Qiang Fei - Academia.edu (original) (raw)
Papers by Qiang Fei
We collected salary information on male and female business school faculty from 13 institutions o... more We collected salary information on male and female business school faculty from 13 institutions of higher learning, from six teaching fields, across five states via collegiatetimes.com, a public salary database. An analysis of variance, with a 2 x 4 x 6 factorial design, is used to test for main effects and interaction effects when gender, rank and teaching fields are the factors and salary is the response variable. Although women earn less than men in academics in general, among business school faculty the salary differences are non-significant after allowing for ranks and teaching fields. The interaction between rank and teaching field is found to be moderately significant. Therefore, today's female business faculty might not be subjected to the pay disparities reported in many other studies.
This study examines the dynamics in the ranking of marketing journals and proposes a simple yet e... more This study examines the dynamics in the ranking of marketing journals and proposes a simple yet effective way of ranking journals. The authors use a 4 x 3 factorial design to investigate the changes of citations for journals over the three time periods. Two important findings emerge from the study. First, the underlying quality gaps as indicated by citations are narrowing for journals of top and bottom tiers. Second, the impact of celebrity authors on the rankings is diminishing. These findings call for caution when schools utilize existing journal rankings for tenure, promotion and merit pay increases.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Jan 5, 2017
In this work, a turn on fluorescent sensor, based on Hg(2+) coordination conjugated polymer, was ... more In this work, a turn on fluorescent sensor, based on Hg(2+) coordination conjugated polymer, was developed to detect cysteine-containing compounds. The fluorescence of conjugated polymer (poly(2,5-bis (sodium 4-oxybutyrate) -1,4 - phenylethynylene-alt-1,4-phenyleneethynylene; PPE-OBS) would be quenched by Hg(2+) because of the coordination-induced aggregation and electron transfers of PPE-OBS toward Hg(2+). When there were some cysteine-containing compounds in PPE-OBS-Hg(2+) system, the fluorescence of PPE-OBS would be recovered. It indicated that the PPE-OBS-Hg(2+) system could be used to detect cysteine-containing compounds. Under the optimized conditions, the experiment results showed that there were particularly linear range, high sensitivity and selectivity over other amino acids. The limit of detection (LOD) of cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) were 0.725μmolL(-1), 0.982μmolL(-1) and 1.21μmolL(-1) by using this sensor. In addition, Cys standard recovery ...
Food chemistry, 2017
A novel hollow fiber membranes-based dynamic liquid-liquid micro-extraction (HF-DLLME) coupled wi... more A novel hollow fiber membranes-based dynamic liquid-liquid micro-extraction (HF-DLLME) coupled with HPLC-UV detection has been developed for the residue analysis of tetracyclines in milk samples without deproteinization and degreasing. The influences of experimental parameters were investigated and optimized. The method showed a good performance. The limits of detection (LOD) are in the range of 0.95-3.6μg/L. The recoveries in spiked samples range from 92.38 to 107.3%. The relative standard deviations (RSDs) are lower than 8.66%. The advantages of this method are simple operation, high efficiency, absence of sample carryover and low cost.
Journal of fluorescence, 2017
A highly selective fluorescent probe 2-(2-(2-aminoethylamino)ethyl)-3',6'-bis(ethylamino)... more A highly selective fluorescent probe 2-(2-(2-aminoethylamino)ethyl)-3',6'-bis(ethylamino)-2',7'-dimethylspiro[isoindoline-1,9'-xanthen]-3-one (ABDO) for Se (IV) had been synthesized in our earlier report. In this study, this fluorescent sensor is applied on analysis fluorescent imaging of Se (IV) in Hela cells. The experiment conditions, such as the MTT assay, different concentration of saline, incubated time of Hela cells with ABDO and Se (IV), and intracellular action position of Se (IV), are investigated. Through a series of experiments, the fluorescent image of Se (IV) in Hela cells can be observed when the cells cultured by 2 μM ABDO and 2 μM Se (IV) for 210 min. And the intracellular action position of Se (IV) is verified after the co-localization experiments are done. It is mitochondria. These experimental results show that ABDO will be an eagerly anticipated sensor for fluorescent imaging analysis of selenium ion in living cells. Besides, we also can use ...
