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Papers by Gurid Mulyo

Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat

Prehypertension is an early condition that can cause arterial hypertension in its later developme... more Prehypertension is an early condition that can cause arterial hypertension in its later development into cardiovascular disease. Low intake of vitamin C and high intake of sodium at productive age have the risk of triggering the development of degenerative diseases such as hypertension. This study aims to determine the effectiveness of giving guava pudding on blood pressure in the prehypertension group in the work area of ​​the Padasuka Public Health Center, Bandung City. This type of research is a quasi two group with a control experimental design using pre-test and post-test. The sampling technique used is simple random sampling. Intake data were collected using a Semiquantitative Food Frequency Questionnaire (SFFQ) method while blood pressure data was measured using a Digital Sphygmomanometer. The research data were analyzed using Paired T-Test and Wilcoxon test. The results showed that the average intake of vitamin C in the treatment group increased by 186% and sodium intake dec...

Jurnal Gizi dan Dietetik

Salah satu masalah yang berkaitan dengan perilaku makan adalah kurangnya konsumsi sayur dan buah.... more Salah satu masalah yang berkaitan dengan perilaku makan adalah kurangnya konsumsi sayur dan buah. Kurangnya pengetahuan mengurangi kemampuan seseorang untuk menerapkan informasi gizi dalam kehidupan sehari-hari. Pendidikan gizi merupakan salah satu upaya untuk menanggulangi masalah konsumsi sayur dan buah. Penelitian ini bertujuan untuk mengetahui pengaruh pendidikan gizi dengan media aplikasi My Food Record berbasis android terhadap pengetahuan serta konsumsi sayur dan buah pada remaja di SMPN 8 Cimahi. Desain penelitian ini yaitu quasi experiment dengan rancangan pretest-posttest with control group design. Teknik pengambilan sampel secara purposive sampling sebanyak 20 orang untuk masing-masing kelompok. Pada kelompok intervensi rata-rata skor pengetahuan sebelum intervensi 40,33 dan setelah intervensi 48,00. Rata-rata jumlah konsumsi sayur per hari sebelum intervensi 108,93 gram dan setelah intervensi 123,12 gram. Rata-rata konsumsi buah per hari sebelum intervensi 294,23 dan set...

Jurnal Gizi dan Dietetik

Egg Roll yang terbuat dari tape ketan hitam dan buah naga merupakan produk makanan selingan tingg... more Egg Roll yang terbuat dari tape ketan hitam dan buah naga merupakan produk makanan selingan tinggi serat dan antioksidan. Tujuan penelitian ini yaitu untuk menetapkan tiga formulasi terbaik dan mengetahui pengaruh imbangan yang berbeda terhadap tingkat kesukaan, kadar serat, kadar antosianin, dan aktivitas antioksidan. Desain penelitian ini adalah eksperimental dengan Rancangan Acak Lengkap (RAL). Metode penelitian menggunakan uji hedonik untuk tingkat kesukaan, enzimatik gravimetri untuk serat, spetrofotometri diferensial untuk antosianin, dan spetrofotometri Uv-Vis DPPH untuk aktivitas antioksidan. Penelitian ini melibatkan 30 panelis agak terlatih yang merupakan mahasiswa Jurusan Gizi Poltekkes Kemenkes Bandung. Data dianalisis menggunakan Uji Kruskal Wallis dan dilanjutkan dengan uji Man Whitney. Hasil penelitian uji hedonik menunjukan bahwa formula 1 dengan imbangan 30% tape ketan hitam : 70% buah naga memiliki tingkat kesukaan paling tinggi pada aspek warna, rasa, aroma, tek...

Current Nutrition & Food Science

Background: Good nutritional intake is very important for pregnant women to prevent stunting in c... more Background: Good nutritional intake is very important for pregnant women to prevent stunting in children. However, the problem of CED in pregnant women in Indonesia remains high. Higher choline intake in pregnant women is associated with better memory in a child by the time the child turns 7 years old. Choline functions in the process of methylation and cholinergic transmission during the process of brain development in children. Modification of the high choline diet in daily menu is needed by pregnant women to increase choline intake and size of MUAC. Objective: This study aims to examine the effectiveness of high choline diet modification on changes in choline intake and size of MUAC in pregnant women. Methods: A total of 14 pregnant women in the treatment group received 2 eggs every day, while 13 pregnant women in the control group received education on balanced nutrition during the study period. Changes in choline intake and size of MUAC were stastiscally compared between the tw...

