Fusheng Tang - Academia.edu (original) (raw)
Papers by Fusheng Tang
<p>In response to environmental triggers such as DR, membrane transporters (Opt2 and others... more <p>In response to environmental triggers such as DR, membrane transporters (Opt2 and others) on the plasma membrane are endocytosed through lipid rafts (ergosterol-sphingolipids) after ubiquitinylation. On early endosomes, proteins and lipids are sorted to late endosomes, Golgi, or other organelles. In late endosomes, different endosomal sorting complexes required for transport (ESCRT) push the target proteins with their membranes into the lumen of late-endosome, or multivesicular bodies (MVB). Matured MVB can fuse with vacuoles, within which proteases and lipases (Atg15) degrade target proteins and lipids. In mammalian cells, maturation of late endosomes is essential for activation of the master regulator for growth, the mammalian target of rapamycin 1 (mTORC1). In yeast cells, TORC1 suppresses meiotic transcription factors which are normally only active during gametogenesis <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002834#pgen.1002834-Colomina1" target="_blank">[110]</a>. The inhibitory effects of DR on TORC1 thus activate these rejuvenation genes. EE: early endosome. LE: late endosome. MVB: multivesicular body. Black arrows indicate movement of vesicles. DR-essential proteins are labelled in their localized organelles. Localization data were extracted from the SGD database. Ypt7 localization on late endosomes was reported by <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002834#pgen.1002834-Balderhaar1" target="_blank">[111]</a>. Green arrows indicate activation and a red line indicates an inhibitory effect.</p
2016 Research on Equity and Sustained Participation in Engineering, Computing, and Technology (RESPECT), 2016
Microbial Cell
Members of the family of oxysterol-binding proteins mediate non-vesicular lipid transport between... more Members of the family of oxysterol-binding proteins mediate non-vesicular lipid transport between membranes and contribute to longevity in different manners. We previously found that a 2-fold up-regulation of Osh6, one of seven yeast oxysterol-binding proteins, remedies vacuolar morphology defects in mid-aged cells, partly down-regulates the target of rapamycin complex 1 (TORC1), and increases the replicative lifespan. At the molecular level, Osh6 transports phosphatidylserine (PS) and phosphatidylinositol-4-phosphate (PI4P) between the endoplasmic reticulum (ER) and the plasma membrane (PM). To decipher how an ER-PM working protein controls vacuolar morphology, we tested genetic interactions between OSH6 and DRS2, whose protein flips PS from the lumen to the cytosolic side of the Golgi, the organelle between ER and vacuoles in many pathways. Up-regulated OSH6 complemented vacuolar morphology of drs2∆ and enriched PI4P on the Golgi, indicating that Osh6 also works on the Golgi. This...
Advances and Applications in Bioinformatics and Chemistry, 2009
Phosphoinositide-signaling lipids function in diverse cellular pathways. Dynamic changes in the l... more Phosphoinositide-signaling lipids function in diverse cellular pathways. Dynamic changes in the levels of these signaling lipids regulate multiple processes. In particular, when Saccharomyces cerevisiae cells are exposed to hyperosmotic shock, PI3,5P2 (phosphatidylinositol [PI] 3,5-bisphosphate) levels transiently increase 20-fold. This causes the vacuole to undergo multiple acute changes. Control of PI3,5P2 levels occurs through regulation of both its synthesis and turnover. Synthesis is catalyzed by the PI3P 5-kinase Fab1p, and turnover is catalyzed by the PI3,5P2 5-phosphatase
Class V myosins are widely distributed among diverse organisms and move cargo along actin filamen... more Class V myosins are widely distributed among diverse organisms and move cargo along actin filaments. Some myosin Vs move multiple types of cargo, where the timing of movement and the destinations of selected cargoes are unique. Here, we report the discovery of an organelle-specific myosin V receptor. Vac17p, a novel protein, is a component of the vacuole-specific receptor for Myo2p, a Saccharomyces cerevisiae myosin V. Vac17p interacts with the Myo2p cargo-binding domain, but not with vacuole inheritance-defective myo2 mutants that have single amino acid changes within this region. Moreover, a region of the
Vac8p, an armadillo (ARM) repeat protein, is required for multiple vacuolar processes. It functio... more Vac8p, an armadillo (ARM) repeat protein, is required for multiple vacuolar processes. It functions in vacuole inher-itance, cytoplasm-to-vacuole protein targeting pathway, formation of the nucleus–vacuole junction and vacuole– vacuole fusion. These functions each utilize a distinct Vac8p-binding partner. Here, we report an additional Vac8p function: caffeine resistance. We show that Vac8p function in caffeine resistance is mediated via a newly identified Vac8p-binding partner, Tco89p. The interaction between Vac8p and each binding partner requires an overlapping subset of Vac8p ARM repeats. Moreover, these partners can compete with each other for access to Vac8p. Furthermore, Vac8p is enriched in three sepa-rate subdomains on the vacuole, each with a unique binding partner dedicated to a different vacuolar func-tion. These findings suggest that a major role of Vac8p is to spatially separate multiple functions thereby enabling vacuole inheritance to occur concurrently with other vac...
