Elena Kasamatsu - Academia.edu (original) (raw)
Papers by Elena Kasamatsu
European Journal of Cancer Prevention
Infection by Helicobacter pylori (Hp) has been causally linked to risk of gastric cancer (GC). Th... more Infection by Helicobacter pylori (Hp) has been causally linked to risk of gastric cancer (GC). The coevolution of Hp and humans shaped the risk of GC as our species left Africa and migrated to the other continents. Latin America (LatAm) is a high GC incidence region where Hp evolved uniquely in the 500 years since European colonization. Differential virulence of the Hp cagA-pathogenicity island (cagPAI) by ancestral origin has been reported. We hypothesized that Hp phylogenetic origin might play a role in determining GC risk in LatAm. We used genotypes of 50 Hp genetic variants mapping to the Hp cagPAI, studied in 1220 subjects from Venezuela, Colombia, Mexico and Paraguay, who were infected with cagA-positive Hp, including 150 GC, 177 high-grade premalignant lesions (HGPMLs) and 893 low-grade premalignant lesions. We estimated the phylogenetic origin of Hp cagPAI in all study subjects by use of the STRUCTURE software and principal component analysis (PCA) and tested whether the est...
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British Journal of Cancer, 2015
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Memorias del Instituto de Investigaciones en Ciencias de la Salud, Jun 1, 2008
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Base de dados : LILACS. Pesquisa : 244046 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 244046 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. experimental, Documentos relacionados. Id: 244046. ...
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European Journal of Cancer Prevention, 2021
Background Gastric cancer is worldwide the fourth more common cancer type by incidence, and the t... more Background Gastric cancer is worldwide the fourth more common cancer type by incidence, and the third by mortality. We analyzed three missense variants of TAS2R38 gene: rs713598 (A49P), rs1726866 (V262A), and rs10246939 (I296V). These variants and their combination in haplotypes (proline, alanine and valine/tasters or alanine, valine and isoleucine/nontasters) and diplotypes are responsible for individual differences in bitter perception. The single-nucleotide polymorphisms and the related phenotypes are known to be associated with susceptibility to Gram-negative bacterial infections, such as Helicobacter pylori, and with risk of various cancer types. An association between intermediate tasters (as defined by TAS2R38 diplotypes) and increased risk of gastric cancer was reported in a Korean population. Methods We analyzed 2616 individuals of Latin American origin, representing the whole spectrum of lesions from gastritis to gastric cancer. Results Comparing cancer cases vs. noncancer...
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Memorias del Instituto de Investigaciones en Ciencias de la Salud, Jun 9, 2012
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Memorias del Instituto de Investigaciones en Ciencias de la Salud, 2020
El cáncer de cuello uterino (CCU) es la primera causa de morbilidad y la segunda causa de muerte ... more El cáncer de cuello uterino (CCU) es la primera causa de morbilidad y la segunda causa de muerte por cáncer en mujeres en Paraguay. La infección genital por el virus del papiloma humano (HPV), es un factor necesario para el desarrollo del CCU, junto a otros cofactores. Este estudio descriptivo transversal en muestras biológicas de cuello uterino, tiene por objetivo determinar las características clínico-demográficas de mujeres remitidas al IICS para detección de HPV de alto riesgo oncogénico por Captura Híbrida II® entre mayo de 2006-2007. De un total de 248 mujeres estudiadas el 85% procedía del área metropolitana, con un promedio de edad de 34±11 años. El 41% de las muestras resultó positiva para HPV de alto riego (HR-HPV). Según resultados citológicos, el 27% de las citologías inflamatorias o normales fue positivo. EL 78% de las muestras analizadas para control post tratamiento de lesiones intraepiteliales de alto grado fue negativa evidenciando la alta efectividad del tratamient...
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Revista de la Universidad Industrial de Santander. Salud, 2016
Introduccion: El cancer de cuello uterino es un problema de salud publica en Paraguay. Objetivo: ... more Introduccion: El cancer de cuello uterino es un problema de salud publica en Paraguay. Objetivo: Determinar conocimientos, actitudes y practicas sobre virus del papiloma humano (VPH) y cancer de cuello uterino en mujeres de 12 Unidades de Salud Familiar (USF) de Banado Sur-Asuncion, periodo abril-octubre 2012. Metodologia: Estudio descriptivo de corte transversal, utilizando cuestionario estructurado autoadministrado. Resultados: La edad promedio de las encuestadas fue 42 anos, la mayoria en union libre o casadas (70%); 65% tienen educacion basica y media, 56% son amas de casa. El 83% tienen seguro medico; 78% escucho hablar sobre cancer de cuello uterino, 74% de estas en los centros de salud. El 10% de las encuestadas conoce el VPH y lo relaciona con la enfermedad, 90 % escucho hablar sobre la prueba de Papanicolaou, el 27 % de ellas sabe en que consiste; 90% de las mujeres demostro actitud favorable y 56% practicas favorables respecto a la prevencion de la enfermedad. Conclusiones...
