Elçin Tören - Academia.edu (original) (raw)
Papers by Elçin Tören
This comprehensive review advances the field by analyzing recent developments in nanofiber-based ... more This comprehensive review advances the field by analyzing recent developments in nanofiber-based systems for acne treatment, focusing on encapsulated electrospun nanofibers. The study demonstrates how these nanofibers facilitate controlled release and targeted delivery, enhancing both efficacy and stability of active ingredients. This technology provides promising applications in the skincare and cosmetic industries by offering tailored, effective solutions to acne treatment, while addressing scalability, regulatory frameworks, and safety through in-depth analysis and future research recommendations for multifunctional and smart drug delivery systems.
This project aims to develop advanced nanocomposite materials for Chemical, Biological, Radiologi... more This project aims to develop advanced nanocomposite materials for Chemical, Biological, Radiological, and Nuclear (CBRN) defence applications by encapsulating conducting copolymers of polyaniline, polythiophene, and polyacetylene within polyamidoamine (PAMAM) dendrimers. The in-situ copolymerisation technique offers an efficient method for encapsulation, resulting in uniform distribution and enhanced stability, processability, and functionality of the conducting copolymers. These encapsulated copolymer nanocomposites have the potential to be utilised in a wide range of CBRN defence applications, including sensing, protective equipment, gas filtration, and decontamination. The successful completion of this project is expected to contribute significantly to the
development of novel materials and solutions for CBRN defence, revolutionising the industry and offering improved protection and detection capabilities.
Regenerative Medicine and Tissue Engineering are interdisciplinary fields that combine cell biolo... more Regenerative Medicine and Tissue Engineering are interdisciplinary fields that combine cell biology, material science, and bioengineering to develop therapies for tissue repair and regeneration. This field has made significant advances in recent years, particularly in the use of stem cells and biomaterials. Advancements in cell-based therapies have involved the use of cells to repair or replace damaged tissues and organs. Tissue engineering involves using scaffolds and growth factors to promote tissue regeneration. However, a major challenge in this field is the formation of adhesions, which can cause complications, such as intestinal obstruction and chronic pain. Adhesion barriers are used to prevent adhesion of tissues and organs during recovery, thereby reducing the risk of complications. Anti-adhesion materials, such as polysaccharides, proteins, and synthetic polymers, are used to create a physical barrier between tissues and prevent adhesion. These materials can be used alone or in combination, but their effectiveness varies.
This study investigates the efficacy of AHA-BHA infused nanofiber skin masks as a topical treatme... more This study investigates the efficacy of AHA-BHA infused nanofiber skin masks as a topical treatment for acne vulgaris. The skin is a vital organ that functions as a barrier to protect the body from external substances. In recent years, there has been a growing emphasis on skin treatment research. Hyaluronic acids (HAs) are commonly used in cosmetic and drug formulations to regulate excessive skin cornification, making them promising candidates for acne treatment. The introduction of HAs in dermatology has revolutionized the field of skin care, and they are used to treat various skin disorders, such as acne, ichthyosis, keratoses, warts, psoriasis, and photoaged skin. The antiaging benefits of HA have gained considerable attention in cosmetic dermatology, resulting in a surge in cosmetic products and skin care systems that contain HA. The study found that AHA-BHA-infused nanofiber skin masks are effective in treating acne vulgaris. The nanofiber masks were found to reduce inflammation, sebum production, and acne lesions. The study suggests that AHA-BHA-infused nanofiber skin masks could be a promising topical treatment for acne vulgaris.