Journal of Environmental Sciences, 2016
Stainless steels generally have extremely good corrosion resistance, but are still susceptible to... more Stainless steels generally have extremely good corrosion resistance, but are still susceptible to pitting corrosion. As a result, corrosion scales can form on the surface of stainless steel after extended exposure to aggressive aqueous environments. Corrosion scales play an important role in affecting water quality. These research results showed that interior regions of stainless steel corrosion scales have a high percentage of chromium phases. We reveal the morphology, micro-structure and physicochemical characteristics of stainless steel corrosion scales. Stainless steel corrosion scale is identified as a podiform chromite deposit according to these characteristics, which is unlike deposit formed during iron corrosion. A conceptual model to explain the formation and growth of stainless steel corrosion scale is proposed based on its composition and structure. The scale growth process involves pitting corrosion on the stainless steel surface and the consecutive generation and homogeneous deposition of corrosion products, which is governed by a series of chemical and electrochemical reactions. This model shows the role of corrosion scales in the mechanism of iron and chromium release from pitting corroded stainless steel materials. The formation of corrosion scale is strongly related to water quality parameters. The presence of HClO results in higher ferric content inside the scales. Cl(-) and SO4(2-) ions in reclaimed water play an important role in corrosion pitting of stainless steel and promote the formation of scales.
2010 Chinese Control and Decision Conference, 2010
Store-operated calcium entry (SOCE) and extracellular calcium sensing are two important feedback ... more Store-operated calcium entry (SOCE) and extracellular calcium sensing are two important feedback control mechanisms of calcium ion uptake into yeast cells observed in experiments. In this work, we design output feedback controllers for these two mechanisms. Using the control model, we simulate the experimental observations on these two mechanisms and on high-affinity calcium ion influx system in pmr1 mutants.
Mathematical Biosciences, 2009
Journal of Theoretical Biology, 2008
Journal of Mathematical Biology, 2010
Cell Cycle, 2012
In yeast cells, the vacuole divides and fuses in each round of cell cycle. While mutants defectiv... more In yeast cells, the vacuole divides and fuses in each round of cell cycle. While mutants defective in vacuole fusion are &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;wild type&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; for vegetative growth, most have shortened replicative lifespans under caloric restriction (CR) condition, a manipulation that extends lifespan in wild type cells. To explore whether vacuole fusion extends lifespan, we screened for genes that can complement the fusion defect of selected mutants (erg6Δ, a sterol mutant; nyv1Δ, a mutant involved in the vacuolar SNARE complex and vac8Δ, a vacuolar membrane protein mutant). This screen revealed that Osh6, a member of the oxysterol-binding protein family, can complement the vacuole fusion defect of nyv1Δ, but not erg6Δ or vac8Δ, suggesting that Osh6&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s function in vacuole fusion is partly dependent on membrane ergosterol and Vac8. To measure the effect of OSH6 on lifespan, we replaced the endogenous promoter of OSH6 with a shorter version of the ERG6 promoter to obtain PERG6-OSH6. This mutant construct significantly extended the replicative lifespan in a wild type background and in a nyv1Δ mutant. Interestingly, PERG6-OSH6 cells were more sensitive to drugs that inhibit the activity of the TOR complex 1 (TORC1) than wild type cells. Moreover, a PERG6-OSH6 tor1Δ double mutant demonstrated a greatly shortened lifespan, suggesting a genetic interaction between Osh6 and Tor1. Since active TORC1 stimulates vacuole scission and CR downregulates TORC1, Osh6 may link these two pathways by adjusting vacuolar membrane organization to extend lifespan.