Arabian Journal of Chemistry, 2015
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2016
A unique water-soluble porphyrin [5,10,15,20-tetra(3-ethoxy-4-hydroxy-5-sulfonate)phenyl porphyri... more A unique water-soluble porphyrin [5,10,15,20-tetra(3-ethoxy-4-hydroxy-5-sulfonate)phenyl porphyrin, H2TEHPPS] was designed and synthesized, which could be used as a potential sensor for the determination of Cu(2+). Studies were performed in the solution. The concentration of H2TEHPPS was 5 μmol L(-1). The optical properties of H2TEHPPS were investigated based on the absorption spectra. The results show that the absorbance of H2TEHPPS at 417 nm is directly proportional to the concentration of Cu(2+) in the range of 0 - 2.5 μmol L(-1). H2TEHPPS can thus be used as a novel class of Cu(2+) sensors.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Jan 25, 2016
A novel water-soluble porphyrin (5,10,15,20-tetra(3-ethoxy-4-hydroxy-5-sulfonate) phenylporphyrin... more A novel water-soluble porphyrin (5,10,15,20-tetra(3-ethoxy-4-hydroxy-5-sulfonate) phenylporphyrin, H2TEHPPS) was synthesized. H2TEHPPS exhibited high sensitivity and selectivity towards Mo(6+). The enhanced fluorescence response of H2TEHPPS after titration with Mo(6+) in aqueous solution at pH3.5 was attributed to the formation of an inclusion complex between the porphyrin ring and Mo(6+), which R(2)=0.999 from 10 to 1000μgL(-1), providing a detection limit of 1.5μgL(-1). The fluorescence response of H2TEHPPS towards Mo(6+) showed excellent selectivity over other transition metal cations.
Bioresource Technology, Feb 1, 2011
The use of volatile fatty acids (VFAs) for microbial lipid accumulation was investigated in flask... more The use of volatile fatty acids (VFAs) for microbial lipid accumulation was investigated in flask cultures of Cryptococcus albidus. The optimum culture temperature and pH were 25°C and pH 6.0, respectively, and the highest lipid content (27.8%) was obtained with ammonia chloride as a nitrogen source. The lipid yield coefficient on VFAs was 0.167 g/g of C. albidus with a VFAs (acetic, propionic, butyric acids) ratio of 8:1:1, which was in good agreement with a theoretically predicted lipid yield coefficient of the VFAs as a carbon source. The major fatty acids of the lipids accumulated by C. albidus were similar to those of soybean oil and jatropha oil. A preliminary cost analysis shows that VFAs-based biodiesel production is competitive with current palm and soybean based biodiesels. Further process development for lower aeration cost and higher lipid yield will make this process more economical.
Bioprocess and Biosystems Engineering, May 1, 2011
We carried out the first simulation on multistage continuous high cell density culture (MSC-HCDC)... more We carried out the first simulation on multistage continuous high cell density culture (MSC-HCDC) to show that the MSC-HCDC can achieve batch/fed-batch product titer with much higher productivity to the fed-batch productivity using published fermentation kinetics of lactic acid, penicillin and ethanol. The system under consideration consists of n-serially connected continuous stirred-tank reactors (CSTRs) with either hollow fiber cell recycling or cell immobilization for high cell-density culture. In each CSTR substrate supply and product removal are possible. Penicillin production is severely limited by glucose metabolite repression that requires multi-CSTR glucose
Oncology reports, Jan 9, 2016
FTY720, also known as fingolimod, is a widely used immunomodulator in multiple sclerosis and mult... more FTY720, also known as fingolimod, is a widely used immunomodulator in multiple sclerosis and multiple organ transplantation. It is also an important protein phosphatase 2A (PP2A) activator. Based on this, a number of studies have recently demonstrated the cytotoxic effect of FTY720 in various cancers. Yet in colorectal cancer (CRC), the underlying mechanisms of FTY720 cytotoxicity remain less clear, especially the relationship between a drug and autophagy. We demonstrate here for the first time that FTY720 promotes the appearance of autophagic hallmarks such as autophagosome formation and light chain 3 (LC3)-II accumulation, indicating the participation of autophagy in FTY720 cytotoxicity on CRC. Moreover, inhibition of autophagy using 3-methyladenine (3-MA), a specific inhibitor of autophagy, enhanced FTY720 cytotoxicity, indicating the protective role of autophagy against the drug's own cytotoxic effect. The protective autophagy was likely affected by cancerous inhibitor of PP...
