Gajanan Mandawad - Academia.edu (original) (raw)
Papers by Gajanan Mandawad
A simple and efficient one-pot synthesis of substituted pyrazolo[3,4 b:4’,3’e] pyridine derivativ... more A simple and efficient one-pot synthesis of substituted pyrazolo[3,4 b:4’,3’e] pyridine derivatives in Polyethylene glycol (PEG-400) as green reaction solvent under microwave irradiation by using basic bleaching earth catalyst (P-9.2). The chemical structure of the compounds was confirmed by IR,H NMR and Mass spectral data. All the compounds of the series screened for their antibacterial and antifungal activity studies. The result revealed that most of the compounds showed good to moderate antimicrobial activity.
Applied Surface Science, 2003
Thin amorphous layers of poly(ethylene terephthalate-ethylene isophthalate) (PETI) containing var... more Thin amorphous layers of poly(ethylene terephthalate-ethylene isophthalate) (PETI) containing variable concentration of an antioxidant additive (Irgafos 168) were deposited by spin casting from solution onto silicon wafers. ToF-secondary ion mass spectrometry (SIMS) results showed that a very low bulk percentages ($1 wt.%) of additive led to an almost uniform covering of the polymer surface, indicating a strong surface segregation (blooming effect). Multivariate statistical methods (PCA) allowed us to quantify the additive surface concentration in the lower concentration range (0.3 wt.%). ToF-SIMS imaging con®rmed the uniform surface covering and, for higher concentration (5.5 additive wt.%), showed the formation of additive crystals on the top of the additive covered PETI surface.
Metallic glasses (MGs) exhibit both high yield stresses and elastic strain limits owing to their ... more Metallic glasses (MGs) exhibit both high yield stresses and elastic strain limits owing to their metallic bonding character and lack of long-range order. Yet the structural state (i.e. local atomic packing), and the corresponding elastic and plastic mechanical response, of MGs is nuanced and dependent on processing history. Moreover, the interplay between small length scales and glass processing routes have produced seemingly conflicting results. Here, the influence of processing on MG mechanical behavior at sub-micron length scales is explored, revealing extreme sensitivity to ion irradiation, enhanced control over the mechanical response, and an underpinning of yield strength in thermodynamic properties. Using in situ testing methods, the deformation response of individual thermoplastically molded MG nanowires is studied. In contrast with previous literature reports the nanowire behavior is observed to be consistent with bulk deformation, exhibiting brittle fracture and shear band...
In the present communication a simple and efficient synthesis of some new acridines are described... more In the present communication a simple and efficient synthesis of some new acridines are described by the one-pot condensation of 3, 4, 9, 10-tetrahydroacridine-1(2H)-one, substituted aldehyde and liquior ammonia in alkaline polyethylene glycol (PEG-400) as green reaction solvent. The newly synthesized products were evaluated for their antibacterial and antifungal activity
Current Organic Synthesis, 2022
Aim: The aim of this present work was to design and establish an efficient synthesis of new thien... more Aim: The aim of this present work was to design and establish an efficient synthesis of new thienyl pyrazolo[1,5‐a] pyrimidines using enviormental friendly reaction solvent. Further, the newly synthesized compounds were evaluated for antimicrobial activity. Materials and Method: A series of thienyl pyrazolo[1,5‐a] pyrimidines have been synthesized by the condensation reaction of 4‐(4’‐chloro‐phenylazo)‐5‐amino pyrazole with α, β‐ unsaturated carbonyl composites (chalcones) using NaOH in polyethylene glycol-400 as green reaction solvent. The dissemination technique recommended by the National Clinical Laboratory Standards Committee was used to study the antimicrobial activities of synthesized compounds. Results and Discussion: Polyethylene glycol-400 prompted an efficient synthesis of thienyl pyrazolo[1,5‐a] pyrimidines has been discussed. By using PEG‐400 as green reaction solvent, excellent yields of the proucts were obtained in shorter reaction reaction time. Reaction solvent was ...
