Géza Dr Vitályos - Academia.edu (original) (raw)
Papers by Géza Dr Vitályos
PubMed, Mar 1, 2015
In parallel with the emergence of new dental materials the number of allergic diseases is continu... more In parallel with the emergence of new dental materials the number of allergic diseases is continuously increasing. Extremely small quantities of the allergens are capable to inducing an allergic reaction. Therefore it is particularly important to examine these materials as antigens and investigate their binding properties to proteins (e.g. formaldehyde, methacrylic acid, benzoyl-peroxide...). The Fourier Transform Surface Plasmon Resonance Spectroscopy (FT-SPR) is a suitable examination method for this type of procedure. FT-SPR measurement is performed at a fixed angel of incident light, and reflectivity is measured over a range of wavelength in the near infrared. The advantages of this method are the outstanding sensitivity, the label-free detection capability and the possibility of the real-time testing procedure. Formaldehyde and methacrylic acid are among the most common dental allergens. In our study we examined these molecules by FT-SPR spectroscopy. The aim of this work was to investigate the suitability of this method to the detection of these materials, with special focuses on the analysis and evaluation concentration-dependent measurements. Different concentrations (0.01 %-0.2%) of formaldehyde and methacrylic acid solutions were measured. The individual spectra were measured for all of the solutions, and calibration curves were calculated for the materials for the possibility of the determination of an unknown concentration. The results confirmed that the method is theoretically capable to detect hundred-thousandths scale concentration-changes in the solution flowing above the SPR-chip. The concentration-dependent studies had proved that the method capable to measure directly these materials and can provide appropriate calibration for quantitative determination. These experiments show the broad applicability of the FT-SPR method, which can greatly facilitate the mapping and understanding of biomolecular interactions in the future.
Orvosi Hetilap, Dec 1, 2019
Bevezetés: A Moyers-féle vegyes fogazati analízis az egyik leggyakrabban használt predikciós móds... more Bevezetés: A Moyers-féle vegyes fogazati analízis az egyik leggyakrabban használt predikciós módszer, melynek segítségével meghatározhatjuk az elő nem tört fogak méretét, így még vegyes fogazati időszakban informálódhatunk a helyviszonyokról. Mivel azonban a fogméretek az egyes etnikai csoportok közt jelentősen eltérhetnek, ahhoz, hogy a helyhiány súlyosságát a lehető legpontosabban tudjuk meghatározni, külön a vizsgált egyén saját etnikai csoportjára vonatkoztatott módszert lenne optimális alkalmazni. Célkitűzés: Célunk, hogy megvizsgáljuk, a Moyers-féle vegyes fogazati analízis mennyire pontosan használható Magyarországon. Módszer: 370 páciens alginátlenyomat alapján készült alsó és felső gipszmintája került kiértékelésre. Pittsburgh digitális tolómérő segítségével határoztuk meg az egyes fogak mesiodistalis szélességét. A kapott értékekből számoltuk ki egyrészt a fogak valós, másrészt a Moyers-féle predikciós táblázat segítségével a várható helyigényét, majd a két értéket összevetettük. Eredmények: Moyers-féle analízist használva minden viszonylatban, mindkét nem esetén szignifikáns különbséget találtunk az általunk mért valós és prediktív értékek között. A felső állcsonton férfiak esetében a 95%-os, 85%-os, 75%-os és 65%-os percentilisértékek is túlbecsülték az általunk mért értékeket, míg nők esetében csak a 65%-os becsülte alá azt. Az alsó állcsont esetén mindegyik percentilisérték túlbecsülte a valós mérések eredményeit. Következtetések: Eredményeink alapján a Moyers-féle vegyes fogazati predikciós módszer nem alkalmazható megbízhatóan a magyar lakosságnál. Amennyiben használjuk, javasolt a klinikumban elterjedt 75% percentilisérték helyett inkább a 65%-os adat alkalmazása, mivel ezzel a valós helyigényhez közelebbi eredményt kaphatunk.
PubMed, Dec 1, 2014
The recognition and treatment of allergy is a great challenge for all fields of medicine. The hig... more The recognition and treatment of allergy is a great challenge for all fields of medicine. The high prevalence of allergic reactions to dental materials and the related financial burden of their treatment make investigation of this disease very important. Our investigation was carried out on patients assigned to our outpatient department for dental allergy test between 1996 and 1998. We determined the distribution of gender and age among the allergic patients in the examined population. We also studied the prevalence of allergic reactions to different dental allergens and the distribution of dental allergens. In a follow-up study we determined the proportion of those patients, who were retreated in conformity with the results of epicutan tests and we followed up the positive effects of these treatments. We have found that dental allergy occurred five times more frequently in women (84%) than in men (16%) and the most affected age group was between 20 to 39 and 40-49 years (31%). Seventy-five percent of the patients suffered from a combination of metal and polymer allergy. The most frequent metal allergen was TEGDMA (triethylene glycol dimethacrylate) (49.7%). The suggested treatment plan was carried out in 63% of the allergic patients. The applied treatment was successful in 48% of these cases. We experienced that 48% of these patients got rid of their earlier signs and symptoms.