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2016
The pneumatic nebulization gas-solid microextraction device fascinating us is because it directly... more The pneumatic nebulization gas-solid microextraction device fascinating us is because it directly atomized organic samples to cross a solid-phase microextraction (SPME) cartridge without any pretreatment. In this work, both the spray chamber and SPME column of the extraction device were heated. We found that this would significantly improve the extraction efficiency of this method. Then, this method was used to detect seven triazine herbicides (atraton, desmetryn, atrazine, terbumeton, terbuthylazine, terbutryn, and dipropetryn) in drinking alcohol samples. The experimental results indicated that this extraction procedure could conveniently, efficiently and accurately concentrate any triazine herbicides from drinking alcohol samples. The limits of detection (LODs) were from 0.08 to 0.23 μg L(-1), the limits of quantification (LOQs) were from 0.27 to 0.78 μg L(-1). We used this method to detect triazine herbicides in five white spirit samples. Four concentrations were chosen (5, 25, ...
Guang Pu Xue Yu Guang Pu Fen Xi Guang Pu, Dec 1, 2007
A unique high resolution simultaneous microwave plasma torch (MPT) atomic emission spectrometer w... more A unique high resolution simultaneous microwave plasma torch (MPT) atomic emission spectrometer was developed and studied preliminarily. Some advanced technologies were applied to the spectrometer, such as echelle grating, UV-intensified CCD array detector, adjustable microwave generator, and water cooling system for the generator, etc. The detection limits of the spectrometer for some elements were determined, the spectral resolution and pixel resolution of the spectrometer were calculated, and an analysis of a practical sample was carried out. The preliminary results demonstrate that such simultaneous spectrometer has advantages of saving sample and time, possessing high sensitivity and resolution, and low-cost for the purchase and maintenance. Taking analytical figures of merit into consideration, the high resolution simultaneous MPT spectrometer will have extended application areas and greater competition potential as compared with sequential MPT spectrometers.
Biotechnology and Bioprocess Engineering, Jun 1, 2011
Chem. Commun., 2015
Two novel probes were designed, sharing the same BODIPY core but differing only by a minimized va... more Two novel probes were designed, sharing the same BODIPY core but differing only by a minimized variation in the recognition site from 4-hydroxyaniline into 4-methoxyaniline. Such a small change in the reaction site could switch the selective detection from peroxynitrite to HOCl. Undoubtedly, the new designed BODIPY core exhibits valuable properties.
International journal of analytical chemistry, 2015
A sensitive mass spectrometric analysis method based on the microwave plasma technique is develop... more A sensitive mass spectrometric analysis method based on the microwave plasma technique is developed for the fast detection of trace rare earth elements (REEs) in aqueous solution. The plasma was produced from a microwave plasma torch (MPT) under atmospheric pressure and was used as ambient ion source of a linear ion trap mass spectrometer (LTQ). Water samples were directly pneumatically nebulized to flow into the plasma through the central tube of MPT. For some REEs, the generated composite ions were detected in both positive and negative ion modes and further characterized in tandem mass spectrometry. Under the optimized conditions, the limit of detection (LOD) was at the level 0.1 ng/mL using MS(2) procedure in negative mode. A single REE analysis can be completed within 2~3 minutes with the relative standard deviation ranging between 2.4% and 21.2% (six repeated measurements) for the 5 experimental runs. Moreover, the recovery rates of these REEs are between the range of 97.6%-12...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Jan 8, 2015
A novel isonicotic acid hydrazide Schiff base derivative N'-(3,5-di-tert-butyl-2-hydroxy-benz... more A novel isonicotic acid hydrazide Schiff base derivative N'-(3,5-di-tert-butyl-2-hydroxy-benzylidene) isonicotinohydrazide (DHIH) has been synthesized and developed as a high selective and sensitive colorimetric probe for Cu(2+) determination. Addition of Cu(2+) to the solution of DHIH resulted in a rapid color change from colorless to yellow together with an obvious new absorption band appeared at the range of 400-440nm by forming a 1:1 complex. Experimental results indicated that the DHIH could provide absorption response to Cu(2+) with a linear dynamic range from 1.0×10(-5) to 1.0×10(-4)mol/L. The detection limit of Cu(2+) was 5.24×10(-7)mol/L with good tolerance of other metal ions.