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El Paraguay es considerado como un pais de baja incidencia en cancer gastrico, sin embargo su mor... more El Paraguay es considerado como un pais de baja incidencia en cancer gastrico, sin embargo su mortalidad es muy elevada, con un pronostico sombrio. Para conocer las caracteristicas demograficas y anatomopatologicas del cancer gastrico y su tendencia a lo largo de 40 anos, se seleccionaron 1100 casos de carcinoma gastrico, registrados en el periodo 1960 a 1999, en cuatro centros Hospitalarios publicos y dos laboratorios privados que concentran la mayor parte de los casos del pais. Se analizaron datos demograficos y patologicos, la relacion entre las variables y la tendencia en este periodo de estudio. Se ha observado un incremento importante de casos a partir de 1980, epoca en que se introdujo en el pais la endoscopia digestiva como metodo de diagnostico. La edad promedio fue de 61±13.56, con predominio de: sexo masculino (razon hombre/mujer de 2/1), localizacion antral (58%), carcinoma avanzado (97.4%), infiltracion extraserosa (80.5%) y tipo histologico difuso (56.7%) El analisis c...
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Barrett's esophagus is the change of the squamous epithelium to columnar (metaplasia) seconda... more Barrett's esophagus is the change of the squamous epithelium to columnar (metaplasia) secondary to gastro-oesophageal reflux. The clinical significance is a predisposition to ulcers, bleeding and development of adenocarcinoma. It is not known the time needed for the development of dysplasia and the transition to carcinoma, which makes necessary to have indicators of neoplastic progression or malignant transformation. p53 protein participates in cell cycle control, DNA synthesis and repair and programmed cell death. Numerous papers describe the accumulation of p53 protein in esophageal dysplastic lesions, suggesting that this alteration would participate in esophageal tumorigenesis. The objective of this work was to determine the expression of p53 by immunohistochemistry in 58 esophageal biopsies of which 42 corresponded to Barret’s esophagus and esophageal and 16 to esophageal adenocarcinoma, describing the frequency of expression of p53, as well as the clinical, endoscopic and ...
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International Journal of Cancer, 2020
Helicobacter pylori (Hp) infects the stomach of about half of the human population and is strongl... more Helicobacter pylori (Hp) infects the stomach of about half of the human population and is strongly associated with the risk of gastric cancer (GC) and its premalignant precursors. The cag pathogenicity island (cagPAI) is a region of the Hp genome encoding for key molecular machinery involved in the infection process. Following a sequencing study, we selected 50 genetic polymorphisms located in seven cagPAI genes and tested their associations with the risk of advanced gastric premalignant lesions and GC in 1220 subjects from various Latin American populations showing the whole spectrum of phenotypes from gastritis to GC. We found that three polymorphisms of cagA are associated with the risk of advanced gastric premalignant lesions (incomplete intestinal metaplasia [ie, Type 2 and 3] or dysplasia), and that six polymorphisms located in cagA, cagL and cagI were associated with risk of GC. When corrected for multiple testing none of the associations were statistically significant. However, scores built by integrating the individual polymorphisms were significantly associated with the risk of advanced gastric premalignant lesions and GC. These results have the potential of establishing markers for risk stratification in the general population, in view of targeting Hp eradication to high‐risk population groups.
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BMJ Open, 2020
IntroductionHuman papillomavirus (HPV) testing is replacing cytology in primary screening. Its li... more IntroductionHuman papillomavirus (HPV) testing is replacing cytology in primary screening. Its limited specificity demands using a second (triage) test to better identify women at high-risk of cervical disease. Cytology represents the immediate triage but its low sensitivity might hamper HPV testing sensitivity, particularly in low-income and middle-income countries (LMICs), where cytology performance has been suboptimal. The ESTAMPA (EStudio multicéntrico de TAMizaje y triaje de cáncer de cuello uterino con pruebas del virus del PApiloma humano; Spanish acronym) study will: (1) evaluate the performance of different triage techniques to detect cervical precancer and (2) inform on how to implement HPV-based screening programmes in LMIC.Methods and analysisWomen aged 30–64 years are screened with HPV testing and Pap across 12 study centres in Latin America. Screened positives have colposcopy with biopsy and treatment of lesions. Women with no evident disease are recalled 18 months lat...