Research Journal of Science and Technology, 2011
Synthesis of bis(indolyl) methanes by the reaction of indoles with structurally diverse aldehydes... more Synthesis of bis(indolyl) methanes by the reaction of indoles with structurally diverse aldehydes and cyclohexanone in the presence of catalytic amount of bleaching earth in polyethylene glycol (PEG-400) as green solvent afforded the corresponding bis(indolyl) methanes in excellent yields. The effects of solvent, nature of substituents on the aromatic ring of aldehydes were investigated. The catalysts and solvent were reusable up to 4 times without significant loss of activity. The remarkable features of this procedure are high conversions, shorter reaction time and cleaner reaction profiles.
In the present communication, a series of some new pyrazole based chalcones were prepared by the ... more In the present communication, a series of some new pyrazole based chalcones were prepared by the conventional Claisen-Schmidt condensation method under mild reaction condition. All the synthesized products were characterized by the spectroscopic and analytical measurements. Furthermore, all the synthesized compounds were screened for their antimicrobial activity.
The efficient and facile protocol was developed for the synthesis of 2-styryl-4H-chromen-4-one 3a... more The efficient and facile protocol was developed for the synthesis of 2-styryl-4H-chromen-4-one 3a-i derivatives. The condensation of substituted 2-hydroxyacetophenone with cinnamic acid to obtained (E)-2-acetylphenylcinnamate 2a-i derivatives, which on treatment with base leads to target 3a-i derivatives. A wide range of functional groups were tolerated in the developed protocol. The target molecules were obtained in good to excellent yield applying the current method. All target compounds are characterized by IR, 1H NMR, and 13C NMR spectral data.
![Research paper thumbnail of PEG-400 : prompted eco-friendly synthesis of some novel pyrazolo [ 1 , 5-a ] pyrimidine derivatives and their in vitro antimicro bial evaluation](https://attachments.academia-assets.com/76240913/thumbnails/1.jpg)
](Several pyrazolo [1, 5-a] pyrimidines derivative we re prepared by the condensation of substitute... more Several pyrazolo [1, 5-a] pyrimidines derivative we re prepared by the condensation of substituted of α, βunsaturated carbonyl compounds (chalcones) with s ubstituted 5-amino pyrazole as an alternative polyethylene glycol (PEG -400) as green reaction medium. The reaction is clean with excellent yield, shorter rea ction time. The entire synthesized products were characterized by spectral analysis. Furthermore, th ese newly synthesized compounds were screened for their antimicrobial activity against E scherichia coli (MTCC443), Bacillus subtilis (MTCC441), Staphylococcus aureus (MTCC96) and Salmo nella typhi. (MTCC98). The antifungal activity was evaluated against Aspergill us niger, Aspergillus flavus (MTCC3008), Candida albicans (MTCC227) and Penicillium chrysoge num (MTCC160).Most of the compounds showed significant antimicrobial activity . Keywards: PEG-400,Chalcones,5-Amino pyrazole, pyrazolo [1, 5 -a] pyrimidines,Antimicrobial activity. __________________________________________...
![Research paper thumbnail of NaOH/PEG-400: An eloquent system for the synthesis of new thienyl benzo[b]1,4-diazepines](https://attachments.academia-assets.com/72476081/thumbnails/1.jpg)
](European Journal of Chemistry
A simple and eloquent procedure for the synthesis of a new series of thienyl benzo[b]1,4-diazepin... more A simple and eloquent procedure for the synthesis of a new series of thienyl benzo[b]1,4-diazepines is reported. They were synthesized by the condensation of o-phenylenediamine (o-PDA) with distinct hetero chalcones using NaOH in polyethylene glycol (PEG-400) as green and alternative reaction solvent. The significances of this present method are shorter reaction time, easy work-up, high yields, and mild reaction conditions. Furthermore, this method is environment friendly and without use of an expensive catalyst. The all newly synthesized compounds are characterized by the spectroscopic methods.
Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds
Orbital the Electronic Journal of Chemistry, Mar 17, 2012
Asian Journal of Research in Chemistry, 2010
Medicinal Chemistry Research, 2014
ABSTRACT Synthesis of novel thiophene substituted isoxazoline libraries is currently of high inte... more ABSTRACT Synthesis of novel thiophene substituted isoxazoline libraries is currently of high interest. Here, we have reported detailed syntheses of 2,5-dichlorothiophene, 5-chloro-2-(benzylthio)thiophene, and 5-chlorothiophene-2-sulphonamide substituted analogs of isoxazoline from chalcones catalyzed by NaOH in PEG-400 as green solvent. In vitro antimycobacterial and antimicrobial activity of newly synthesized compounds were investigated. Compounds 2j, 2k, and 2l showed excellent activity against Mycobacterium tuberculosis and other Mycobacterium strains tested. Compounds 2a–2c, 2i showed excellent activity against all bacterial and fungal species tested. The isoxazoline scaffold synthesized in the present study may be useful in the development of novel new antimicrobial agents. Graphical abstract An efficient synthesis of isoxazoline libraries of thiophene analogs and its antimycobacterial investigation.