Drug delivery systems, including liposomes, gels, prodrugs, and so forth, are used to enhance the... more Drug delivery systems, including liposomes, gels, prodrugs, and so forth, are used to enhance the tissue benefit of a pharmaceutical drug or conventional substance at a specific diseased site with little toxicological impact. Nanotechnology can be a rapidly developing multidisciplinary science that enables the production of polymers at the manometer scale for different medical applications. The use of biopolymers in drug delivery systems provides compatibility, biodegradability and low immunogenicity
This article discusses the use of nanotechnology in the development of transdermal delivery syste... more This article discusses the use of nanotechnology in the development of transdermal delivery systems for herbal extracts for dermatological therapeutics and skin care. Nanotechnology involves manipulating nanoscale materials to create nanoparticles that can penetrate the skin and deliver active ingredients more effectively. Natural products are commonly used in cosmetics because of their therapeutic properties and minimal side effects; however, the safety of nanoparticles in cosmetic products is a concern that requires further research. Chronic and nonhealing wounds pose a significant threat to patients' lives, and there is a pressing need for novel materials and approaches to wound healing. Nanomaterials exhibit unique physicochemical properties owing to their distinct structures, resulting in small size, surface, and macroscopic quantum tunnelling effects, making them ideal for use in wound dressings. Herbal transdermal patches offer advantages such as better patient tolerance, minimal side effects, renewable sources of medication, extensive availability, and costeffectiveness; however, they also have disadvantages such as slower growth in demand, testing difficulties, and limited availability. This article concludes that by following a regimen that includes both natural ingredients and over-the-counter treatments, consumers can improve their skin health and appearance.
This study investigated the potential of electrospun collagen/hyaluronic acid nanofibers for use ... more This study investigated the potential of electrospun collagen/hyaluronic acid nanofibers for use in biomedicine and skincare. Needleless electrospinning technology employed in the production process resulted in nanofibers with consistent fiber diameters and improved mechanical properties. The composite nanofibers demon
In this research, a novel drug delivery system shell was created by loading doxorubicin hydrochlo... more In this research, a novel drug delivery system shell was created by loading doxorubicin hydrochloride (DOX) into Pullulan and integrating the core into a polyvinyl alcohol (PVA) and Polydimethoxysilane (PDMS) composite matrix. The incorporation of DOX into the pullulan solution was carried out to take advantage of Pullulan's biocompatibility, biodegradability and hydrophilic nature. The hydrophilic nature of PVA can result in rapid drug release, while the hydrophobic nature of PDMS allows for slower drug release. The use of PVA-PDMS polymers together in the shell offers an initial rapid release followed by a prolonged and controlled drug release. This combination is superior to PVA or PDMS in terms of safety, mechanical strength, flexibility, controlled drug release and structural stability. This innovative composite system was designed to optimise DOX's controlled release to increase its therapeutic efficacy and reduce systemic toxicity. The kinetics of the drug release was characterised by an initial burst release followed by a sustained release phase, allowing controlled and prolonged release of the chemotherapeutic agent. Our results indicate that the pullulan/PVA-PDMS composite is a promising candidate for practical drug delivery applications, especially in cancer therapy.
This study investigated the development of Pullulan/Collagen nanofiber scaffolds integrated with ... more This study investigated the development of Pullulan/Collagen nanofiber scaffolds integrated with mesenchymal stem cells (MSCs) to enhance chronic wound healing. The combination of these biopolymers aims to optimize the scaffold properties for cell growth, viability, and tissue regeneration. Materials and Methods: Pullulan, Collagen, and Pullulan/Collagen composite nanofibers were fabricated using electrospinning. The fibers were characterized using scanning electron microscopy (SEM) to determine the fiber diameter, and Fourier-transform infrared spectroscopy (FTIR) was employed to assess the molecular interactions. Cell viability was evaluated using MSCs cultured on the scaffolds and apoptosis assays were conducted to assess cell health. Distilled water was used as the solvent to maximize biocompatibility. Results: SEM analysis revealed that Pullulan nanofibers exhibited a larger average diameter (274 ± 20 nm) compared to Collagen fibers (167.03 ± 40.04 nm), while the Pullulan/Collagen composite fibers averaged 280 ± 102 nm. FTIR confirmed the molecular interactions between Pullulan and Collagen. Regarding biocompatibility, the Pullulan/Collagen scaffold demonstrated superior cell viability at 99% compared to 91% for Pullulan alone. Apoptosis assays indicated significantly lower necrosis rates for the composite scaffold (1.29%) than for the Pullulan-only scaffolds (2.35%). Conclusion: Using distilled water as a solvent was critical in increasing cell viability and facilitating the healthy proliferation of MSCs without cellular damage. Additionally, the reduced platelet activation and macrophage activity (0.75-fold for both) further supported the biocompatibility of the Pullulan/Collagen scaffold, demonstrating its potential for tissue engineering and chronic wound healing applications.
