Stuart Feldman - Academia.edu (original) (raw)

Papers by Stuart Feldman

Research paper thumbnail of 236 Pharmacokinetics of Amikacin in Children with Malignancies

Pediatric Research, Apr 1, 1978

Research paper thumbnail of Principles of medical chemistry

Lea and Febiger, 1981

861 p. : il.; 29 cm

Research paper thumbnail of Bioavailability of allopurinol oral and rectal dosage forms

American Journal of Health-System Pharmacy, 1981

The bioavailability of allopurinol from orally administered tablets and rectally administered sup... more The bioavailability of allopurinol from orally administered tablets and rectally administered suppositories is reported. Two types of rectal suppositories (cocoa butter and polyethylene glycol) were compounded and contained 300 mg allopurinol (from oral tablets). Five healthy volunteers received 300 mg allopurinol orally from tablets or rectally from suppositories in a randomized, three-way crossover design. Serial blood samples were drawn for 72 hours following administration and were analyzed by high-pressure liquid chromatography for allopurinol and its metabolite, oxipurinol. The interaction between allopurinol and PEG was studied in vitro using a dialysis method. Serum allopurinol levels following oral administration of tablets peaked at 1.5 +/- 0.23 microgram/ml at 5.20 +/- 0.65 hours. Allopurinol was not detectable after administration of cocoa butter/allopurinol suppositories; oxipurinol peaked at 0.34 +/- 0.14 microgram/ml at 13 +/- 11 hours. The bioavailability of allopurinol from the cocoa butter suppository, relative to the tablet, was 5.77 +/- 2.5%. Neither allopurinol nor oxipurinol was detectable (less than 0.1 microgram/ml) in the sera of persons following administration of PEG suppositories. Dialysis studies showed decreased loss of allopurinol from the dialysis sac as PEG concentration increased. The rectal suppositories of allopurinol used in this study did not appear to be an efficient means of administering this drug.

Research paper thumbnail of Contents, Vol. 15, 1977

Pharmacology, 1977

All rights reserved. No part of this publication may be translated into other languages, reproduc... more All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photo copying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

Research paper thumbnail of Effect of Bile Salts on Gastric Emptying and Intestinal Transit in the Rat

Gastroenterology, 1968

Although much work has been done on the effects of bile salts on gastric and intestinal motility,... more Although much work has been done on the effects of bile salts on gastric and intestinal motility,l-7 there have been few reports of the effects of bile salts on gastric emptying and intestinal transit. 6 ,7 Studies, presently being conducted in our laboratory on the effect of orally administered bile salts on drug absorption, have led to a consideration of the influence of bile salts on gastric emptying and intestinal transit rates. The absorption of many drugs depends upon their presence in specific areas of the gastrointestinal tract. An increase or delay in gastric emptying or intestina l transit could markedly affect the absorption characteristics of these drugs. The following study was designed to investigate these areas. Materials and Methods 1Vlaterials. Sodium taurodeoxycholate was obtained from Maybridge Chemical Company, Ltd., North Cornwall, United Kingdom. It was chromatographically pure. Sodium deoxycholate (special enzyme grade) was obtained from Mann Research Laboratories, Inc., New York, New York. Methods. Male Sprague-Dawley descent rats (Blue Spruce Farms, Altamont, New York) weighing between 130 and 180 g were fasted for 24 hr prior to the experiment. Water was allowed ad libitum. One and one-half milliliters of a 0.07% phenol red solution (prewarmed to 35 to 37 C),

Research paper thumbnail of Student Scientific Inquiry in the Core Doctor of Pharmacy Curriculum: Critical Issues in Designing and Implementing a Student Research Program

INNOVATIONS in pharmacy, 2013

While student-driven research has been credited with many learning benefits, few schools of pharm... more While student-driven research has been credited with many learning benefits, few schools of pharmacy require such activities. Professional organizations repeatedly urge for incorporating research content in schools' curricula, yet no guiding principles or recommendations currently exist to guide such implementation efforts. This paper provides an overview of the critical issues, guiding principles, benefits and challenges encountered in designing and implementing a required, research program in the Pharm.D. curriculum. Several critical issues are reviewed: goals, unitary focus and expectations, structure and deliverables, time and curricular integration, monitoring and institutional oversight, outcomes measurement, resources, students and faculty response, and dissemination. These general critical issues are then discussed as implemented in the student research program at Touro College of Pharmacy-New York. Different schools can address these core issues, based on their academic...