Advances and Applications in Bioinformatics and Chemistry Aabc, 2009
Identification of genes involved in the aging process is critical for understanding the mechanism... more Identification of genes involved in the aging process is critical for understanding the mechanisms of age-dependent diseases such as cancer and diabetes. Measuring the mutant gene lifespan, each missing one gene, is traditionally employed to identify longevity genes. While such screening is impractical for the whole genome due to the time-consuming nature of lifespan assays, it can be achieved by in silico genetic manipulations with systems biology approaches. In this review, we will introduce pilot explorations applying two approaches of systems biology in aging studies. One approach is to predict the role of a specific gene in the aging process by comparing its expression profile and protein–protein interaction pattern with those of known longevity genes (top-down systems biology). The other approach is to construct mathematical models from previous kinetics data and predict how a specific protein contributes to aging and antiaging processes (bottom-up systems biology). These approaches allow researchers to simulate the effect of each gene’s product in aging by in silico genetic manipulations such as deletion or over-expression. Since simulation-based approaches are not as widely used as the other approaches, we will focus our review on this effort in more detail. A combination of hypothesis from data-mining, in silico experimentation from simulations, and wet laboratory validation will make the systematic identification of all longevity genes possible.
Materials Science Engineering B Solid State Materials For Advanced Technology, 2006
The Journal of Cell Biology, 2006
Materials Research Bulletin, Sep 1, 2007
Lead-free piezoelectric ceramics (1−x)(K0.5Na0.5)NbO3–xLiNbO3 have been synthesized by traditiona... more Lead-free piezoelectric ceramics (1−x)(K0.5Na0.5)NbO3–xLiNbO3 have been synthesized by traditional ceramics process without cold-isostatic pressing. The effect of the content of LiNbO3 and the sintering temperature on the phase structure, the microstructure and piezoelectric properties of (1−x)(K0.5Na0.5)NbO3–xLiNbO3 ceramics were investigated. The result shows that the phase structure transforms from the orthorhombic phase to tetragonal phase with the increase of the content
Materials Science and Engineering B
Lead-free piezoelectric ceramics (1−x)(K0.5Na0.5)NbO3–xLiNbO3 have been synthesized by traditiona... more Lead-free piezoelectric ceramics (1−x)(K0.5Na0.5)NbO3–xLiNbO3 have been synthesized by traditional ceramics process without cold-isostatic pressing. Effect of the amount of LiNbO3 on the phase structure, microstructure, ferroelectric and piezoelectric properties of (1−x)(K0.5Na0.5)NbO3–xLiNbO3 ceramics were investigated. Results show that the pure perovskite phase is in all ceramics specimens (x&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.08). With the content of LiNbO3 increases, remnant polarization Pr, coercive field Ec and
<p>In response to environmental triggers such as DR, membrane transporters (Opt2 and others... more <p>In response to environmental triggers such as DR, membrane transporters (Opt2 and others) on the plasma membrane are endocytosed through lipid rafts (ergosterol-sphingolipids) after ubiquitinylation. On early endosomes, proteins and lipids are sorted to late endosomes, Golgi, or other organelles. In late endosomes, different endosomal sorting complexes required for transport (ESCRT) push the target proteins with their membranes into the lumen of late-endosome, or multivesicular bodies (MVB). Matured MVB can fuse with vacuoles, within which proteases and lipases (Atg15) degrade target proteins and lipids. In mammalian cells, maturation of late endosomes is essential for activation of the master regulator for growth, the mammalian target of rapamycin 1 (mTORC1). In yeast cells, TORC1 suppresses meiotic transcription factors which are normally only active during gametogenesis <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002834#pgen.1002834-Colomina1" target="_blank">[110]</a>. The inhibitory effects of DR on TORC1 thus activate these rejuvenation genes. EE: early endosome. LE: late endosome. MVB: multivesicular body. Black arrows indicate movement of vesicles. DR-essential proteins are labelled in their localized organelles. Localization data were extracted from the SGD database. Ypt7 localization on late endosomes was reported by <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1002834#pgen.1002834-Balderhaar1" target="_blank">[111]</a>. Green arrows indicate activation and a red line indicates an inhibitory effect.</p
2016 Research on Equity and Sustained Participation in Engineering, Computing, and Technology (RESPECT), 2016
Microbial Cell
Members of the family of oxysterol-binding proteins mediate non-vesicular lipid transport between... more Members of the family of oxysterol-binding proteins mediate non-vesicular lipid transport between membranes and contribute to longevity in different manners. We previously found that a 2-fold up-regulation of Osh6, one of seven yeast oxysterol-binding proteins, remedies vacuolar morphology defects in mid-aged cells, partly down-regulates the target of rapamycin complex 1 (TORC1), and increases the replicative lifespan. At the molecular level, Osh6 transports phosphatidylserine (PS) and phosphatidylinositol-4-phosphate (PI4P) between the endoplasmic reticulum (ER) and the plasma membrane (PM). To decipher how an ER-PM working protein controls vacuolar morphology, we tested genetic interactions between OSH6 and DRS2, whose protein flips PS from the lumen to the cytosolic side of the Golgi, the organelle between ER and vacuoles in many pathways. Up-regulated OSH6 complemented vacuolar morphology of drs2∆ and enriched PI4P on the Golgi, indicating that Osh6 also works on the Golgi. This...
