Frank King - Academia.edu (original) (raw)

1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists

by Steven Bromidge and Frank King

Bioorganic & Medicinal Chemistry Letters, 2000

AbstractÐBisarylmethoxyethers have been identi®ed with nanomolar 5-HT 2C anity and selectivity ov... more AbstractÐBisarylmethoxyethers have been identi®ed with nanomolar 5-HT 2C anity and selectivity over both 5-HT 2A and 5-HT 2B receptors. Compounds such as 1, 2, 8, 12, 14 and 18 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT 2C function and their therapeutic potential is currently under further investigation. #

DownloadEdit