Bioorganic & Medicinal Chemistry, 2013
Xanthine oxidase (XO) generates superoxide anions and H(2)O(2) for the self-defence system of org... more Xanthine oxidase (XO) generates superoxide anions and H(2)O(2) for the self-defence system of organism. Abnormal production of this superoxide's (reactive oxygen species) is responsible for a number of complications including inflammation, metabolic disorder, cellular aging, reperfusion damage, atherosclerosis and carcinogenesis. Series of novel trisubstituted thiophenyl-1-thiazolyl-2-pyrazoline libraries are synthesized containing 2,5-dichloro thiophene, 5-chloro-2-(benzylthio) thiophene and 5-chlorothiophene-2-sulphonamide, from chalcones in PEG-400 as green solvent. Superoxide (XO) inhibitory and free radical scavenging activities were also figured out with molecular modeling analysis, bearing in mind their possible future for super oxide inhibitor (Gout) therapeutics, compound 3k shows interesting superoxide inhibitory and free radical scavenger activity with IC(50)=6.2 μM, in comparison with allopurinol.
Several 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-c... more Several 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-chloro-1H-imidazol-5yl)-2-pyrazoline derivatives were prepared by the base catalyzed treatment of appropriate chalcones with 4-(4'-chlorophenyl)-2-hydrazino-thiazole in poly (ethylene glycol) (PEG-400) as an alternative reaction solvent. All the synthesized compounds were tested for their antimicrobial activities against Escherichia coli (MTCC 2939), Salmonella typhi (MTCC 98), Staphylococcus aureus (MTCC 96), Bacillus subtilis (MTCC 441), Aspergillus niger (MTCC 281), Trichoderma viridae (MTCC 167), Penicillium chrysogenum (MTCC 160), Fusarium moniliforme (MTCC 156) and Candida albicans (MTCC 183). Most of the compounds showed potent antibacterial and antifungal activity.
A simple and efficient one-pot synthesis of substituted pyrazolo[3,4 b:4’,3’e] pyridine derivativ... more A simple and efficient one-pot synthesis of substituted pyrazolo[3,4 b:4’,3’e] pyridine derivatives in Polyethylene glycol (PEG-400) as green reaction solvent under microwave irradiation by using basic bleaching earth catalyst (P-9.2). The chemical structure of the compounds was confirmed by IR,H NMR and Mass spectral data. All the compounds of the series screened for their antibacterial and antifungal activity studies. The result revealed that most of the compounds showed good to moderate antimicrobial activity.
Applied Surface Science, 2003
Thin amorphous layers of poly(ethylene terephthalate-ethylene isophthalate) (PETI) containing var... more Thin amorphous layers of poly(ethylene terephthalate-ethylene isophthalate) (PETI) containing variable concentration of an antioxidant additive (Irgafos 168) were deposited by spin casting from solution onto silicon wafers. ToF-secondary ion mass spectrometry (SIMS) results showed that a very low bulk percentages ($1 wt.%) of additive led to an almost uniform covering of the polymer surface, indicating a strong surface segregation (blooming effect). Multivariate statistical methods (PCA) allowed us to quantify the additive surface concentration in the lower concentration range (0.3 wt.%). ToF-SIMS imaging con®rmed the uniform surface covering and, for higher concentration (5.5 additive wt.%), showed the formation of additive crystals on the top of the additive covered PETI surface.