Jurnal Riset Kesehatan Poltekkes Depkes Bandung, May 30, 2021

Obesity is a global health problem. Recently, the composition of the gut microbiota, especially F... more Obesity is a global health problem. Recently, the composition of the gut microbiota, especially Firmicutes and Bacteroidetes, has been suggested to be one of the factors that play a role in the incidence of obesity. The purpose of this study was to describe the composition of Firmicutes and Bacteroidetes in obesity. The research design used is a literature study. The literature used is journals that meet the inclusion criteria, namely a total of 6 articles. The results of the literature study showed that there were different results on the composition of the gut microbiota in obesity. Several journals showed that the composition of Firmicutes increased and Bacteroidetes decreased in obesity, while other studies showed Firmicutes and Bacteroidetes increased in the obese group compared to the normal weight group. Furthermore, in another study, it was found that Bacteroidetes and Firmicutes were higher in the lean group compared to the obese group. However, it was also found that there was no clear difference between the phyla Firmicutes and Bacteroidetes according to BMI

PubMed, Dec 27, 2022

Green tea (Camellia sinensis) has benefits. Its main potential content is epigallocatechin gallat... more Green tea (Camellia sinensis) has benefits. Its main potential content is epigallocatechin gallate, which has many bioactivity and pharmacological properties. However, herbal medicines have limitations on low solubility and stability. A nanoparticle delivery system is a perfect form of active ingredient development, because it can mediate the increase in solubility, dissolution rate, and strength of a targeted delivery system. This study aimed to make and test the formulation of the ethanol and ethyl acetate fraction from green tea leaves in the form of a nanoparticle delivery system using chitosan biopolymer as the primary carrier polymer combined with sodium tripolyphosphate as a crosslinker and then carried out the tests on the MDA-MB-231 breast cancer cell line. The results showed that the particle size value was 199.7 nm, the zeta potential was-56.7 mV, and the polydispersity index was 0.337. X-ray diffraction and differential scanning calorimetry test results showed that the C. sinensis fraction was perfectly dispersed molecularly in the nanoparticle system. The results of the cytotoxic test on the MDA-MB-231 breast cancer cell line obtained IC50 values for both fractions, namely 10.70 μg/mL (nano ethanol fraction) and 12.72 μg/mL (nano ethyl acetate fraction). This result showed a significant increase in anticancer activity in both fractions compared to those not formulated (P < 0.05). These results also show that the C. sinensis tea fraction formulated in a nanoparticle delivery system has a great potential as a new therapeutic agent for breast cancer.

AcTion : Aceh nutrition journal, Aug 17, 2019

ASI eksklusif sangat bermanfaat bagi bayi, dampak yang dapat terjadi apabila bayi tidak diberikan... more ASI eksklusif sangat bermanfaat bagi bayi, dampak yang dapat terjadi apabila bayi tidak diberikan ASI eksklusif adalah meningkatnya angka kesakitan dan kematian bayi, masalah gizi, gangguan tumbuh kembang anak, terjadinya loss generation, meningkatkan beban pengeluaran keluarga serta negara untuk pengeluaran susu formula dan masih banyak lagi. Tujuan penelitian untuk menganalisis hubungan pengetahuan, sikap, perilaku dan karakteristik Ibu terhadap pemberian ASI eksklusif dengan status gizi bayi. Penelitian menggunakan metode kuantitatif dengan desain observasional secara kasus kontrol. Penelitian dilakukan 110 ibu yang memiliki bayi usia 6-12 bulan di kelurahan Cibangkong Bandung yang terdiri dari 55 ibu yang memiliki bayi dengan masalah gizi dan 55 ibu yang memiliki bayi dengan status gizi normal. Pengambilan data menggunakan kuesioner. Penilaian status gizi menggunakan standar WHO child growth standards. Sampel diambil dengan teknik simple random sampling. Analisis data menggunakan Uji Regresi logistik. Hasil menunjukkan bahwa terdapat hubungan antara pengetahuan (p= 0,006), dan perilaku pemberian ASI eksklusif (p=0,013) dengan status gizi bayi. Selain itu, karakteristik ibu yaitu umur dan paritas berpengaruh sebesar 4,3 kali dalam status gizi bayi. Dengan diketahuinya hubungan faktor pegetahuan, sikap, perilaku dan karakteristik ibu dengan status gizi bayi, diharapkan mempunyai daya ungkit terhadap peningkatan status gizi bayi.

