Emilio González-jiménez - Academia.edu (original) (raw)
Papers by Emilio González-jiménez
BioFactors (Oxford, England), Jan 4, 2016
The metabolic syndrome (MetS) is precisely defined and the cardiovascular risk associated with th... more The metabolic syndrome (MetS) is precisely defined and the cardiovascular risk associated with the clustering of its components has been demonstrated in adults. However, data on children and adolescents are still scarce, in part, because of difficulties in transposing the definition from adults. The identification of risk factors for the development of MetS at an early age is essential for prevention purposes with low-grade inflammation acting as a determinant for the association among the MetS components. The aim of this study was to investigate the associations of the MetS with systemic markers of inflammation and ceruloplasmin in a population of adolescents. The present is a cross-sectional study whose sample population consisted of 976 adolescents, 13.2 ± 1.2 years of age. Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were determined by ELISA. High-sensitivity C-reactive protein (hs-CRP) was determined by a solid-phase chemiluminiscent immunometric assay. Ceruloplasmi...
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Resumen Objetivo: determinar los valores del índice cintura/cadera (ICC) en una población escolar... more Resumen Objetivo: determinar los valores del índice cintura/cadera (ICC) en una población escolar de Bogotá, Colombia, pertenecientes al estudio FUPRECOL. Métodos: estudio descriptivo y transversal, realizado en 3.005 niños y 2.916 adolescentes de entre 9 y 17,9 años de edad, pertenecientes a instituciones educativas oficiales de Bogotá, Colombia. Se tomaron medidas de peso, talla, circunferencia de cintura, circunferencia de cadera y estado de maduración sexual por autorreporte. Se calcularon los percentiles (P 3, P 10, P 25, P 50, P 75, P 90 y P 97) según sexo y edad y se realizó una comparación entre los valores del ICC observados y los estándares internacionales. Resultados: de la población general (n = 5.921), el 57,0% eran chicas (promedio de edad 12,7 ± 2,3 años). En todas las edades el ICC fue mayor en los chicos que en las chicas, observándose un descenso en la media de los valores obtenidos desde los 9 hasta los 17,9 años. En los chicos, los valores del ICC mayores del P 90 (asociados a riesgo cardiovascular) estuvieron en el rango 0,87 y 0,93 y en las chicas entre 0,85 y 0,89. Al comparar los resultados de este estudio, por grupos de edad y sexo, con trabajos internacionales de niños y adolescentes de Europa, Suramérica, Asia y África, se observa que los valores del ICC fueron menores en este estudio en ambos sexos, con excepción de los escolares originarios de Grecia y Venezuela. Conclusiones: se presentan percentiles del ICC según edad y sexo que podrán ser usados como de referencia en la evaluación del estado nutricional y en la predicción del riesgo cardiovascular desde edades tempranas.
Nurse Education Today
BACKGROUND According to previous studies on nursing education, although the use of games can prod... more BACKGROUND According to previous studies on nursing education, although the use of games can produce positive results, the vast majority are based on questions and answers or on clinical situations. As an alternative, the 'Escape Room' teaching game is a much more dynamic option to asses theoretical and practical knowledge, and it may also promote teamwork and the ability to perform under pressure. OBJECTIVES To analyse nursing students' opinions and study motivations after using the nursing 'Escape Room' teaching game. DESIGN Cross-sectional descriptive study. PARTICIPANTS Second-year nursing students enrolled in the 'Adult Nursing 1' subject. METHOD After completing the teaching game, the students who had taken part in it were asked to fill in an ad-hoc questionnaire on the matter. In this game, students have 30 min in which they must solve the riddles and puzzles presented, and thus escape. In doing so, they must demonstrate both theoretical and practical knowledge, and a teacher will remain in the classroom to assess whether the nursing techniques in question are correctly performed. RESULTS The nursing students who took part in the game strongly believed that this 'helped them learn the subject' (4.8 points) and that 'more games of this type should be included in their nursing studies' (4.8 points). Overall, they considered that 'the game was enjoyable' (4.6 points), 'helped them in the exam' (4.6 points), and 'motivated them to study' (4.5 points). CONCLUSIONS The 'Escape Room' is a useful game; it stimulates learning, is fun to play, and motivates studying.