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Cancer Epidemiology, 2020
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Frontiers in Microbiology, 2019
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European Journal of Cancer Prevention
Infection by Helicobacter pylori (Hp) has been causally linked to risk of gastric cancer (GC). Th... more Infection by Helicobacter pylori (Hp) has been causally linked to risk of gastric cancer (GC). The coevolution of Hp and humans shaped the risk of GC as our species left Africa and migrated to the other continents. Latin America (LatAm) is a high GC incidence region where Hp evolved uniquely in the 500 years since European colonization. Differential virulence of the Hp cagA-pathogenicity island (cagPAI) by ancestral origin has been reported. We hypothesized that Hp phylogenetic origin might play a role in determining GC risk in LatAm. We used genotypes of 50 Hp genetic variants mapping to the Hp cagPAI, studied in 1220 subjects from Venezuela, Colombia, Mexico and Paraguay, who were infected with cagA-positive Hp, including 150 GC, 177 high-grade premalignant lesions (HGPMLs) and 893 low-grade premalignant lesions. We estimated the phylogenetic origin of Hp cagPAI in all study subjects by use of the STRUCTURE software and principal component analysis (PCA) and tested whether the est...
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British Journal of Cancer, 2015
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Memorias del Instituto de Investigaciones en Ciencias de la Salud, Jun 1, 2008
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Base de dados : LILACS. Pesquisa : 244046 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 244046 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. experimental, Documentos relacionados. Id: 244046. ...
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European Journal of Cancer Prevention, 2021
Background Gastric cancer is worldwide the fourth more common cancer type by incidence, and the t... more Background Gastric cancer is worldwide the fourth more common cancer type by incidence, and the third by mortality. We analyzed three missense variants of TAS2R38 gene: rs713598 (A49P), rs1726866 (V262A), and rs10246939 (I296V). These variants and their combination in haplotypes (proline, alanine and valine/tasters or alanine, valine and isoleucine/nontasters) and diplotypes are responsible for individual differences in bitter perception. The single-nucleotide polymorphisms and the related phenotypes are known to be associated with susceptibility to Gram-negative bacterial infections, such as Helicobacter pylori, and with risk of various cancer types. An association between intermediate tasters (as defined by TAS2R38 diplotypes) and increased risk of gastric cancer was reported in a Korean population. Methods We analyzed 2616 individuals of Latin American origin, representing the whole spectrum of lesions from gastritis to gastric cancer. Results Comparing cancer cases vs. noncancer...
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Memorias del Instituto de Investigaciones en Ciencias de la Salud, Jun 9, 2012
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Memorias del Instituto de Investigaciones en Ciencias de la Salud, 2020
El cáncer de cuello uterino (CCU) es la primera causa de morbilidad y la segunda causa de muerte ... more El cáncer de cuello uterino (CCU) es la primera causa de morbilidad y la segunda causa de muerte por cáncer en mujeres en Paraguay. La infección genital por el virus del papiloma humano (HPV), es un factor necesario para el desarrollo del CCU, junto a otros cofactores. Este estudio descriptivo transversal en muestras biológicas de cuello uterino, tiene por objetivo determinar las características clínico-demográficas de mujeres remitidas al IICS para detección de HPV de alto riesgo oncogénico por Captura Híbrida II® entre mayo de 2006-2007. De un total de 248 mujeres estudiadas el 85% procedía del área metropolitana, con un promedio de edad de 34±11 años. El 41% de las muestras resultó positiva para HPV de alto riego (HR-HPV). Según resultados citológicos, el 27% de las citologías inflamatorias o normales fue positivo. EL 78% de las muestras analizadas para control post tratamiento de lesiones intraepiteliales de alto grado fue negativa evidenciando la alta efectividad del tratamient...
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Revista de la Universidad Industrial de Santander. Salud, 2016
Introduccion: El cancer de cuello uterino es un problema de salud publica en Paraguay. Objetivo: ... more Introduccion: El cancer de cuello uterino es un problema de salud publica en Paraguay. Objetivo: Determinar conocimientos, actitudes y practicas sobre virus del papiloma humano (VPH) y cancer de cuello uterino en mujeres de 12 Unidades de Salud Familiar (USF) de Banado Sur-Asuncion, periodo abril-octubre 2012. Metodologia: Estudio descriptivo de corte transversal, utilizando cuestionario estructurado autoadministrado. Resultados: La edad promedio de las encuestadas fue 42 anos, la mayoria en union libre o casadas (70%); 65% tienen educacion basica y media, 56% son amas de casa. El 83% tienen seguro medico; 78% escucho hablar sobre cancer de cuello uterino, 74% de estas en los centros de salud. El 10% de las encuestadas conoce el VPH y lo relaciona con la enfermedad, 90 % escucho hablar sobre la prueba de Papanicolaou, el 27 % de ellas sabe en que consiste; 90% de las mujeres demostro actitud favorable y 56% practicas favorables respecto a la prevencion de la enfermedad. Conclusiones...