Open Access Macedonian Journal of Medical Sciences, Jan 2, 2022

BACKGROUND: Patients with hypertension are estimated to reach 1 billion globally, where 972 milli... more BACKGROUND: Patients with hypertension are estimated to reach 1 billion globally, where 972 million (26%) of the adults in the world suffer from hypertension. Predicted by 2025, about 29% of adults worldwide suffer from hypertension, and two-thirds of them are in developing countries. Increased blood pressure (BP) that takes place in a long time can cause damage to the kidneys, heart, and brain when not detected early and received adequate treatment. The intervention of hypertension is still constrained in chemical drug pharmacological therapy. For nonpharmacological or complementary treatment such as deep breath relaxation and roasted garlic, consumption is already known in the community but not maximized utilized. AIM: Hence, a combination of this intervention needs to be developed to assess the effect of synergies. METHODS: The study was conducted in the west Bogor district with samples of 34 Pre-elderly and elderly respondents. Design of pre-experiment One Group Pre-Post Test Design by working combination intervention. Analysis of T-dependent tests and simple linear regression correlation. RESULTS: There is an influence of combination intervention on the second measurement of the day of intervention of the Systolic BP (p-value 0.006), a mean of 6.56 mmHg decrease, against diastole BP (p-value Vauile) is disclosed difference of 3.82 mmHg. In the post-intervention measurement of the Systolic BP (p-value 0.000) is a mean 8.86 mmHg, of diastole BP not the influence (p-value 0.103) with a decrease of 2.60 mmHg, there is an age correlation to the average of the decision of BP of the system of the Systole (p-value 0.006) shows the relationship and patterned positive. CONCLUSION: They recommended research results to alternative, complementary therapy effectively lowering BP in the community.

Open Access Macedonian Journal of Medical Sciences, Jan 3, 2022

BACKGROUND: Foods consumed with fiber sources will be different from foods not consumed with fibe... more BACKGROUND: Foods consumed with fiber sources will be different from foods not consumed with fiber sources because fiber has a mechanism to lower blood sugar levels. However, the difference or the correlation factor is not yet known. AIM: This study aims to determine the differences in changes in blood sugar levels in the fruit or vegetable intervention and to determine the correction factor for changes in blood sugar levels and the glycemic index (GI) of food. METHODS: The research design used was experimental with a pre-post design; the sampling technique used purposive sampling totaling 13 people divided into two groups, namely, the fruit and vegetable group. The sample was selected under normal circumstances and had no history of diabetes mellitus. Blood sugar levels taken were fasting blood sugar levels at 0', 30', 60', 90', and 120' after the intervention to see a graph of changes in blood sugar levels. The statistical analysis used is ANOVA/Kruskal-Wallis. RESULTS: The results showed a significant difference (p < 0.005) in comparing standard bread with bread and avocado and bread and beans at 30' after the intervention. After the intervention, bread with watermelon showed significant results at 120' and bread with carrots at 90'. The highest GI and the lowest correction factor for changes in blood sugar levels were shown in watermelon. In contrast, the lowest GI and the highest correction factor were shown in avocado. CONCLUSION: When compared between the four interventions, giving avocados were more able to lower blood sugar levels.