This article presents a comprehensive overview of the utilisation of nanotechnology in the cosmet... more This article presents a comprehensive overview of the utilisation of nanotechnology in the cosmetics industry, with a specific focus on developing nanoparticles for the efficient delivery of active ingredients through skin penetration. The review delves into incorporating natural ingredients in cosmetics, exploring their therapeutic properties and the advantages and limitations associated with their use. Furthermore, the article examines the benefits of integrating natural ingredients into skincare products to enhance skin conditions, highlighting the application of nonfibrous technology in areas such as UV protection, anti-ageing effects, moisturisation improvement, and wound healing. Ultimately, the article emphasises the immense potential of nanotechnology to create innovative opportunities and positive societal impacts across various industries.
Nanotechnology has become an increasingly promising medical field, particularly scar removal. Sca... more Nanotechnology has become an increasingly promising medical field, particularly scar removal. Scar removal is a complex process involving regenerating damaged skin tissue, and nanotechnology presents unique solutions to this issue. One potential application of nanotechnology is using nanofibers as scaffolds to support the growth of new skin tissue. These fibres can also be loaded with drugs or growth factors to promote tissue regeneration and reduce scarring. Another potential application is nanocarriers for drug delivery to specific body areas, which can promote tissue regeneration and reduce scarring.Additionally, nanotechnology has been utilized to create new materials for skin regeneration, such as "nano skin" that mimics the structure of natural skin. Nanoprobes have also been developed for the detection of scar tissue and the monitoring of its progression. These potential nanotechnology applications offer exciting possibilities for the future of scar removal and skin...
Acne vulgaris is a prevalent skin condition that affects people of all ages and can have signific... more Acne vulgaris is a prevalent skin condition that affects people of all ages and can have significant physical and psychological impacts. Hydroxy acids, such as alpha-hydroxy acids (AHA) and beta-hydroxy acids (BHA), have demonstrated potential as effective ingredients for topical acne treatments due to their exfoliating and skin-rejuvenating properties. This study assessed the effectiveness of encapsulating AHA and BHA in pullulan-collagen nanofibers as a novel approach to acne treatment. The study involved preparing Pullulan and polyvinyl alcohol (PVA) solutions combined with sodium chloride (NaCl) to create a stable mixture. Collagen and Pullulan were then dissolved in deionized water and mixed to form a collagen-pullulan solution. Various weight ratios of Collagen to Pullulan were tested to optimize nanofiber formation. This research achieved electrospinning of nanofibers, confirmed by scanning electron microscopy (SEM) analysis, which revealed well-formed and continuous nanofibe...
Encapsulated nanofibers have emerged as a promising approach for the treatment of acne, owing to ... more Encapsulated nanofibers have emerged as a promising approach for the treatment of acne, owing to their ability to provide controlled release, targeted delivery, increased efficacy, and improved stability. Electrospinning is a well-established method for producing encapsulated nanofibers and has been shown to be effective for encapsulating various active ingredients. However, there are still several challenges that need to be addressed in the development of encapsulated nanofibers for acne treatment. One major challenge is the need for comprehensive in vitro and in vivo studies to evaluate the safety and efficacy of these treatments. The cost and scalability of production also need to be considered to make these treatments accessible and affordable for patients. In addition, the long-term stability of encapsulated active ingredients is another challenge in the development of encapsulated nanofibers for acne treatment. Regulatory frameworks need to be developed to ensure the safety an...
Encapsulated nanofibers have emerged as a promising approach for the treatment of acne, owing to ... more Encapsulated nanofibers have emerged as a promising approach for the treatment of acne, owing to their ability to provide controlled release, targeted delivery, increased efficacy, and improved stability. Electrospinning is a well-established method for producing encapsulated nanofibers and has been shown to be effective for encapsulating various active ingredients. However, there are still several challenges that need to be addressed in the development of encapsulated nanofibers for acne treatment. One major challenge is the need for comprehensive in vitro and in vivo studies to evaluate the safety and efficacy of these treatments. The cost and scalability of production also need to be considered to make these treatments accessible and affordable for patients. In addition, the long-term stability of encapsulated active ingredients is another challenge in the development of encapsulated nanofibers for acne treatment. Regulatory frameworks need to be developed to ensure the safety an...
