Ernesto Cortés - Profile on Academia.edu (original) (raw)
Papers by Ernesto Cortés
![Research paper thumbnail of [Quality of the diet and lifestyles in health sciences students]](https://attachments.academia-assets.com/122815406/thumbnails/1.jpg)
](PubMed, 2014
Objective: To evaluate the eating habits of the students of the University of Alicante of the deg... more Objective: To evaluate the eating habits of the students of the University of Alicante of the degrees of Human Nutrition and Dietetics and Nursing. Material and methods: The study was carried out to 184 students of both sexes (96 of Human Nutrition and Dietetics and Nursing 88) of the University of Alicante. Were weighed and carved to calculate BMI; food consumption was estimated by the reminder of 24 hours; intake of macro and micronutrients were calculated using the program Easydiet. Comparing the results obtained in both qualifications and according to nutritional status by performing the corresponding statistical analysis. Results: The majority of the students analyzed are normal weight (80%). There were significant differences in the quality of the diet both degrees, being the same characteristics: low in carbohydrates and high in protein. It also shows an imbalance in the type of fat consumed, with a higher consumption of saturated and less from polyunsaturated than recommended. Likewise, analyzed that nutrition students do more exercise than the nurses, although they sleep fewer hours and spend more time in front of the computer and TV. Conclusion: While the levels of overweight and obesity among students is less than that of the general population, there are imbalances in your diet, noting that consumption of macronutrients is located away from the recommendations, and that there are deficiencies in the intake of micronutrients. Showing that have knowledge of nutrition, does not affect healthy decision-making to a diet and lifestyle.
Scientific Reports, May 22, 2015
Orphanet Journal of Rare Diseases, Nov 7, 2014
Background: We studied the differences in immunoreactive trypsin (IRT) in neonatal screening for ... more Background: We studied the differences in immunoreactive trypsin (IRT) in neonatal screening for cystic fibrosis (CF) associated individually with the age of the newborn, ethnicity and environmental temperature. In this study, we determine the overall influence of environmental temperature at birth, gender, feeding, gestational age, maternal age and ethnic origin on an abnormal IRT result. Methods: Cross-sectional observational study. A sample was selected of newborns from Alicante (Spain) who underwent neonatal CF screening in 2012-2013. Primary variable: abnormal IRT levels (≥65 ng/ml). Secondary variables: gender, maternal origin, maternal age (years) (<20, 20-40, >40), gestational age (weeks) (<32, 32-37, >37), type of feeding (natural, formula, mixed and special nutrition), >20 days from birth to blood collection, and average temperature during the month of birth (in°C). Using a multivariate logistic regression model the adjusted odds ratios (ORs) were estimated to analyze the association between atypical IRT levels and the study variables. The α error was 5% and confidence intervals (CI) were calculated for the most relevant parameters. Results: Of a total of 13,310 samples, 199 were abnormal (1.34%). Significant associated factors: feeding method (natural → OR = 1; mixed → OR = 0.53, 95% CI: 0.31-0.89; formula → OR = 0.72, 95% CI: 0.48-1.07; special → OR = 21.88, 95% CI: 6.92-69.14; p < 0.001). Conclusions: Newborns receiving special nutrition have a 20-fold higher risk for abnormal IRT levels, and screening is advisable once normalized feeding is initiated. It is advisable to consider ethnic variability. Seasonality was not important.
Objetivo: Evaluar la respuesta al tratamiento segun sexo en una consulta de nutricion por sobrepe... more Objetivo: Evaluar la respuesta al tratamiento segun sexo en una consulta de nutricion por sobrepeso y obesidad. Metodos: Se realiza un estudio clinico entre pacientes de un centro medico nutricional en tratamiento estetico de sobrepeso y obesidad, realizado mediante valoracion y tratamiento medico nutricional por seguimiento continuo semanal y personalizado durante 16 semanas, basado en su consumo habitual de alimentos, adecuacion de la cantidad de alimentos y percepcion de su estado de salud y bajada de peso. Resultados: De la muestra inicial de 271 pacientes que acudieron a consulta para bajar de peso y mejorar su imagen corporal (233?/ 38?) se excluyeron a 100 pacientes (98? y 2?) por encontrase en normopeso (IMC<25) (test Chi2 p<0.001, OR=0,08; IC 95% 0,01-0,32 de unicamente razones de estetica de los hombres frente a las mujeres). De los 171 pacientes con sobrepeso u obesidad, siguieron el tratamiento 155 (122? y 33?), con un 68,4% de exito en la perdida de peso y cintura...
![Research paper thumbnail of [Correspondence between the fatty acids in healthy children serum and in membrane phospholipids]](https://attachments.academia-assets.com/122815404/thumbnails/1.jpg)
](Nutrición hospitalaria
The diet is important in the supply of fatty acids in humans, especially those of the n-3 and n-6... more The diet is important in the supply of fatty acids in humans, especially those of the n-3 and n-6 families by its essentiality and related physiological function. It is important to have reference values in accessible biological samples: serum and erythrocyte membranes, in order to alleviate potential shortfalls. The objective is quantifying fatty acids present in these samples from C6 to C26. the determinations of the fatty acids of 30 healthy children in serum and its corresponding membrane phospholipids from blood cells by lipid extraction, methylation, separation and quantification in gas chromatography with detection of masses have been. It is comparing the values obtained in each serum and its partner of cell membranes. It is have obtained normal values in healthy children. The C16, which represent a quarter of all fatty acids, it is in the same proportion in both samples, in the rest of fatty acids, there is no clear correspondence between both values. In the n-6 family, the ...