Western Journal of Nursing Research, 2016
The aim of this study was to investigate the association between cardiorespiratory fitness (CRF) ... more The aim of this study was to investigate the association between cardiorespiratory fitness (CRF) and cardiovascular risk factors (CVRF) in schoolchildren. A secondary aim was to evaluate the degree of association between overall and abdominal adiposity and CRF in a total of 1,875 children and adolescents attending public schools. We expressed CRF performance as the nearest stage (minute) completed and the estimated peak oxygen consumption. A CVRF ( Z score) was calculated and participants were divided into tertiles according to low and high levels of overall (sum of the skinfold thicknesses) and abdominal adiposity. Schoolchildren with a high-level of overall adiposity demonstrated significant differences in seven of the 10 variables analyzed (i.e., systolic and diastolic blood pressure, triglycerides, triglycerides/high density lipoproteins [HDL-c] ratio, total cholesterol, glucose, C-reactive protein [usCRP], HDL-c, low density lipoproteins [LDL-c], and cardiovascular risk score)....
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
... M a . J. Aguilar Cordero 1 , E. González Jiménez 1 , CJ García García 2 , PA García López 3 ,... more ... M a . J. Aguilar Cordero 1 , E. González Jiménez 1 , CJ García García 2 , PA García López 3 , J. Álvarez Ferre 4 , CA Padilla López 5 y JL González Mendoza 5 y E. Ocete Hita 6. ... [ Links ]. 9. Martínez JA, Moreno B, Martínez González A. Prevalence of obesity in Spain. ...
Objective: To establish the influence of exercise interventions on tumor microenvironment-related... more Objective: To establish the influence of exercise interventions on tumor microenvironment-related markers, including inflammatory cytokines, C-reactive protein (CRP) and Insulin-like growth factors (IGF's) in breast cancer survivors. Methods: PRISMA statement was followed. MEDLINE, Ovid, EMBASE and CENTRAL were searched for randomized controlled trials until February 2014. Heterogeneity was measured by using the I2 statistics. A random-effects models was used in presence of high statistical heterogeneity (I2>50%). Meta-regression analyses were also conducted. Results: Data from 15 studies were pooled (n=1,447; mean age= 51.6 years old). Exercise interventions resulted in positive effects for CRP, IL-2, IL-10, IGF-I, IGF-II and IGFBP-3 (p<.05). Non-significant differences were found for IL-6 and TNF-α. Meta-regression models showed that duration (>40 minutes/session) and training intensity (>70% maximum heart rate) of the exercise were predictors of the effects on tum...
Medicine & Science in Sports & Exercise
PURPOSE: Does supervised physical activity reduce cancer-related fatigue? METHODS: Systematic rev... more PURPOSE: Does supervised physical activity reduce cancer-related fatigue? METHODS: Systematic review with meta-analysis of randomised trials. Participants: People diagnosed with any type of cancer, without restriction to a particular stage of diagnosis or treatment. Intervention: Supervised physical activity interventions (eg, aerobic, resistance and stretching exercise), defined as any planned or structured body movement causing an increase in energy expenditure, designed to maintain or enhance health-related outcomes, and performed with systematic frequency, intensity and duration. Outcome measures: The primary outcome measure was fatigue. Secondary outcomes were physical and functional wellbeing assessed using the Functional Assessment of Cancer Therapy FACT-Fatigue Scale, EORTC, QLQ-C30, PFS, SCFS, MFI. Methodological quality including risk of bias of the studies was evaluated using the PEDro Scale. RESULTS: Eleven studies involving 1530 participants were included in the review....
Asia-Pacific Journal of Clinical Oncology
![Research paper thumbnail of [Evaluation of the Nutritional Status, Insulin Resistance and Cardiovascular Risk in a Population of Adolescents in the Cities of Granada and Almeria (SPAIN).]](https://attachments.academia-assets.com/45796461/thumbnails/1.jpg)
](Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Objectives: The first objective of this study was to evaluate the nutritional status and insulin ... more Objectives: The first objective of this study was to evaluate the nutritional status and insulin resistance index in a population of adolescents as calculated by Homeostatic Model Assessment (HOMA). The second objective was to establish correlations between the nutritional status of the subjects, the possible existence of insulin resistance, and the risk of high blood pressure. Population sample and methodology: The sample was composed of 1001 adolescents, 9-17 years of age, from 18 schools in the provinces of Granada and Almeria. Their nutritional status was determined by means of anthropometric evaluation. For the metabolic study, a blood sample was collected from each subject by venipuncture. An analysis was performed of the basal glucose and insulin levels as well as the Homeostatic Model Assessment- Insulin Resistance (HOMAIR) index. Also evaluated were the levels of glycosylated haemoglobin (HbA1c), serum lipoprotein (a), and non-esterified fatty acids (NEFAs). Insulin resista...