PULLULAN/PVA/ DOXORUBICIN CORE-SHELL ELECTROSPUN NANOFIBERS DRUG DELIVERY SYSTEM FOR THE CHEMOTHERAPY AGAINST CANCER, 2022
Cancer is one of the foremost dangerous illnesses which has been encountered the human beings for... more Cancer is one of the foremost dangerous illnesses which has been encountered the human beings for the last several decades. In 2022, 1,918,030 new cancer cases and 609,360
OBTAINING ANTIBACTERIAL ECOLOGICAL NONOCELLULOSE FIBRE FROM ROSE PLANT, 2020
The aim of this study is to produce biodegradable, biocompatible and compatible ecological nano t... more The aim of this study is to produce biodegradable, biocompatible and compatible ecological nano textile materials used in medical applications.
PULLULAN/PVA NANOFIBER FOR FUNCTIONAL APPLICATIONS, 2021
The aim of this thesis is to use nanofibers obtained from pullulan polysaccharide in production f... more The aim of this thesis is to use nanofibers obtained from pullulan polysaccharide in production for functional use. Pullulan is a natural compound, and there may be recent interest in the use of natural polymers in medical applications, for example, as proteins in biotechnological materials, as well as biocompatibility.
Během relativně dlouhé lidské existence na Zemi prošel lidský druh dobou kamennou, železnou a tak... more Během relativně dlouhé lidské existence na Zemi prošel lidský druh dobou kamennou, železnou a také dobou bronzovou. Tato období vždy přinášela nové informace a materiály. Posledních několik desetiletí bylo označeno jako doba polymerních materiálů. Tyto materiály jsou široce používány v každodenním životě. V dnešní době je jasné, že technologie dochází k miniaturizaci a společnost nepochybně prochází procesem, který lze nazvat časem nanotechnologií, a tento vývoj také vytváří řadu potřeb.Nanotechnologie hraje důležitou roli v široké oblasti použití a zvyšování kvality života. Nabízí zdravější a bezpečnější život s výhodami, které přináší do oblasti medicíny. Čas, který se nad tím tráví, je pod kontrolou a je zajištěno, že práce bude poskytována s nejnižší ztrátou nákladů. Díky nanotechnologii se zvyšuje rychlost vývoje technologie a využívá se efektivněji. Efektivita technologie prospívá práci i času.Cílem této práce je použít nanovlákna získaná z pullulan polysacharidu ve výrobě pro...
This comprehensive review advances the field by analyzing recent developments in nanofiber-based ... more This comprehensive review advances the field by analyzing recent developments in nanofiber-based systems for acne treatment, focusing on encapsulated electrospun nanofibers. The study demonstrates how these nanofibers facilitate controlled release and targeted delivery, enhancing both efficacy and stability of active ingredients. This technology provides promising applications in the skincare and cosmetic industries by offering tailored, effective solutions to acne treatment, while addressing scalability, regulatory frameworks, and safety through in-depth analysis and future research recommendations for multifunctional and smart drug delivery systems.
This project aims to develop advanced nanocomposite materials for Chemical, Biological, Radiologi... more This project aims to develop advanced nanocomposite materials for Chemical, Biological, Radiological, and Nuclear (CBRN) defence applications by encapsulating conducting copolymers of polyaniline, polythiophene, and polyacetylene within polyamidoamine (PAMAM) dendrimers. The in-situ copolymerisation technique offers an efficient method for encapsulation, resulting in uniform distribution and enhanced stability, processability, and functionality of the conducting copolymers. These encapsulated copolymer nanocomposites have the potential to be utilised in a wide range of CBRN defence applications, including sensing, protective equipment, gas filtration, and decontamination. The successful completion of this project is expected to contribute significantly to the
development of novel materials and solutions for CBRN defence, revolutionising the industry and offering improved protection and detection capabilities.
Regenerative Medicine and Tissue Engineering are interdisciplinary fields that combine cell biolo... more Regenerative Medicine and Tissue Engineering are interdisciplinary fields that combine cell biology, material science, and bioengineering to develop therapies for tissue repair and regeneration. This field has made significant advances in recent years, particularly in the use of stem cells and biomaterials. Advancements in cell-based therapies have involved the use of cells to repair or replace damaged tissues and organs. Tissue engineering involves using scaffolds and growth factors to promote tissue regeneration. However, a major challenge in this field is the formation of adhesions, which can cause complications, such as intestinal obstruction and chronic pain. Adhesion barriers are used to prevent adhesion of tissues and organs during recovery, thereby reducing the risk of complications. Anti-adhesion materials, such as polysaccharides, proteins, and synthetic polymers, are used to create a physical barrier between tissues and prevent adhesion. These materials can be used alone or in combination, but their effectiveness varies.