European Journal of Clinical Nutrition, 2001
Background=objective: Long chain polyunsaturated fatty acids have beneficial effects in preterm n... more Background=objective: Long chain polyunsaturated fatty acids have beneficial effects in preterm neurophysiological development and are semi-essential. Their levels and variation in plasma and red cells in term and preterms are better known than their intestinal absorption. In this paper the absorption of supplemented arachidonic acid (AA) and docosahexaenoic acid (DHA) is evaluated in a preterm group. Design: Four newborn randomized groups were studied. Group T comprised 11 terms on regular formula. Preterms: group P (n ¼ 9) was on a classic preterm formula. Intervention: groups PA (n ¼ 9) and PB (n ¼ 13) were on the same formula but PB contained AA and DHA in similar proportion to breast milk. At 20 days a 3 day metabolic balance was taken for Ca, P i , Mg, total fat and individual fatty acids (C8 -C24, saturated unsaturated). Results: Calcium absorption was (mean AE s.d.) 51 AE 13% in terms. In preterms it was respectively 45 AE 18, 38 AE 11 and 37 AE 21%. Total fat absorption was 92.0AE 8.0% in terms, and from 95.0 AE 2.0 to 91.0 AE 8.0% in preterms. Absorption of 8:0, 10:0 and 12:0 showed a very high and constant rate despite significant intake differences (715 -33 mg=kg=day). Linoleic acid and a-linolenic acid were absorbed in the three groups at around 94% regardless of a greater LA intake in group P. Details of absorption (mg=kg=day) were: for AA, intake 17 AE 7, fecal excretion 5 AE 4, net retention 12 AE 5 (75.0 AE 18%); for DHA, intake 10 AE 3, fecal excretion 3 AE 2, net retention 6 AE 4 (62.3AE 30%). Conclusion: Intestinal absorption of fatty acids is high and is comparable in terms and preterms as regards the studied acids. Longer acids were less well absorbed. The supplemented amounts of AA and DHA were less well absorbed and probably not impairing calcium absorption.
Anales De Pediatria, 1998
Ffundamento: la ausencia de lactosa comporta una disminucion de la absorcion intestinal de calcio... more Ffundamento: la ausencia de lactosa comporta una disminucion de la absorcion intestinal de calcio y si este no es absorbido, puede formar jabones calcicos con los acidos grasos en la luz intestinal. Se ha comparado la absorcion de grasa total, da acido grasos y la absorcion y retencion de calcio, magnesio y fosfato en dos grupos de nnos alimentados con una formula sin lactosa (FSL) frente a otra de inicio convencional identica (FI). Ningunas de ellas estaba adicionada de acido araquidonico ni docosahexaenoico. Conclusion: el patron absortivo de los acidos grasos en el recien nacido a termino no presenta anomalias ni disminuciones llamativas.
Chemistry and Physics of Lipids, 1984
In the microsomal fraction of thyroid glands, the temperature dependence of DPH fluorescence pola... more In the microsomal fraction of thyroid glands, the temperature dependence of DPH fluorescence polarization showed a discontinuity in the range of 29-33°C. 2. The transition temperatures of DMPC, DPPC and DSPC are near to the observed for the microsomal fraction. So that, thyroid peroxidase (TPO) was incorporated into liposomes made with these phospholipids. 3. When DPH was incorporated in this peroxidase-liposome complex, a less pronounced phase transition was observed in the profiles of temperature dependence of DPH polarization, and the incorporation of the enzyme decreased the Tc. 4. Arrhenius plots of TPO incorporated into liposomes showed discontinuities at similar temperatures observed by fluorescence polarization. 5. The decrease of transition temperature of liposomes induced by thyroid peroxidase incorporation suggests that this enzyme seems to need a fluid medium for its enzyme activity.
PeerJ, 2014
Objective. To explore anthropometric changes in normal-weight, overweight and obese subjects who ... more Objective. To explore anthropometric changes in normal-weight, overweight and obese subjects who did not dropout or fail a weight loss program over the 16 treatment weeks to improve patient motivation and treatment adherence. Methods. A clinical intervention study was conducted among 271 (including 100 dropouts and/or failures) obese and overweight patients who consulted a nutrition clinic in Barranquilla (Colombia) for the purpose of nutritional assessment. They were subject to a personalized weekly follow-up consultation over the course of 16 weeks in which initial and the final Body Mass Index (BMI, kg/m 2), photographs, food consumption patterns, percentage weight loss, waist and hip circumference were registered and grouped according to BMI, measuring treatment response. Data's nonparametric statistical comparison was made. Results. In 62 patients from the BMI < 25 group, there is weight loss of 2.6% (3.1 SD), 5.5% (3.3 SD) in waist circumference and 3.0% (2.5 SD) in hip circumference. In 67 patients from the 25 ≥ BMI < 30 group, there is weight loss of 3.8% (4.1 SD), 5.7% (4.5 SD) in waist circumference loss and 3.7% (3.0 SD) in hip circumference loss. In 42 patients from the BMI > 30 group, there is weight loss of 4.8% (3.7 SD), 7.0% (3.6 SD) in waist circumference loss and 3.9% (2.4 SD) in hip circumference loss. Monitoring is done every 4 weeks by the Friedman test, with significant differences between the three groups (p < 0.001). Patients do not drop out of treatment because they start to see physical results in waist decrease. When comparing final values of initial waist/hip circumference ratios and waist/height ratios, a clear decrease in the three BMI groups was observed (p < 0.001). Conclusion. After three weeks of continuous treatment patients improved in all overweight and obesity parameter indicators; there were not statistically significant differences in hip circumference (HC) and waist loss (WC) (%) among the three BMI groups (normal-weight, overweight, and obesity). In contrast, there were statistically significant differences in weight loss (%) and waist-to-hip ratios. Based on anthropometric outcomes and patient perception of their body image it can be concluded that the waist circumference loss is the parameter that retains obese patients in the weight loss program.