Scientific Reports, Mar 4, 2019
Our purpose was to prospectively analyze the age-related changes of corneal Scheimpflug parameter... more Our purpose was to prospectively analyze the age-related changes of corneal Scheimpflug parameters in healthy subjects. Thirty-five eyes of 35 volunteers (age 14-67 years) were investigated with an average interval of 3.6 years. Changes of corneal parameters (flattest keratometric reading at anterior (K1F) and posterior surface (K1B), steepest keratometric reading at anterior (K2F) and posterior surface, anterior astigmatism, posterior astigmatism (AstigB), flat axis of anterior and posterior astigmatism (AxisB), thinnest pachymetric value (PachyMin), corneal volume (CV10-mm)) were analyzed. K1F and K2F decreased significantly during observation and showed stronger decrease in younger than in older individuals. Higher values proved to be more stable. K1B decreased significantly and the degree of decrease was dependent on its baseline value and age: in young subjects low values increased, high values decreased. AstigB decreased significantly and showed a baseline-dependent significant increase from lower and a significant decrease from higher initial values. Over time, the mean AxisB shifted significantly. PachyMin and CV decreased significantly with age, especially from higher baseline values in younger subjects. The results of this longitudinal study suggest that both corneal surfaces change significantly with age. We demonstrate for the first time that age and baseline values influence agerelated changes of corneal parameters. Aging is a physiological process and occasionally it is hard to differentiate between time dependent biological changes and damages from environmental insults 1. Age-related changes occur in all structures of the eye, with various consequences 2. Age has been identified as an important individual variable affecting the outcome after keratorefractive surgery 3. Corneal aging generates structural and functional changes including steepening of keratometry indices, and a rotation of the axis of astigmatism resulting in a shift from with-the-rule to against-the-rule astigmatism 1,4-11. Alterations of higher-order aberrations of the cornea are also well known 9. The level of astigmatism decreased significantly with age both of the anterior and posterior corneal surfaces in a study by Nemeth et al. 9 , although age as a primary factor was not analyzed in this report. To differentiate between physiological and pathological changes of the aging cornea, it is indispensable to know what the physiological changes are. There are clinical situations where it is important to distinguish between pathological and normal age-related changes. The assessment of the progression of ectatic corneal disorders in young patients determines the optimal treatment and the glaucoma management in the elderly can only be personalized if we take account the changes of corneal thickness. A complete and precise evaluation of the cornea must take keratometric, astigmatic vectorial as well as pachymetric characteristics into account. Age-dependent change of corneal thickness has been studied extensively. Corneal thickness decreases throughout infancy; during babyhood (around 3 years of age) it reaches adult thickness and, from that point on, central corneal thickness (CCT) appears to be stable over time 12. However, age-related change in corneal thickness appears to be rather controversial in other studies 13-18. CCT has been extensively investigated in glaucoma
Ocular Immunology and Inflammation, Mar 4, 2020
Purpose: To find immunomediator combinations which could sensitively indicate keratoconus progres... more Purpose: To find immunomediator combinations which could sensitively indicate keratoconus progression. Methods: Tear samples of 42 patients with keratoconus were collected at baseline and at the end of a one-year follow-up. The concentrations of 13 mediators were measured by CBA. Based on Pentacam HR examination, eyes were divided into a non-progressive and a progressive group. Results: At the end of the follow-up, significant differences were observed in the release of IFNγ, IL-13, IL-17A, CCL5, MMP-13 and PAI-1 between the two groups. Changes in five Pentacam parameters correlated positively with changes in IFNγ, IL-13, IL-17A, CXCL8, CCL5, TIMP-1 and t-PA. We found that tear level of IL-13 in combination with NGF can predict the progression of keratoconus with 100% specificity and 80% sensitivity. Conclusion: The findings of our longitudinal study may underscore the importance of NGF and IL-13 tear levels in the prediction of keratoconus progression.
Fogorvosi Szemle, 2015
A fogászatban az új anyagrendszerek megjelenésével párhuzamosan egyre nagyobb ütemben növekszik a... more A fogászatban az új anyagrendszerek megjelenésével párhuzamosan egyre nagyobb ütemben növekszik a potenciálisan allergiás tünetek kiváltására alkalmas anyagok köre. Az adott allergénnek rendkívül kis mennyisége is képes allergiás reakció kiváltására, ezért kiemelt jelentősége van ezen antigénként szereplő anyagok (például: formaldehid, metakrilsav, benzoil-peroxid) fehérjékhez való kötődési lehetőségeinek vizsgálatának. Ezen sajátosságok vizsgálatáraa Fourier-Transzformációs Felületi Plazmon Rezonancia Spektroszkópia (FT-SPR) jól alkalmazható eljárás. A módszer előnyei közé sorolható a kiemelkedő érzékenység, a jelölés nélküli detektálás képessége, valamint a valós idejű vizsgálatok kivitelezésének lehetősége.Kísérleteink célja a formaldehid és metakrilsav mint a leggyakoribb fogászati allergének közé tartozó anyagokFT-SPR spektroszkópiás vizsgálata volt, kiemelt hangsúlyt fektetve koncentrációfüggő mérések elemzésére és kiérté-kelésére.Méréseinket formaldehid és metakrilsav desztil...