Objective To determine the pooled effects of supervised exercise interventions on cancer-related ... more Objective To determine the pooled effects of supervised exercise interventions on cancer-related fatigue (CRF) in breast cancer survivors. Participants Breast cancer survivors (>20 years old) without restriction to treatment stage. Methods PRISMA statement was followed. Databases of Pubmed/Medline, Embase, Scopus Central and CINAHL were searched until January 2014 without language restrictions. Risk of bias and methodological quality were evaluated with the Pedro score. Polled effects were calculated in stata version 11 through a random-effects model. Heterogeneity was evaluated with the chi2 test (p<0.10) and i2 statistics (i2>50%). Results Nine high quality studies (n=1156) were included. Supervised aerobic exercise was statistically more effective than conventional care in improving CRF among breast cancer survivors (SMD= -0.37 95%CI [-0.70 -0.40]) p<0.00001; i2= 80%. Resistance training produced significant improvements on CRF SMD=-0.55 95%CI (-1.09 to -0.01) p<0....
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
The excess weight that characterizes much of the population of the world today has led the World ... more The excess weight that characterizes much of the population of the world today has led the World Health Organization to declare a obesity pandemic. The number of overweight and obese children in Spain is among the highest in Europe, and this number is even higher in Andalusia. The health consequences of excess weight for children are not as evident as for adults. However, child obesity is now being associated with pathologies, such as the metabolic syndrome, which were previously believed to be only found in adults. Resistance to insulin is an important risk factor in subjects with severe obesity, which along with visceral obesity, make postprandial triglyceridemia more severe. This increases cardiovascular risk. However, in our opinion, this phenomenon has not been adequately studied in children. The hearthealthy properties of olive oil, the main ingredient of the Mediterranean diet, have been clearly highlighted in various studies. These properties include an improved postprandial...
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
There is a general consensus that obesity is an eminently inflammatory process. This is justified... more There is a general consensus that obesity is an eminently inflammatory process. This is justified by alterations observed in obese patients, which affect the secretion of certain cytokines such as ceruloplasmin, leptin, adiponectin, and interleukin-6 (IL-6), among others. In a parallel way, other research has also pointed out alterations in the composition of fatty acids in the erythrocyte membrane of overweight adults. The results obtained in our study confirm the existence of a significant correlation between the serum levels of some of the cytokines studied and the nutritional state of the sample studied. This means that for the population of children evaluated in our study, the serum concentrations of these biomolecules can be an important tool for the prediction of cardiovascular risk when they become adults. Furthermore significant differences were found regarding the composition of saturated fatty acids in the erythrocyte membrane.
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Numerous studies have focused on establishing a relation between the serum values of biomolecules... more Numerous studies have focused on establishing a relation between the serum values of biomolecules such as leptin, ceruloplasmin, and lipoprotein (a), and the nutritional state and levels of diastolic and systolic blood pressure in subjects with problems of overweight or obesity. However, in many cases, the results obtained have not been conclusive. The results of our study confirm the existence of a statistically significant association between the serum levels of these biomolecules, the nutritional state of the subjects, and levels of diastolic and systolic blood pressure. For the population of overweight and obese adolescents studied, the evaluation of the serum concentrations of these biomolecules was found to be an important instrument that could be used to identify those subjects with an elevated risk of suffering cardiovascular disorders basically derived from a hypertensive status.
Behavioural pharmacology
The aim of this study was to explore the effects of a multidisciplinary behavioral intervention i... more The aim of this study was to explore the effects of a multidisciplinary behavioral intervention including cognitive behavioral therapy, structured physical activity, and dietary counseling on impulsive personality and cognitive skills and subsequent BMI loss in excess weight adolescents. Forty-two adolescents with excess weight (14 males and 28 females, range 12-17 years), as defined by the International Obesity Task Force Criteria, participated in our study. We used a longitudinal observational design with two assessments: before and after treatment. We collected baseline measures of impulsive personality (UPPS-P scale), cognitive performance (letter number sequencing, Stroop and Iowa gambling task), and biometric parameters. After 12 weeks of intervention, parallel measures were used to determine whether treatment-induced changes in impulsivity and cognition predicted changes in BMI. BMI showed a statistically significant reduction after treatment [from mean (SD) 29.36 (4.51) to 2...
