Fatma Bozkurt - Academia.edu (original) (raw)

Papers by Fatma Bozkurt

Journal of Clinical and Experimental Investigations, Sep 11, 2012

Türkiye parazitoloji dergisi, Oct 10, 2014

Bruselloz birçok organı ve sistemi etkileyebilen çok farklı klinik tablolara yol açan zoonotik bi... more Bruselloz birçok organı ve sistemi etkileyebilen çok farklı klinik tablolara yol açan zoonotik bir enfeksiyon hastalığıdır. Brusellozun farklı enfeksiyon etkenleri ile birlikteliği nadirdir. Fascioliazis; halk arasında büyük karaciğer kelebeği olarak adlandırılan yaprak şeklindeki Fasciola hepatica'nın neden olduğu zoonotik bir hastalıktır. Olgumuz 39 yaşında erkek hasta bir hafta önce başlayan üşüme, titreme, ateş, karın ağrısı, bulantı, kusma, halsizlik, terleme ve yaygın vücut ağrısı şikâyetleri olmuştu. Hastanın ön tanısında bruselloz düşünüldü. Buna yönelik olarak istenen tetkiklerde rose bengal testi pozitif, Wright testi (1/640) pozitif saptandı. Karaciğer enzim yüksekliği olması üzerine batın ultrasonografisi (USG) yapılan hastada karaciğerde lezyon görülmesi nedeniyle batın bilgisayarlı tomografi (BT) çekildi. BT sonucu karaciğer sol lob segment 2'de büyük oranda nekrotik görünümde yaklaşık olarak 61x63 mm boyutlarında kontrast tutulum göstermeyen (fascioliazis ile uyumlu) alan izlendi şeklinde sonuç geldi. Fascioliazise yönelik olarak IHA testi istenen hastanın sonucu 1/320 pozitif saptandı. Zoonotik hastalıklar için yüksek endemisiteye sahip olan bölgelerde, risk grubunda olan hastalarda birden fazla enfeksiyon etkeninin bir arada olabileceği göz önünde bulundurulmalıdır.

Türkiye parazitoloji dergisi, 2014

PubMed, Sep 1, 2013

In the context of the substantial increase in antibiotic resistance rates of Acinetobacter bauman... more In the context of the substantial increase in antibiotic resistance rates of Acinetobacter baumannii, we aimed to evaluate the susceptibility rate changes of A. baumannii strains for carbapenems. A. baumannii strains isolated from patients diagnosed with healthcare-associated infections between 2007-2010 were included. A total of 127 A. baumannii strains [53 (42%) from the intensive care unit and 74 (58%) from the non-intensive care unit] were isolated. Conventional methods and an automated microbiology system were used for identification. Susceptibility testing was studied by Kirby-Bauer disk diffusion method. In 2007, five of 26 strains, in 2008, 18 of 31, in 2009, 10 of 35, in 2010, and 20 of 35 were obtained from intensive care unit patients. The susceptibility rate for imipenem was 50% in 2007 but 20% in 2010, while for meropenem it was 55% in 2007 but 12% in 2010. Prevention and control of antibiotic resistance among Acinetobacter species needs antibiotic usage restrictions and infection control precautions.

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 1997

Ciddi enfeksiyon etkenleri arasında yer alan stafilokoklarda giderek artan oranlarda görülen meti... more Ciddi enfeksiyon etkenleri arasında yer alan stafilokoklarda giderek artan oranlarda görülen metisilin direnci önemli bir sorundur. Metisiline Rezistan Staphylococcus Aureus (MRSA) epidemilere yol açabilen önemli bir nozokomiyal enfeksiyon etkenidir. Ayrıca nozokomiyal enfeksiyon etkenleri arasında koagülaz negatif stafilokokların önemi her geçen yıl giderek artmaktadır. 3u çalışmada, 1995 ve 1996 yılları arasında SSK Ankara Eğitim Hastanesi Infeksiyon Hastalıkları kliniği tarafından altı farklı klinikte yatan 103 hastadan alınan toplam 107 klinik örnekten izole edilen stafilokok suşlarında metisilin direnci ve bu dirençli suşlaıın antibiyotik duyarlılıkları incelendi. Metisilin direnci koagülaz (+) stafilokoklarda %35, koagülaz (-) stafilokoklarda ise %50 oranında saptandı. Yoğun bakım ünitesinde ise MRSA oranı en yüksekti (%52). Tüm stafilokok suşları vankomisine duyarlı idi.

