Fahad Samadi - Academia.edu (original) (raw)

Papers by Fahad Samadi

Pediatric and Developmental Pathology

Rhabdomyosarcoma with TFCP2 rearrangement is a newly introduced spindle cell neoplasm showing pre... more Rhabdomyosarcoma with TFCP2 rearrangement is a newly introduced spindle cell neoplasm showing predilection for craniofacial bones exhibiting highly aggressive nature and poor prognosis. Therefore, an attempt was made to delineate the entity for improved understanding and treatment outcomes through comprehensive analysis of the clinicopathological and molecular characteristics. An electronic search was carried out using MEDLINE by PubMed, Scopus, Google scholar, Cochrane library, and EMBASE databases. Original articles and case reports involving intraosseous rhabdomyosarcoma arising in head and neck region with TFCP2 fusion were included. Data were compiled and risk of bias was analyzed using JBI tool. Thirteen eligible articles were included for the quantitative analysis, which revealed 33 cases with TFCP2 fusion. Majority of the affected individuals were females (58%) with mandible being the common site. Most of the patients died within few months after diagnosis demonstrating a lo...

Indian Journal of Dentistry, 2012

Abstract Herpes zoster (HZ) or ‘shingles’ results from reactivation of the Varicella zoster virus... more Abstract Herpes zoster (HZ) or ‘shingles’ results from reactivation of the Varicella zoster virus (VZV). Primary VZV infections in sero negative individuals are known as varicella or chicken pox. Secondary or reactivated disease is known as shingles or herpes zoster. Early diagnosis and use of antiviral agents should be the mainstay of its management. This paper presents a case report of such an infection and its management.

Cheiloscopy is a forensic investigation technique that deals with identification of humans based ... more Cheiloscopy is a forensic investigation technique that deals with identification of humans based on lips traces. This is unique for individuals like the finger prints. Lip prints are hereditary yet considered to be individualistic, each possessing their own unique characteristics. For this reason it is safe to suggest that lip prints can be included in the forensic sciences arena as a legitimate means of identifying persons of interest connected with criminal activity. Lip prints thus hold potential promise as an instrumental tool in forensic odontology. The purpose of this article is to give an insight into this branch of forensic odontology with an emphasis on its historical background, techniques of recording it and its future perspectives.

Oral Science International, Sep 27, 2022

National Journal of Maxillofacial Surgery, 2018

Introduction: Cancer of oral cavity is the uncontrolled expansion of damaged cell within the mout... more Introduction: Cancer of oral cavity is the uncontrolled expansion of damaged cell within the mouth cavity. 5-fluorouracil (5-FU) chemotherapy was focused to kill the cancer cell, but it would affect the surrounding normal cells during oral cancer treatment. This study included the evaluation of chemoprotective effects of curcumin (CU), as an herbal remedy, on 5-FU-induced-cytotoxicity toward oral cancer treatment, loaded within a nanocarrier system. CU was combined with 5-FU chemotherapy as a combinational drug-delivery system to evaluate synergistic effects. Materials and Methods: Nanoformulation of CU (nano-CU) and nanoformulation of 5-FU (nano-FU) were prepared by employing homogenization with high-energy sonication. The characterizations of prepared nanoformulations were evaluated on the basis of particle size, zeta potential, and polydispersity index (PDI) values. The chemopreventive effect of nano-CU on 5-FU induced-toxicity and synergistic efficacy were optimized through different in-vitro assays. Results: The average particle size of nano-CU and nano-FU were up to 200 nm, negatively-charged, and shown up to 4 th-day control release of the drug within the acceptable concentration. IC 50 value for growth inhibition was calculated as 47.89 and 26.19 µg/ml, respectively, for nano-CU and nano-FU. OCC was pretreated with nano-CU and shown the protective effect by reducing 5-FU induced-cytotoxicity by preventing normal cells through reduced viability. The DPPH-indicated fluorescence-tagged cells had quantified for antioxidant effect as it reduces intracellular reactive oxygen species level in OCC. Along with alteration in cell protein expression, Blc2, and Bax, shows enhanced apoptosis rate in OCC. Conclusion: Nano-CU provides chemoprotective nature towards 5-FU induced-toxicity, along with synergistic effects in oral cancer treatment.