This study investigates the efficacy of AHA-BHA infused nanofiber skin masks as a topical treatme... more This study investigates the efficacy of AHA-BHA infused nanofiber skin masks as a topical treatment for acne vulgaris. The skin is a vital organ that functions as a barrier to protect the body from external substances. In recent years, there has been a growing emphasis on skin treatment research. Hyaluronic acids (HAs) are commonly used in cosmetic and drug formulations to regulate excessive skin cornification, making them promising candidates for acne treatment. The introduction of HAs in dermatology has revolutionized the field of skin care, and they are used to treat various skin disorders, such as acne, ichthyosis, keratoses, warts, psoriasis, and photoaged skin. The antiaging benefits of HA have gained considerable attention in cosmetic dermatology, resulting in a surge in cosmetic products and skin care systems that contain HA. The study found that AHA-BHA-infused nanofiber skin masks are effective in treating acne vulgaris. The nanofiber masks were found to reduce inflammation, sebum production, and acne lesions. The study suggests that AHA-BHA-infused nanofiber skin masks could be a promising topical treatment for acne vulgaris.
Drug delivery systems, including liposomes, gels, prodrugs, and so forth, are used to enhance the... more Drug delivery systems, including liposomes, gels, prodrugs, and so forth, are used to enhance the tissue benefit of a pharmaceutical drug or conventional substance at a specific diseased site with little toxicological impact. Nanotechnology can be a rapidly developing multidisciplinary science that enables the production of polymers at the manometer scale for different medical applications. The use of biopolymers in drug delivery systems provides compatibility, biodegradability and low immunogenicity
This article discusses the use of nanotechnology in the development of transdermal delivery syste... more This article discusses the use of nanotechnology in the development of transdermal delivery systems for herbal extracts for dermatological therapeutics and skin care. Nanotechnology involves manipulating nanoscale materials to create nanoparticles that can penetrate the skin and deliver active ingredients more effectively. Natural products are commonly used in cosmetics because of their therapeutic properties and minimal side effects; however, the safety of nanoparticles in cosmetic products is a concern that requires further research. Chronic and nonhealing wounds pose a significant threat to patients' lives, and there is a pressing need for novel materials and approaches to wound healing. Nanomaterials exhibit unique physicochemical properties owing to their distinct structures, resulting in small size, surface, and macroscopic quantum tunnelling effects, making them ideal for use in wound dressings. Herbal transdermal patches offer advantages such as better patient tolerance, minimal side effects, renewable sources of medication, extensive availability, and costeffectiveness; however, they also have disadvantages such as slower growth in demand, testing difficulties, and limited availability. This article concludes that by following a regimen that includes both natural ingredients and over-the-counter treatments, consumers can improve their skin health and appearance.
This study investigated the potential of electrospun collagen/hyaluronic acid nanofibers for use ... more This study investigated the potential of electrospun collagen/hyaluronic acid nanofibers for use in biomedicine and skincare. Needleless electrospinning technology employed in the production process resulted in nanofibers with consistent fiber diameters and improved mechanical properties. The composite nanofibers demon
In this research, a novel drug delivery system shell was created by loading doxorubicin hydrochlo... more In this research, a novel drug delivery system shell was created by loading doxorubicin hydrochloride (DOX) into Pullulan and integrating the core into a polyvinyl alcohol (PVA) and Polydimethoxysilane (PDMS) composite matrix. The incorporation of DOX into the pullulan solution was carried out to take advantage of Pullulan's biocompatibility, biodegradability and hydrophilic nature. The hydrophilic nature of PVA can result in rapid drug release, while the hydrophobic nature of PDMS allows for slower drug release. The use of PVA-PDMS polymers together in the shell offers an initial rapid release followed by a prolonged and controlled drug release. This combination is superior to PVA or PDMS in terms of safety, mechanical strength, flexibility, controlled drug release and structural stability. This innovative composite system was designed to optimise DOX's controlled release to increase its therapeutic efficacy and reduce systemic toxicity. The kinetics of the drug release was characterised by an initial burst release followed by a sustained release phase, allowing controlled and prolonged release of the chemotherapeutic agent. Our results indicate that the pullulan/PVA-PDMS composite is a promising candidate for practical drug delivery applications, especially in cancer therapy.