Research paper thumbnail of Serum antipyrine concentrations determined by micellar electrokinetic capillary chromatography

Journal of Chromatography B: Biomedical Sciences and Applications, 1993

We developed an assay for antipyrine in serum using micellar electrokinetic capillary chromatogra... more We developed an assay for antipyrine in serum using micellar electrokinetic capillary chromatography. A capillary electrophoresis system with a 70-cm fused-silica capillary and pH 8.2 borate-sodium dodecyl sulfate buffer was used. Standard curves ranging from 0.5 microgram/ml to 25 micrograms/ml were analyzed. The resulting electropherograms showed no interfering endogenous peaks and the assay was linear in the range of concentrations analyzed. The intra-day and inter-day relative standard deviations ranged from 0.7 to 5.2% and 1.7 to 8.1%, respectively. Analytical recovery of antipyrine ranged from 78.2 to 105.0%. The theoretical plate number for antipyrine was calculated to be 561,000 +/- 79,000 plates/m.

Research paper thumbnail of Comparative pharmacokinetics of halocarbons in the rat

Research paper thumbnail of The Pharmacokinetics of Bleomycin in Man

The Journal of Clinical Pharmacology, 1978

A series of studies were carried out to investigate the pharmacokinetics of the antineoplastic an... more A series of studies were carried out to investigate the pharmacokinetics of the antineoplastic antibiotic bleomycin in patients with neoplastic disorders. Drug was administered by long (four to five days) and short (10 minutes) zero-order infusions, and serial plasma and urine samples were collected. Serum and urine bleomycin concentrations were determined by radioimmunoassay. The disposition of bleomycin after the 10-minute infusion was described by a two-compartment open model. However, following multiple-day infusion estimates were obtained that were inconsistent with those from the short infusion. Parameters from the long infusions agreed with those from the short infusion when terminal plasma bleomycin levels less than 10 microunits/ml were excluded. The time to reach steady state following the long infusion (ca. 12 hours) was consistent with the half-life (3 hours) predicted by the short infusion and the long infusion excluding levels less than 10 microunits/ml. Possible explanations include assay interference by an unknown metabolite or strong binding of drug to tissues with release at a rate much less than the apparent rate of elimination of drug from the body.

Research paper thumbnail of Small Animal Model of Weightlessness for Pharmacokinetic Evaluation

The Journal of Clinical Pharmacology, 1994

Research paper thumbnail of Hydrodynamic and Diffusional Considerations in Assessing the Effects of Surface Active Agents on the Dissolution Rate of Drugs

CHEMICAL & PHARMACEUTICAL BULLETIN, 1970

Research paper thumbnail of High-performance liquid chromatographic assay for allopurinol and oxipurinol in human plasma

Journal of Chromatography B: Biomedical Sciences and Applications, 1979

Research paper thumbnail of Disposition of Bismuth in the Rat. I. Red Blood Cell and Plasma Protein Binding

Research paper thumbnail of Effects of Gender, Pregnancy, and Anesthesia on the Pharmacokinetics of Zidovudine in Rats

Pharmaceut Res, 1995

The effects of gender, pregnancy and anesthesia on the pharmacokinetics of zidovudine (AZT) were ... more The effects of gender, pregnancy and anesthesia on the pharmacokinetics of zidovudine (AZT) were studied in rats. Unanesthetized male (MR), female (FR) and pregnant (day 20, PR) rats received 50 mg/kg AZT via a jugular vein cannula. Female (FRA), pregnant (day 20, PRA) and pregnant (day 20, PRR) rats maintained under ketamine: acepromazine:xylazine anesthesia also received 50 mg/kg AZT. Two fetuses were removed at each sampling time from the PRR group. Plasma samples were collected and analyzed by RIA. With the exception of a lower non-renal clearance in female rats, there were no gender differences in the disposition of AZT. No significant differences were noted in total clearance, non-renal clearance or volume of distribution between pregnant and female rats, however, significant differences in renal clearance values were evident. Anesthesia resulted in decreased total, renal and non-renal clearances in female and pregnant rats. The removal of fetuses during the experiments did not alter the total clearance of AZT in pregnant rats, however, renal clearance and volume of distribution were decreased by cesarian section. The rat appears to be a suitable laboratory animal model for investigating AZT disposition during pregnancy. However, results of pharmacokinetic studies when animals are maintained under anesthesia with ketamine:acepromazine:xylazine must be interpreted with caution.