International orthodontics, Jan 11, 2018
The aim of the present study was to comprehensively assess the posttreatment effect of premolar e... more The aim of the present study was to comprehensively assess the posttreatment effect of premolar extraction versus non-extraction on the position and development of the lower third molars. The sample consisted of 227 patient's pre- and posttreatment panoramic radiographs (53 with four premolar extractions, 174 without extractions). The position and developmental stage of the lower third molars were evaluated by using Pell-Gregory's, Winter's, modified Miloro-DaBell's and Demirjian's classifications, respectively. Premolar extraction had a considerably positive influence on the position and development of the lower third molars and therefore could provide better prognosis for their eruption.
Fogorvosi Szemle, Dec 1, 2014
The recognition and treatment of allergy is a great challenge for all fields of medicine. The hig... more The recognition and treatment of allergy is a great challenge for all fields of medicine. The high prevalence of allergic reactions to dental materials and the related financial burden of their treatment make investigation of this disease very important. Our investigation was carried out on patients assigned to our outpatient department for dental allergy test between 1996 and 1998. We determined the distribution of gender and age among the allergic patients in the examined population. We also studied the prevalence of allergic reactions to different dental allergens and the distribution of dental allergens. In a follow-up study we determined the proportion of those patients, who were retreated in conformity with the results of epicutan tests and we followed up the positive effects of these treatments. We have found that dental allergy occurred five times more frequently in women (84%) than in men (16%) and the most affected age group was between 20 to 39 and 40-49 years (31%). Seventy-five percent of the patients suffered from a combination of metal and polymer allergy. The most frequent metal allergen was TEGDMA (triethylene glycol dimethacrylate) (49.7%). The suggested treatment plan was carried out in 63% of the allergic patients. The applied treatment was successful in 48% of these cases. We experienced that 48% of these patients got rid of their earlier signs and symptoms.
Fogorvosi szemle, 2015
In parallel with the emergence of new dental materials the number of allergic diseases is continu... more In parallel with the emergence of new dental materials the number of allergic diseases is continuously increasing. Extremely small quantities of the allergens are capable to inducing an allergic reaction. Therefore it is particularly important to examine these materials as antigens and investigate their binding properties to proteins (e.g. formaldehyde, methacrylic acid, benzoyl-peroxide...). The Fourier Transform Surface Plasmon Resonance Spectroscopy (FT-SPR) is a suitable examination method for this type of procedure. FT-SPR measurement is performed at a fixed angel of incident light, and reflectivity is measured over a range of wavelength in the near infrared. The advantages of this method are the outstanding sensitivity, the label-free detection capability and the possibility of the real-time testing procedure. Formaldehyde and methacrylic acid are among the most common dental allergens. In our study we examined these molecules by FT-SPR spectroscopy. The aim of this work was t...
Fogorvosi szemle
During the past two decades the incidence of allergies against dental materials has been rising. ... more During the past two decades the incidence of allergies against dental materials has been rising. The most common allergens are nickel, mercury, benzoxyl-peroxide, formaldehyde, MMA, HEMA, EGDMA and TEGDMA. Contact allergy develops in predisposed individuals as a consequence of environmental exposures to allergens. Although the relatively high frequency of contact allergies in children is well documented, its importance during orthodontic treatments is still often underestimated. The most common metal to cause dental allergic reactions is nickel. Nickel-containing metal alloys, such as nickel-titanium, are widely used in orthodontics because of their favorable physical properties. Coated wires (epoxi coating, teflon, etc.) are not only more aesthetic, but can play a role in the orthodontic treatment of patients with nickel allergy. In our case report we present two patients with nickel allergy, and their treatment with alternative orthodontic appliances. During the orthodontic treatment our patients did not have any objective or subjective allergy-related symptoms.