Disaster and Emergency Medicine Journal, Dec 30, 2022

This article is available in open access under Creative Common Attribution-Non-Commercial-No Deri... more This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, 2019

The safe ice cream which is consumed by Diabetes Mellitus sufferers is made by subtituting skim m... more The safe ice cream which is consumed by Diabetes Mellitus sufferers is made by subtituting skim milk, cream and sugar with kefir, pure pumpkin, cornstarch, vegetable oil, and artificial sweetener special gor Diabetes Mellitus. The aim of this research is knowing predilection level test to ice cream pumpkin kefir, microbes total, beta-caroten levels, and antioxidant levels. This research is conducted with experimental method. The research method used hedonic test to determine the level of preference, total plate count method to determine the number of microbes, UV-Vis spectrophotometry method for testing beta-carotene levels, and DPPH method for testing antioxidant levels. The results of the Kruskal Wallis test showed differences in the level of texture preference and there were no differences that appreciated the level of taste, color, and aroma. Ice cream pumpkin kefir that is liked most are from texture, taste, color and aroma side exists in balance F2 with the ratio of kefir and ...

Potravinarstvo, Sep 1, 2022

In disaster conditions, the elderly are vulnerable groups that require special attention. With in... more In disaster conditions, the elderly are vulnerable groups that require special attention. With increasing age, there is a decrease in biological function and psychological disorders. The elderly tend to have anxiety, especially during disaster conditions. This anxiety has an impact on the diet and health of the elderly. Soybean (Glycine max L.) flour biscuits and Ambon banana (Musa paradisiaca var. sapientum L.) flour is a food product that meets disaster emergency food requirements and food requirements for the elderly. It is appropriate to be used as an alternative disaster emergency food for the elderly. This study aims to determine the effect of the balance of the soybean flour biscuit formula Ambon banana flour on the organoleptic and protein properties. The research design used is an experimental study, with the research method used is a hedonic test for testing organoleptic properties and the Kjeldahl procedure for testing protein content. The formula of Ambon banana and soybean flour biscuits consisted of three balances, with the ratio of Ambon banana flour soybean flour (%) F1 (45:55), F2 (35:65), and F3 (25:75). From the study results, it can be concluded that there is a significant difference in the test results of organoleptic properties only for colour. Moreover, there are no significant differences in the test results of organoleptic properties, including aroma, taste, texture, and overall. In the test results of organoleptic properties, the balance (25:75) was declared superior overall. The 45:55 balance contains 8.01% protein, the 35:65 balance contains 7.23% protein, and the 25:75 balance includes 7.42%.

Open Access Macedonian Journal of Medical Sciences, Mar 25, 2022

BACKGROUND: Older toddlers period (children aged 6-23 months) is often referred to as the "golden... more BACKGROUND: Older toddlers period (children aged 6-23 months) is often referred to as the "golden age," "critical period." The World Bank (2006) refers to it as the "window of opportunity" because it is one of the periods of dealing with stunted and severe stunted the most effective. The immediate cause of stunting is a lack of food intake and infectious diseases. Therefore, maternal knowledge about nutrition influences behavior and attitudes in choosing food. Ignorance of foods with good nutrition will cause the selection of the wrong food, and poor nutrition will cause the child's nutritional status to be poor and lacking. AIM: This study aimed to determine the relationship of nutritional knowledge to the nutritional status of the height/age index in older toddlers in Sumbang District, Banyumas Regency, Central Java. METHODS: This descriptive-analytic study was taken from secondary data using a cross-sectional design conducted on 736 mothers who have older toddlers in Sumbang District, Banyumas Regency, Central Java. RESULTS: There is no relationship between the nutritional status of children under 2 years old (H/A) with maternal age (p = 0.441), mother's education (p = 0.232), and mother's occupation (p = 0.284). There is a relationship between the nutritional status of children under 2 years (H/A) and mother's knowledge (p = 0.002). CONCLUSION: This study aimed to determine the relationship of nutritional knowledge to the nutritional status of the height/age index in older toddlers in Sumbang District, Banyumas Regency, Central Java. There is no relationship between the nutritional status of children under 2 years old (H/A) with maternal age (p = 0.441), mother's education (p = 0.232), and mother's occupation (p = 0.284). There is a relationship between the nutritional status of children under 2 years (H/A) and mother's knowledge (p = 0.002).