![Research paper thumbnail of [C-reactive protein as a biochemical marker of cardiovascular risk]](https://attachments.academia-assets.com/45796451/thumbnails/1.jpg)
](Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Objectives: The first objective of this study was to analyze the metabolic profile of the populat... more Objectives: The first objective of this study was to analyze the metabolic profile of the population to be studied. The second one was to ascertain whether there was a significant association between the nutritional status of the subjects and the serum level of C-reactive protein. Finally, the third objective was to discover whether there was a correlation between C-reactive protein serum levels and waist to hip ratio values. Sample and methodology: The sample was composed of 1001 adolescents, 9-17 years of age, from 18 schools in the provinces of Granada and Almeria. Their nutritional status was determined by means of anthropometric evaluation. For the metabolic study, a blood sample was collected from each subject by venipuncture. An analysis was performed of C-reactive protein, basal glycemia, ceruloplasmin, glycated hemoglobin (HBA1c), basal insulin, serum levels of lipoprotein (a), and non-esterified fatty acids (NEFA). Results: The biochemical study reflected a normal metaboli...
Endocrinología y Nutrición
Liver steatosis, also called non-alcoholic fatty liver, is characterized by a pathological fat ac... more Liver steatosis, also called non-alcoholic fatty liver, is characterized by a pathological fat accumulation in the liver, leading to liver damage in the form of inflammation and fibrosis. These histological features are similar to those in alcoholic hepatitis. Obesity is known to be the most common cause of simple steatosis in the preadolescent and adolescent population with a consequent serious health risk. The aim of this study was to provide an update on the concepts, pathophysiology and clinical management of hepatic steatosis secondary to obesity at an early age.
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Introducción: los estudiantes universitarios representan un colectivo social en riesgo desde el p... more Introducción: los estudiantes universitarios representan un colectivo social en riesgo desde el punto de vista nutricional, ya que a menudo mantienen estilos de vida y hábitos nutricionales inapropiados. Objetivos: analizar el estilo de vida de los alumnos del Campus de la Universidad de Granada en Melilla. Analizar la evolución de los hábitos alimentarios de los estudiantes del campus durante el curso académico 2013-2014. Material y método: se realizó un estudio longitudinal durante el curso académico 2013-2014 en el cual, a su inicio, se evaluó el estilo de vida y, de forma continuada los hábitos nutricionales de un grupo representativo de 257 estudiantes, 90 chicos (35%) y 167 chicas (65%), todos ellos del campus de la Universidad de Granada en la Ciudad Autónoma de Melilla (norte de África). Resultados: los hábitos nutricionales empeoran a medida que avanza el curso académico, caracterizándose por una reducción significativa (p < 0.001) en la ingesta de carbohidratos, así com...
BioMed Research International, 2015
Objective. Cancer-related fatigue (CRF) is the most common and devastating problem in cancer pati... more Objective. Cancer-related fatigue (CRF) is the most common and devastating problem in cancer patients even after successful treatment. This study aimed to determine the effects of supervised multimodal exercise interventions on cancer-related fatigue through a systematic review and meta-analysis. Design. A systematic review was conducted to determine the effectiveness of multimodal exercise interventions on CRF. Databases of PubMed, CENTRAL, EMBASE, and OVID were searched between January and March 2014 to retrieve randomized controlled trials. Risk of bias was evaluated using the PEDro scale. Results. Nine studies ( = 772) were included in both systematic review and meta-analysis. Multimodal interventions including aerobic exercise, resistance training, and stretching improved CRF symptoms (SMD = −0.23; 95% CI: −0.37 to −0.09; = 0.001). These effects were also significant in patients undergoing chemotherapy ( < 0.0001). Nonsignificant differences were found for resistance training interventions ( = 0.30). Slight evidence of publication bias was observed ( = 0.04). The studies had a low risk of bias (PEDro scale mean score of 6.4 (standard deviation (SD) ± 1.0)). Conclusion. Supervised multimodal exercise interventions including aerobic, resistance, and stretching exercises are effective in controlling CRF. These findings suggest that these exercise protocols should be included as a crucial part of the rehabilitation programs for cancer survivors and patients during anticancer treatments.