Advances and Applications in Bioinformatics and Chemistry, 2009
Phosphoinositide-signaling lipids function in diverse cellular pathways. Dynamic changes in the l... more Phosphoinositide-signaling lipids function in diverse cellular pathways. Dynamic changes in the levels of these signaling lipids regulate multiple processes. In particular, when Saccharomyces cerevisiae cells are exposed to hyperosmotic shock, PI3,5P2 (phosphatidylinositol [PI] 3,5-bisphosphate) levels transiently increase 20-fold. This causes the vacuole to undergo multiple acute changes. Control of PI3,5P2 levels occurs through regulation of both its synthesis and turnover. Synthesis is catalyzed by the PI3P 5-kinase Fab1p, and turnover is catalyzed by the PI3,5P2 5-phosphatase
Class V myosins are widely distributed among diverse organisms and move cargo along actin filamen... more Class V myosins are widely distributed among diverse organisms and move cargo along actin filaments. Some myosin Vs move multiple types of cargo, where the timing of movement and the destinations of selected cargoes are unique. Here, we report the discovery of an organelle-specific myosin V receptor. Vac17p, a novel protein, is a component of the vacuole-specific receptor for Myo2p, a Saccharomyces cerevisiae myosin V. Vac17p interacts with the Myo2p cargo-binding domain, but not with vacuole inheritance-defective myo2 mutants that have single amino acid changes within this region. Moreover, a region of the
Vac8p, an armadillo (ARM) repeat protein, is required for multiple vacuolar processes. It functio... more Vac8p, an armadillo (ARM) repeat protein, is required for multiple vacuolar processes. It functions in vacuole inher-itance, cytoplasm-to-vacuole protein targeting pathway, formation of the nucleus–vacuole junction and vacuole– vacuole fusion. These functions each utilize a distinct Vac8p-binding partner. Here, we report an additional Vac8p function: caffeine resistance. We show that Vac8p function in caffeine resistance is mediated via a newly identified Vac8p-binding partner, Tco89p. The interaction between Vac8p and each binding partner requires an overlapping subset of Vac8p ARM repeats. Moreover, these partners can compete with each other for access to Vac8p. Furthermore, Vac8p is enriched in three sepa-rate subdomains on the vacuole, each with a unique binding partner dedicated to a different vacuolar func-tion. These findings suggest that a major role of Vac8p is to spatially separate multiple functions thereby enabling vacuole inheritance to occur concurrently with other vac...
Journal of Environmental Sciences, 2016
Stainless steels generally have extremely good corrosion resistance, but are still susceptible to... more Stainless steels generally have extremely good corrosion resistance, but are still susceptible to pitting corrosion. As a result, corrosion scales can form on the surface of stainless steel after extended exposure to aggressive aqueous environments. Corrosion scales play an important role in affecting water quality. These research results showed that interior regions of stainless steel corrosion scales have a high percentage of chromium phases. We reveal the morphology, micro-structure and physicochemical characteristics of stainless steel corrosion scales. Stainless steel corrosion scale is identified as a podiform chromite deposit according to these characteristics, which is unlike deposit formed during iron corrosion. A conceptual model to explain the formation and growth of stainless steel corrosion scale is proposed based on its composition and structure. The scale growth process involves pitting corrosion on the stainless steel surface and the consecutive generation and homogeneous deposition of corrosion products, which is governed by a series of chemical and electrochemical reactions. This model shows the role of corrosion scales in the mechanism of iron and chromium release from pitting corroded stainless steel materials. The formation of corrosion scale is strongly related to water quality parameters. The presence of HClO results in higher ferric content inside the scales. Cl(-) and SO4(2-) ions in reclaimed water play an important role in corrosion pitting of stainless steel and promote the formation of scales.
2010 Chinese Control and Decision Conference, 2010
Store-operated calcium entry (SOCE) and extracellular calcium sensing are two important feedback ... more Store-operated calcium entry (SOCE) and extracellular calcium sensing are two important feedback control mechanisms of calcium ion uptake into yeast cells observed in experiments. In this work, we design output feedback controllers for these two mechanisms. Using the control model, we simulate the experimental observations on these two mechanisms and on high-affinity calcium ion influx system in pmr1 mutants.