This study investigated the development of Pullulan/Collagen nanofiber scaffolds integrated with ... more This study investigated the development of Pullulan/Collagen nanofiber scaffolds integrated with mesenchymal stem cells (MSCs) to enhance chronic wound healing. The combination of these biopolymers aims to optimize the scaffold properties for cell growth, viability, and tissue regeneration. Materials and Methods: Pullulan, Collagen, and Pullulan/Collagen composite nanofibers were fabricated using electrospinning. The fibers were characterized using scanning electron microscopy (SEM) to determine the fiber diameter, and Fourier-transform infrared spectroscopy (FTIR) was employed to assess the molecular interactions. Cell viability was evaluated using MSCs cultured on the scaffolds and apoptosis assays were conducted to assess cell health. Distilled water was used as the solvent to maximize biocompatibility. Results: SEM analysis revealed that Pullulan nanofibers exhibited a larger average diameter (274 ± 20 nm) compared to Collagen fibers (167.03 ± 40.04 nm), while the Pullulan/Collagen composite fibers averaged 280 ± 102 nm. FTIR confirmed the molecular interactions between Pullulan and Collagen. Regarding biocompatibility, the Pullulan/Collagen scaffold demonstrated superior cell viability at 99% compared to 91% for Pullulan alone. Apoptosis assays indicated significantly lower necrosis rates for the composite scaffold (1.29%) than for the Pullulan-only scaffolds (2.35%). Conclusion: Using distilled water as a solvent was critical in increasing cell viability and facilitating the healthy proliferation of MSCs without cellular damage. Additionally, the reduced platelet activation and macrophage activity (0.75-fold for both) further supported the biocompatibility of the Pullulan/Collagen scaffold, demonstrating its potential for tissue engineering and chronic wound healing applications.
This article presents a comprehensive overview of the utilisation of nanotechnology in the cosmet... more This article presents a comprehensive overview of the utilisation of nanotechnology in the cosmetics industry, with a specific focus on developing nanoparticles for the efficient delivery of active ingredients through skin penetration. The review delves into incorporating natural ingredients in cosmetics, exploring their therapeutic properties and the advantages and limitations associated with their use. Furthermore, the article examines the benefits of integrating natural ingredients into skincare products to enhance skin conditions, highlighting the application of nonfibrous technology in areas such as UV protection, anti-ageing effects, moisturisation improvement, and wound healing. Ultimately, the article emphasises the immense potential of nanotechnology to create innovative opportunities and positive societal impacts across various industries.
Nanotechnology has become an increasingly promising medical field, particularly scar removal. Sca... more Nanotechnology has become an increasingly promising medical field, particularly scar removal. Scar removal is a complex process involving regenerating damaged skin tissue, and nanotechnology presents unique solutions to this issue. One potential application of nanotechnology is using nanofibers as scaffolds to support the growth of new skin tissue. These fibres can also be loaded with drugs or growth factors to promote tissue regeneration and reduce scarring. Another potential application is nanocarriers for drug delivery to specific body areas, which can promote tissue regeneration and reduce scarring.Additionally, nanotechnology has been utilized to create new materials for skin regeneration, such as "nano skin" that mimics the structure of natural skin. Nanoprobes have also been developed for the detection of scar tissue and the monitoring of its progression. These potential nanotechnology applications offer exciting possibilities for the future of scar removal and skin...
Acne vulgaris is a prevalent skin condition that affects people of all ages and can have signific... more Acne vulgaris is a prevalent skin condition that affects people of all ages and can have significant physical and psychological impacts. Hydroxy acids, such as alpha-hydroxy acids (AHA) and beta-hydroxy acids (BHA), have demonstrated potential as effective ingredients for topical acne treatments due to their exfoliating and skin-rejuvenating properties. This study assessed the effectiveness of encapsulating AHA and BHA in pullulan-collagen nanofibers as a novel approach to acne treatment. The study involved preparing Pullulan and polyvinyl alcohol (PVA) solutions combined with sodium chloride (NaCl) to create a stable mixture. Collagen and Pullulan were then dissolved in deionized water and mixed to form a collagen-pullulan solution. Various weight ratios of Collagen to Pullulan were tested to optimize nanofiber formation. This research achieved electrospinning of nanofibers, confirmed by scanning electron microscopy (SEM) analysis, which revealed well-formed and continuous nanofibe...