The aim of this study was to determine the concordance ratio between microorganisms isolated from... more The aim of this study was to determine the concordance ratio between microorganisms isolated from deep tissue culture and those from superficial culture in patients with diabetic foot according to Wagner's wound classification method. Materials and methods: A total of 63 patients with Diabetic foot infection, who were admitted to Dicle University Hospital between October 2006 and November 2007, were included into the study. Wagner's classification method was used for wound classification. For microbiologic studies superficial and deep tissue specimens were obtained from each patient, and were rapidly sent to laboratory for aerob and anaerob cultures. Microbiologic data were analyzed and interpreted in line with sensitivity and specifity formula. Results: Thirty-eight (60%) of the patients were in Wagner's classification ≤2, while 25 (40%) patients were Wagner's classification ≥3. According to our culture results, 66 (69%) Gr (+) and 30 (31%) Gr (-) microorganisms grew in Wagner classification ≤2 patients. While in Wagner classification ≥3; 25 (35%) Gr (+) and 46 (65%) Gr (-) microorganisms grew. Microorganisms grew in 89% of superficial cultures and 64% of the deep tissue cultures in patients with Wagner classification ≤2, while microorganism grew in 64% of Wagner classification ≥3. Conclusion: In ulcers of diabetic food infections, initial treatment should be started according to result of sterile superficial culture, but deep tissue culture should be taken, if unresponsive to initial treatment.

Giris: Ayak enfeksiyonlari diyabetik hastalarda sikca gorulen ve multidisipliner yaklasim gerekti... more Giris: Ayak enfeksiyonlari diyabetik hastalarda sikca gorulen ve multidisipliner yaklasim gerektiren bir problemdir. Yumusak doku nekrozu ve osteomyelite ilerleyerek ekstremite amputasyonu icin risk olusturabilir. Bu nedenle tedavi icin bakteriyolojik analiz cok onemlidir. Amac: Bu calismada etken mikroorganizmalar ve bunlarin antibiyotik duyarliliklarinin belirlenerek, uygun tedavinin planlanmasi amaclandi. Yontemler: Calismaya Ekim 2006 ile Kasim 2007 tarihleri arasinda, Dicle Universitesi Hastanesi’nde yatan diyabetik ayak enfeksiyonlu hasta alindi. Yara siniflandirilmasinda Wagner evrelemesi kullanildi. Bakteriyolojik analiz icin derin doku kulturu yapildi. Bulgular: Hastalarin 38’i (% 60) Wagner evre ≤2 iken, 25’i (% 40) Wagner evre ≥3 idi. En sik izole edilen mikroorganizma S. aureus (20 hastadan, % 32) olup bunu Klebsiella spp. ve Enterobacter cloaca izledi. Tum Gr (-) izolatlara karsi en etkili antibiyotikler amikasin, meropenem, piperasillin-tazobaktam ve sefepim idi. En di...

Türkiye parazitoloji dergisi, 2014

African Health Sciences, 2021

Background: In pregnancy, Coronavirus disease-2019 (COVID-19) infection disease may be more sever... more Background: In pregnancy, Coronavirus disease-2019 (COVID-19) infection disease may be more severe due to existingphysiological changes. Similarly, changes during and after birth can make the patient more subceptible. Objective: To investigate possible laboratory findings that was related to postpartum progression of COVID-19 disease. Methods: Pregnant women who are pregnant at 28 weeks or more and who are COVID-19 positive at the time of delivery were investigated in this study. Progressed post- delivery and non-progressed COVID-19 positive pregnants’ laboratory findings were analyzed. Hematological and immunological parameters associated with postpartum progressed COVID-19 disease were evaluated. Results: Totally 151 individuals were conducted to the study. In the prenatal analysis, higher BMI and lower albumin levels were detected in the progressed group (p<0.05). In the postpartum analysis; White Blood Cell, lymphocyte and albumin were increased, while neutrophil, NLR, LDH, C...

La Clinica terapeutica, 2013

In developing countries HAV infection is very common in the first years of life and it is often a... more In developing countries HAV infection is very common in the first years of life and it is often asymptomatic. However especially in regions of intermediate endemicity, exposure to the virus may delay and outbreaks of hepatitis A may be encountered in adults. The aim of this study is to evaluate the clinical and laboratory findings and risk factors of adults with acute viral hepatitis A. In present study we evaluated 203 patient with acute viral hepatitis A, who were admitted to four different hospitals of three cities of Turkey between January 2000-December 2011, retrospectively. The diagnosis of acute viral hepatitis A was performed by laboratory findings and clinically. In a total of 203 patients, 120 (59.1%) patients were male and 83 (40.9%) were female. Mean age of cases with acute viral hepatitis A was 24.7 +11.8 years (ranged 15 to 82 years old). Acute viral hepatitis A were seen in patient who were 15-20 years and 21-30 years old, commonly. Jaundice (74%), fatigue (68%), naus...