Research paper thumbnail of High-performance liquid chromatographic assay for allopurinol and oxipurinol in human plasma

Journal of Chromatography B: Biomedical Sciences and Applications, 1979

Research paper thumbnail of Disposition of Bismuth in the Rat. II. Pharmacokinetics and Biliary Excretion

Pharmaceutical Research, Apr 1, 1990

Research paper thumbnail of Let Freedom Ring! The journey towards independence of a community and academic partnership in Harlem, New York

Research paper thumbnail of Oral and intravenous trichloroethylene pharmacokinetics in the rat

Journal of Toxicology and Environmental Health, 1985

... Richard W. D'Souza Department of Pharmaceutics, University of Houston, University Park, ... more ... Richard W. D'Souza Department of Pharmaceutics, University of Houston, University Park, Houston, Texas James V. Bruckner Department of Pharmacology and Toxicology, University of Georgia, Athens, Georgia Stuart Feldman Department of ... Page 6. 592 RW D'SO UZA ET AL. ...

Research paper thumbnail of Infection-Induced Stones: Status of Clinic Trials with Urostat™ (Acetohydroxamic Acid)

Research paper thumbnail of Effects of gender, pregnancy, and anesthesia on the pharmacokinetics of zidovudine in rats

Pharmaceutical research, 1995

The effects of gender, pregnancy and anesthesia on the pharmacokinetics of zidovudine (AZT) were ... more The effects of gender, pregnancy and anesthesia on the pharmacokinetics of zidovudine (AZT) were studied in rats. Unanesthetized male (MR), female (FR) and pregnant (day 20, PR) rats received 50 mg/kg AZT via a jugular vein cannula. Female (FRA), pregnant (day 20, PRA) and pregnant (day 20, PRR) rats maintained under ketamine: acepromazine:xylazine anesthesia also received 50 mg/kg AZT. Two fetuses were removed at each sampling time from the PRR group. Plasma samples were collected and analyzed by RIA. With the exception of a lower non-renal clearance in female rats, there were no gender differences in the disposition of AZT. No significant differences were noted in total clearance, non-renal clearance or volume of distribution between pregnant and female rats, however, significant differences in renal clearance values were evident. Anesthesia resulted in decreased total, renal and non-renal clearances in female and pregnant rats. The removal of fetuses during the experiments did no...

Research paper thumbnail of 236 Pharmacokinetics of Amikacin in Children with Malignancies

Pediatric Research, Apr 1, 1978

Research paper thumbnail of Principles of medical chemistry

Lea and Febiger, 1981

861 p. : il.; 29 cm

Research paper thumbnail of Bioavailability of allopurinol oral and rectal dosage forms

American Journal of Health-System Pharmacy, 1981

The bioavailability of allopurinol from orally administered tablets and rectally administered sup... more The bioavailability of allopurinol from orally administered tablets and rectally administered suppositories is reported. Two types of rectal suppositories (cocoa butter and polyethylene glycol) were compounded and contained 300 mg allopurinol (from oral tablets). Five healthy volunteers received 300 mg allopurinol orally from tablets or rectally from suppositories in a randomized, three-way crossover design. Serial blood samples were drawn for 72 hours following administration and were analyzed by high-pressure liquid chromatography for allopurinol and its metabolite, oxipurinol. The interaction between allopurinol and PEG was studied in vitro using a dialysis method. Serum allopurinol levels following oral administration of tablets peaked at 1.5 +/- 0.23 microgram/ml at 5.20 +/- 0.65 hours. Allopurinol was not detectable after administration of cocoa butter/allopurinol suppositories; oxipurinol peaked at 0.34 +/- 0.14 microgram/ml at 13 +/- 11 hours. The bioavailability of allopurinol from the cocoa butter suppository, relative to the tablet, was 5.77 +/- 2.5%. Neither allopurinol nor oxipurinol was detectable (less than 0.1 microgram/ml) in the sera of persons following administration of PEG suppositories. Dialysis studies showed decreased loss of allopurinol from the dialysis sac as PEG concentration increased. The rectal suppositories of allopurinol used in this study did not appear to be an efficient means of administering this drug.

