.68 Pa, SEM, 0.027 Pa). They did not depend significantly on Q (r=0.07; P=0.60) and the CSA (r=0.24, P=0.08) but the second relationship approached significance. The obtained mean WSS value (0.68 Pa) is half the value predicted for coronary arteries from optimality principles. It is also smaller than many values reported for human carotid, renal, and femoral arteries.
Leukemia Lymphoma, 2007
The genomic profile of mantle cell lymphoma (MCL) has been reported to be significantly different... more The genomic profile of mantle cell lymphoma (MCL) has been reported to be significantly different from that of other indolent lymphoproliferative disorders, Topoisomerase IIα, glutathione-s-transferaseπ (GSTπ) and ABCG2 (BCRP) chemoresistance genes being ...
Background-Intimal hyperplasia is the principal mechanism of in-stent restenosis. Matrix metallop... more Background-Intimal hyperplasia is the principal mechanism of in-stent restenosis. Matrix metalloproteinases (MMPs) play a key role in intimal growth after balloon angioplasty (BA). Little is known, however, about MMP expression after stent implantation (ST). We investigated whether MMP9 and MMP2 are differentially expressed after ST and BA. Methods and Results-Hypercholesterolemic rabbits underwent ST and BA in the right and left iliac arteries, respectively.
The Journal of Invasive Cardiology, 2003
At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Neverth... more At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Nevertheless, edge restenosis often related to geographical miss has been identified as a major limitation of the technique. The non-slippery cutting balloon has the potential to limit vascular barotraumas, which, together with low-dose irradiation at both ends of the radioactive source, are the prerequisite for geographical miss. This prospective study aimed to examine the efficacy of combining cutting balloon angioplasty and brachytherapy for in-stent restenosis. The Radiation in Europe NOvoste (RENO) registry prospectively tracked all patients who had been treated by coronary ß-radiation with the Beta-Cath ™ System (Novoste Corporation, Brussels, Belgium) but were not included in a randomized radiation trial. A subgroup of patients with in-stent restenosis treated by cutting balloon angioplasty and coronary ß-radiation (group 1, n = 166) was prospectively defined, and clinical outcomes of patients at 6 months were compared with those of patients treated by conventional angioplasty and coronary ß-radiation (group 2, n = 712). At 6-month follow-up, there was a significant difference between groups 1 and 2 in target vessel revascularization (10.2% versus 16.6% respectively; p = 0.04) and in the incidence of major adverse clinical events (MACE) including death, myocardial infarction, and revascularization (10.8% versus 19.2%; p = 0.01). This observation was confirmed by a multivariate analysis indicating a lower risk for MACE at 6 months (odds ratio: 0.49; confidence intervals: 0.27-0.88; p = 0.02). Compared to conventional angioplasty, cutting balloon angioplasty prior to coronary beta-radiation with the Beta-Cath ™ System seems to improve the 6-month clinical outcome in patients with instent restenosis. J INVAS CARDIOL 2003;15:5xx-5xx
International Surgery, 1998
MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of ... more MTX-induced hepatic injury and liver enzyme elevations have been demonstrated after treatment of leukemia, gestational disease and during treatment of psoriasis and rheumatoid arthritis. A 40-year-old man with a long standing history of rheumatoid arthritis was treated with MTX over a 6 month period and developed an overwhelming hepatic necrosis. He was successfully transplanted.
The Journal of invasive cardiology, 2003
At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Neverth... more At present, vascular brachytherapy is the only efficient therapy for in-stent restenosis. Nevertheless, edge restenosis often related to geographical miss has been identified as a major limitation of the technique. The non-slippery cutting balloon has the potential to limit vascular barotraumas, which, together with low-dose irradiation at both ends of the radioactive source, are the prerequisite for geographical miss. This prospective study aimed to examine the efficacy of combining cutting balloon angioplasty and brachytherapy for in-stent restenosis. The Radiation in Europe NOvoste (RENO) registry prospectively tracked all patients who had been treated by coronary beta-radiation with the Beta-Cath System (Novoste Corporation, Brussels, Belgium) but were not included in a randomized radiation trial. A subgroup of patients with in-stent restenosis treated by cutting balloon angioplasty and coronary beta-radiation (group 1, n = 166) was prospectively defined, and clinical outcomes o...
Human hair has been examined by means of FT-IR microspectroscopy (FT-IR-M) using a high-pressure ... more Human hair has been examined by means of FT-IR microspectroscopy (FT-IR-M) using a high-pressure diamond cell. Microareas of the order of one hundred microns in diameter were analyzed, proceeding from bulb to shaft, for hairs in anagen, catagen, and telogen phases. The trends of the ratio values of integrated areas of the bands at 1080 and 1540 cm-• and at 1080 and 1238 cm-• in the three different phases showed remarkable differences in the bulb region near the root, probably due to a major DNA content with respect to proteinic components. Less evident spectral differences were observed in the suprabulbar region and in the shaft. The spectra of the shaft did not give rise to any spectral differences in the three hair phases. These findings offer a better insight into the structural changes of hairs submitted to exogenous and endogenous stresses.
The technique for the generation of ultrafast pulses of extreme-ultraviolet (XUV) radiation is pr... more The technique for the generation of ultrafast pulses of extreme-ultraviolet (XUV) radiation is presented here as a tool for time-resolved interaction of radiation in the single-photon ionization regime. The intrinsic synchronization of the XUV with an IR pulse fosters to devise its application in a pump-probe scheme in this very interesting spectral region.
Leukemia & Lymphoma, 2007
Swiss Medical Weekly, 2012
Origins of Life and Evolution of the Biosphere, 1996