Journal of Clinical and Experimental Investigations, 2012

Çalışmamızda; Türkiye'nin Güneydoğu Anadolu bölgesinde yer alan Diyarbakır, Mardin ve Batman ille... more Çalışmamızda; Türkiye'nin Güneydoğu Anadolu bölgesinde yer alan Diyarbakır, Mardin ve Batman illerindeki brusellozlu hastaların klinik, laboratuvar ve tedavi özellikleri yönünden değerlendirilmesi amaçlanmıştır. Gereç ve yöntem: Haziran 2007-Temmuz 2009 tarihleri arasında Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniğinde bruselloz tanısı ile izlenen 286 hasta geriye dönük olarak değerlendirilmiştir. Bulgular: Hastaların 156 (%55)'i kadın, 130 (%45)'i erkek ve yaş ortalamaları 32,8 + 15,3 (15-78) idi. Vakaların %75 akut, %23 subakut ve %2'sini kronik olarak gruplandırıldı. Hastalığın bulaşmasındaki en önemli faktörün taze peynir yeme olduğu ve bölgede hayvan hareketlerinin kontrolünün olmadığı belirlendi. Hastalarda en sık rastlanan şikayetler yorgunluk, ateş, kas ve eklem ağrıları ve gece terlemesi idi. Ateş (%90,8), artrit (%54,1), splenomegali (%18,3) ve hepatomegali (%11) en sık rastlanan muayene bulgularıydı. Laboratuvarda ise C-Reaktif Protein (CRP) değerinin %60 yüksek olarak saptanması en sık rastlanan bulguydu. Tanı klinik belirtilerle birlikte pozitif Rose-Bengal ve Brusella tüp aglütinasyon testinin 1/160 ve üzeri olması ile konuldu. Tedavide ise çoğunlukla rifampisin ve doksisiklin kombinasyonu tercih edildi. Sonuç: Bruselloz hala ülkemizde önemli mortalite ve morbiditeye neden olan bir halk sağlığı sorunudur. Brucella, özellikle endemik bölgelerde, ateş, lökopeni ve osteoartiküler bulguların varlığında ayırıcı tanıda mutlaka akılda bulundurulmalıdır.

Results in Physics, 2020

The mathematical models of infections are essential tools in understanding the dynamical behavior... more The mathematical models of infections are essential tools in understanding the dynamical behavior of disease transmission. In this paper, we establish a model of differential equations with piecewise constant arguments that explores the outbreak of Covid-19 including the control mechanisms such as health organizations and police supplements for the sake of controlling the pandemic spread and protecting the susceptible population. The local asymptotic stability of the equilibrium points, the disease-free equilibrium point, the apocalypse equilibrium point and the co-existing equilibrium point are analyzed by the aide of Schur-Cohn criteria. Furthermore and by incorporating the Allee function at time t, we consider the extinction case of the outbreak to analyze the conditions for a strong Allee Effect. Our study has demonstarted that the awareness of the police personal and the management of professional health organizations play a vital role to protect the susceptible class and to prevent the spreading. Numerical simulations are presented to support our theoretical findings. We end the paper by a describtive conclusion.

Biomedical Research-tokyo, 2017

Liver biopsy and histopathological evaluation are the main methods to assess liver pathology. How... more Liver biopsy and histopathological evaluation are the main methods to assess liver pathology. However, liver biopsy is not widely used due to implementation challenge. We aimed to investigate non-invasive parameters for evaluation of liver fibrosis in chronic Hepatitis B patients. A total of 65 patients who admitted to outpatient clinic and diagnosed as chronic hepatitis were included in this study. Liver puncture biopsy was performed for all patients and was evaluated according to the Modified Ishak Fibrosis Score. The patients without fibrosis or with mild and moderate fibrosis were evaluated as Group I (Stage O, I, II), the patients with advanced fibrosis were evaluated as Group II (stage III, IV, V, VI). Among 65 patients, 42 were male and 23 were female; 48 of the patients were in group I while 17 patients belonged to group II. Gamma-Glutamyl Transferase (GGT), Alkaline Phosphatase (ALP), Aspartat Transaminaz (AST) and Alanin Aminotransferaz (ALT) levels were significantly high...

Clinical and Experimental Nephrology, 2020

Background In our study, diagnostic and demographic characteristics of patients diagnosed with RP... more Background In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune). Results Of 3875 patients, 200 patients with RPGN (mean age 47.9 ± 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9–5.7) mg/dl, glomerular filtration rate was 18 (10–37) ml/min/1.73m 2 and proteinuria 2100 (1229–3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio. Conclusions Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed.

Acta Biochimica Polonica, 2020

Previous studies detected higher Golgi protein 73 levels in the serum of patients with chronic li... more Previous studies detected higher Golgi protein 73 levels in the serum of patients with chronic liver disease. The Beta-2 microglobulin levels were also observed to be higher in patients with chronic hepatitis B infection compared to the inactive carriers and the protein plays an important role in the response to viral infections. The aim of the present study was to assess the liver fibrosis through non-invasive methods in chronic hepatitis B patients. Three groups were included in the study. The first group comprised of the patients who were admitted to the Infectious Diseases and Clinical Microbiology clinic to undergo a liver biopsy, while the second group included the patients who were admitted inactive hepatitis B carriers. The third group comprised the healthy controls. The Golgi p-73 and Beta-2 microglobulin levels in the plasma were determined using the ELISA method. Beta-2 microglobulin level was highest in the patients group and the difference was statistically significant....