Jurnal Riset Kesehatan Poltekkes Depkes Bandung, 2014

Open Access Macedonian Journal of Medical Sciences, 2022

BACKGROUND: Sexually transmitted infections (STIs) are preventable and treatable diseases. Female... more BACKGROUND: Sexually transmitted infections (STIs) are preventable and treatable diseases. Female sex workers are more susceptible to contracting STIs. Successful prevention of STIs will not be achieved without community involvement and patient compliance in implementing prevention programs. AIM: The study aimed to analyze the effect of integrative counseling on knowledge and attitudes about STIs. METHODS: This type of research is a quasi-experiment with a pre-post test two-group design. The population was female sexual workers (FSW) at the Mawar PKBI clinic in Bandung City. The number of samples per group was 28 people. The sampling technique was the purposive sampling technique. The knowledge and attitude instruments used a questionnaire. Differences in knowledge and attitudes pre and post-test in the treatment and control groups used the dependent t-test. The effect of integrative counseling on knowledge and attitudes was used in the independent t-test. RESULTS: This study showed...

Open Access Macedonian Journal of Medical Sciences, 2022

BACKGROUND: Exclusive breastfeeding is the cornerstone of a child’s survival and health because i... more BACKGROUND: Exclusive breastfeeding is the cornerstone of a child’s survival and health because it provides essential and irreplaceable nutrients for their growth and development. The coverage rate for exclusive breastfeeding for infants 0–6 months in West Java in 2017 was 55.4%, below the national figure of 61.33%. AIM: The purpose of this article is to identify the failure factors for exclusive breastfeeding. METHODS: The study began with a quasi-experimental period with a pre- and post-test group design approach through a health education process about exclusive breastfeeding in the third trimester of pregnancy, followed by a prospective study on breastfeeding practice in infants in the first 6 months of life. The analysis used was Chi-square analysis (χ2) and Paired t-test. Then, followed by a qualitative study to explore the supports and barriers to exclusive breastfeeding through in-depth interviews and carried out an analysis with modified Aronso’s qualitative analysis steps....

Open Access Macedonian Journal of Medical Sciences, 2021

The strategy for reducing maternal mortality is through increasing empowerment of women, families... more The strategy for reducing maternal mortality is through increasing empowerment of women, families, and communities. Families are expected to play an active role in knowing and making efforts to prevent maternal and infant morbidity and mortality—the number of cases of maternal death in Kab. Karawang in 2015 and 2016, respectively, as many as 68 cases and 61 cases, the main causes are preeclampsia, bleeding, and comorbidities. The aim is to determine the effect of Warneng’s booklet on increasing knowledge and attitudes of pregnant women towards early detection of pregnancy complications. The research design used a quasi-experimental design, non-equivalent control group. The research location was carried out in the areas of Purwasari Health Center and Rengasdengklok Health Center. The population is pregnant women in trimester I-III, with a total sample of 70 respondents. The analysis test used t-test and Mann Whitney U. The sampling technique used purposive random sampling. Degree of ...

Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat

Prehypertension is an early condition that can cause arterial hypertension in its later developme... more Prehypertension is an early condition that can cause arterial hypertension in its later development into cardiovascular disease. Low intake of vitamin C and high intake of sodium at productive age have the risk of triggering the development of degenerative diseases such as hypertension. This study aims to determine the effectiveness of giving guava pudding on blood pressure in the prehypertension group in the work area of ​​the Padasuka Public Health Center, Bandung City. This type of research is a quasi two group with a control experimental design using pre-test and post-test. The sampling technique used is simple random sampling. Intake data were collected using a Semiquantitative Food Frequency Questionnaire (SFFQ) method while blood pressure data was measured using a Digital Sphygmomanometer. The research data were analyzed using Paired T-Test and Wilcoxon test. The results showed that the average intake of vitamin C in the treatment group increased by 186% and sodium intake dec...