Metallic glasses (MGs) exhibit both high yield stresses and elastic strain limits owing to their ... more Metallic glasses (MGs) exhibit both high yield stresses and elastic strain limits owing to their metallic bonding character and lack of long-range order. Yet the structural state (i.e. local atomic packing), and the corresponding elastic and plastic mechanical response, of MGs is nuanced and dependent on processing history. Moreover, the interplay between small length scales and glass processing routes have produced seemingly conflicting results. Here, the influence of processing on MG mechanical behavior at sub-micron length scales is explored, revealing extreme sensitivity to ion irradiation, enhanced control over the mechanical response, and an underpinning of yield strength in thermodynamic properties. Using in situ testing methods, the deformation response of individual thermoplastically molded MG nanowires is studied. In contrast with previous literature reports the nanowire behavior is observed to be consistent with bulk deformation, exhibiting brittle fracture and shear band...
In the present communication a simple and efficient synthesis of some new acridines are described... more In the present communication a simple and efficient synthesis of some new acridines are described by the one-pot condensation of 3, 4, 9, 10-tetrahydroacridine-1(2H)-one, substituted aldehyde and liquior ammonia in alkaline polyethylene glycol (PEG-400) as green reaction solvent. The newly synthesized products were evaluated for their antibacterial and antifungal activity
Current Organic Synthesis, 2022
Aim: The aim of this present work was to design and establish an efficient synthesis of new thien... more Aim: The aim of this present work was to design and establish an efficient synthesis of new thienyl pyrazolo[1,5‐a] pyrimidines using enviormental friendly reaction solvent. Further, the newly synthesized compounds were evaluated for antimicrobial activity. Materials and Method: A series of thienyl pyrazolo[1,5‐a] pyrimidines have been synthesized by the condensation reaction of 4‐(4’‐chloro‐phenylazo)‐5‐amino pyrazole with α, β‐ unsaturated carbonyl composites (chalcones) using NaOH in polyethylene glycol-400 as green reaction solvent. The dissemination technique recommended by the National Clinical Laboratory Standards Committee was used to study the antimicrobial activities of synthesized compounds. Results and Discussion: Polyethylene glycol-400 prompted an efficient synthesis of thienyl pyrazolo[1,5‐a] pyrimidines has been discussed. By using PEG‐400 as green reaction solvent, excellent yields of the proucts were obtained in shorter reaction reaction time. Reaction solvent was ...
Research Journal of Science and Technology, 2011
Synthesis of bis(indolyl) methanes by the reaction of indoles with structurally diverse aldehydes... more Synthesis of bis(indolyl) methanes by the reaction of indoles with structurally diverse aldehydes and cyclohexanone in the presence of catalytic amount of bleaching earth in polyethylene glycol (PEG-400) as green solvent afforded the corresponding bis(indolyl) methanes in excellent yields. The effects of solvent, nature of substituents on the aromatic ring of aldehydes were investigated. The catalysts and solvent were reusable up to 4 times without significant loss of activity. The remarkable features of this procedure are high conversions, shorter reaction time and cleaner reaction profiles.
In the present communication, a series of some new pyrazole based chalcones were prepared by the ... more In the present communication, a series of some new pyrazole based chalcones were prepared by the conventional Claisen-Schmidt condensation method under mild reaction condition. All the synthesized products were characterized by the spectroscopic and analytical measurements. Furthermore, all the synthesized compounds were screened for their antimicrobial activity.
The efficient and facile protocol was developed for the synthesis of 2-styryl-4H-chromen-4-one 3a... more The efficient and facile protocol was developed for the synthesis of 2-styryl-4H-chromen-4-one 3a-i derivatives. The condensation of substituted 2-hydroxyacetophenone with cinnamic acid to obtained (E)-2-acetylphenylcinnamate 2a-i derivatives, which on treatment with base leads to target 3a-i derivatives. A wide range of functional groups were tolerated in the developed protocol. The target molecules were obtained in good to excellent yield applying the current method. All target compounds are characterized by IR, 1H NMR, and 13C NMR spectral data.
Several pyrazolo [1, 5-a] pyrimidines derivative we re prepared by the condensation of substitute... more Several pyrazolo [1, 5-a] pyrimidines derivative we re prepared by the condensation of substituted of α, βunsaturated carbonyl compounds (chalcones) with s ubstituted 5-amino pyrazole as an alternative polyethylene glycol (PEG -400) as green reaction medium. The reaction is clean with excellent yield, shorter rea ction time. The entire synthesized products were characterized by spectral analysis. Furthermore, th ese newly synthesized compounds were screened for their antimicrobial activity against E scherichia coli (MTCC443), Bacillus subtilis (MTCC441), Staphylococcus aureus (MTCC96) and Salmo nella typhi. (MTCC98). The antifungal activity was evaluated against Aspergill us niger, Aspergillus flavus (MTCC3008), Candida albicans (MTCC227) and Penicillium chrysoge num (MTCC160).Most of the compounds showed significant antimicrobial activity . Keywards: PEG-400,Chalcones,5-Amino pyrazole, pyrazolo [1, 5 -a] pyrimidines,Antimicrobial activity. __________________________________________...