[Neonatal screening for hereditary metabolic diseases. Nursing action]
Revista de enfermería (Barcelona, Spain)
The authors provide the information necessary so that nurses are capable of adequately carrying o... more The authors provide the information necessary so that nurses are capable of adequately carrying out the duties which pertain to neonatal screening programs for hereditary metabolic diseases. The authors briefly describe those diseases which are subject to neonatal screening with the objective of providing their basic features, especially in relation to neonatal screening and the benefits which this may provide. The authors explain the method to correctly take a blood sample on the paper filter sample cards and they describe the most frequently committed errors as a way to prepare nursing personnel which may at some time have contact with these functions so that these are properly performed.
Y Regularidad De Los Ciclos
Age group, menarche and regularity of menstrual cycles as efficiency predictors in the treatment ... more Age group, menarche and regularity of menstrual cycles as efficiency predictors in the treatment of overweight
RESEARCH ARTICLE Safety of Ferric Carboxymaltose Immediately after Infliximab Administration, in a Single Session, in Inflammatory Bowel Disease Patients with Iron Deficiency: A Pilot Study
Aim To obtain preliminary safety and efficacy data on intravenous (IV) administration of inflixi-... more Aim To obtain preliminary safety and efficacy data on intravenous (IV) administration of inflixi-mab (IFX) and ferric carboxymaltose (FCM) to inflammatory bowel disease (IBD) patients in a single treatment session. Methods A two-phase non-interventional, observational, prospective pilot study was performed to evaluate safety and efficacy of FCM given immediately after IFX. IBD patients were re-cruited consecutively in the outpatient clinic in two groups. Control group patients (n = 12) received FCM on a separate day from IFX. Subsequently, single-session group patients (n = 33) received FCM after IFX on the same day. All patients received 5mg/kg IFX and 1000mg FCM for iron-restricted anemia (IRA) or 500mg FCM for iron deficiency without anemia. Safety assessment was performed by recording adverse events (AEs) during and immediately after infusion, 30 minutes afterwards, and via follow-up at 7 days and 8 weeks. For efficacy assessment, hematological parameters were assessed prior to ...
Clinical Chemistry, 1987
In this new method for quantifying vitamin D in infants' formulas and breast milk, after repe... more In this new method for quantifying vitamin D in infants' formulas and breast milk, after repeated lipid extraction, samples are further purified by passage through Sep-Pak cartridges, followed by liquid chromatography, then quantified by competitive protein-binding assay. Analytical recovery is estimated by use of added 3H-labeled vitamin D. For repeated assays of a reconstituted proprietary powdered milk formula in two runs, the intra-assay vitamin D values were 9.0 (SD 1.4) (n = 6) and 8.9 (SD 1.6) micrograms/L (n = 7) (t = 0.07). Assay of a proprietary liquid formula yielded values of 14.9 (SD 0.9) micrograms/L (n = 6). For each, the results agreed with the vitamin D content shown on the label. Vitamin D concentrations in breast milk from two groups of lactating mothers of different social class and nutritional status were 2.3 (SD 1.4) (n = 7) and 2.0 (SD 1.7) micrograms/L (n = 7). Overall recoveries ranged from 65 to 75%. Only 2 mL of milk is required, which facilitates samp...
PeerJ, 2016
In January 2012, a review of the cases of chromosome 15q24 microdeletion syndrome was published. ... more In January 2012, a review of the cases of chromosome 15q24 microdeletion syndrome was published. However, this study did not include inferential statistics. The aims of the present study were to update the literature search and calculate confidence intervals for the prevalence of each phenotype using bootstrap methodology. Published case reports of patients with the syndrome that included detailed information about breakpoints and phenotype were sought and 36 were included. Deletions in megabase (Mb) pairs were determined to calculate the size of the interstitial deletion of the phenotypes studied in 2012. To determine confidence intervals for the prevalence of the phenotype and the interstitial loss, we used bootstrap methodology. Using the bootstrap percentiles method, we found wide variability in the prevalence of the different phenotypes (3–100%). The mean interstitial deletion size was 2.72 Mb (95% CI [2.35–3.10 Mb]). In comparison with our work, which expanded the literature s...
PeerJ, 2015
Of the numerous instruments available to detect nutritional risk, the most widely used is the Min... more Of the numerous instruments available to detect nutritional risk, the most widely used is the Mini Nutritional Assessment (MNA), but it takes 15–20 min to complete and its systematic administration in primary care units is not feasible in practice. We developed a tool to evaluate malnutrition risk that can be completed more rapidly using just clinical variables. Between 2008 and 2013, we conducted a cross-sectional study of 418 women aged ≥60 years from Mexico. Our outcome was positive MNA and our secondary variables included were: physical activity, diabetes mellitus, hypertension, educational level, dentition, psychological problems, living arrangements, history of falls, age and the number of tablets taken daily. The sample was divided randomly into two groups: construction and validation. Construction: a risk table was constructed to estimate the likelihood of the outcome, and risk groups were formed. Validation: the area under the ROC curve (AUC) was calculated and we compared ...