Jurnal Gizi dan Dietetik

Salah satu masalah yang berkaitan dengan perilaku makan adalah kurangnya konsumsi sayur dan buah.... more Salah satu masalah yang berkaitan dengan perilaku makan adalah kurangnya konsumsi sayur dan buah. Kurangnya pengetahuan mengurangi kemampuan seseorang untuk menerapkan informasi gizi dalam kehidupan sehari-hari. Pendidikan gizi merupakan salah satu upaya untuk menanggulangi masalah konsumsi sayur dan buah. Penelitian ini bertujuan untuk mengetahui pengaruh pendidikan gizi dengan media aplikasi My Food Record berbasis android terhadap pengetahuan serta konsumsi sayur dan buah pada remaja di SMPN 8 Cimahi. Desain penelitian ini yaitu quasi experiment dengan rancangan pretest-posttest with control group design. Teknik pengambilan sampel secara purposive sampling sebanyak 20 orang untuk masing-masing kelompok. Pada kelompok intervensi rata-rata skor pengetahuan sebelum intervensi 40,33 dan setelah intervensi 48,00. Rata-rata jumlah konsumsi sayur per hari sebelum intervensi 108,93 gram dan setelah intervensi 123,12 gram. Rata-rata konsumsi buah per hari sebelum intervensi 294,23 dan set...

Jurnal Gizi dan Dietetik

Egg Roll yang terbuat dari tape ketan hitam dan buah naga merupakan produk makanan selingan tingg... more Egg Roll yang terbuat dari tape ketan hitam dan buah naga merupakan produk makanan selingan tinggi serat dan antioksidan. Tujuan penelitian ini yaitu untuk menetapkan tiga formulasi terbaik dan mengetahui pengaruh imbangan yang berbeda terhadap tingkat kesukaan, kadar serat, kadar antosianin, dan aktivitas antioksidan. Desain penelitian ini adalah eksperimental dengan Rancangan Acak Lengkap (RAL). Metode penelitian menggunakan uji hedonik untuk tingkat kesukaan, enzimatik gravimetri untuk serat, spetrofotometri diferensial untuk antosianin, dan spetrofotometri Uv-Vis DPPH untuk aktivitas antioksidan. Penelitian ini melibatkan 30 panelis agak terlatih yang merupakan mahasiswa Jurusan Gizi Poltekkes Kemenkes Bandung. Data dianalisis menggunakan Uji Kruskal Wallis dan dilanjutkan dengan uji Man Whitney. Hasil penelitian uji hedonik menunjukan bahwa formula 1 dengan imbangan 30% tape ketan hitam : 70% buah naga memiliki tingkat kesukaan paling tinggi pada aspek warna, rasa, aroma, tek...

Current Nutrition & Food Science

Background: Good nutritional intake is very important for pregnant women to prevent stunting in c... more Background: Good nutritional intake is very important for pregnant women to prevent stunting in children. However, the problem of CED in pregnant women in Indonesia remains high. Higher choline intake in pregnant women is associated with better memory in a child by the time the child turns 7 years old. Choline functions in the process of methylation and cholinergic transmission during the process of brain development in children. Modification of the high choline diet in daily menu is needed by pregnant women to increase choline intake and size of MUAC. Objective: This study aims to examine the effectiveness of high choline diet modification on changes in choline intake and size of MUAC in pregnant women. Methods: A total of 14 pregnant women in the treatment group received 2 eggs every day, while 13 pregnant women in the control group received education on balanced nutrition during the study period. Changes in choline intake and size of MUAC were stastiscally compared between the tw...

Jurnal Riset Kesehatan Poltekkes Depkes Bandung, May 30, 2021

Obesity is a global health problem. Recently, the composition of the gut microbiota, especially F... more Obesity is a global health problem. Recently, the composition of the gut microbiota, especially Firmicutes and Bacteroidetes, has been suggested to be one of the factors that play a role in the incidence of obesity. The purpose of this study was to describe the composition of Firmicutes and Bacteroidetes in obesity. The research design used is a literature study. The literature used is journals that meet the inclusion criteria, namely a total of 6 articles. The results of the literature study showed that there were different results on the composition of the gut microbiota in obesity. Several journals showed that the composition of Firmicutes increased and Bacteroidetes decreased in obesity, while other studies showed Firmicutes and Bacteroidetes increased in the obese group compared to the normal weight group. Furthermore, in another study, it was found that Bacteroidetes and Firmicutes were higher in the lean group compared to the obese group. However, it was also found that there was no clear difference between the phyla Firmicutes and Bacteroidetes according to BMI