Objective: Polymers (Polymethyl methacrylate; PMMA) are one the most frequently used material in ... more Objective: Polymers (Polymethyl methacrylate; PMMA) are one the most frequently used material in dentistry, which is often causing allergic reactions. The aim of our study was to investigate peptide structures bound to PMMA in order to deduct molecules may bind to PMMA and responsible for allergic reactions. Method: The investigated heat cured polymethyl methacrylate was Orthocryl (Dentaurum, Germany). We used phage display technology to select peptides on PMMA surface. The phage work was carried out by linear peptide library. Ph.D.-7TM and Ph.D.-12TM Peptide Library Kits (Biolabs, England) were based on a combinatorial library of random peptide 7-mers and random peptide 12-mers fused to a minor coat protein of M13 Phage respectively. The phage selection was carried out five times on the PMMA surface. Colonies of the third rounds of each phage selection were used to isolate DNS for amino acid sequence determination. The binding of the selected peptides was quantitated by ELISA and b...
Fogorvosi szemle, 2007
During the past two decades the incidence of allergies against dental materials has been rising. ... more During the past two decades the incidence of allergies against dental materials has been rising. The most common allergens are nickel, mercury, benzoxyl-peroxide, formaldehyde, MMA, HEMA, EGDMA and TEGDMA. Contact allergy develops in predisposed individuals as a consequence of environmental exposures to allergens. Although the relatively high frequency of contact allergies in children is well documented, its importance during orthodontic treatments is still often underestimated. The most common metal to cause dental allergic reactions is nickel. Nickel-containing metal alloys, such as nickel-titanium, are widely used in orthodontics because of their favorable physical properties. Coated wires (epoxi coating, teflon, etc.) are not only more aesthetic, but can play a role in the orthodontic treatment of patients with nickel allergy. In our case report we present two patients with nickel allergy, and their treatment with alternative orthodontic appliances. During the orthodontic treatm...
Fogorvosi szemle, 2005
The early loss of permanent teeth following trauma or congenital aplasia and agenesia need to be ... more The early loss of permanent teeth following trauma or congenital aplasia and agenesia need to be corrected by orthodontic or prosthetic means, sometimes combined with implant therapy. Preprosthetic orthodontic measures are often an integral part of comprehensive oral rehabilitation. The individual aspects of treatment are aimed at optimizing dentofacial esthetics and at improving masticatory function and hygiene potential of prosthetic restorations. The orthodontic solution results usually in different anatomic, functional, and esthetic problems. In the present study the treatment possibilities of two patients with missing upper lateral incisors are presented. In the first case the problem of the missing upper lateral incisors was solved by adhesive bridges, after the fixed appliance orthodontic treatment, where the diasthema medianum was closed, and the upper canines were distalized. In our second case the same problem was solved by inserting implants, with single, metal free crown...
Fogorvosi szemle, 2004
Owing to its excellent biocompatibility, titanium has been used in health care, including dental ... more Owing to its excellent biocompatibility, titanium has been used in health care, including dental care, for a long time. The unalloyed light metal is a non-allergic one, it resists corrosion, has low heat conducting ability, it tastes neutral and is relatively cheap to apply. Titanium's biocompatibility may be associated with its fast oxidizing capacity, which can inhibit its binding with proteins. Due to titanium's oxidizing capacity, its applicability in dentistry is difficult, because such prostheses are not easy to cover with ceramics, which is essential for aesthetic reasons. The bond between the ceramic, developed specially for titanium, and the metal surface is weaker than in the case of NiCr alloys or alloys of noble alloys. The strength of the bond, however, meets ISO requirements, and, according to the latest literature, it can be further strengthened by surface treatment techniques and new bond systems. These solutions are aimed at stopping cavity formation on the ...
The Journal of clinical dentistry, 2000
The plaque-retentive effects of fixed orthodontic appliances may induce a rapid increase in the a... more The plaque-retentive effects of fixed orthodontic appliances may induce a rapid increase in the amount of plaque. The aim of the present study was to conduct a longitudinal clinical investigation on the antibacterial effect of chlorhexidine-containing Cervitec varnish during orthodontic treatment. Twenty-four subjects (9 male, 15 female), aged 16.5 +/- 2.5 years, participated in the study. At baseline, the subjects' DMF-S scores, stimulated salivary flow rates (ml/min) and levels of salivary Streptococcus mutans (SM) and lactobacilli (LB) were determined using Dentocult SM strip and Dentocult LB methods. After placing the orthodontic appliances, the subjects were treated with Cervitec or a placebo varnish around the bands and brackets. The chlorhexidine varnish was applied randomly in the first or second quadrant, and placebo varnish in the opposite quadrant, according to the split-mouth technique. The varnish application was repeated every 3 months to the same sites. Follow-up ...
Fogorvosi szemle, 2000
The aim of the study is to assess the cephalometric values of patients with Turner syndrome and t... more The aim of the study is to assess the cephalometric values of patients with Turner syndrome and to compare them to those of healthy patients in order to determine the severity of orthodontic anomalies and the possibilities of treatment. For our work the modified Ricketts analysis was used. Significant differences were found between the two groups regarding the B1, B2, P, AB ii angles and in relations of C:R. Early stomatologic treatment seems to be very important in this patient's group to prevent dental, periodontal and temporomandibular disorders.