Fatty Acid Composition of Mature Breast Milk According to the Mothers Diet During Pregnancy
Advances in Experimental Medicine and Biology
Mothers taking 200 g of fish per week, showed a greater content in mature breast milk of n-3 fatt... more Mothers taking 200 g of fish per week, showed a greater content in mature breast milk of n-3 fatty acids, particularly DHA. AA was not decreased. Vitamin D content was low despite mothers were living in a sunny and temperate area. The content of 25 hydroxyvitamin D is increased in the group on fish intake, probably pointing out its marine source.
Tendencia en el sobrepeso y obesidad: ¿en qué enfocar el tratamiento?
Objective: To evaluate the eating habits of the students of the University of Alicante of the deg... more Objective: To evaluate the eating habits of the students of the University of Alicante of the degrees of Human Nutrition and Dietetics and Nursing. Material and methods: The study was carried out to 184 students of both sexes (96 of Human Nutrition and Dietetics and Nursing 88) of the University of Alicante. Were weighed and carved to calculate BMI; food consumption was estimated by the reminder of 24 hours; intake of macro and micronutrients were calculated using the program Easydiet. Comparing the results obtained in both qualifications and according to nutritional status by performing the corresponding statistical analysis. Results: The majority of the students analyzed are normal weight (80%). There were significant differences in the quality of the diet both degrees, being the same characteristics: low in carbohydrates and high in protein. It also shows an imbalance in the type of fat consumed, with a higher consumption of saturated and less from polyunsaturated than recommended. Likewise, analyzed that nutrition students do more exercise than the nurses, although they sleep fewer hours and spend more time in front of the computer and TV. Conclusion: While the levels of overweight and obesity among students is less than that of the general population, there are imbalances in your diet, noting that consumption of macronutrients is located away from the recommendations, and that there are deficiencies in the intake of micronutrients. Showing that have knowledge of nutrition, does not affect healthy decision-making to a diet and lifestyle.
PeerJ, 2015
Others have analysed the relationship between inadequate behaviour by healthcare professionals in... more Others have analysed the relationship between inadequate behaviour by healthcare professionals in the diagnosis of dyslipidaemia (diagnostic inertia) and the history of cardiovascular risk factors. However, since no study has assessed cardiovascular risk scores as associated factors, we carried out a study to quantify diagnostic inertia in dyslipidaemia and to determine if cardiovascular risk scores are associated with this inertia. In the Valencian Community (Spain), a preventive programme (cardiovascular, gynaecologic and vaccination) was started in 2003 inviting persons aged ≥40 years to undergo a health check-up at their health centre. This cross-sectional study examined persons with no known dyslipidaemia seen during the first six months of the programme (n = 16,905) but whose total cholesterol (TC) was ≥5.17 mmol/L. Diagnostic inertia was defined as lack of follow-up to confirm/discard the dyslipidaemia diagnosis. Other variables included in the analysis were gender, history of cardiovascular risk factors/cardiovascular disease, counselling (diet/exercise), body mass index (BMI), age, blood pressure, fasting blood glucose and lipids. TC was grouped as ≥/<6.20 mmol/L. In patients without cardiovascular disease and <75/≤65 years (n = 15,778/13,597), the REGICOR (REgistre GIroní del COr)/SCORE (Systematic COronary Risk Evaluation) cardiovascular risk functions were used to classify risk (high/low). Inertia was quantified and the adjusted odds ratios calculated from multivariate models. In the overall sample, the rate of diagnostic inertia was 52% (95% CI [51.2-52.7]); associated factors were TC ≥ 6.20 mmol/L, high or "not measured" BMI, hypertension, smoking and higher values of fasting blood glucose, systolic blood pressure and TC. In the REGICOR sample, the rate of diagnostic inertia was 51.9% (95% CI [51.1-52.7]); associated factors were REGICOR high and high or "not measured" BMI. In the SCORE sample the rate of diagnostic inertia was 51.7% (95% CI [50.9-52.5]); associated factors were SCORE high and high or "not measured" BMI. Diagnostic inertia existed in over half the patients and was associated with a greater cardiovascular risk.