BioFactors (Oxford, England), Jan 4, 2016
The metabolic syndrome (MetS) is precisely defined and the cardiovascular risk associated with th... more The metabolic syndrome (MetS) is precisely defined and the cardiovascular risk associated with the clustering of its components has been demonstrated in adults. However, data on children and adolescents are still scarce, in part, because of difficulties in transposing the definition from adults. The identification of risk factors for the development of MetS at an early age is essential for prevention purposes with low-grade inflammation acting as a determinant for the association among the MetS components. The aim of this study was to investigate the associations of the MetS with systemic markers of inflammation and ceruloplasmin in a population of adolescents. The present is a cross-sectional study whose sample population consisted of 976 adolescents, 13.2 ± 1.2 years of age. Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were determined by ELISA. High-sensitivity C-reactive protein (hs-CRP) was determined by a solid-phase chemiluminiscent immunometric assay. Ceruloplasmi...
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Resumen Objetivo: determinar los valores del índice cintura/cadera (ICC) en una población escolar... more Resumen Objetivo: determinar los valores del índice cintura/cadera (ICC) en una población escolar de Bogotá, Colombia, pertenecientes al estudio FUPRECOL. Métodos: estudio descriptivo y transversal, realizado en 3.005 niños y 2.916 adolescentes de entre 9 y 17,9 años de edad, pertenecientes a instituciones educativas oficiales de Bogotá, Colombia. Se tomaron medidas de peso, talla, circunferencia de cintura, circunferencia de cadera y estado de maduración sexual por autorreporte. Se calcularon los percentiles (P 3, P 10, P 25, P 50, P 75, P 90 y P 97) según sexo y edad y se realizó una comparación entre los valores del ICC observados y los estándares internacionales. Resultados: de la población general (n = 5.921), el 57,0% eran chicas (promedio de edad 12,7 ± 2,3 años). En todas las edades el ICC fue mayor en los chicos que en las chicas, observándose un descenso en la media de los valores obtenidos desde los 9 hasta los 17,9 años. En los chicos, los valores del ICC mayores del P 90 (asociados a riesgo cardiovascular) estuvieron en el rango 0,87 y 0,93 y en las chicas entre 0,85 y 0,89. Al comparar los resultados de este estudio, por grupos de edad y sexo, con trabajos internacionales de niños y adolescentes de Europa, Suramérica, Asia y África, se observa que los valores del ICC fueron menores en este estudio en ambos sexos, con excepción de los escolares originarios de Grecia y Venezuela. Conclusiones: se presentan percentiles del ICC según edad y sexo que podrán ser usados como de referencia en la evaluación del estado nutricional y en la predicción del riesgo cardiovascular desde edades tempranas.
Nurse Education Today
BACKGROUND According to previous studies on nursing education, although the use of games can prod... more BACKGROUND According to previous studies on nursing education, although the use of games can produce positive results, the vast majority are based on questions and answers or on clinical situations. As an alternative, the 'Escape Room' teaching game is a much more dynamic option to asses theoretical and practical knowledge, and it may also promote teamwork and the ability to perform under pressure. OBJECTIVES To analyse nursing students' opinions and study motivations after using the nursing 'Escape Room' teaching game. DESIGN Cross-sectional descriptive study. PARTICIPANTS Second-year nursing students enrolled in the 'Adult Nursing 1' subject. METHOD After completing the teaching game, the students who had taken part in it were asked to fill in an ad-hoc questionnaire on the matter. In this game, students have 30 min in which they must solve the riddles and puzzles presented, and thus escape. In doing so, they must demonstrate both theoretical and practical knowledge, and a teacher will remain in the classroom to assess whether the nursing techniques in question are correctly performed. RESULTS The nursing students who took part in the game strongly believed that this 'helped them learn the subject' (4.8 points) and that 'more games of this type should be included in their nursing studies' (4.8 points). Overall, they considered that 'the game was enjoyable' (4.6 points), 'helped them in the exam' (4.6 points), and 'motivated them to study' (4.5 points). CONCLUSIONS The 'Escape Room' is a useful game; it stimulates learning, is fun to play, and motivates studying.