Balkan Medical Journal, 2016

Background: The clinical spectrum of Brucella infection is quite diverse and characterized by mul... more Background: The clinical spectrum of Brucella infection is quite diverse and characterized by multi-system involvement. Patients present with myocarditis, endocarditis, or pericarditis. Infective endocarditis is the most common cardiovascular complication in patients with brucellosis. Although conduction abnormalities are seen in cases with endocarditis, they are reported very rarely in the setting of cardiac Brucella infection. Case Report: An eight and a half-year-old male patient was referred to our clinic due to inadequate response to cotrimaxazole plus streptomycin treatment at the 15th day of admission. Although local hospital records on the patient showed a heart rate of 80 bpm, we determined a heart rate of 46 bpm. The electrocardiogram showed complete atrioventricular (AV) block. The average heart rate was determined as 48 bpm with 24-hour Holter electrocardiogram (ECG) monitoring. The echocardiographic examination showed normal-sized heart chambers and the absence of valvular involvement. An agglutination test for brucellosis was found to be positive with a titer of 1/320. High fever, arthralgia, and splenomegaly regressed following doxycycline plus rifampicin therapy, but there was no improvement in the AV block. A permanent pacemaker was implanted because of the detection of an average heart rate of 48 bpm. Conclusion: Because cardiac failure and rhythm abnormalities are reported in the course of Brucella infection and may be associated with significant outcomes, cases with brucellosis should be evaluated carefully in terms of cardiac involvement. This report aims to draw attention to complete AV block as an extremely rare complication of Brucella infection.

Pediatrics International, 2016

Background: Urinary tract infections (UTI) are one of the most common bacterial infections in chi... more Background: Urinary tract infections (UTI) are one of the most common bacterial infections in children and a major cause of hospitalization. In this study we investigated the clinical characteristics, causative uropathogens; their antibiotic susceptibility and resistance patterns, treatment modalities and efficacy in children hospitalized for UTI in a tertiary care setting. Methods: Patients hospitalized for an upper UTI between March 2009 and July 2014 were enrolled. The urine cultureantibiogram results and accompanying urinary tract abnormalities were recorded retrospectively. Results: A total of 142 patients (104 girls, 73.2%; 38 boys, 26.8%) were enrolled. Mean patient age was 32.6 ± 4.1 months. History of recurrent UTI was present in 45.8% (n = 65), with prior hospitalization in 12.0% (n = 17). Frequency of vesicoureteral reflux was 18.3% (n = 26). Gram-negative enteric microorganisms yielded growth in all culture-positive UTI and the most common microorganism was Escherichia coli (n = 114, 80.3%). Extended spectrum beta-lactamaseproducing (ESBL (+)) bacterial strains were detected in 49.3% (n = 70), with third-generation cephalosporin resistance in all and increased duration of hospitalization. Conclusions: The prevalence of UTI with ESBL (+) bacterial strains with multi-drug resistance is increasing in the hospitalized pediatric population, therefore rational use of antibiotics is essential.

Journal of Microbiology and Infectious Diseases, 2012

Dicle Medical Journal / Dicle Tip Dergisi, 2012

Bu çalışmayla, iki ilimizde çalışan pratisyen hekimlerin üst solunum yolu enfeksiyonlarında (ÜSYE... more Bu çalışmayla, iki ilimizde çalışan pratisyen hekimlerin üst solunum yolu enfeksiyonlarında (ÜSYE) antibiyotik kullanım farkındalığı ve sağlık ile ilgili eğitim seminerlerinin etkileri, özel olarak hazırlanan bir anket yardımıyla değerlendirmek amaçlandı. Gereç ve yöntem: Düzenlenen eğitim semineri önce ve sonrasında, pratisyen hekimlere ÜSYE'nu epidemiyoloji, etyoloji, tanı ve tedavisi hakkında yedi soruyu içeren standart bir anket uygulanarak bilgi ve tutumları değerlendirildi ve cevap oranları karşılaştırıldı. Bulgular: Toplamda 110 pratisyen hekim çalışmaya katıldı. Seminer öncesi katılımcıların %30'undan fazlası ÜSYE'larının etyolojisinin en az %50'sini bakterilerin oluşturduğu ve %88'i anaerop ve Neisseriaların etyolojide yer almadığını düşünürken, katılımcıların yalnız %14'ü Streptococcus pyogenes suşunun prokain penisiline tam duyarlı olduğunu, başka bir deyişle % 95'i Beta-hemolytic-Streptococcus'un etken olduğu ÜSYE'ununun tedavisinde penesilinin ilk seçenek olduğu cevabını verdi. Seminer sonrası katılan hekimlerin bilgilerinde önemli bir ilerleme görüldü. .Doğru cevap oranlarında (seminer öncesi %27.7 ve sonrası %92.7) anlamlı bir fark vardı (p< 0.001). Sonuç: Pratisyen hekimlerin bilgi ve davranışlarının, eğitim seminerleriyle geliştirilebileceği sonucuna varıldı.