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El Paraguay es considerado como un pais de baja incidencia en cancer gastrico, sin embargo su mor... more El Paraguay es considerado como un pais de baja incidencia en cancer gastrico, sin embargo su mortalidad es muy elevada, con un pronostico sombrio. Para conocer las caracteristicas demograficas y anatomopatologicas del cancer gastrico y su tendencia a lo largo de 40 anos, se seleccionaron 1100 casos de carcinoma gastrico, registrados en el periodo 1960 a 1999, en cuatro centros Hospitalarios publicos y dos laboratorios privados que concentran la mayor parte de los casos del pais. Se analizaron datos demograficos y patologicos, la relacion entre las variables y la tendencia en este periodo de estudio. Se ha observado un incremento importante de casos a partir de 1980, epoca en que se introdujo en el pais la endoscopia digestiva como metodo de diagnostico. La edad promedio fue de 61±13.56, con predominio de: sexo masculino (razon hombre/mujer de 2/1), localizacion antral (58%), carcinoma avanzado (97.4%), infiltracion extraserosa (80.5%) y tipo histologico difuso (56.7%) El analisis c...
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Barrett's esophagus is the change of the squamous epithelium to columnar (metaplasia) seconda... more Barrett's esophagus is the change of the squamous epithelium to columnar (metaplasia) secondary to gastro-oesophageal reflux. The clinical significance is a predisposition to ulcers, bleeding and development of adenocarcinoma. It is not known the time needed for the development of dysplasia and the transition to carcinoma, which makes necessary to have indicators of neoplastic progression or malignant transformation. p53 protein participates in cell cycle control, DNA synthesis and repair and programmed cell death. Numerous papers describe the accumulation of p53 protein in esophageal dysplastic lesions, suggesting that this alteration would participate in esophageal tumorigenesis. The objective of this work was to determine the expression of p53 by immunohistochemistry in 58 esophageal biopsies of which 42 corresponded to Barret’s esophagus and esophageal and 16 to esophageal adenocarcinoma, describing the frequency of expression of p53, as well as the clinical, endoscopic and ...
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International Journal of Cancer, 2020
Helicobacter pylori (Hp) infects the stomach of about half of the human population and is strongl... more Helicobacter pylori (Hp) infects the stomach of about half of the human population and is strongly associated with the risk of gastric cancer (GC) and its premalignant precursors. The cag pathogenicity island (cagPAI) is a region of the Hp genome encoding for key molecular machinery involved in the infection process. Following a sequencing study, we selected 50 genetic polymorphisms located in seven cagPAI genes and tested their associations with the risk of advanced gastric premalignant lesions and GC in 1220 subjects from various Latin American populations showing the whole spectrum of phenotypes from gastritis to GC. We found that three polymorphisms of cagA are associated with the risk of advanced gastric premalignant lesions (incomplete intestinal metaplasia [ie, Type 2 and 3] or dysplasia), and that six polymorphisms located in cagA, cagL and cagI were associated with risk of GC. When corrected for multiple testing none of the associations were statistically significant. However, scores built by integrating the individual polymorphisms were significantly associated with the risk of advanced gastric premalignant lesions and GC. These results have the potential of establishing markers for risk stratification in the general population, in view of targeting Hp eradication to high‐risk population groups.
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BMJ Open, 2020
IntroductionHuman papillomavirus (HPV) testing is replacing cytology in primary screening. Its li... more IntroductionHuman papillomavirus (HPV) testing is replacing cytology in primary screening. Its limited specificity demands using a second (triage) test to better identify women at high-risk of cervical disease. Cytology represents the immediate triage but its low sensitivity might hamper HPV testing sensitivity, particularly in low-income and middle-income countries (LMICs), where cytology performance has been suboptimal. The ESTAMPA (EStudio multicéntrico de TAMizaje y triaje de cáncer de cuello uterino con pruebas del virus del PApiloma humano; Spanish acronym) study will: (1) evaluate the performance of different triage techniques to detect cervical precancer and (2) inform on how to implement HPV-based screening programmes in LMIC.Methods and analysisWomen aged 30–64 years are screened with HPV testing and Pap across 12 study centres in Latin America. Screened positives have colposcopy with biopsy and treatment of lesions. Women with no evident disease are recalled 18 months lat...
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Cancer Epidemiology, 2020
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Frontiers in Microbiology, 2019
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