Journal of Oral Biology and Craniofacial Research, 2016

Indian Journal of Mednodent and Allied Sciences, 2014

Myofibroblasts differentiate, invade and repair injured tissues by secreting and organizing the e... more Myofibroblasts differentiate, invade and repair injured tissues by secreting and organizing the extracellular matrix and by developing contractile forces. Under physiological conditions, the secretory and contractile activities of myofibroblasts are terminated when the repair is complete (scar formation) but the functionality of the tissue is only rarely perfectly restored. At the end of the normal repair process, myofibroblasts disappear by apoptosis but in pathological situations, myofibroblasts likely remain leading to excessive scarring. These diverse cell types probably contribute to the appearance of myofibroblast subpopulations which show specific biological properties and which are important to understand in order to develop new therapeutic strategies for treatment of fibrotic and scarring diseases.

Oral & Maxillofacial Pathology …

Abstract: The past two decades have been golden years for the genetics of cancer. It has become c... more Abstract: The past two decades have been golden years for the genetics of cancer. It has become clear through the work of countless laboratory groups that both inherited and sporadic cancers arise through defects or misregulations of their genomes. Despite ...

Aim: To assess the antibiotic prescribing practice among general dental practitioners in Chennai.... more Aim: To assess the antibiotic prescribing practice among general dental practitioners in Chennai. Materials and Methods: Cross sectional survey involving 100 general dental practitioners was conducted through a questionnaire about the prescribing pattern of antibiotics. Results: 71% of the dentists in the study prescribe antibiotics to all the patients. 88% of the participants preferred broad spectrum antibiotics. 97% used antibiotics for prophylaxis. Conclusion: Our study revealed that the antibiotic prescribing practice among dentists in Chennai lack guidelines or protocols leading to its over-usage.

International Journal of Applied Biology and P, 2020

Ameloblastic Carcinoma is a rare malignant odontogenic neoplasm that exhibits features of amelobl... more Ameloblastic Carcinoma is a rare malignant odontogenic neoplasm that exhibits features of ameloblastoma along with features of cytological atypia. Owing to its varied clinical presentations and its histologic resemblance with Ameloblastoma, it is often misdiagnosed. Since few cases have been reported due to its rare frequency, there is paucity in the literature and there is no distinct recommendations regarding the same. The current paper reported two cases of Ameloblastic Carcinoma with different clinical presentations, one reported in a nineteen year old male patient with features of benign ameloblastoma in the superficial lesion and deeper aspect revealed features of ameloblastic carcinoma with lymph node metastasis while the second case reported in a forty-five year old female patient with classic features of Ameloblastic Carcinoma.

Central giant cell granuloma (CGCG) is an uncommon, benign, proliferative, and nonodontogenic les... more Central giant cell granuloma (CGCG) is an uncommon, benign, proliferative, and nonodontogenic lesion whose etiology is not defined. Thought to represent a reparative response to intrabony haemorrhage and inflammation, CGCG was once regarded as a reactive lesion. Central giant cell granuloma usually is an asymptomatic lesion, which may become evident during routine radiographic examination or as a result of painless but visible expansion of the affected jaw. The clinical differential diagnosis for a solitary or multilocular CGCG includes ameloblastoma, odontogenic myxoma, and odontogenic keratocyst. Here, we present a review on the clinical, radiological, histological features of central giant cell granuloma along with discussion on treatment modalities.

A percent of cancer populations is increasing sharply, the incidence of oral squamous cell carcin... more A percent of cancer populations is increasing sharply, the incidence of oral squamous cell carcinoma (OSCC) has also been expected to increase. Cancer prevention is more important than treatment for overcoming increased cancer death in the future. Oral cancer is the most common cancer worldwide which continues to be the most prevalent cancer resulting from the consumption of tobacco and other carcinogenic products. A large part of cancer load in parts of India is formed from Oral cancer. Oral cancer is categorized into precancerous and cancerous stages. Precancerous stage includes Leukoplakia, Erythroplakia and Lichen Planus, while cancerous or malignant stage is Squamous Cell Carcinoma. Oral cancer development is a multistep process which arises from preexisting malignant lesions. Oral carcinogenesis is a highly complex, multistep process which involves accumulation of genetic alterations that lead to the induction of proteins promoting cell growth (encoded by oncogenes), increased...