Journal of Clinical and Experimental Investigations, Sep 11, 2012

Türkiye parazitoloji dergisi, Oct 10, 2014

Bruselloz birçok organı ve sistemi etkileyebilen çok farklı klinik tablolara yol açan zoonotik bi... more Bruselloz birçok organı ve sistemi etkileyebilen çok farklı klinik tablolara yol açan zoonotik bir enfeksiyon hastalığıdır. Brusellozun farklı enfeksiyon etkenleri ile birlikteliği nadirdir. Fascioliazis; halk arasında büyük karaciğer kelebeği olarak adlandırılan yaprak şeklindeki Fasciola hepatica'nın neden olduğu zoonotik bir hastalıktır. Olgumuz 39 yaşında erkek hasta bir hafta önce başlayan üşüme, titreme, ateş, karın ağrısı, bulantı, kusma, halsizlik, terleme ve yaygın vücut ağrısı şikâyetleri olmuştu. Hastanın ön tanısında bruselloz düşünüldü. Buna yönelik olarak istenen tetkiklerde rose bengal testi pozitif, Wright testi (1/640) pozitif saptandı. Karaciğer enzim yüksekliği olması üzerine batın ultrasonografisi (USG) yapılan hastada karaciğerde lezyon görülmesi nedeniyle batın bilgisayarlı tomografi (BT) çekildi. BT sonucu karaciğer sol lob segment 2'de büyük oranda nekrotik görünümde yaklaşık olarak 61x63 mm boyutlarında kontrast tutulum göstermeyen (fascioliazis ile uyumlu) alan izlendi şeklinde sonuç geldi. Fascioliazise yönelik olarak IHA testi istenen hastanın sonucu 1/320 pozitif saptandı. Zoonotik hastalıklar için yüksek endemisiteye sahip olan bölgelerde, risk grubunda olan hastalarda birden fazla enfeksiyon etkeninin bir arada olabileceği göz önünde bulundurulmalıdır.

Türkiye parazitoloji dergisi, 2014

PubMed, Sep 1, 2013

In the context of the substantial increase in antibiotic resistance rates of Acinetobacter bauman... more In the context of the substantial increase in antibiotic resistance rates of Acinetobacter baumannii, we aimed to evaluate the susceptibility rate changes of A. baumannii strains for carbapenems. A. baumannii strains isolated from patients diagnosed with healthcare-associated infections between 2007-2010 were included. A total of 127 A. baumannii strains [53 (42%) from the intensive care unit and 74 (58%) from the non-intensive care unit] were isolated. Conventional methods and an automated microbiology system were used for identification. Susceptibility testing was studied by Kirby-Bauer disk diffusion method. In 2007, five of 26 strains, in 2008, 18 of 31, in 2009, 10 of 35, in 2010, and 20 of 35 were obtained from intensive care unit patients. The susceptibility rate for imipenem was 50% in 2007 but 20% in 2010, while for meropenem it was 55% in 2007 but 12% in 2010. Prevention and control of antibiotic resistance among Acinetobacter species needs antibiotic usage restrictions and infection control precautions.

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 1997

Ciddi enfeksiyon etkenleri arasında yer alan stafilokoklarda giderek artan oranlarda görülen meti... more Ciddi enfeksiyon etkenleri arasında yer alan stafilokoklarda giderek artan oranlarda görülen metisilin direnci önemli bir sorundur. Metisiline Rezistan Staphylococcus Aureus (MRSA) epidemilere yol açabilen önemli bir nozokomiyal enfeksiyon etkenidir. Ayrıca nozokomiyal enfeksiyon etkenleri arasında koagülaz negatif stafilokokların önemi her geçen yıl giderek artmaktadır. 3u çalışmada, 1995 ve 1996 yılları arasında SSK Ankara Eğitim Hastanesi Infeksiyon Hastalıkları kliniği tarafından altı farklı klinikte yatan 103 hastadan alınan toplam 107 klinik örnekten izole edilen stafilokok suşlarında metisilin direnci ve bu dirençli suşlaıın antibiyotik duyarlılıkları incelendi. Metisilin direnci koagülaz (+) stafilokoklarda %35, koagülaz (-) stafilokoklarda ise %50 oranında saptandı. Yoğun bakım ünitesinde ise MRSA oranı en yüksekti (%52). Tüm stafilokok suşları vankomisine duyarlı idi.