Mathematical Biosciences, 2009
Journal of Theoretical Biology, 2008
Journal of Mathematical Biology, 2010
Cell Cycle, 2012
In yeast cells, the vacuole divides and fuses in each round of cell cycle. While mutants defectiv... more In yeast cells, the vacuole divides and fuses in each round of cell cycle. While mutants defective in vacuole fusion are &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;wild type&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; for vegetative growth, most have shortened replicative lifespans under caloric restriction (CR) condition, a manipulation that extends lifespan in wild type cells. To explore whether vacuole fusion extends lifespan, we screened for genes that can complement the fusion defect of selected mutants (erg6Δ, a sterol mutant; nyv1Δ, a mutant involved in the vacuolar SNARE complex and vac8Δ, a vacuolar membrane protein mutant). This screen revealed that Osh6, a member of the oxysterol-binding protein family, can complement the vacuole fusion defect of nyv1Δ, but not erg6Δ or vac8Δ, suggesting that Osh6&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s function in vacuole fusion is partly dependent on membrane ergosterol and Vac8. To measure the effect of OSH6 on lifespan, we replaced the endogenous promoter of OSH6 with a shorter version of the ERG6 promoter to obtain PERG6-OSH6. This mutant construct significantly extended the replicative lifespan in a wild type background and in a nyv1Δ mutant. Interestingly, PERG6-OSH6 cells were more sensitive to drugs that inhibit the activity of the TOR complex 1 (TORC1) than wild type cells. Moreover, a PERG6-OSH6 tor1Δ double mutant demonstrated a greatly shortened lifespan, suggesting a genetic interaction between Osh6 and Tor1. Since active TORC1 stimulates vacuole scission and CR downregulates TORC1, Osh6 may link these two pathways by adjusting vacuolar membrane organization to extend lifespan.
Advances and Applications in Bioinformatics and Chemistry Aabc, 2009
Identification of genes involved in the aging process is critical for understanding the mechanism... more Identification of genes involved in the aging process is critical for understanding the mechanisms of age-dependent diseases such as cancer and diabetes. Measuring the mutant gene lifespan, each missing one gene, is traditionally employed to identify longevity genes. While such screening is impractical for the whole genome due to the time-consuming nature of lifespan assays, it can be achieved by in silico genetic manipulations with systems biology approaches. In this review, we will introduce pilot explorations applying two approaches of systems biology in aging studies. One approach is to predict the role of a specific gene in the aging process by comparing its expression profile and protein–protein interaction pattern with those of known longevity genes (top-down systems biology). The other approach is to construct mathematical models from previous kinetics data and predict how a specific protein contributes to aging and antiaging processes (bottom-up systems biology). These approaches allow researchers to simulate the effect of each gene’s product in aging by in silico genetic manipulations such as deletion or over-expression. Since simulation-based approaches are not as widely used as the other approaches, we will focus our review on this effort in more detail. A combination of hypothesis from data-mining, in silico experimentation from simulations, and wet laboratory validation will make the systematic identification of all longevity genes possible.
Materials Science Engineering B Solid State Materials For Advanced Technology, 2006
The Journal of Cell Biology, 2006
Materials Research Bulletin, Sep 1, 2007
Lead-free piezoelectric ceramics (1−x)(K0.5Na0.5)NbO3–xLiNbO3 have been synthesized by traditiona... more Lead-free piezoelectric ceramics (1−x)(K0.5Na0.5)NbO3–xLiNbO3 have been synthesized by traditional ceramics process without cold-isostatic pressing. The effect of the content of LiNbO3 and the sintering temperature on the phase structure, the microstructure and piezoelectric properties of (1−x)(K0.5Na0.5)NbO3–xLiNbO3 ceramics were investigated. The result shows that the phase structure transforms from the orthorhombic phase to tetragonal phase with the increase of the content
Materials Science and Engineering B
Lead-free piezoelectric ceramics (1−x)(K0.5Na0.5)NbO3–xLiNbO3 have been synthesized by traditiona... more Lead-free piezoelectric ceramics (1−x)(K0.5Na0.5)NbO3–xLiNbO3 have been synthesized by traditional ceramics process without cold-isostatic pressing. Effect of the amount of LiNbO3 on the phase structure, microstructure, ferroelectric and piezoelectric properties of (1−x)(K0.5Na0.5)NbO3–xLiNbO3 ceramics were investigated. Results show that the pure perovskite phase is in all ceramics specimens (x&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.08). With the content of LiNbO3 increases, remnant polarization Pr, coercive field Ec and