Western Journal of Nursing Research, 2016
The aim of this study was to investigate the association between cardiorespiratory fitness (CRF) ... more The aim of this study was to investigate the association between cardiorespiratory fitness (CRF) and cardiovascular risk factors (CVRF) in schoolchildren. A secondary aim was to evaluate the degree of association between overall and abdominal adiposity and CRF in a total of 1,875 children and adolescents attending public schools. We expressed CRF performance as the nearest stage (minute) completed and the estimated peak oxygen consumption. A CVRF ( Z score) was calculated and participants were divided into tertiles according to low and high levels of overall (sum of the skinfold thicknesses) and abdominal adiposity. Schoolchildren with a high-level of overall adiposity demonstrated significant differences in seven of the 10 variables analyzed (i.e., systolic and diastolic blood pressure, triglycerides, triglycerides/high density lipoproteins [HDL-c] ratio, total cholesterol, glucose, C-reactive protein [usCRP], HDL-c, low density lipoproteins [LDL-c], and cardiovascular risk score)....
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
... M a . J. Aguilar Cordero 1 , E. González Jiménez 1 , CJ García García 2 , PA García López 3 ,... more ... M a . J. Aguilar Cordero 1 , E. González Jiménez 1 , CJ García García 2 , PA García López 3 , J. Álvarez Ferre 4 , CA Padilla López 5 y JL González Mendoza 5 y E. Ocete Hita 6. ... [ Links ]. 9. Martínez JA, Moreno B, Martínez González A. Prevalence of obesity in Spain. ...
Objective: To establish the influence of exercise interventions on tumor microenvironment-related... more Objective: To establish the influence of exercise interventions on tumor microenvironment-related markers, including inflammatory cytokines, C-reactive protein (CRP) and Insulin-like growth factors (IGF's) in breast cancer survivors. Methods: PRISMA statement was followed. MEDLINE, Ovid, EMBASE and CENTRAL were searched for randomized controlled trials until February 2014. Heterogeneity was measured by using the I2 statistics. A random-effects models was used in presence of high statistical heterogeneity (I2>50%). Meta-regression analyses were also conducted. Results: Data from 15 studies were pooled (n=1,447; mean age= 51.6 years old). Exercise interventions resulted in positive effects for CRP, IL-2, IL-10, IGF-I, IGF-II and IGFBP-3 (p<.05). Non-significant differences were found for IL-6 and TNF-α. Meta-regression models showed that duration (>40 minutes/session) and training intensity (>70% maximum heart rate) of the exercise were predictors of the effects on tum...
Medicine & Science in Sports & Exercise
PURPOSE: Does supervised physical activity reduce cancer-related fatigue? METHODS: Systematic rev... more PURPOSE: Does supervised physical activity reduce cancer-related fatigue? METHODS: Systematic review with meta-analysis of randomised trials. Participants: People diagnosed with any type of cancer, without restriction to a particular stage of diagnosis or treatment. Intervention: Supervised physical activity interventions (eg, aerobic, resistance and stretching exercise), defined as any planned or structured body movement causing an increase in energy expenditure, designed to maintain or enhance health-related outcomes, and performed with systematic frequency, intensity and duration. Outcome measures: The primary outcome measure was fatigue. Secondary outcomes were physical and functional wellbeing assessed using the Functional Assessment of Cancer Therapy FACT-Fatigue Scale, EORTC, QLQ-C30, PFS, SCFS, MFI. Methodological quality including risk of bias of the studies was evaluated using the PEDro Scale. RESULTS: Eleven studies involving 1530 participants were included in the review....
Asia-Pacific Journal of Clinical Oncology
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Objectives: The first objective of this study was to evaluate the nutritional status and insulin ... more Objectives: The first objective of this study was to evaluate the nutritional status and insulin resistance index in a population of adolescents as calculated by Homeostatic Model Assessment (HOMA). The second objective was to establish correlations between the nutritional status of the subjects, the possible existence of insulin resistance, and the risk of high blood pressure. Population sample and methodology: The sample was composed of 1001 adolescents, 9-17 years of age, from 18 schools in the provinces of Granada and Almeria. Their nutritional status was determined by means of anthropometric evaluation. For the metabolic study, a blood sample was collected from each subject by venipuncture. An analysis was performed of the basal glucose and insulin levels as well as the Homeostatic Model Assessment- Insulin Resistance (HOMAIR) index. Also evaluated were the levels of glycosylated haemoglobin (HbA1c), serum lipoprotein (a), and non-esterified fatty acids (NEFAs). Insulin resista...