The aim of this study was to determine the concordance ratio between microorganisms isolated from... more The aim of this study was to determine the concordance ratio between microorganisms isolated from deep tissue culture and those from superficial culture in patients with diabetic foot according to Wagner's wound classification method. Materials and methods: A total of 63 patients with Diabetic foot infection, who were admitted to Dicle University Hospital between October 2006 and November 2007, were included into the study. Wagner's classification method was used for wound classification. For microbiologic studies superficial and deep tissue specimens were obtained from each patient, and were rapidly sent to laboratory for aerob and anaerob cultures. Microbiologic data were analyzed and interpreted in line with sensitivity and specifity formula. Results: Thirty-eight (60%) of the patients were in Wagner's classification ≤2, while 25 (40%) patients were Wagner's classification ≥3. According to our culture results, 66 (69%) Gr (+) and 30 (31%) Gr (-) microorganisms grew in Wagner classification ≤2 patients. While in Wagner classification ≥3; 25 (35%) Gr (+) and 46 (65%) Gr (-) microorganisms grew. Microorganisms grew in 89% of superficial cultures and 64% of the deep tissue cultures in patients with Wagner classification ≤2, while microorganism grew in 64% of Wagner classification ≥3. Conclusion: In ulcers of diabetic food infections, initial treatment should be started according to result of sterile superficial culture, but deep tissue culture should be taken, if unresponsive to initial treatment.

Giris: Ayak enfeksiyonlari diyabetik hastalarda sikca gorulen ve multidisipliner yaklasim gerekti... more Giris: Ayak enfeksiyonlari diyabetik hastalarda sikca gorulen ve multidisipliner yaklasim gerektiren bir problemdir. Yumusak doku nekrozu ve osteomyelite ilerleyerek ekstremite amputasyonu icin risk olusturabilir. Bu nedenle tedavi icin bakteriyolojik analiz cok onemlidir. Amac: Bu calismada etken mikroorganizmalar ve bunlarin antibiyotik duyarliliklarinin belirlenerek, uygun tedavinin planlanmasi amaclandi. Yontemler: Calismaya Ekim 2006 ile Kasim 2007 tarihleri arasinda, Dicle Universitesi Hastanesi’nde yatan diyabetik ayak enfeksiyonlu hasta alindi. Yara siniflandirilmasinda Wagner evrelemesi kullanildi. Bakteriyolojik analiz icin derin doku kulturu yapildi. Bulgular: Hastalarin 38’i (% 60) Wagner evre ≤2 iken, 25’i (% 40) Wagner evre ≥3 idi. En sik izole edilen mikroorganizma S. aureus (20 hastadan, % 32) olup bunu Klebsiella spp. ve Enterobacter cloaca izledi. Tum Gr (-) izolatlara karsi en etkili antibiyotikler amikasin, meropenem, piperasillin-tazobaktam ve sefepim idi. En di...

Türkiye parazitoloji dergisi, 2014

African Health Sciences, 2021

Background: In pregnancy, Coronavirus disease-2019 (COVID-19) infection disease may be more sever... more Background: In pregnancy, Coronavirus disease-2019 (COVID-19) infection disease may be more severe due to existingphysiological changes. Similarly, changes during and after birth can make the patient more subceptible. Objective: To investigate possible laboratory findings that was related to postpartum progression of COVID-19 disease. Methods: Pregnant women who are pregnant at 28 weeks or more and who are COVID-19 positive at the time of delivery were investigated in this study. Progressed post- delivery and non-progressed COVID-19 positive pregnants’ laboratory findings were analyzed. Hematological and immunological parameters associated with postpartum progressed COVID-19 disease were evaluated. Results: Totally 151 individuals were conducted to the study. In the prenatal analysis, higher BMI and lower albumin levels were detected in the progressed group (p<0.05). In the postpartum analysis; White Blood Cell, lymphocyte and albumin were increased, while neutrophil, NLR, LDH, C...

La Clinica terapeutica, 2013

In developing countries HAV infection is very common in the first years of life and it is often a... more In developing countries HAV infection is very common in the first years of life and it is often asymptomatic. However especially in regions of intermediate endemicity, exposure to the virus may delay and outbreaks of hepatitis A may be encountered in adults. The aim of this study is to evaluate the clinical and laboratory findings and risk factors of adults with acute viral hepatitis A. In present study we evaluated 203 patient with acute viral hepatitis A, who were admitted to four different hospitals of three cities of Turkey between January 2000-December 2011, retrospectively. The diagnosis of acute viral hepatitis A was performed by laboratory findings and clinically. In a total of 203 patients, 120 (59.1%) patients were male and 83 (40.9%) were female. Mean age of cases with acute viral hepatitis A was 24.7 +11.8 years (ranged 15 to 82 years old). Acute viral hepatitis A were seen in patient who were 15-20 years and 21-30 years old, commonly. Jaundice (74%), fatigue (68%), naus...