Ameloblastomas are tumors of odontogenic epithelium. Although benign, they are quite aggressive, ... more Ameloblastomas are tumors of odontogenic epithelium. Although benign, they are quite aggressive, invasive, and at times reach gigantic proportions. Patients with giant ameloblastomas are very rare, but are still encountered in developing countries due to painless growth and patient’s fear of surgery leading to delayed treatment. Management of giant ameloblastomas poses a challenge in terms of acceptable functional and esthetic outcome. It has been advocated that large ameloblastomas are best managed in single stage procedures which involves resection and reconstruction, thus reducing patient stay, cost factor and related morbidity. This paper presents a case of large ameloblastoma of the mandible of 25-year-old male which was successfully managed in a modifi ed single stage procedure, thus restoring patient function and esthetics.

Background and Aims: Inflammation is considered to be the seventh hallmark of cancer and plays a ... more Background and Aims: Inflammation is considered to be the seventh hallmark of cancer and plays a pivotal role in all stages of tumor development. Systemic inflammatory responses in particular neutrophil to lymphocyte ratio (NLR) have garnered immense attention of current researchers and its role is well proven in various solid malignancies. Its prognostic role in oral cancer have been extensively studied. However, its diagnostic role is yet to be explored. The current study aims to investigate diagnostic utility of NLR in oral potentially malignant disorders and oral cancer, when compared to normal subjects. Methods: A total of 150 subjects were involved in the study, a total of 2.5 ml of blood was drawn from the median cubital vein of the patient in an EDTA vial and hematological parameters were assessed using Erba-Transasia B7256 Autoanalyzer and reassessed manually by two experts. Statistical Analysis: The NLR values were recorded and tabulated as Mean ± S.D. and comparisons were...

Objective: To assess the association between oral hygiene practice and occurrence of oral squamou... more Objective: To assess the association between oral hygiene practice and occurrence of oral squamous cell carcinoma. Methods: An epidemiologic study of total 1254 persons including 480 oral squamous cell carcinoma cases and 774 persons selected as controls without any oral precancerous and cancerous lesion, cases and controls matching with same socioeconomic background and with almost similar tobacco consumption habits. Detailed information on smoking, alcohol consumption, years of schooling, oral health status and hygiene practices were obtained through a question nairetested with a pilot study. Age, sex, educational status, habits of smoking, drinking, and tooth brushing along with estimation of oral health status using unconditional logistic regression was analyzed. Results: The complain of regular gum bleeding associated with plaque and calculus showed significant positive correlation with oral squamous cell carcinoma. Neglected oral health and no dental visiting patients are on h...

Halitosis or bad breath is a problem faced by many and can limit their potential to even interact... more Halitosis or bad breath is a problem faced by many and can limit their potential to even interact with the society in a positive manner. It is very subjective in that for many this malady is “A perception rather than a real thing, everybody's breath smells to a certain extent”. However real halitosis is an unpleasant condition which creates huge embarrassment with potentially grave consequences. Most of the individuals suffering from halitosis seek help from general practioners initially, not the dentist.

The analysis of DNA, RNA and proteins obtained from diagnostic specimens, is currently revolution... more The analysis of DNA, RNA and proteins obtained from diagnostic specimens, is currently revolutionizing the practice of surgical pathology and heralds a new era of diagnostic and prognostic tests that will greatly influence our day to day clinical decision making. The diagnosis of cancer and many other diseases is fundamentally based on the microscopic study of cells and tissues. Nevertheless, the era of the pathologist relying entirely on the examination of tissue sections stained by histochemical methods is gradually being replaced by a time when advanced immunologic and molecular techniques augment the process by which complicated infectious, inflammatory, metabolic and neoplastic diseases are diagnosed and classified. The pathologists will continue to play a fundamental role in diagnosis and will likely be in a pivotal position to guide the implementation and interpretation of these tests as they move from the research laboratory into diagnostic pathology. As we move further into...