Angewandte Chemie (International ed. in English), Jan 4, 2015
γ-Glutamyltranspeptidase (GGT) is a tumor biomarker that selectively catalyzes the cleavage of gl... more γ-Glutamyltranspeptidase (GGT) is a tumor biomarker that selectively catalyzes the cleavage of glutamate overexpressed on the plasma membrane of tumor cells. Here, we developed two novel fluorescent in situ targeting (FIST) probes that specifically target GGT in tumor cells, which comprise 1) a GGT-specific substrate unit (GSH), and 2) a boron-dipyrromethene (BODIPY) moiety for fluorescent signalling. In the presence of GGT, sulfur-substituted BODIPY was converted to amino-substituted BODIPY, resulting in dramatic fluorescence variations. By exploiting this enzyme-triggered photophysical property, we employed these FIST probes to monitor the GGT activity in living cells, which showed remarkable differentiation between ovarian cancer cells and normal cells. These probes represent two first-generation chemodosimeters featuring enzyme-mediated rapid, irreversible aromatic hydrocarbon transfer between the sulfur and nitrogen atoms accompanied by switching of photophysical properties.
We collected salary information on male and female business school faculty from 13 institutions o... more We collected salary information on male and female business school faculty from 13 institutions of higher learning, from six teaching fields, across five states via collegiatetimes.com, a public salary database. An analysis of variance, with a 2 x 4 x 6 factorial design, is used to test for main effects and interaction effects when gender, rank and teaching fields are the factors and salary is the response variable. Although women earn less than men in academics in general, among business school faculty the salary differences are non-significant after allowing for ranks and teaching fields. The interaction between rank and teaching field is found to be moderately significant. Therefore, today's female business faculty might not be subjected to the pay disparities reported in many other studies.
This study examines the dynamics in the ranking of marketing journals and proposes a simple yet e... more This study examines the dynamics in the ranking of marketing journals and proposes a simple yet effective way of ranking journals. The authors use a 4 x 3 factorial design to investigate the changes of citations for journals over the three time periods. Two important findings emerge from the study. First, the underlying quality gaps as indicated by citations are narrowing for journals of top and bottom tiers. Second, the impact of celebrity authors on the rankings is diminishing. These findings call for caution when schools utilize existing journal rankings for tenure, promotion and merit pay increases.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Jan 5, 2017
In this work, a turn on fluorescent sensor, based on Hg(2+) coordination conjugated polymer, was ... more In this work, a turn on fluorescent sensor, based on Hg(2+) coordination conjugated polymer, was developed to detect cysteine-containing compounds. The fluorescence of conjugated polymer (poly(2,5-bis (sodium 4-oxybutyrate) -1,4 - phenylethynylene-alt-1,4-phenyleneethynylene; PPE-OBS) would be quenched by Hg(2+) because of the coordination-induced aggregation and electron transfers of PPE-OBS toward Hg(2+). When there were some cysteine-containing compounds in PPE-OBS-Hg(2+) system, the fluorescence of PPE-OBS would be recovered. It indicated that the PPE-OBS-Hg(2+) system could be used to detect cysteine-containing compounds. Under the optimized conditions, the experiment results showed that there were particularly linear range, high sensitivity and selectivity over other amino acids. The limit of detection (LOD) of cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) were 0.725μmolL(-1), 0.982μmolL(-1) and 1.21μmolL(-1) by using this sensor. In addition, Cys standard recovery ...