Journal of Clinical and Experimental Investigations, 2012

Çalışmamızda; Türkiye'nin Güneydoğu Anadolu bölgesinde yer alan Diyarbakır, Mardin ve Batman ille... more Çalışmamızda; Türkiye'nin Güneydoğu Anadolu bölgesinde yer alan Diyarbakır, Mardin ve Batman illerindeki brusellozlu hastaların klinik, laboratuvar ve tedavi özellikleri yönünden değerlendirilmesi amaçlanmıştır. Gereç ve yöntem: Haziran 2007-Temmuz 2009 tarihleri arasında Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniğinde bruselloz tanısı ile izlenen 286 hasta geriye dönük olarak değerlendirilmiştir. Bulgular: Hastaların 156 (%55)'i kadın, 130 (%45)'i erkek ve yaş ortalamaları 32,8 + 15,3 (15-78) idi. Vakaların %75 akut, %23 subakut ve %2'sini kronik olarak gruplandırıldı. Hastalığın bulaşmasındaki en önemli faktörün taze peynir yeme olduğu ve bölgede hayvan hareketlerinin kontrolünün olmadığı belirlendi. Hastalarda en sık rastlanan şikayetler yorgunluk, ateş, kas ve eklem ağrıları ve gece terlemesi idi. Ateş (%90,8), artrit (%54,1), splenomegali (%18,3) ve hepatomegali (%11) en sık rastlanan muayene bulgularıydı. Laboratuvarda ise C-Reaktif Protein (CRP) değerinin %60 yüksek olarak saptanması en sık rastlanan bulguydu. Tanı klinik belirtilerle birlikte pozitif Rose-Bengal ve Brusella tüp aglütinasyon testinin 1/160 ve üzeri olması ile konuldu. Tedavide ise çoğunlukla rifampisin ve doksisiklin kombinasyonu tercih edildi. Sonuç: Bruselloz hala ülkemizde önemli mortalite ve morbiditeye neden olan bir halk sağlığı sorunudur. Brucella, özellikle endemik bölgelerde, ateş, lökopeni ve osteoartiküler bulguların varlığında ayırıcı tanıda mutlaka akılda bulundurulmalıdır.

Results in Physics, 2020

The mathematical models of infections are essential tools in understanding the dynamical behavior... more The mathematical models of infections are essential tools in understanding the dynamical behavior of disease transmission. In this paper, we establish a model of differential equations with piecewise constant arguments that explores the outbreak of Covid-19 including the control mechanisms such as health organizations and police supplements for the sake of controlling the pandemic spread and protecting the susceptible population. The local asymptotic stability of the equilibrium points, the disease-free equilibrium point, the apocalypse equilibrium point and the co-existing equilibrium point are analyzed by the aide of Schur-Cohn criteria. Furthermore and by incorporating the Allee function at time t, we consider the extinction case of the outbreak to analyze the conditions for a strong Allee Effect. Our study has demonstarted that the awareness of the police personal and the management of professional health organizations play a vital role to protect the susceptible class and to prevent the spreading. Numerical simulations are presented to support our theoretical findings. We end the paper by a describtive conclusion.

Biomedical Research-tokyo, 2017

Liver biopsy and histopathological evaluation are the main methods to assess liver pathology. How... more Liver biopsy and histopathological evaluation are the main methods to assess liver pathology. However, liver biopsy is not widely used due to implementation challenge. We aimed to investigate non-invasive parameters for evaluation of liver fibrosis in chronic Hepatitis B patients. A total of 65 patients who admitted to outpatient clinic and diagnosed as chronic hepatitis were included in this study. Liver puncture biopsy was performed for all patients and was evaluated according to the Modified Ishak Fibrosis Score. The patients without fibrosis or with mild and moderate fibrosis were evaluated as Group I (Stage O, I, II), the patients with advanced fibrosis were evaluated as Group II (stage III, IV, V, VI). Among 65 patients, 42 were male and 23 were female; 48 of the patients were in group I while 17 patients belonged to group II. Gamma-Glutamyl Transferase (GGT), Alkaline Phosphatase (ALP), Aspartat Transaminaz (AST) and Alanin Aminotransferaz (ALT) levels were significantly high...

Clinical and Experimental Nephrology, 2020

Background In our study, diagnostic and demographic characteristics of patients diagnosed with RP... more Background In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune). Results Of 3875 patients, 200 patients with RPGN (mean age 47.9 ± 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9–5.7) mg/dl, glomerular filtration rate was 18 (10–37) ml/min/1.73m 2 and proteinuria 2100 (1229–3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio. Conclusions Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed.

Acta Biochimica Polonica, 2020

Previous studies detected higher Golgi protein 73 levels in the serum of patients with chronic li... more Previous studies detected higher Golgi protein 73 levels in the serum of patients with chronic liver disease. The Beta-2 microglobulin levels were also observed to be higher in patients with chronic hepatitis B infection compared to the inactive carriers and the protein plays an important role in the response to viral infections. The aim of the present study was to assess the liver fibrosis through non-invasive methods in chronic hepatitis B patients. Three groups were included in the study. The first group comprised of the patients who were admitted to the Infectious Diseases and Clinical Microbiology clinic to undergo a liver biopsy, while the second group included the patients who were admitted inactive hepatitis B carriers. The third group comprised the healthy controls. The Golgi p-73 and Beta-2 microglobulin levels in the plasma were determined using the ELISA method. Beta-2 microglobulin level was highest in the patients group and the difference was statistically significant....

