Gary Takeoka - Academia.edu (original) (raw)

Papers by Gary Takeoka

Flavour and Fragrance Journal, May 26, 2004

Journal of Food Biochemistry, Apr 1, 1992

Journal of Food Processing and Preservation, Jul 12, 2017

Phytotherapy Research, Aug 11, 2008

Piperlongumine, a pyridone alkaloid isolated from Piper longum L., exhibited a potential inhibito... more Piperlongumine, a pyridone alkaloid isolated from Piper longum L., exhibited a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid (AA) and platelet activating factor (PAF), without any inhibitory effect on that induced by thrombin. Piperlongumine was used as a lead compound for the synthesis of new antiplatelet agents. Seven synthetic compounds were newly synthesized from 3,4,5-trimethoxycinnamic acid (TMCA). They were 1-piperidin-1-yl-3-(3,4,5-trimethoxy-phenyl)prop-2-en-1-one (1'), 1-morpholin-4-yl-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (2'), 1-(3,5-dimethylpiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (3'), 1-(2-methylpiperidin-1-yl)-3-(3,4,5-tri-methoxyphenyl)prop-2-en-1-one (4'), 1-(3-hydroxypiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)- prop-2-en-1-one (5'), 1-[3-(3,4,5-tri-methoxyphenyl) acryloyl]-piperidin-2-one (6') and ethyl 1-[3-(3,4,5-trimethoxyphenyl)-acryloyl]piperidine-4-carboxylate (7'). Among those seven synthetic derivatives, 1-(3,5-dimethylpiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (3') had the most inhibitory effect on platelet aggregation induced by collagen, AA and PAF.

Journal of Agricultural and Food Chemistry, Jun 9, 2001

Journal of Agricultural and Food Chemistry, Jul 8, 2000

Acs Symposium Series, Aug 13, 1996

Springer eBooks, 1999

Vegetables are edible plant products which can be modified stems, roots, leaves, flowers, or even... more Vegetables are edible plant products which can be modified stems, roots, leaves, flowers, or even fruits. They are usually classified on the basis of the part of the plant that is used for food. Stem vegetables include asparagus and kohlrabi while beets, carrots, radishes and turnips are root vegetables. Among the leaf and leafstalk vegetables are brussel sprouts, cabbage, celery, endive, kale, lettuce, rhubarb and spinach. The head or flower vegetables include artichokes, broccoli, and cauliflower. Garlic, leeks, and onions are classified as bulb vegetables. Botanically, the term “fruit” applies to the structure, usually containing seeds, which develops from the flower ovary after pollination and fertilization (Vaughan and Geissler, 1997). Therefore, beans, cucumbers, eggplant, okra, peppers, squash, sweet corn and tomatoes would be classified as fruits according to this definition. However, the important distinction between fruits and vegetables has come to be made on a usage basis; those plant products that are usually consumed with the main course of a meal are considered to be vegetables while those used mainly as desserts are considered fruits.

American Chemical Society eBooks, Nov 8, 1985

Phytochemistry, Sep 1, 2010

Acs Symposium Series, May 13, 1992

Journal of Agricultural and Food Chemistry, Aug 1, 1994

Journal of Agricultural and Food Chemistry, Oct 1, 1991

Journal of Agricultural and Food Chemistry, Aug 1, 1997

Acs Symposium Series, Sep 30, 2008

Functional foods & nutraceuticals series, Apr 16, 2002

Phytomedicine, Jun 1, 2008

Journal of Agricultural and Food Chemistry, Jan 29, 2005

The growth-inhibiting activity of anthraquinone-2-carboxylic acid and lapachol identified in the ... more The growth-inhibiting activity of anthraquinone-2-carboxylic acid and lapachol identified in the inner bark of taheebo, Tabebuia impetiginosa, toward 10 human intestinal bacteria was evaluated by using a paper disk diffusion bioassay and compared to those of seven lapachol congeners (1,4-naphthoquinone, naphthazarin, menadione, lawsone, plumbagin, juglone, and dichlone) as well as two commercially available antibiotics, chloramphenicol and tetracycline. Anthraquinone-2-carboxylic acid exhibited very strong growth inhibition of Clostridium paraputrificum at 1 microg/disk while 100 microg/disk of lapachol was needed for moderate growth inhibition of the same organism. These two isolates exhibited weak inhibition of Clostridium perfringens and Escherichia coli at 100 microg/disk while no adverse effects were observed on the growth of Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium infantis, Lactobacillus acidophilus, and Lactobacillus casei at 1000 microg/disk. Structure-activity relationships indicate that a methyl group in the C-2 position of 1,4-naphthoquinone derivatives might play an important role in antibacterial activity.