Encapsulated nanofibers have emerged as a promising approach for the treatment of acne, owing to ... more Encapsulated nanofibers have emerged as a promising approach for the treatment of acne, owing to their ability to provide controlled release, targeted delivery, increased efficacy, and improved stability. Electrospinning is a well-established method for producing encapsulated nanofibers and has been shown to be effective for encapsulating various active ingredients. However, there are still several challenges that need to be addressed in the development of encapsulated nanofibers for acne treatment. One major challenge is the need for comprehensive in vitro and in vivo studies to evaluate the safety and efficacy of these treatments. The cost and scalability of production also need to be considered to make these treatments accessible and affordable for patients. In addition, the long-term stability of encapsulated active ingredients is another challenge in the development of encapsulated nanofibers for acne treatment. Regulatory frameworks need to be developed to ensure the safety an...
Encapsulated nanofibers have emerged as a promising approach for the treatment of acne, owing to ... more Encapsulated nanofibers have emerged as a promising approach for the treatment of acne, owing to their ability to provide controlled release, targeted delivery, increased efficacy, and improved stability. Electrospinning is a well-established method for producing encapsulated nanofibers and has been shown to be effective for encapsulating various active ingredients. However, there are still several challenges that need to be addressed in the development of encapsulated nanofibers for acne treatment. One major challenge is the need for comprehensive in vitro and in vivo studies to evaluate the safety and efficacy of these treatments. The cost and scalability of production also need to be considered to make these treatments accessible and affordable for patients. In addition, the long-term stability of encapsulated active ingredients is another challenge in the development of encapsulated nanofibers for acne treatment. Regulatory frameworks need to be developed to ensure the safety an...
PULLULAN/PVA/ DOXORUBICIN CORE-SHELL ELECTROSPUN NANOFIBERS DRUG DELIVERY SYSTEM FOR THE CHEMOTHERAPY AGAINST CANCER, 2022
Cancer is one of the foremost dangerous illnesses which has been encountered the human beings for... more Cancer is one of the foremost dangerous illnesses which has been encountered the human beings for the last several decades. In 2022, 1,918,030 new cancer cases and 609,360
OBTAINING ANTIBACTERIAL ECOLOGICAL NONOCELLULOSE FIBRE FROM ROSE PLANT, 2020
The aim of this study is to produce biodegradable, biocompatible and compatible ecological nano t... more The aim of this study is to produce biodegradable, biocompatible and compatible ecological nano textile materials used in medical applications.
PULLULAN/PVA NANOFIBER FOR FUNCTIONAL APPLICATIONS, 2021
The aim of this thesis is to use nanofibers obtained from pullulan polysaccharide in production f... more The aim of this thesis is to use nanofibers obtained from pullulan polysaccharide in production for functional use. Pullulan is a natural compound, and there may be recent interest in the use of natural polymers in medical applications, for example, as proteins in biotechnological materials, as well as biocompatibility.
Během relativně dlouhé lidské existence na Zemi prošel lidský druh dobou kamennou, železnou a tak... more Během relativně dlouhé lidské existence na Zemi prošel lidský druh dobou kamennou, železnou a také dobou bronzovou. Tato období vždy přinášela nové informace a materiály. Posledních několik desetiletí bylo označeno jako doba polymerních materiálů. Tyto materiály jsou široce používány v každodenním životě. V dnešní době je jasné, že technologie dochází k miniaturizaci a společnost nepochybně prochází procesem, který lze nazvat časem nanotechnologií, a tento vývoj také vytváří řadu potřeb.Nanotechnologie hraje důležitou roli v široké oblasti použití a zvyšování kvality života. Nabízí zdravější a bezpečnější život s výhodami, které přináší do oblasti medicíny. Čas, který se nad tím tráví, je pod kontrolou a je zajištěno, že práce bude poskytována s nejnižší ztrátou nákladů. Díky nanotechnologii se zvyšuje rychlost vývoje technologie a využívá se efektivněji. Efektivita technologie prospívá práci i času.Cílem této práce je použít nanovlákna získaná z pullulan polysacharidu ve výrobě pro...