Balkan Medical Journal, 2016

Background: The clinical spectrum of Brucella infection is quite diverse and characterized by mul... more Background: The clinical spectrum of Brucella infection is quite diverse and characterized by multi-system involvement. Patients present with myocarditis, endocarditis, or pericarditis. Infective endocarditis is the most common cardiovascular complication in patients with brucellosis. Although conduction abnormalities are seen in cases with endocarditis, they are reported very rarely in the setting of cardiac Brucella infection. Case Report: An eight and a half-year-old male patient was referred to our clinic due to inadequate response to cotrimaxazole plus streptomycin treatment at the 15th day of admission. Although local hospital records on the patient showed a heart rate of 80 bpm, we determined a heart rate of 46 bpm. The electrocardiogram showed complete atrioventricular (AV) block. The average heart rate was determined as 48 bpm with 24-hour Holter electrocardiogram (ECG) monitoring. The echocardiographic examination showed normal-sized heart chambers and the absence of valvular involvement. An agglutination test for brucellosis was found to be positive with a titer of 1/320. High fever, arthralgia, and splenomegaly regressed following doxycycline plus rifampicin therapy, but there was no improvement in the AV block. A permanent pacemaker was implanted because of the detection of an average heart rate of 48 bpm. Conclusion: Because cardiac failure and rhythm abnormalities are reported in the course of Brucella infection and may be associated with significant outcomes, cases with brucellosis should be evaluated carefully in terms of cardiac involvement. This report aims to draw attention to complete AV block as an extremely rare complication of Brucella infection.

Pediatrics International, 2016

Background: Urinary tract infections (UTI) are one of the most common bacterial infections in chi... more Background: Urinary tract infections (UTI) are one of the most common bacterial infections in children and a major cause of hospitalization. In this study we investigated the clinical characteristics, causative uropathogens; their antibiotic susceptibility and resistance patterns, treatment modalities and efficacy in children hospitalized for UTI in a tertiary care setting. Methods: Patients hospitalized for an upper UTI between March 2009 and July 2014 were enrolled. The urine cultureantibiogram results and accompanying urinary tract abnormalities were recorded retrospectively. Results: A total of 142 patients (104 girls, 73.2%; 38 boys, 26.8%) were enrolled. Mean patient age was 32.6 ± 4.1 months. History of recurrent UTI was present in 45.8% (n = 65), with prior hospitalization in 12.0% (n = 17). Frequency of vesicoureteral reflux was 18.3% (n = 26). Gram-negative enteric microorganisms yielded growth in all culture-positive UTI and the most common microorganism was Escherichia coli (n = 114, 80.3%). Extended spectrum beta-lactamaseproducing (ESBL (+)) bacterial strains were detected in 49.3% (n = 70), with third-generation cephalosporin resistance in all and increased duration of hospitalization. Conclusions: The prevalence of UTI with ESBL (+) bacterial strains with multi-drug resistance is increasing in the hospitalized pediatric population, therefore rational use of antibiotics is essential.

Journal of Microbiology and Infectious Diseases, 2012

Dicle Medical Journal / Dicle Tip Dergisi, 2012

Bu çalışmayla, iki ilimizde çalışan pratisyen hekimlerin üst solunum yolu enfeksiyonlarında (ÜSYE... more Bu çalışmayla, iki ilimizde çalışan pratisyen hekimlerin üst solunum yolu enfeksiyonlarında (ÜSYE) antibiyotik kullanım farkındalığı ve sağlık ile ilgili eğitim seminerlerinin etkileri, özel olarak hazırlanan bir anket yardımıyla değerlendirmek amaçlandı. Gereç ve yöntem: Düzenlenen eğitim semineri önce ve sonrasında, pratisyen hekimlere ÜSYE'nu epidemiyoloji, etyoloji, tanı ve tedavisi hakkında yedi soruyu içeren standart bir anket uygulanarak bilgi ve tutumları değerlendirildi ve cevap oranları karşılaştırıldı. Bulgular: Toplamda 110 pratisyen hekim çalışmaya katıldı. Seminer öncesi katılımcıların %30'undan fazlası ÜSYE'larının etyolojisinin en az %50'sini bakterilerin oluşturduğu ve %88'i anaerop ve Neisseriaların etyolojide yer almadığını düşünürken, katılımcıların yalnız %14'ü Streptococcus pyogenes suşunun prokain penisiline tam duyarlı olduğunu, başka bir deyişle % 95'i Beta-hemolytic-Streptococcus'un etken olduğu ÜSYE'ununun tedavisinde penesilinin ilk seçenek olduğu cevabını verdi. Seminer sonrası katılan hekimlerin bilgilerinde önemli bir ilerleme görüldü. .Doğru cevap oranlarında (seminer öncesi %27.7 ve sonrası %92.7) anlamlı bir fark vardı (p< 0.001). Sonuç: Pratisyen hekimlerin bilgi ve davranışlarının, eğitim seminerleriyle geliştirilebileceği sonucuna varıldı.