PubMed, Mar 1, 2015
In parallel with the emergence of new dental materials the number of allergic diseases is continu... more In parallel with the emergence of new dental materials the number of allergic diseases is continuously increasing. Extremely small quantities of the allergens are capable to inducing an allergic reaction. Therefore it is particularly important to examine these materials as antigens and investigate their binding properties to proteins (e.g. formaldehyde, methacrylic acid, benzoyl-peroxide...). The Fourier Transform Surface Plasmon Resonance Spectroscopy (FT-SPR) is a suitable examination method for this type of procedure. FT-SPR measurement is performed at a fixed angel of incident light, and reflectivity is measured over a range of wavelength in the near infrared. The advantages of this method are the outstanding sensitivity, the label-free detection capability and the possibility of the real-time testing procedure. Formaldehyde and methacrylic acid are among the most common dental allergens. In our study we examined these molecules by FT-SPR spectroscopy. The aim of this work was to investigate the suitability of this method to the detection of these materials, with special focuses on the analysis and evaluation concentration-dependent measurements. Different concentrations (0.01 %-0.2%) of formaldehyde and methacrylic acid solutions were measured. The individual spectra were measured for all of the solutions, and calibration curves were calculated for the materials for the possibility of the determination of an unknown concentration. The results confirmed that the method is theoretically capable to detect hundred-thousandths scale concentration-changes in the solution flowing above the SPR-chip. The concentration-dependent studies had proved that the method capable to measure directly these materials and can provide appropriate calibration for quantitative determination. These experiments show the broad applicability of the FT-SPR method, which can greatly facilitate the mapping and understanding of biomolecular interactions in the future.
Orvosi Hetilap, Dec 1, 2019
Bevezetés: A Moyers-féle vegyes fogazati analízis az egyik leggyakrabban használt predikciós móds... more Bevezetés: A Moyers-féle vegyes fogazati analízis az egyik leggyakrabban használt predikciós módszer, melynek segítségével meghatározhatjuk az elő nem tört fogak méretét, így még vegyes fogazati időszakban informálódhatunk a helyviszonyokról. Mivel azonban a fogméretek az egyes etnikai csoportok közt jelentősen eltérhetnek, ahhoz, hogy a helyhiány súlyosságát a lehető legpontosabban tudjuk meghatározni, külön a vizsgált egyén saját etnikai csoportjára vonatkoztatott módszert lenne optimális alkalmazni. Célkitűzés: Célunk, hogy megvizsgáljuk, a Moyers-féle vegyes fogazati analízis mennyire pontosan használható Magyarországon. Módszer: 370 páciens alginátlenyomat alapján készült alsó és felső gipszmintája került kiértékelésre. Pittsburgh digitális tolómérő segítségével határoztuk meg az egyes fogak mesiodistalis szélességét. A kapott értékekből számoltuk ki egyrészt a fogak valós, másrészt a Moyers-féle predikciós táblázat segítségével a várható helyigényét, majd a két értéket összevetettük. Eredmények: Moyers-féle analízist használva minden viszonylatban, mindkét nem esetén szignifikáns különbséget találtunk az általunk mért valós és prediktív értékek között. A felső állcsonton férfiak esetében a 95%-os, 85%-os, 75%-os és 65%-os percentilisértékek is túlbecsülték az általunk mért értékeket, míg nők esetében csak a 65%-os becsülte alá azt. Az alsó állcsont esetén mindegyik percentilisérték túlbecsülte a valós mérések eredményeit. Következtetések: Eredményeink alapján a Moyers-féle vegyes fogazati predikciós módszer nem alkalmazható megbízhatóan a magyar lakosságnál. Amennyiben használjuk, javasolt a klinikumban elterjedt 75% percentilisérték helyett inkább a 65%-os adat alkalmazása, mivel ezzel a valós helyigényhez közelebbi eredményt kaphatunk.
PubMed, Dec 1, 2014
The recognition and treatment of allergy is a great challenge for all fields of medicine. The hig... more The recognition and treatment of allergy is a great challenge for all fields of medicine. The high prevalence of allergic reactions to dental materials and the related financial burden of their treatment make investigation of this disease very important. Our investigation was carried out on patients assigned to our outpatient department for dental allergy test between 1996 and 1998. We determined the distribution of gender and age among the allergic patients in the examined population. We also studied the prevalence of allergic reactions to different dental allergens and the distribution of dental allergens. In a follow-up study we determined the proportion of those patients, who were retreated in conformity with the results of epicutan tests and we followed up the positive effects of these treatments. We have found that dental allergy occurred five times more frequently in women (84%) than in men (16%) and the most affected age group was between 20 to 39 and 40-49 years (31%). Seventy-five percent of the patients suffered from a combination of metal and polymer allergy. The most frequent metal allergen was TEGDMA (triethylene glycol dimethacrylate) (49.7%). The suggested treatment plan was carried out in 63% of the allergic patients. The applied treatment was successful in 48% of these cases. We experienced that 48% of these patients got rid of their earlier signs and symptoms.