PLOS ONE, 2015
To obtain preliminary safety and efficacy data on intravenous (IV) administration of infliximab (... more To obtain preliminary safety and efficacy data on intravenous (IV) administration of infliximab (IFX) and ferric carboxymaltose (FCM) to inflammatory bowel disease (IBD) patients in a single treatment session. A two-phase non-interventional, observational, prospective pilot study was performed to evaluate safety and efficacy of FCM given immediately after IFX. IBD patients were recruited consecutively in the outpatient clinic in two groups. Control group patients (n = 12) received FCM on a separate day from IFX. Subsequently, single-session group patients (n = 33) received FCM after IFX on the same day. All patients received 5mg/kg IFX and 1000mg FCM for iron-restricted anemia (IRA) or 500mg FCM for iron deficiency without anemia. Safety assessment was performed by recording adverse events (AEs) during and immediately after infusion, 30 minutes afterwards, and via follow-up at 7 days and 8 weeks. For efficacy assessment, hematological parameters were assessed prior to FCM infusion (pre-FCM) and after 8 weeks. Economic impact of FCM given immediately after IFX was assessed. All 45 patients (35 Crohn´s disease, 10 ulcerative colitis) received IFX 5mg/kg. 21 patients received 500mg FCM and 24 received 1000mg. FCM administration immediately after IFX corrected iron deficiency or IRA as shown by increases in hematological parameters. No AEs were reported during the safety evaluation at the end of FCM or IFX administration,
PubMed, 2014
Objective: To evaluate the eating habits of the students of the University of Alicante of the deg... more Objective: To evaluate the eating habits of the students of the University of Alicante of the degrees of Human Nutrition and Dietetics and Nursing. Material and methods: The study was carried out to 184 students of both sexes (96 of Human Nutrition and Dietetics and Nursing 88) of the University of Alicante. Were weighed and carved to calculate BMI; food consumption was estimated by the reminder of 24 hours; intake of macro and micronutrients were calculated using the program Easydiet. Comparing the results obtained in both qualifications and according to nutritional status by performing the corresponding statistical analysis. Results: The majority of the students analyzed are normal weight (80%). There were significant differences in the quality of the diet both degrees, being the same characteristics: low in carbohydrates and high in protein. It also shows an imbalance in the type of fat consumed, with a higher consumption of saturated and less from polyunsaturated than recommended. Likewise, analyzed that nutrition students do more exercise than the nurses, although they sleep fewer hours and spend more time in front of the computer and TV. Conclusion: While the levels of overweight and obesity among students is less than that of the general population, there are imbalances in your diet, noting that consumption of macronutrients is located away from the recommendations, and that there are deficiencies in the intake of micronutrients. Showing that have knowledge of nutrition, does not affect healthy decision-making to a diet and lifestyle.
Scientific Reports, May 22, 2015
Orphanet Journal of Rare Diseases, Nov 7, 2014
Background: We studied the differences in immunoreactive trypsin (IRT) in neonatal screening for ... more Background: We studied the differences in immunoreactive trypsin (IRT) in neonatal screening for cystic fibrosis (CF) associated individually with the age of the newborn, ethnicity and environmental temperature. In this study, we determine the overall influence of environmental temperature at birth, gender, feeding, gestational age, maternal age and ethnic origin on an abnormal IRT result. Methods: Cross-sectional observational study. A sample was selected of newborns from Alicante (Spain) who underwent neonatal CF screening in 2012-2013. Primary variable: abnormal IRT levels (≥65 ng/ml). Secondary variables: gender, maternal origin, maternal age (years) (<20, 20-40, >40), gestational age (weeks) (<32, 32-37, >37), type of feeding (natural, formula, mixed and special nutrition), >20 days from birth to blood collection, and average temperature during the month of birth (in°C). Using a multivariate logistic regression model the adjusted odds ratios (ORs) were estimated to analyze the association between atypical IRT levels and the study variables. The α error was 5% and confidence intervals (CI) were calculated for the most relevant parameters. Results: Of a total of 13,310 samples, 199 were abnormal (1.34%). Significant associated factors: feeding method (natural → OR = 1; mixed → OR = 0.53, 95% CI: 0.31-0.89; formula → OR = 0.72, 95% CI: 0.48-1.07; special → OR = 21.88, 95% CI: 6.92-69.14; p < 0.001). Conclusions: Newborns receiving special nutrition have a 20-fold higher risk for abnormal IRT levels, and screening is advisable once normalized feeding is initiated. It is advisable to consider ethnic variability. Seasonality was not important.
Objetivo: Evaluar la respuesta al tratamiento segun sexo en una consulta de nutricion por sobrepe... more Objetivo: Evaluar la respuesta al tratamiento segun sexo en una consulta de nutricion por sobrepeso y obesidad. Metodos: Se realiza un estudio clinico entre pacientes de un centro medico nutricional en tratamiento estetico de sobrepeso y obesidad, realizado mediante valoracion y tratamiento medico nutricional por seguimiento continuo semanal y personalizado durante 16 semanas, basado en su consumo habitual de alimentos, adecuacion de la cantidad de alimentos y percepcion de su estado de salud y bajada de peso. Resultados: De la muestra inicial de 271 pacientes que acudieron a consulta para bajar de peso y mejorar su imagen corporal (233?/ 38?) se excluyeron a 100 pacientes (98? y 2?) por encontrase en normopeso (IMC<25) (test Chi2 p<0.001, OR=0,08; IC 95% 0,01-0,32 de unicamente razones de estetica de los hombres frente a las mujeres). De los 171 pacientes con sobrepeso u obesidad, siguieron el tratamiento 155 (122? y 33?), con un 68,4% de exito en la perdida de peso y cintura...
Nutrición hospitalaria
The diet is important in the supply of fatty acids in humans, especially those of the n-3 and n-6... more The diet is important in the supply of fatty acids in humans, especially those of the n-3 and n-6 families by its essentiality and related physiological function. It is important to have reference values in accessible biological samples: serum and erythrocyte membranes, in order to alleviate potential shortfalls. The objective is quantifying fatty acids present in these samples from C6 to C26. the determinations of the fatty acids of 30 healthy children in serum and its corresponding membrane phospholipids from blood cells by lipid extraction, methylation, separation and quantification in gas chromatography with detection of masses have been. It is comparing the values obtained in each serum and its partner of cell membranes. It is have obtained normal values in healthy children. The C16, which represent a quarter of all fatty acids, it is in the same proportion in both samples, in the rest of fatty acids, there is no clear correspondence between both values. In the n-6 family, the ...