Journal of Agricultural and Food Chemistry, Oct 1, 1992

Flavour and Fragrance Journal, May 26, 2004

Journal of Food Biochemistry, Apr 1, 1992

Journal of Food Processing and Preservation, Jul 12, 2017

Phytotherapy Research, Aug 11, 2008

Piperlongumine, a pyridone alkaloid isolated from Piper longum L., exhibited a potential inhibito... more Piperlongumine, a pyridone alkaloid isolated from Piper longum L., exhibited a potential inhibitory effect on washed rabbit platelet aggregation induced by collagen, arachidonic acid (AA) and platelet activating factor (PAF), without any inhibitory effect on that induced by thrombin. Piperlongumine was used as a lead compound for the synthesis of new antiplatelet agents. Seven synthetic compounds were newly synthesized from 3,4,5-trimethoxycinnamic acid (TMCA). They were 1-piperidin-1-yl-3-(3,4,5-trimethoxy-phenyl)prop-2-en-1-one (1'), 1-morpholin-4-yl-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (2'), 1-(3,5-dimethylpiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (3'), 1-(2-methylpiperidin-1-yl)-3-(3,4,5-tri-methoxyphenyl)prop-2-en-1-one (4'), 1-(3-hydroxypiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)- prop-2-en-1-one (5'), 1-[3-(3,4,5-tri-methoxyphenyl) acryloyl]-piperidin-2-one (6') and ethyl 1-[3-(3,4,5-trimethoxyphenyl)-acryloyl]piperidine-4-carboxylate (7'). Among those seven synthetic derivatives, 1-(3,5-dimethylpiperidin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (3') had the most inhibitory effect on platelet aggregation induced by collagen, AA and PAF.

Journal of Agricultural and Food Chemistry, Jun 9, 2001

Journal of Agricultural and Food Chemistry, Jul 8, 2000

Acs Symposium Series, Aug 13, 1996

Springer eBooks, 1999

Vegetables are edible plant products which can be modified stems, roots, leaves, flowers, or even... more Vegetables are edible plant products which can be modified stems, roots, leaves, flowers, or even fruits. They are usually classified on the basis of the part of the plant that is used for food. Stem vegetables include asparagus and kohlrabi while beets, carrots, radishes and turnips are root vegetables. Among the leaf and leafstalk vegetables are brussel sprouts, cabbage, celery, endive, kale, lettuce, rhubarb and spinach. The head or flower vegetables include artichokes, broccoli, and cauliflower. Garlic, leeks, and onions are classified as bulb vegetables. Botanically, the term “fruit” applies to the structure, usually containing seeds, which develops from the flower ovary after pollination and fertilization (Vaughan and Geissler, 1997). Therefore, beans, cucumbers, eggplant, okra, peppers, squash, sweet corn and tomatoes would be classified as fruits according to this definition. However, the important distinction between fruits and vegetables has come to be made on a usage basis; those plant products that are usually consumed with the main course of a meal are considered to be vegetables while those used mainly as desserts are considered fruits.

American Chemical Society eBooks, Nov 8, 1985

Phytochemistry, Sep 1, 2010

Acs Symposium Series, May 13, 1992

Journal of Agricultural and Food Chemistry, Aug 1, 1994

Journal of Agricultural and Food Chemistry, Oct 1, 1991

Journal of Agricultural and Food Chemistry, Aug 1, 1997

Acs Symposium Series, Sep 30, 2008

Functional foods & nutraceuticals series, Apr 16, 2002

Phytomedicine, Jun 1, 2008

Journal of Agricultural and Food Chemistry, Jan 29, 2005

The growth-inhibiting activity of anthraquinone-2-carboxylic acid and lapachol identified in the ... more The growth-inhibiting activity of anthraquinone-2-carboxylic acid and lapachol identified in the inner bark of taheebo, Tabebuia impetiginosa, toward 10 human intestinal bacteria was evaluated by using a paper disk diffusion bioassay and compared to those of seven lapachol congeners (1,4-naphthoquinone, naphthazarin, menadione, lawsone, plumbagin, juglone, and dichlone) as well as two commercially available antibiotics, chloramphenicol and tetracycline. Anthraquinone-2-carboxylic acid exhibited very strong growth inhibition of Clostridium paraputrificum at 1 microg/disk while 100 microg/disk of lapachol was needed for moderate growth inhibition of the same organism. These two isolates exhibited weak inhibition of Clostridium perfringens and Escherichia coli at 100 microg/disk while no adverse effects were observed on the growth of Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium infantis, Lactobacillus acidophilus, and Lactobacillus casei at 1000 microg/disk. Structure-activity relationships indicate that a methyl group in the C-2 position of 1,4-naphthoquinone derivatives might play an important role in antibacterial activity.

Journal of Agricultural and Food Chemistry, Oct 1, 1992