Food chemistry, 2017
A novel hollow fiber membranes-based dynamic liquid-liquid micro-extraction (HF-DLLME) coupled wi... more A novel hollow fiber membranes-based dynamic liquid-liquid micro-extraction (HF-DLLME) coupled with HPLC-UV detection has been developed for the residue analysis of tetracyclines in milk samples without deproteinization and degreasing. The influences of experimental parameters were investigated and optimized. The method showed a good performance. The limits of detection (LOD) are in the range of 0.95-3.6μg/L. The recoveries in spiked samples range from 92.38 to 107.3%. The relative standard deviations (RSDs) are lower than 8.66%. The advantages of this method are simple operation, high efficiency, absence of sample carryover and low cost.
Journal of fluorescence, 2017
A highly selective fluorescent probe 2-(2-(2-aminoethylamino)ethyl)-3',6'-bis(ethylamino)... more A highly selective fluorescent probe 2-(2-(2-aminoethylamino)ethyl)-3',6'-bis(ethylamino)-2',7'-dimethylspiro[isoindoline-1,9'-xanthen]-3-one (ABDO) for Se (IV) had been synthesized in our earlier report. In this study, this fluorescent sensor is applied on analysis fluorescent imaging of Se (IV) in Hela cells. The experiment conditions, such as the MTT assay, different concentration of saline, incubated time of Hela cells with ABDO and Se (IV), and intracellular action position of Se (IV), are investigated. Through a series of experiments, the fluorescent image of Se (IV) in Hela cells can be observed when the cells cultured by 2 μM ABDO and 2 μM Se (IV) for 210 min. And the intracellular action position of Se (IV) is verified after the co-localization experiments are done. It is mitochondria. These experimental results show that ABDO will be an eagerly anticipated sensor for fluorescent imaging analysis of selenium ion in living cells. Besides, we also can use ...
Arabian Journal of Chemistry, 2015
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2016
A unique water-soluble porphyrin [5,10,15,20-tetra(3-ethoxy-4-hydroxy-5-sulfonate)phenyl porphyri... more A unique water-soluble porphyrin [5,10,15,20-tetra(3-ethoxy-4-hydroxy-5-sulfonate)phenyl porphyrin, H2TEHPPS] was designed and synthesized, which could be used as a potential sensor for the determination of Cu(2+). Studies were performed in the solution. The concentration of H2TEHPPS was 5 μmol L(-1). The optical properties of H2TEHPPS were investigated based on the absorption spectra. The results show that the absorbance of H2TEHPPS at 417 nm is directly proportional to the concentration of Cu(2+) in the range of 0 - 2.5 μmol L(-1). H2TEHPPS can thus be used as a novel class of Cu(2+) sensors.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Jan 25, 2016
A novel water-soluble porphyrin (5,10,15,20-tetra(3-ethoxy-4-hydroxy-5-sulfonate) phenylporphyrin... more A novel water-soluble porphyrin (5,10,15,20-tetra(3-ethoxy-4-hydroxy-5-sulfonate) phenylporphyrin, H2TEHPPS) was synthesized. H2TEHPPS exhibited high sensitivity and selectivity towards Mo(6+). The enhanced fluorescence response of H2TEHPPS after titration with Mo(6+) in aqueous solution at pH3.5 was attributed to the formation of an inclusion complex between the porphyrin ring and Mo(6+), which R(2)=0.999 from 10 to 1000μgL(-1), providing a detection limit of 1.5μgL(-1). The fluorescence response of H2TEHPPS towards Mo(6+) showed excellent selectivity over other transition metal cations.