European Journal of Clinical Nutrition, 2001
Background=objective: Long chain polyunsaturated fatty acids have beneficial effects in preterm n... more Background=objective: Long chain polyunsaturated fatty acids have beneficial effects in preterm neurophysiological development and are semi-essential. Their levels and variation in plasma and red cells in term and preterms are better known than their intestinal absorption. In this paper the absorption of supplemented arachidonic acid (AA) and docosahexaenoic acid (DHA) is evaluated in a preterm group. Design: Four newborn randomized groups were studied. Group T comprised 11 terms on regular formula. Preterms: group P (n ¼ 9) was on a classic preterm formula. Intervention: groups PA (n ¼ 9) and PB (n ¼ 13) were on the same formula but PB contained AA and DHA in similar proportion to breast milk. At 20 days a 3 day metabolic balance was taken for Ca, P i , Mg, total fat and individual fatty acids (C8 -C24, saturated unsaturated). Results: Calcium absorption was (mean AE s.d.) 51 AE 13% in terms. In preterms it was respectively 45 AE 18, 38 AE 11 and 37 AE 21%. Total fat absorption was 92.0AE 8.0% in terms, and from 95.0 AE 2.0 to 91.0 AE 8.0% in preterms. Absorption of 8:0, 10:0 and 12:0 showed a very high and constant rate despite significant intake differences (715 -33 mg=kg=day). Linoleic acid and a-linolenic acid were absorbed in the three groups at around 94% regardless of a greater LA intake in group P. Details of absorption (mg=kg=day) were: for AA, intake 17 AE 7, fecal excretion 5 AE 4, net retention 12 AE 5 (75.0 AE 18%); for DHA, intake 10 AE 3, fecal excretion 3 AE 2, net retention 6 AE 4 (62.3AE 30%). Conclusion: Intestinal absorption of fatty acids is high and is comparable in terms and preterms as regards the studied acids. Longer acids were less well absorbed. The supplemented amounts of AA and DHA were less well absorbed and probably not impairing calcium absorption.
Anales De Pediatria, 1998
Ffundamento: la ausencia de lactosa comporta una disminucion de la absorcion intestinal de calcio... more Ffundamento: la ausencia de lactosa comporta una disminucion de la absorcion intestinal de calcio y si este no es absorbido, puede formar jabones calcicos con los acidos grasos en la luz intestinal. Se ha comparado la absorcion de grasa total, da acido grasos y la absorcion y retencion de calcio, magnesio y fosfato en dos grupos de nnos alimentados con una formula sin lactosa (FSL) frente a otra de inicio convencional identica (FI). Ningunas de ellas estaba adicionada de acido araquidonico ni docosahexaenoico. Conclusion: el patron absortivo de los acidos grasos en el recien nacido a termino no presenta anomalias ni disminuciones llamativas.
Chemistry and Physics of Lipids, 1984
In the microsomal fraction of thyroid glands, the temperature dependence of DPH fluorescence pola... more In the microsomal fraction of thyroid glands, the temperature dependence of DPH fluorescence polarization showed a discontinuity in the range of 29-33°C. 2. The transition temperatures of DMPC, DPPC and DSPC are near to the observed for the microsomal fraction. So that, thyroid peroxidase (TPO) was incorporated into liposomes made with these phospholipids. 3. When DPH was incorporated in this peroxidase-liposome complex, a less pronounced phase transition was observed in the profiles of temperature dependence of DPH polarization, and the incorporation of the enzyme decreased the Tc. 4. Arrhenius plots of TPO incorporated into liposomes showed discontinuities at similar temperatures observed by fluorescence polarization. 5. The decrease of transition temperature of liposomes induced by thyroid peroxidase incorporation suggests that this enzyme seems to need a fluid medium for its enzyme activity.
PeerJ, 2014
Objective. To explore anthropometric changes in normal-weight, overweight and obese subjects who ... more Objective. To explore anthropometric changes in normal-weight, overweight and obese subjects who did not dropout or fail a weight loss program over the 16 treatment weeks to improve patient motivation and treatment adherence. Methods. A clinical intervention study was conducted among 271 (including 100 dropouts and/or failures) obese and overweight patients who consulted a nutrition clinic in Barranquilla (Colombia) for the purpose of nutritional assessment. They were subject to a personalized weekly follow-up consultation over the course of 16 weeks in which initial and the final Body Mass Index (BMI, kg/m 2), photographs, food consumption patterns, percentage weight loss, waist and hip circumference were registered and grouped according to BMI, measuring treatment response. Data's nonparametric statistical comparison was made. Results. In 62 patients from the BMI < 25 group, there is weight loss of 2.6% (3.1 SD), 5.5% (3.3 SD) in waist circumference and 3.0% (2.5 SD) in hip circumference. In 67 patients from the 25 ≥ BMI < 30 group, there is weight loss of 3.8% (4.1 SD), 5.7% (4.5 SD) in waist circumference loss and 3.7% (3.0 SD) in hip circumference loss. In 42 patients from the BMI > 30 group, there is weight loss of 4.8% (3.7 SD), 7.0% (3.6 SD) in waist circumference loss and 3.9% (2.4 SD) in hip circumference loss. Monitoring is done every 4 weeks by the Friedman test, with significant differences between the three groups (p < 0.001). Patients do not drop out of treatment because they start to see physical results in waist decrease. When comparing final values of initial waist/hip circumference ratios and waist/height ratios, a clear decrease in the three BMI groups was observed (p < 0.001). Conclusion. After three weeks of continuous treatment patients improved in all overweight and obesity parameter indicators; there were not statistically significant differences in hip circumference (HC) and waist loss (WC) (%) among the three BMI groups (normal-weight, overweight, and obesity). In contrast, there were statistically significant differences in weight loss (%) and waist-to-hip ratios. Based on anthropometric outcomes and patient perception of their body image it can be concluded that the waist circumference loss is the parameter that retains obese patients in the weight loss program.