Objective To determine the pooled effects of supervised exercise interventions on cancer-related ... more Objective To determine the pooled effects of supervised exercise interventions on cancer-related fatigue (CRF) in breast cancer survivors. Participants Breast cancer survivors (>20 years old) without restriction to treatment stage. Methods PRISMA statement was followed. Databases of Pubmed/Medline, Embase, Scopus Central and CINAHL were searched until January 2014 without language restrictions. Risk of bias and methodological quality were evaluated with the Pedro score. Polled effects were calculated in stata version 11 through a random-effects model. Heterogeneity was evaluated with the chi2 test (p<0.10) and i2 statistics (i2>50%). Results Nine high quality studies (n=1156) were included. Supervised aerobic exercise was statistically more effective than conventional care in improving CRF among breast cancer survivors (SMD= -0.37 95%CI [-0.70 -0.40]) p<0.00001; i2= 80%. Resistance training produced significant improvements on CRF SMD=-0.55 95%CI (-1.09 to -0.01) p<0....
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
The excess weight that characterizes much of the population of the world today has led the World ... more The excess weight that characterizes much of the population of the world today has led the World Health Organization to declare a obesity pandemic. The number of overweight and obese children in Spain is among the highest in Europe, and this number is even higher in Andalusia. The health consequences of excess weight for children are not as evident as for adults. However, child obesity is now being associated with pathologies, such as the metabolic syndrome, which were previously believed to be only found in adults. Resistance to insulin is an important risk factor in subjects with severe obesity, which along with visceral obesity, make postprandial triglyceridemia more severe. This increases cardiovascular risk. However, in our opinion, this phenomenon has not been adequately studied in children. The hearthealthy properties of olive oil, the main ingredient of the Mediterranean diet, have been clearly highlighted in various studies. These properties include an improved postprandial...
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
There is a general consensus that obesity is an eminently inflammatory process. This is justified... more There is a general consensus that obesity is an eminently inflammatory process. This is justified by alterations observed in obese patients, which affect the secretion of certain cytokines such as ceruloplasmin, leptin, adiponectin, and interleukin-6 (IL-6), among others. In a parallel way, other research has also pointed out alterations in the composition of fatty acids in the erythrocyte membrane of overweight adults. The results obtained in our study confirm the existence of a significant correlation between the serum levels of some of the cytokines studied and the nutritional state of the sample studied. This means that for the population of children evaluated in our study, the serum concentrations of these biomolecules can be an important tool for the prediction of cardiovascular risk when they become adults. Furthermore significant differences were found regarding the composition of saturated fatty acids in the erythrocyte membrane.
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Numerous studies have focused on establishing a relation between the serum values of biomolecules... more Numerous studies have focused on establishing a relation between the serum values of biomolecules such as leptin, ceruloplasmin, and lipoprotein (a), and the nutritional state and levels of diastolic and systolic blood pressure in subjects with problems of overweight or obesity. However, in many cases, the results obtained have not been conclusive. The results of our study confirm the existence of a statistically significant association between the serum levels of these biomolecules, the nutritional state of the subjects, and levels of diastolic and systolic blood pressure. For the population of overweight and obese adolescents studied, the evaluation of the serum concentrations of these biomolecules was found to be an important instrument that could be used to identify those subjects with an elevated risk of suffering cardiovascular disorders basically derived from a hypertensive status.
Behavioural pharmacology
The aim of this study was to explore the effects of a multidisciplinary behavioral intervention i... more The aim of this study was to explore the effects of a multidisciplinary behavioral intervention including cognitive behavioral therapy, structured physical activity, and dietary counseling on impulsive personality and cognitive skills and subsequent BMI loss in excess weight adolescents. Forty-two adolescents with excess weight (14 males and 28 females, range 12-17 years), as defined by the International Obesity Task Force Criteria, participated in our study. We used a longitudinal observational design with two assessments: before and after treatment. We collected baseline measures of impulsive personality (UPPS-P scale), cognitive performance (letter number sequencing, Stroop and Iowa gambling task), and biometric parameters. After 12 weeks of intervention, parallel measures were used to determine whether treatment-induced changes in impulsivity and cognition predicted changes in BMI. BMI showed a statistically significant reduction after treatment [from mean (SD) 29.36 (4.51) to 2...
