Elena Ivanova - Academia.edu (original) (raw)
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Papers by Elena Ivanova
Current Opinion in Colloid and Interface Science, Oct 1, 2023
Journal of Synchrotron Radiation, Apr 25, 2018
Applied Microbiology and Biotechnology, Mar 1, 2017
Scientific Reports, Mar 18, 2019
Journal of Materials Chemistry B, 2019
Nature Reviews Microbiology, Aug 17, 2020
Journal of Colloid and Interface Science, Dec 1, 2021
Interface Focus, Apr 20, 2018
Journal of Colloid and Interface Science, Feb 1, 2020
ACS Applied Materials & Interfaces, Jun 27, 2022
Scientific Reports, Sep 7, 2017
Nano-micro Letters, Feb 6, 2018
Advanced NanoBiomed Research
Ultrasmall gold nanoclusters (AuNC) show great promise for application in theranostics due to the... more Ultrasmall gold nanoclusters (AuNC) show great promise for application in theranostics due to their unique optical and physicochemical properties; however, the associated nanotoxicology concerns need to be carefully considered because of their high diffusion across the cellular barrier. Herein, new insights into the role of surface modification of 2 nm AuNC on their toxicity with impact on the metabolism of COS‐7 fibroblast‐like cells are revealed. AuNCs are chemically modified with either a monodentate‐thiolated molecule (AuNC‐MHA) or a modified‐bidentate sulfobetaine zwitterionic molecule (AuNC‐ZwBuEt). Uptake and localization inside fibroblasts and the resultant influence on cell ultrastructure are carefully evaluated using scanning transmission electron microscopy (STEM) and cryo‐soft‐X‐ray tomography (cryo‐SXT). At concentrations of ≥25 μg Au mL−1, AuNC‐ZwBuEt are cytotoxic toward COS‐7 cells and are observed to cross the nuclear membrane. Cryo‐SXT analysis shows that fibroblas...
Journal of Colloid and Interface Science, 2021
Nano Select, 2021
Polymer matrix composite materials have the capacity to aid the indirect transmission of viral di... more Polymer matrix composite materials have the capacity to aid the indirect transmission of viral diseases. Published research shows that respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 or COVID‐19), can attach to polymer substrata as a result of being contacted by airborne droplets resulting from infected people sneezing or coughing in close proximity. Polymer matrix composites are used to produce a wide range of products that are “high‐touch” surfaces, such as sporting goods, laptop computers and household fittings, and these surfaces can be readily contaminated by pathogens. This article reviews published research on the retention of SARS‐CoV‐2 and other virus types on plastics. The factors controlling the viral retention time on plastic surfaces are examined and the implications for viral retention on polymer composite materials are discussed. Potential strategies that can be used to impart antiviral properties to polymer composite surface...
ACS nano, Jan 11, 2018
The threat of a global rise in the number of untreatable infections caused by antibiotic-resistan... more The threat of a global rise in the number of untreatable infections caused by antibiotic-resistant bacteria calls for the design and fabrication of a new generation of bactericidal materials. Here, we report a concept for the design of antibacterial surfaces, whereby cell death results from the ability of the nanofeatures to deflect when in contact with attaching cells. We show, using three-dimensional transmission electron microscopy, that the exceptionally high aspect ratio (100-3000) of vertically aligned carbon nanotubes (VACNTs) imparts extreme flexibility, which enhances the elastic energy storage in CNTs as they bend in contact with bacteria. Our experimental and theoretical analyses demonstrate that, for high aspect ratio structures, the bending energy stored in the CNTs is a substantial factor for the physical rupturing of both Gram-positive and Gram-negative bacteria. The highest bactericidal rates (99.3% for Pseudomonas aeruginosa and 84.9% for Staphylococcus aureus) were...
Journal of Visualized Experiments, 2016
Current Opinion in Colloid and Interface Science, Oct 1, 2023
Journal of Synchrotron Radiation, Apr 25, 2018
Applied Microbiology and Biotechnology, Mar 1, 2017
Scientific Reports, Mar 18, 2019
Journal of Materials Chemistry B, 2019
Nature Reviews Microbiology, Aug 17, 2020
Journal of Colloid and Interface Science, Dec 1, 2021
Interface Focus, Apr 20, 2018
Journal of Colloid and Interface Science, Feb 1, 2020
ACS Applied Materials & Interfaces, Jun 27, 2022
Scientific Reports, Sep 7, 2017
Nano-micro Letters, Feb 6, 2018
Advanced NanoBiomed Research
Ultrasmall gold nanoclusters (AuNC) show great promise for application in theranostics due to the... more Ultrasmall gold nanoclusters (AuNC) show great promise for application in theranostics due to their unique optical and physicochemical properties; however, the associated nanotoxicology concerns need to be carefully considered because of their high diffusion across the cellular barrier. Herein, new insights into the role of surface modification of 2 nm AuNC on their toxicity with impact on the metabolism of COS‐7 fibroblast‐like cells are revealed. AuNCs are chemically modified with either a monodentate‐thiolated molecule (AuNC‐MHA) or a modified‐bidentate sulfobetaine zwitterionic molecule (AuNC‐ZwBuEt). Uptake and localization inside fibroblasts and the resultant influence on cell ultrastructure are carefully evaluated using scanning transmission electron microscopy (STEM) and cryo‐soft‐X‐ray tomography (cryo‐SXT). At concentrations of ≥25 μg Au mL−1, AuNC‐ZwBuEt are cytotoxic toward COS‐7 cells and are observed to cross the nuclear membrane. Cryo‐SXT analysis shows that fibroblas...
Journal of Colloid and Interface Science, 2021
Nano Select, 2021
Polymer matrix composite materials have the capacity to aid the indirect transmission of viral di... more Polymer matrix composite materials have the capacity to aid the indirect transmission of viral diseases. Published research shows that respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2 or COVID‐19), can attach to polymer substrata as a result of being contacted by airborne droplets resulting from infected people sneezing or coughing in close proximity. Polymer matrix composites are used to produce a wide range of products that are “high‐touch” surfaces, such as sporting goods, laptop computers and household fittings, and these surfaces can be readily contaminated by pathogens. This article reviews published research on the retention of SARS‐CoV‐2 and other virus types on plastics. The factors controlling the viral retention time on plastic surfaces are examined and the implications for viral retention on polymer composite materials are discussed. Potential strategies that can be used to impart antiviral properties to polymer composite surface...
ACS nano, Jan 11, 2018
The threat of a global rise in the number of untreatable infections caused by antibiotic-resistan... more The threat of a global rise in the number of untreatable infections caused by antibiotic-resistant bacteria calls for the design and fabrication of a new generation of bactericidal materials. Here, we report a concept for the design of antibacterial surfaces, whereby cell death results from the ability of the nanofeatures to deflect when in contact with attaching cells. We show, using three-dimensional transmission electron microscopy, that the exceptionally high aspect ratio (100-3000) of vertically aligned carbon nanotubes (VACNTs) imparts extreme flexibility, which enhances the elastic energy storage in CNTs as they bend in contact with bacteria. Our experimental and theoretical analyses demonstrate that, for high aspect ratio structures, the bending energy stored in the CNTs is a substantial factor for the physical rupturing of both Gram-positive and Gram-negative bacteria. The highest bactericidal rates (99.3% for Pseudomonas aeruginosa and 84.9% for Staphylococcus aureus) were...
Journal of Visualized Experiments, 2016