[Neonatal screening for hereditary metabolic diseases. Nursing action]
Revista de enfermería (Barcelona, Spain)
The authors provide the information necessary so that nurses are capable of adequately carrying o... more The authors provide the information necessary so that nurses are capable of adequately carrying out the duties which pertain to neonatal screening programs for hereditary metabolic diseases. The authors briefly describe those diseases which are subject to neonatal screening with the objective of providing their basic features, especially in relation to neonatal screening and the benefits which this may provide. The authors explain the method to correctly take a blood sample on the paper filter sample cards and they describe the most frequently committed errors as a way to prepare nursing personnel which may at some time have contact with these functions so that these are properly performed.
Y Regularidad De Los Ciclos
Age group, menarche and regularity of menstrual cycles as efficiency predictors in the treatment ... more Age group, menarche and regularity of menstrual cycles as efficiency predictors in the treatment of overweight
RESEARCH ARTICLE Safety of Ferric Carboxymaltose Immediately after Infliximab Administration, in a Single Session, in Inflammatory Bowel Disease Patients with Iron Deficiency: A Pilot Study
Aim To obtain preliminary safety and efficacy data on intravenous (IV) administration of inflixi-... more Aim To obtain preliminary safety and efficacy data on intravenous (IV) administration of inflixi-mab (IFX) and ferric carboxymaltose (FCM) to inflammatory bowel disease (IBD) patients in a single treatment session. Methods A two-phase non-interventional, observational, prospective pilot study was performed to evaluate safety and efficacy of FCM given immediately after IFX. IBD patients were re-cruited consecutively in the outpatient clinic in two groups. Control group patients (n = 12) received FCM on a separate day from IFX. Subsequently, single-session group patients (n = 33) received FCM after IFX on the same day. All patients received 5mg/kg IFX and 1000mg FCM for iron-restricted anemia (IRA) or 500mg FCM for iron deficiency without anemia. Safety assessment was performed by recording adverse events (AEs) during and immediately after infusion, 30 minutes afterwards, and via follow-up at 7 days and 8 weeks. For efficacy assessment, hematological parameters were assessed prior to ...
Clinical Chemistry, 1987
In this new method for quantifying vitamin D in infants' formulas and breast milk, after repe... more In this new method for quantifying vitamin D in infants' formulas and breast milk, after repeated lipid extraction, samples are further purified by passage through Sep-Pak cartridges, followed by liquid chromatography, then quantified by competitive protein-binding assay. Analytical recovery is estimated by use of added 3H-labeled vitamin D. For repeated assays of a reconstituted proprietary powdered milk formula in two runs, the intra-assay vitamin D values were 9.0 (SD 1.4) (n = 6) and 8.9 (SD 1.6) micrograms/L (n = 7) (t = 0.07). Assay of a proprietary liquid formula yielded values of 14.9 (SD 0.9) micrograms/L (n = 6). For each, the results agreed with the vitamin D content shown on the label. Vitamin D concentrations in breast milk from two groups of lactating mothers of different social class and nutritional status were 2.3 (SD 1.4) (n = 7) and 2.0 (SD 1.7) micrograms/L (n = 7). Overall recoveries ranged from 65 to 75%. Only 2 mL of milk is required, which facilitates samp...
PeerJ, 2016
In January 2012, a review of the cases of chromosome 15q24 microdeletion syndrome was published. ... more In January 2012, a review of the cases of chromosome 15q24 microdeletion syndrome was published. However, this study did not include inferential statistics. The aims of the present study were to update the literature search and calculate confidence intervals for the prevalence of each phenotype using bootstrap methodology. Published case reports of patients with the syndrome that included detailed information about breakpoints and phenotype were sought and 36 were included. Deletions in megabase (Mb) pairs were determined to calculate the size of the interstitial deletion of the phenotypes studied in 2012. To determine confidence intervals for the prevalence of the phenotype and the interstitial loss, we used bootstrap methodology. Using the bootstrap percentiles method, we found wide variability in the prevalence of the different phenotypes (3–100%). The mean interstitial deletion size was 2.72 Mb (95% CI [2.35–3.10 Mb]). In comparison with our work, which expanded the literature s...
PeerJ, 2015
Of the numerous instruments available to detect nutritional risk, the most widely used is the Min... more Of the numerous instruments available to detect nutritional risk, the most widely used is the Mini Nutritional Assessment (MNA), but it takes 15–20 min to complete and its systematic administration in primary care units is not feasible in practice. We developed a tool to evaluate malnutrition risk that can be completed more rapidly using just clinical variables. Between 2008 and 2013, we conducted a cross-sectional study of 418 women aged ≥60 years from Mexico. Our outcome was positive MNA and our secondary variables included were: physical activity, diabetes mellitus, hypertension, educational level, dentition, psychological problems, living arrangements, history of falls, age and the number of tablets taken daily. The sample was divided randomly into two groups: construction and validation. Construction: a risk table was constructed to estimate the likelihood of the outcome, and risk groups were formed. Validation: the area under the ROC curve (AUC) was calculated and we compared ...