Research paper thumbnail of Contents, Vol. 15, 1977

Pharmacology, 1977

All rights reserved. No part of this publication may be translated into other languages, reproduc... more All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photo copying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

Research paper thumbnail of Effect of Bile Salts on Gastric Emptying and Intestinal Transit in the Rat

Gastroenterology, 1968

Although much work has been done on the effects of bile salts on gastric and intestinal motility,... more Although much work has been done on the effects of bile salts on gastric and intestinal motility,l-7 there have been few reports of the effects of bile salts on gastric emptying and intestinal transit. 6 ,7 Studies, presently being conducted in our laboratory on the effect of orally administered bile salts on drug absorption, have led to a consideration of the influence of bile salts on gastric emptying and intestinal transit rates. The absorption of many drugs depends upon their presence in specific areas of the gastrointestinal tract. An increase or delay in gastric emptying or intestina l transit could markedly affect the absorption characteristics of these drugs. The following study was designed to investigate these areas. Materials and Methods 1Vlaterials. Sodium taurodeoxycholate was obtained from Maybridge Chemical Company, Ltd., North Cornwall, United Kingdom. It was chromatographically pure. Sodium deoxycholate (special enzyme grade) was obtained from Mann Research Laboratories, Inc., New York, New York. Methods. Male Sprague-Dawley descent rats (Blue Spruce Farms, Altamont, New York) weighing between 130 and 180 g were fasted for 24 hr prior to the experiment. Water was allowed ad libitum. One and one-half milliliters of a 0.07% phenol red solution (prewarmed to 35 to 37 C),

Research paper thumbnail of Student Scientific Inquiry in the Core Doctor of Pharmacy Curriculum: Critical Issues in Designing and Implementing a Student Research Program

INNOVATIONS in pharmacy, 2013

While student-driven research has been credited with many learning benefits, few schools of pharm... more While student-driven research has been credited with many learning benefits, few schools of pharmacy require such activities. Professional organizations repeatedly urge for incorporating research content in schools' curricula, yet no guiding principles or recommendations currently exist to guide such implementation efforts. This paper provides an overview of the critical issues, guiding principles, benefits and challenges encountered in designing and implementing a required, research program in the Pharm.D. curriculum. Several critical issues are reviewed: goals, unitary focus and expectations, structure and deliverables, time and curricular integration, monitoring and institutional oversight, outcomes measurement, resources, students and faculty response, and dissemination. These general critical issues are then discussed as implemented in the student research program at Touro College of Pharmacy-New York. Different schools can address these core issues, based on their academic...

Research paper thumbnail of Serum antipyrine concentrations determined by micellar electrokinetic capillary chromatography

Journal of Chromatography B: Biomedical Sciences and Applications, 1993

We developed an assay for antipyrine in serum using micellar electrokinetic capillary chromatogra... more We developed an assay for antipyrine in serum using micellar electrokinetic capillary chromatography. A capillary electrophoresis system with a 70-cm fused-silica capillary and pH 8.2 borate-sodium dodecyl sulfate buffer was used. Standard curves ranging from 0.5 microgram/ml to 25 micrograms/ml were analyzed. The resulting electropherograms showed no interfering endogenous peaks and the assay was linear in the range of concentrations analyzed. The intra-day and inter-day relative standard deviations ranged from 0.7 to 5.2% and 1.7 to 8.1%, respectively. Analytical recovery of antipyrine ranged from 78.2 to 105.0%. The theoretical plate number for antipyrine was calculated to be 561,000 +/- 79,000 plates/m.

Research paper thumbnail of Comparative pharmacokinetics of halocarbons in the rat

Research paper thumbnail of The Pharmacokinetics of Bleomycin in Man

The Journal of Clinical Pharmacology, 1978

A series of studies were carried out to investigate the pharmacokinetics of the antineoplastic an... more A series of studies were carried out to investigate the pharmacokinetics of the antineoplastic antibiotic bleomycin in patients with neoplastic disorders. Drug was administered by long (four to five days) and short (10 minutes) zero-order infusions, and serial plasma and urine samples were collected. Serum and urine bleomycin concentrations were determined by radioimmunoassay. The disposition of bleomycin after the 10-minute infusion was described by a two-compartment open model. However, following multiple-day infusion estimates were obtained that were inconsistent with those from the short infusion. Parameters from the long infusions agreed with those from the short infusion when terminal plasma bleomycin levels less than 10 microunits/ml were excluded. The time to reach steady state following the long infusion (ca. 12 hours) was consistent with the half-life (3 hours) predicted by the short infusion and the long infusion excluding levels less than 10 microunits/ml. Possible explanations include assay interference by an unknown metabolite or strong binding of drug to tissues with release at a rate much less than the apparent rate of elimination of drug from the body.