Scientific Reports, Mar 4, 2019
Our purpose was to prospectively analyze the age-related changes of corneal Scheimpflug parameter... more Our purpose was to prospectively analyze the age-related changes of corneal Scheimpflug parameters in healthy subjects. Thirty-five eyes of 35 volunteers (age 14-67 years) were investigated with an average interval of 3.6 years. Changes of corneal parameters (flattest keratometric reading at anterior (K1F) and posterior surface (K1B), steepest keratometric reading at anterior (K2F) and posterior surface, anterior astigmatism, posterior astigmatism (AstigB), flat axis of anterior and posterior astigmatism (AxisB), thinnest pachymetric value (PachyMin), corneal volume (CV10-mm)) were analyzed. K1F and K2F decreased significantly during observation and showed stronger decrease in younger than in older individuals. Higher values proved to be more stable. K1B decreased significantly and the degree of decrease was dependent on its baseline value and age: in young subjects low values increased, high values decreased. AstigB decreased significantly and showed a baseline-dependent significant increase from lower and a significant decrease from higher initial values. Over time, the mean AxisB shifted significantly. PachyMin and CV decreased significantly with age, especially from higher baseline values in younger subjects. The results of this longitudinal study suggest that both corneal surfaces change significantly with age. We demonstrate for the first time that age and baseline values influence agerelated changes of corneal parameters. Aging is a physiological process and occasionally it is hard to differentiate between time dependent biological changes and damages from environmental insults 1. Age-related changes occur in all structures of the eye, with various consequences 2. Age has been identified as an important individual variable affecting the outcome after keratorefractive surgery 3. Corneal aging generates structural and functional changes including steepening of keratometry indices, and a rotation of the axis of astigmatism resulting in a shift from with-the-rule to against-the-rule astigmatism 1,4-11. Alterations of higher-order aberrations of the cornea are also well known 9. The level of astigmatism decreased significantly with age both of the anterior and posterior corneal surfaces in a study by Nemeth et al. 9 , although age as a primary factor was not analyzed in this report. To differentiate between physiological and pathological changes of the aging cornea, it is indispensable to know what the physiological changes are. There are clinical situations where it is important to distinguish between pathological and normal age-related changes. The assessment of the progression of ectatic corneal disorders in young patients determines the optimal treatment and the glaucoma management in the elderly can only be personalized if we take account the changes of corneal thickness. A complete and precise evaluation of the cornea must take keratometric, astigmatic vectorial as well as pachymetric characteristics into account. Age-dependent change of corneal thickness has been studied extensively. Corneal thickness decreases throughout infancy; during babyhood (around 3 years of age) it reaches adult thickness and, from that point on, central corneal thickness (CCT) appears to be stable over time 12. However, age-related change in corneal thickness appears to be rather controversial in other studies 13-18. CCT has been extensively investigated in glaucoma
Ocular Immunology and Inflammation, Mar 4, 2020
Purpose: To find immunomediator combinations which could sensitively indicate keratoconus progres... more Purpose: To find immunomediator combinations which could sensitively indicate keratoconus progression. Methods: Tear samples of 42 patients with keratoconus were collected at baseline and at the end of a one-year follow-up. The concentrations of 13 mediators were measured by CBA. Based on Pentacam HR examination, eyes were divided into a non-progressive and a progressive group. Results: At the end of the follow-up, significant differences were observed in the release of IFNγ, IL-13, IL-17A, CCL5, MMP-13 and PAI-1 between the two groups. Changes in five Pentacam parameters correlated positively with changes in IFNγ, IL-13, IL-17A, CXCL8, CCL5, TIMP-1 and t-PA. We found that tear level of IL-13 in combination with NGF can predict the progression of keratoconus with 100% specificity and 80% sensitivity. Conclusion: The findings of our longitudinal study may underscore the importance of NGF and IL-13 tear levels in the prediction of keratoconus progression.
Fogorvosi Szemle, 2015
A fogászatban az új anyagrendszerek megjelenésével párhuzamosan egyre nagyobb ütemben növekszik a... more A fogászatban az új anyagrendszerek megjelenésével párhuzamosan egyre nagyobb ütemben növekszik a potenciálisan allergiás tünetek kiváltására alkalmas anyagok köre. Az adott allergénnek rendkívül kis mennyisége is képes allergiás reakció kiváltására, ezért kiemelt jelentősége van ezen antigénként szereplő anyagok (például: formaldehid, metakrilsav, benzoil-peroxid) fehérjékhez való kötődési lehetőségeinek vizsgálatának. Ezen sajátosságok vizsgálatáraa Fourier-Transzformációs Felületi Plazmon Rezonancia Spektroszkópia (FT-SPR) jól alkalmazható eljárás. A módszer előnyei közé sorolható a kiemelkedő érzékenység, a jelölés nélküli detektálás képessége, valamint a valós idejű vizsgálatok kivitelezésének lehetősége.Kísérleteink célja a formaldehid és metakrilsav mint a leggyakoribb fogászati allergének közé tartozó anyagokFT-SPR spektroszkópiás vizsgálata volt, kiemelt hangsúlyt fektetve koncentrációfüggő mérések elemzésére és kiérté-kelésére.Méréseinket formaldehid és metakrilsav desztil...