Fatty Acid Composition of Mature Breast Milk According to the Mothers Diet During Pregnancy
Advances in Experimental Medicine and Biology
Mothers taking 200 g of fish per week, showed a greater content in mature breast milk of n-3 fatt... more Mothers taking 200 g of fish per week, showed a greater content in mature breast milk of n-3 fatty acids, particularly DHA. AA was not decreased. Vitamin D content was low despite mothers were living in a sunny and temperate area. The content of 25 hydroxyvitamin D is increased in the group on fish intake, probably pointing out its marine source.
Tendencia en el sobrepeso y obesidad: ¿en qué enfocar el tratamiento?
Objective: To evaluate the eating habits of the students of the University of Alicante of the deg... more Objective: To evaluate the eating habits of the students of the University of Alicante of the degrees of Human Nutrition and Dietetics and Nursing. Material and methods: The study was carried out to 184 students of both sexes (96 of Human Nutrition and Dietetics and Nursing 88) of the University of Alicante. Were weighed and carved to calculate BMI; food consumption was estimated by the reminder of 24 hours; intake of macro and micronutrients were calculated using the program Easydiet. Comparing the results obtained in both qualifications and according to nutritional status by performing the corresponding statistical analysis. Results: The majority of the students analyzed are normal weight (80%). There were significant differences in the quality of the diet both degrees, being the same characteristics: low in carbohydrates and high in protein. It also shows an imbalance in the type of fat consumed, with a higher consumption of saturated and less from polyunsaturated than recommended. Likewise, analyzed that nutrition students do more exercise than the nurses, although they sleep fewer hours and spend more time in front of the computer and TV. Conclusion: While the levels of overweight and obesity among students is less than that of the general population, there are imbalances in your diet, noting that consumption of macronutrients is located away from the recommendations, and that there are deficiencies in the intake of micronutrients. Showing that have knowledge of nutrition, does not affect healthy decision-making to a diet and lifestyle.
PeerJ, 2015
Others have analysed the relationship between inadequate behaviour by healthcare professionals in... more Others have analysed the relationship between inadequate behaviour by healthcare professionals in the diagnosis of dyslipidaemia (diagnostic inertia) and the history of cardiovascular risk factors. However, since no study has assessed cardiovascular risk scores as associated factors, we carried out a study to quantify diagnostic inertia in dyslipidaemia and to determine if cardiovascular risk scores are associated with this inertia. In the Valencian Community (Spain), a preventive programme (cardiovascular, gynaecologic and vaccination) was started in 2003 inviting persons aged ≥40 years to undergo a health check-up at their health centre. This cross-sectional study examined persons with no known dyslipidaemia seen during the first six months of the programme (n = 16,905) but whose total cholesterol (TC) was ≥5.17 mmol/L. Diagnostic inertia was defined as lack of follow-up to confirm/discard the dyslipidaemia diagnosis. Other variables included in the analysis were gender, history of cardiovascular risk factors/cardiovascular disease, counselling (diet/exercise), body mass index (BMI), age, blood pressure, fasting blood glucose and lipids. TC was grouped as ≥/<6.20 mmol/L. In patients without cardiovascular disease and <75/≤65 years (n = 15,778/13,597), the REGICOR (REgistre GIroní del COr)/SCORE (Systematic COronary Risk Evaluation) cardiovascular risk functions were used to classify risk (high/low). Inertia was quantified and the adjusted odds ratios calculated from multivariate models. In the overall sample, the rate of diagnostic inertia was 52% (95% CI [51.2-52.7]); associated factors were TC ≥ 6.20 mmol/L, high or "not measured" BMI, hypertension, smoking and higher values of fasting blood glucose, systolic blood pressure and TC. In the REGICOR sample, the rate of diagnostic inertia was 51.9% (95% CI [51.1-52.7]); associated factors were REGICOR high and high or "not measured" BMI. In the SCORE sample the rate of diagnostic inertia was 51.7% (95% CI [50.9-52.5]); associated factors were SCORE high and high or "not measured" BMI. Diagnostic inertia existed in over half the patients and was associated with a greater cardiovascular risk.
PLOS ONE, 2015
To obtain preliminary safety and efficacy data on intravenous (IV) administration of infliximab (... more To obtain preliminary safety and efficacy data on intravenous (IV) administration of infliximab (IFX) and ferric carboxymaltose (FCM) to inflammatory bowel disease (IBD) patients in a single treatment session. A two-phase non-interventional, observational, prospective pilot study was performed to evaluate safety and efficacy of FCM given immediately after IFX. IBD patients were recruited consecutively in the outpatient clinic in two groups. Control group patients (n = 12) received FCM on a separate day from IFX. Subsequently, single-session group patients (n = 33) received FCM after IFX on the same day. All patients received 5mg/kg IFX and 1000mg FCM for iron-restricted anemia (IRA) or 500mg FCM for iron deficiency without anemia. Safety assessment was performed by recording adverse events (AEs) during and immediately after infusion, 30 minutes afterwards, and via follow-up at 7 days and 8 weeks. For efficacy assessment, hematological parameters were assessed prior to FCM infusion (pre-FCM) and after 8 weeks. Economic impact of FCM given immediately after IFX was assessed. All 45 patients (35 Crohn´s disease, 10 ulcerative colitis) received IFX 5mg/kg. 21 patients received 500mg FCM and 24 received 1000mg. FCM administration immediately after IFX corrected iron deficiency or IRA as shown by increases in hematological parameters. No AEs were reported during the safety evaluation at the end of FCM or IFX administration,