European Journal of Chemistry
A simple and eloquent procedure for the synthesis of a new series of thienyl benzo[b]1,4-diazepin... more A simple and eloquent procedure for the synthesis of a new series of thienyl benzo[b]1,4-diazepines is reported. They were synthesized by the condensation of o-phenylenediamine (o-PDA) with distinct hetero chalcones using NaOH in polyethylene glycol (PEG-400) as green and alternative reaction solvent. The significances of this present method are shorter reaction time, easy work-up, high yields, and mild reaction conditions. Furthermore, this method is environment friendly and without use of an expensive catalyst. The all newly synthesized compounds are characterized by the spectroscopic methods.
Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds
Orbital the Electronic Journal of Chemistry, Mar 17, 2012
Asian Journal of Research in Chemistry, 2010
Medicinal Chemistry Research, 2014
ABSTRACT Synthesis of novel thiophene substituted isoxazoline libraries is currently of high inte... more ABSTRACT Synthesis of novel thiophene substituted isoxazoline libraries is currently of high interest. Here, we have reported detailed syntheses of 2,5-dichlorothiophene, 5-chloro-2-(benzylthio)thiophene, and 5-chlorothiophene-2-sulphonamide substituted analogs of isoxazoline from chalcones catalyzed by NaOH in PEG-400 as green solvent. In vitro antimycobacterial and antimicrobial activity of newly synthesized compounds were investigated. Compounds 2j, 2k, and 2l showed excellent activity against Mycobacterium tuberculosis and other Mycobacterium strains tested. Compounds 2a–2c, 2i showed excellent activity against all bacterial and fungal species tested. The isoxazoline scaffold synthesized in the present study may be useful in the development of novel new antimicrobial agents. Graphical abstract An efficient synthesis of isoxazoline libraries of thiophene analogs and its antimycobacterial investigation.
Bioorganic & Medicinal Chemistry, 2013
Xanthine oxidase (XO) generates superoxide anions and H(2)O(2) for the self-defence system of org... more Xanthine oxidase (XO) generates superoxide anions and H(2)O(2) for the self-defence system of organism. Abnormal production of this superoxide's (reactive oxygen species) is responsible for a number of complications including inflammation, metabolic disorder, cellular aging, reperfusion damage, atherosclerosis and carcinogenesis. Series of novel trisubstituted thiophenyl-1-thiazolyl-2-pyrazoline libraries are synthesized containing 2,5-dichloro thiophene, 5-chloro-2-(benzylthio) thiophene and 5-chlorothiophene-2-sulphonamide, from chalcones in PEG-400 as green solvent. Superoxide (XO) inhibitory and free radical scavenging activities were also figured out with molecular modeling analysis, bearing in mind their possible future for super oxide inhibitor (Gout) therapeutics, compound 3k shows interesting superoxide inhibitory and free radical scavenger activity with IC(50)=6.2 μM, in comparison with allopurinol.
Several 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-c... more Several 1-(4-(4'-chlorophenyl)-2-thiazolyl)-3-aryl-5-(2-butyl-4-chloro-1H-imidazol-5yl)-2-pyrazoline derivatives were prepared by the base catalyzed treatment of appropriate chalcones with 4-(4'-chlorophenyl)-2-hydrazino-thiazole in poly (ethylene glycol) (PEG-400) as an alternative reaction solvent. All the synthesized compounds were tested for their antimicrobial activities against Escherichia coli (MTCC 2939), Salmonella typhi (MTCC 98), Staphylococcus aureus (MTCC 96), Bacillus subtilis (MTCC 441), Aspergillus niger (MTCC 281), Trichoderma viridae (MTCC 167), Penicillium chrysogenum (MTCC 160), Fusarium moniliforme (MTCC 156) and Candida albicans (MTCC 183). Most of the compounds showed potent antibacterial and antifungal activity.