International orthodontics, Jan 11, 2018
The aim of the present study was to comprehensively assess the posttreatment effect of premolar e... more The aim of the present study was to comprehensively assess the posttreatment effect of premolar extraction versus non-extraction on the position and development of the lower third molars. The sample consisted of 227 patient's pre- and posttreatment panoramic radiographs (53 with four premolar extractions, 174 without extractions). The position and developmental stage of the lower third molars were evaluated by using Pell-Gregory's, Winter's, modified Miloro-DaBell's and Demirjian's classifications, respectively. Premolar extraction had a considerably positive influence on the position and development of the lower third molars and therefore could provide better prognosis for their eruption.
Fogorvosi Szemle, Dec 1, 2014
The recognition and treatment of allergy is a great challenge for all fields of medicine. The hig... more The recognition and treatment of allergy is a great challenge for all fields of medicine. The high prevalence of allergic reactions to dental materials and the related financial burden of their treatment make investigation of this disease very important. Our investigation was carried out on patients assigned to our outpatient department for dental allergy test between 1996 and 1998. We determined the distribution of gender and age among the allergic patients in the examined population. We also studied the prevalence of allergic reactions to different dental allergens and the distribution of dental allergens. In a follow-up study we determined the proportion of those patients, who were retreated in conformity with the results of epicutan tests and we followed up the positive effects of these treatments. We have found that dental allergy occurred five times more frequently in women (84%) than in men (16%) and the most affected age group was between 20 to 39 and 40-49 years (31%). Seventy-five percent of the patients suffered from a combination of metal and polymer allergy. The most frequent metal allergen was TEGDMA (triethylene glycol dimethacrylate) (49.7%). The suggested treatment plan was carried out in 63% of the allergic patients. The applied treatment was successful in 48% of these cases. We experienced that 48% of these patients got rid of their earlier signs and symptoms.
Fogorvosi szemle, 2015
In parallel with the emergence of new dental materials the number of allergic diseases is continu... more In parallel with the emergence of new dental materials the number of allergic diseases is continuously increasing. Extremely small quantities of the allergens are capable to inducing an allergic reaction. Therefore it is particularly important to examine these materials as antigens and investigate their binding properties to proteins (e.g. formaldehyde, methacrylic acid, benzoyl-peroxide...). The Fourier Transform Surface Plasmon Resonance Spectroscopy (FT-SPR) is a suitable examination method for this type of procedure. FT-SPR measurement is performed at a fixed angel of incident light, and reflectivity is measured over a range of wavelength in the near infrared. The advantages of this method are the outstanding sensitivity, the label-free detection capability and the possibility of the real-time testing procedure. Formaldehyde and methacrylic acid are among the most common dental allergens. In our study we examined these molecules by FT-SPR spectroscopy. The aim of this work was t...
Fogorvosi szemle
During the past two decades the incidence of allergies against dental materials has been rising. ... more During the past two decades the incidence of allergies against dental materials has been rising. The most common allergens are nickel, mercury, benzoxyl-peroxide, formaldehyde, MMA, HEMA, EGDMA and TEGDMA. Contact allergy develops in predisposed individuals as a consequence of environmental exposures to allergens. Although the relatively high frequency of contact allergies in children is well documented, its importance during orthodontic treatments is still often underestimated. The most common metal to cause dental allergic reactions is nickel. Nickel-containing metal alloys, such as nickel-titanium, are widely used in orthodontics because of their favorable physical properties. Coated wires (epoxi coating, teflon, etc.) are not only more aesthetic, but can play a role in the orthodontic treatment of patients with nickel allergy. In our case report we present two patients with nickel allergy, and their treatment with alternative orthodontic appliances. During the orthodontic treatment our patients did not have any objective or subjective allergy-related symptoms.