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Objectives: The first objective of this study was to analyze the metabolic profile of the populat... more Objectives: The first objective of this study was to analyze the metabolic profile of the population to be studied. The second one was to ascertain whether there was a significant association between the nutritional status of the subjects and the serum level of C-reactive protein. Finally, the third objective was to discover whether there was a correlation between C-reactive protein serum levels and waist to hip ratio values. Sample and methodology: The sample was composed of 1001 adolescents, 9-17 years of age, from 18 schools in the provinces of Granada and Almeria. Their nutritional status was determined by means of anthropometric evaluation. For the metabolic study, a blood sample was collected from each subject by venipuncture. An analysis was performed of C-reactive protein, basal glycemia, ceruloplasmin, glycated hemoglobin (HBA1c), basal insulin, serum levels of lipoprotein (a), and non-esterified fatty acids (NEFA). Results: The biochemical study reflected a normal metaboli...
Endocrinología y Nutrición
Liver steatosis, also called non-alcoholic fatty liver, is characterized by a pathological fat ac... more Liver steatosis, also called non-alcoholic fatty liver, is characterized by a pathological fat accumulation in the liver, leading to liver damage in the form of inflammation and fibrosis. These histological features are similar to those in alcoholic hepatitis. Obesity is known to be the most common cause of simple steatosis in the preadolescent and adolescent population with a consequent serious health risk. The aim of this study was to provide an update on the concepts, pathophysiology and clinical management of hepatic steatosis secondary to obesity at an early age.
Nutricion hospitalaria: organo oficial de la Sociedad Espanola de Nutricion Parenteral y Enteral
Introducción: los estudiantes universitarios representan un colectivo social en riesgo desde el p... more Introducción: los estudiantes universitarios representan un colectivo social en riesgo desde el punto de vista nutricional, ya que a menudo mantienen estilos de vida y hábitos nutricionales inapropiados. Objetivos: analizar el estilo de vida de los alumnos del Campus de la Universidad de Granada en Melilla. Analizar la evolución de los hábitos alimentarios de los estudiantes del campus durante el curso académico 2013-2014. Material y método: se realizó un estudio longitudinal durante el curso académico 2013-2014 en el cual, a su inicio, se evaluó el estilo de vida y, de forma continuada los hábitos nutricionales de un grupo representativo de 257 estudiantes, 90 chicos (35%) y 167 chicas (65%), todos ellos del campus de la Universidad de Granada en la Ciudad Autónoma de Melilla (norte de África). Resultados: los hábitos nutricionales empeoran a medida que avanza el curso académico, caracterizándose por una reducción significativa (p < 0.001) en la ingesta de carbohidratos, así com...
BioMed Research International, 2015
Objective. Cancer-related fatigue (CRF) is the most common and devastating problem in cancer pati... more Objective. Cancer-related fatigue (CRF) is the most common and devastating problem in cancer patients even after successful treatment. This study aimed to determine the effects of supervised multimodal exercise interventions on cancer-related fatigue through a systematic review and meta-analysis. Design. A systematic review was conducted to determine the effectiveness of multimodal exercise interventions on CRF. Databases of PubMed, CENTRAL, EMBASE, and OVID were searched between January and March 2014 to retrieve randomized controlled trials. Risk of bias was evaluated using the PEDro scale. Results. Nine studies ( = 772) were included in both systematic review and meta-analysis. Multimodal interventions including aerobic exercise, resistance training, and stretching improved CRF symptoms (SMD = −0.23; 95% CI: −0.37 to −0.09; = 0.001). These effects were also significant in patients undergoing chemotherapy ( < 0.0001). Nonsignificant differences were found for resistance training interventions ( = 0.30). Slight evidence of publication bias was observed ( = 0.04). The studies had a low risk of bias (PEDro scale mean score of 6.4 (standard deviation (SD) ± 1.0)). Conclusion. Supervised multimodal exercise interventions including aerobic, resistance, and stretching exercises are effective in controlling CRF. These findings suggest that these exercise protocols should be included as a crucial part of the rehabilitation programs for cancer survivors and patients during anticancer treatments.