Research paper thumbnail of Small Animal Model of Weightlessness for Pharmacokinetic Evaluation

The Journal of Clinical Pharmacology, 1994

Research paper thumbnail of Hydrodynamic and Diffusional Considerations in Assessing the Effects of Surface Active Agents on the Dissolution Rate of Drugs

CHEMICAL & PHARMACEUTICAL BULLETIN, 1970

Research paper thumbnail of High-performance liquid chromatographic assay for allopurinol and oxipurinol in human plasma

Journal of Chromatography B: Biomedical Sciences and Applications, 1979

Research paper thumbnail of Disposition of Bismuth in the Rat. I. Red Blood Cell and Plasma Protein Binding

Research paper thumbnail of Effects of Gender, Pregnancy, and Anesthesia on the Pharmacokinetics of Zidovudine in Rats

Pharmaceut Res, 1995

The effects of gender, pregnancy and anesthesia on the pharmacokinetics of zidovudine (AZT) were ... more The effects of gender, pregnancy and anesthesia on the pharmacokinetics of zidovudine (AZT) were studied in rats. Unanesthetized male (MR), female (FR) and pregnant (day 20, PR) rats received 50 mg/kg AZT via a jugular vein cannula. Female (FRA), pregnant (day 20, PRA) and pregnant (day 20, PRR) rats maintained under ketamine: acepromazine:xylazine anesthesia also received 50 mg/kg AZT. Two fetuses were removed at each sampling time from the PRR group. Plasma samples were collected and analyzed by RIA. With the exception of a lower non-renal clearance in female rats, there were no gender differences in the disposition of AZT. No significant differences were noted in total clearance, non-renal clearance or volume of distribution between pregnant and female rats, however, significant differences in renal clearance values were evident. Anesthesia resulted in decreased total, renal and non-renal clearances in female and pregnant rats. The removal of fetuses during the experiments did not alter the total clearance of AZT in pregnant rats, however, renal clearance and volume of distribution were decreased by cesarian section. The rat appears to be a suitable laboratory animal model for investigating AZT disposition during pregnancy. However, results of pharmacokinetic studies when animals are maintained under anesthesia with ketamine:acepromazine:xylazine must be interpreted with caution.

Research paper thumbnail of High-performance liquid chromatographic assay for allopurinol and oxipurinol in human plasma

Journal of Chromatography B: Biomedical Sciences and Applications, 1979

Research paper thumbnail of Disposition of Bismuth in the Rat. II. Pharmacokinetics and Biliary Excretion

Pharmaceutical Research, Apr 1, 1990

Research paper thumbnail of Let Freedom Ring! The journey towards independence of a community and academic partnership in Harlem, New York

Research paper thumbnail of Oral and intravenous trichloroethylene pharmacokinetics in the rat

Journal of Toxicology and Environmental Health, 1985

... Richard W. D'Souza Department of Pharmaceutics, University of Houston, University Park, ... more ... Richard W. D'Souza Department of Pharmaceutics, University of Houston, University Park, Houston, Texas James V. Bruckner Department of Pharmacology and Toxicology, University of Georgia, Athens, Georgia Stuart Feldman Department of ... Page 6. 592 RW D'SO UZA ET AL. ...

Research paper thumbnail of Infection-Induced Stones: Status of Clinic Trials with Urostat™ (Acetohydroxamic Acid)

Research paper thumbnail of Effects of gender, pregnancy, and anesthesia on the pharmacokinetics of zidovudine in rats

Pharmaceutical research, 1995

The effects of gender, pregnancy and anesthesia on the pharmacokinetics of zidovudine (AZT) were ... more The effects of gender, pregnancy and anesthesia on the pharmacokinetics of zidovudine (AZT) were studied in rats. Unanesthetized male (MR), female (FR) and pregnant (day 20, PR) rats received 50 mg/kg AZT via a jugular vein cannula. Female (FRA), pregnant (day 20, PRA) and pregnant (day 20, PRR) rats maintained under ketamine: acepromazine:xylazine anesthesia also received 50 mg/kg AZT. Two fetuses were removed at each sampling time from the PRR group. Plasma samples were collected and analyzed by RIA. With the exception of a lower non-renal clearance in female rats, there were no gender differences in the disposition of AZT. No significant differences were noted in total clearance, non-renal clearance or volume of distribution between pregnant and female rats, however, significant differences in renal clearance values were evident. Anesthesia resulted in decreased total, renal and non-renal clearances in female and pregnant rats. The removal of fetuses during the experiments did no...