Objective: Polymers (Polymethyl methacrylate; PMMA) are one the most frequently used material in ... more Objective: Polymers (Polymethyl methacrylate; PMMA) are one the most frequently used material in dentistry, which is often causing allergic reactions. The aim of our study was to investigate peptide structures bound to PMMA in order to deduct molecules may bind to PMMA and responsible for allergic reactions. Method: The investigated heat cured polymethyl methacrylate was Orthocryl (Dentaurum, Germany). We used phage display technology to select peptides on PMMA surface. The phage work was carried out by linear peptide library. Ph.D.-7TM and Ph.D.-12TM Peptide Library Kits (Biolabs, England) were based on a combinatorial library of random peptide 7-mers and random peptide 12-mers fused to a minor coat protein of M13 Phage respectively. The phage selection was carried out five times on the PMMA surface. Colonies of the third rounds of each phage selection were used to isolate DNS for amino acid sequence determination. The binding of the selected peptides was quantitated by ELISA and b...
Fogorvosi szemle, 2007
During the past two decades the incidence of allergies against dental materials has been rising. ... more During the past two decades the incidence of allergies against dental materials has been rising. The most common allergens are nickel, mercury, benzoxyl-peroxide, formaldehyde, MMA, HEMA, EGDMA and TEGDMA. Contact allergy develops in predisposed individuals as a consequence of environmental exposures to allergens. Although the relatively high frequency of contact allergies in children is well documented, its importance during orthodontic treatments is still often underestimated. The most common metal to cause dental allergic reactions is nickel. Nickel-containing metal alloys, such as nickel-titanium, are widely used in orthodontics because of their favorable physical properties. Coated wires (epoxi coating, teflon, etc.) are not only more aesthetic, but can play a role in the orthodontic treatment of patients with nickel allergy. In our case report we present two patients with nickel allergy, and their treatment with alternative orthodontic appliances. During the orthodontic treatm...
Fogorvosi szemle, 2005
The early loss of permanent teeth following trauma or congenital aplasia and agenesia need to be ... more The early loss of permanent teeth following trauma or congenital aplasia and agenesia need to be corrected by orthodontic or prosthetic means, sometimes combined with implant therapy. Preprosthetic orthodontic measures are often an integral part of comprehensive oral rehabilitation. The individual aspects of treatment are aimed at optimizing dentofacial esthetics and at improving masticatory function and hygiene potential of prosthetic restorations. The orthodontic solution results usually in different anatomic, functional, and esthetic problems. In the present study the treatment possibilities of two patients with missing upper lateral incisors are presented. In the first case the problem of the missing upper lateral incisors was solved by adhesive bridges, after the fixed appliance orthodontic treatment, where the diasthema medianum was closed, and the upper canines were distalized. In our second case the same problem was solved by inserting implants, with single, metal free crown...
Fogorvosi szemle, 2004
Owing to its excellent biocompatibility, titanium has been used in health care, including dental ... more Owing to its excellent biocompatibility, titanium has been used in health care, including dental care, for a long time. The unalloyed light metal is a non-allergic one, it resists corrosion, has low heat conducting ability, it tastes neutral and is relatively cheap to apply. Titanium's biocompatibility may be associated with its fast oxidizing capacity, which can inhibit its binding with proteins. Due to titanium's oxidizing capacity, its applicability in dentistry is difficult, because such prostheses are not easy to cover with ceramics, which is essential for aesthetic reasons. The bond between the ceramic, developed specially for titanium, and the metal surface is weaker than in the case of NiCr alloys or alloys of noble alloys. The strength of the bond, however, meets ISO requirements, and, according to the latest literature, it can be further strengthened by surface treatment techniques and new bond systems. These solutions are aimed at stopping cavity formation on the ...
The Journal of clinical dentistry, 2000
The plaque-retentive effects of fixed orthodontic appliances may induce a rapid increase in the a... more The plaque-retentive effects of fixed orthodontic appliances may induce a rapid increase in the amount of plaque. The aim of the present study was to conduct a longitudinal clinical investigation on the antibacterial effect of chlorhexidine-containing Cervitec varnish during orthodontic treatment. Twenty-four subjects (9 male, 15 female), aged 16.5 +/- 2.5 years, participated in the study. At baseline, the subjects' DMF-S scores, stimulated salivary flow rates (ml/min) and levels of salivary Streptococcus mutans (SM) and lactobacilli (LB) were determined using Dentocult SM strip and Dentocult LB methods. After placing the orthodontic appliances, the subjects were treated with Cervitec or a placebo varnish around the bands and brackets. The chlorhexidine varnish was applied randomly in the first or second quadrant, and placebo varnish in the opposite quadrant, according to the split-mouth technique. The varnish application was repeated every 3 months to the same sites. Follow-up ...
Fogorvosi szemle, 2000
The aim of the study is to assess the cephalometric values of patients with Turner syndrome and t... more The aim of the study is to assess the cephalometric values of patients with Turner syndrome and to compare them to those of healthy patients in order to determine the severity of orthodontic anomalies and the possibilities of treatment. For our work the modified Ricketts analysis was used. Significant differences were found between the two groups regarding the B1, B2, P, AB ii angles and in relations of C:R. Early stomatologic treatment seems to be very important in this patient's group to prevent dental, periodontal and temporomandibular disorders.