Bioresource Technology, Feb 1, 2011
The use of volatile fatty acids (VFAs) for microbial lipid accumulation was investigated in flask... more The use of volatile fatty acids (VFAs) for microbial lipid accumulation was investigated in flask cultures of Cryptococcus albidus. The optimum culture temperature and pH were 25°C and pH 6.0, respectively, and the highest lipid content (27.8%) was obtained with ammonia chloride as a nitrogen source. The lipid yield coefficient on VFAs was 0.167 g/g of C. albidus with a VFAs (acetic, propionic, butyric acids) ratio of 8:1:1, which was in good agreement with a theoretically predicted lipid yield coefficient of the VFAs as a carbon source. The major fatty acids of the lipids accumulated by C. albidus were similar to those of soybean oil and jatropha oil. A preliminary cost analysis shows that VFAs-based biodiesel production is competitive with current palm and soybean based biodiesels. Further process development for lower aeration cost and higher lipid yield will make this process more economical.
Bioprocess and Biosystems Engineering, May 1, 2011
We carried out the first simulation on multistage continuous high cell density culture (MSC-HCDC)... more We carried out the first simulation on multistage continuous high cell density culture (MSC-HCDC) to show that the MSC-HCDC can achieve batch/fed-batch product titer with much higher productivity to the fed-batch productivity using published fermentation kinetics of lactic acid, penicillin and ethanol. The system under consideration consists of n-serially connected continuous stirred-tank reactors (CSTRs) with either hollow fiber cell recycling or cell immobilization for high cell-density culture. In each CSTR substrate supply and product removal are possible. Penicillin production is severely limited by glucose metabolite repression that requires multi-CSTR glucose
Oncology reports, Jan 9, 2016
FTY720, also known as fingolimod, is a widely used immunomodulator in multiple sclerosis and mult... more FTY720, also known as fingolimod, is a widely used immunomodulator in multiple sclerosis and multiple organ transplantation. It is also an important protein phosphatase 2A (PP2A) activator. Based on this, a number of studies have recently demonstrated the cytotoxic effect of FTY720 in various cancers. Yet in colorectal cancer (CRC), the underlying mechanisms of FTY720 cytotoxicity remain less clear, especially the relationship between a drug and autophagy. We demonstrate here for the first time that FTY720 promotes the appearance of autophagic hallmarks such as autophagosome formation and light chain 3 (LC3)-II accumulation, indicating the participation of autophagy in FTY720 cytotoxicity on CRC. Moreover, inhibition of autophagy using 3-methyladenine (3-MA), a specific inhibitor of autophagy, enhanced FTY720 cytotoxicity, indicating the protective role of autophagy against the drug's own cytotoxic effect. The protective autophagy was likely affected by cancerous inhibitor of PP...
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2016
The pneumatic nebulization gas-solid microextraction device fascinating us is because it directly... more The pneumatic nebulization gas-solid microextraction device fascinating us is because it directly atomized organic samples to cross a solid-phase microextraction (SPME) cartridge without any pretreatment. In this work, both the spray chamber and SPME column of the extraction device were heated. We found that this would significantly improve the extraction efficiency of this method. Then, this method was used to detect seven triazine herbicides (atraton, desmetryn, atrazine, terbumeton, terbuthylazine, terbutryn, and dipropetryn) in drinking alcohol samples. The experimental results indicated that this extraction procedure could conveniently, efficiently and accurately concentrate any triazine herbicides from drinking alcohol samples. The limits of detection (LODs) were from 0.08 to 0.23 μg L(-1), the limits of quantification (LOQs) were from 0.27 to 0.78 μg L(-1). We used this method to detect triazine herbicides in five white spirit samples. Four concentrations were chosen (5, 25, ...
Guang Pu Xue Yu Guang Pu Fen Xi Guang Pu, Dec 1, 2007
A unique high resolution simultaneous microwave plasma torch (MPT) atomic emission spectrometer w... more A unique high resolution simultaneous microwave plasma torch (MPT) atomic emission spectrometer was developed and studied preliminarily. Some advanced technologies were applied to the spectrometer, such as echelle grating, UV-intensified CCD array detector, adjustable microwave generator, and water cooling system for the generator, etc. The detection limits of the spectrometer for some elements were determined, the spectral resolution and pixel resolution of the spectrometer were calculated, and an analysis of a practical sample was carried out. The preliminary results demonstrate that such simultaneous spectrometer has advantages of saving sample and time, possessing high sensitivity and resolution, and low-cost for the purchase and maintenance. Taking analytical figures of merit into consideration, the high resolution simultaneous MPT spectrometer will have extended application areas and greater competition potential as compared with sequential MPT spectrometers.
Biotechnology and Bioprocess Engineering, Jun 1, 2011
Chem. Commun., 2015
Two novel probes were designed, sharing the same BODIPY core but differing only by a minimized va... more Two novel probes were designed, sharing the same BODIPY core but differing only by a minimized variation in the recognition site from 4-hydroxyaniline into 4-methoxyaniline. Such a small change in the reaction site could switch the selective detection from peroxynitrite to HOCl. Undoubtedly, the new designed BODIPY core exhibits valuable properties.
International journal of analytical chemistry, 2015
A sensitive mass spectrometric analysis method based on the microwave plasma technique is develop... more A sensitive mass spectrometric analysis method based on the microwave plasma technique is developed for the fast detection of trace rare earth elements (REEs) in aqueous solution. The plasma was produced from a microwave plasma torch (MPT) under atmospheric pressure and was used as ambient ion source of a linear ion trap mass spectrometer (LTQ). Water samples were directly pneumatically nebulized to flow into the plasma through the central tube of MPT. For some REEs, the generated composite ions were detected in both positive and negative ion modes and further characterized in tandem mass spectrometry. Under the optimized conditions, the limit of detection (LOD) was at the level 0.1 ng/mL using MS(2) procedure in negative mode. A single REE analysis can be completed within 2~3 minutes with the relative standard deviation ranging between 2.4% and 21.2% (six repeated measurements) for the 5 experimental runs. Moreover, the recovery rates of these REEs are between the range of 97.6%-12...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, Jan 8, 2015
A novel isonicotic acid hydrazide Schiff base derivative N'-(3,5-di-tert-butyl-2-hydroxy-benz... more A novel isonicotic acid hydrazide Schiff base derivative N'-(3,5-di-tert-butyl-2-hydroxy-benzylidene) isonicotinohydrazide (DHIH) has been synthesized and developed as a high selective and sensitive colorimetric probe for Cu(2+) determination. Addition of Cu(2+) to the solution of DHIH resulted in a rapid color change from colorless to yellow together with an obvious new absorption band appeared at the range of 400-440nm by forming a 1:1 complex. Experimental results indicated that the DHIH could provide absorption response to Cu(2+) with a linear dynamic range from 1.0×10(-5) to 1.0×10(-4)mol/L. The detection limit of Cu(2+) was 5.24×10(-7)mol/L with good tolerance of other metal ions.
Angewandte Chemie (International ed. in English), Jan 4, 2015
γ-Glutamyltranspeptidase (GGT) is a tumor biomarker that selectively catalyzes the cleavage of gl... more γ-Glutamyltranspeptidase (GGT) is a tumor biomarker that selectively catalyzes the cleavage of glutamate overexpressed on the plasma membrane of tumor cells. Here, we developed two novel fluorescent in situ targeting (FIST) probes that specifically target GGT in tumor cells, which comprise 1) a GGT-specific substrate unit (GSH), and 2) a boron-dipyrromethene (BODIPY) moiety for fluorescent signalling. In the presence of GGT, sulfur-substituted BODIPY was converted to amino-substituted BODIPY, resulting in dramatic fluorescence variations. By exploiting this enzyme-triggered photophysical property, we employed these FIST probes to monitor the GGT activity in living cells, which showed remarkable differentiation between ovarian cancer cells and normal cells. These probes represent two first-generation chemodosimeters featuring enzyme-mediated rapid, irreversible aromatic hydrocarbon transfer between the sulfur and nitrogen atoms accompanied by switching of photophysical properties.