PubMed, Dec 27, 2022

Green tea (Camellia sinensis) has benefits. Its main potential content is epigallocatechin gallat... more Green tea (Camellia sinensis) has benefits. Its main potential content is epigallocatechin gallate, which has many bioactivity and pharmacological properties. However, herbal medicines have limitations on low solubility and stability. A nanoparticle delivery system is a perfect form of active ingredient development, because it can mediate the increase in solubility, dissolution rate, and strength of a targeted delivery system. This study aimed to make and test the formulation of the ethanol and ethyl acetate fraction from green tea leaves in the form of a nanoparticle delivery system using chitosan biopolymer as the primary carrier polymer combined with sodium tripolyphosphate as a crosslinker and then carried out the tests on the MDA-MB-231 breast cancer cell line. The results showed that the particle size value was 199.7 nm, the zeta potential was-56.7 mV, and the polydispersity index was 0.337. X-ray diffraction and differential scanning calorimetry test results showed that the C. sinensis fraction was perfectly dispersed molecularly in the nanoparticle system. The results of the cytotoxic test on the MDA-MB-231 breast cancer cell line obtained IC50 values for both fractions, namely 10.70 μg/mL (nano ethanol fraction) and 12.72 μg/mL (nano ethyl acetate fraction). This result showed a significant increase in anticancer activity in both fractions compared to those not formulated (P < 0.05). These results also show that the C. sinensis tea fraction formulated in a nanoparticle delivery system has a great potential as a new therapeutic agent for breast cancer.

AcTion : Aceh nutrition journal, Aug 17, 2019

ASI eksklusif sangat bermanfaat bagi bayi, dampak yang dapat terjadi apabila bayi tidak diberikan... more ASI eksklusif sangat bermanfaat bagi bayi, dampak yang dapat terjadi apabila bayi tidak diberikan ASI eksklusif adalah meningkatnya angka kesakitan dan kematian bayi, masalah gizi, gangguan tumbuh kembang anak, terjadinya loss generation, meningkatkan beban pengeluaran keluarga serta negara untuk pengeluaran susu formula dan masih banyak lagi. Tujuan penelitian untuk menganalisis hubungan pengetahuan, sikap, perilaku dan karakteristik Ibu terhadap pemberian ASI eksklusif dengan status gizi bayi. Penelitian menggunakan metode kuantitatif dengan desain observasional secara kasus kontrol. Penelitian dilakukan 110 ibu yang memiliki bayi usia 6-12 bulan di kelurahan Cibangkong Bandung yang terdiri dari 55 ibu yang memiliki bayi dengan masalah gizi dan 55 ibu yang memiliki bayi dengan status gizi normal. Pengambilan data menggunakan kuesioner. Penilaian status gizi menggunakan standar WHO child growth standards. Sampel diambil dengan teknik simple random sampling. Analisis data menggunakan Uji Regresi logistik. Hasil menunjukkan bahwa terdapat hubungan antara pengetahuan (p= 0,006), dan perilaku pemberian ASI eksklusif (p=0,013) dengan status gizi bayi. Selain itu, karakteristik ibu yaitu umur dan paritas berpengaruh sebesar 4,3 kali dalam status gizi bayi. Dengan diketahuinya hubungan faktor pegetahuan, sikap, perilaku dan karakteristik ibu dengan status gizi bayi, diharapkan mempunyai daya ungkit terhadap peningkatan status gizi bayi.

Open Access Macedonian Journal of Medical Sciences, Jan 2, 2022

BACKGROUND: Patients with hypertension are estimated to reach 1 billion globally, where 972 milli... more BACKGROUND: Patients with hypertension are estimated to reach 1 billion globally, where 972 million (26%) of the adults in the world suffer from hypertension. Predicted by 2025, about 29% of adults worldwide suffer from hypertension, and two-thirds of them are in developing countries. Increased blood pressure (BP) that takes place in a long time can cause damage to the kidneys, heart, and brain when not detected early and received adequate treatment. The intervention of hypertension is still constrained in chemical drug pharmacological therapy. For nonpharmacological or complementary treatment such as deep breath relaxation and roasted garlic, consumption is already known in the community but not maximized utilized. AIM: Hence, a combination of this intervention needs to be developed to assess the effect of synergies. METHODS: The study was conducted in the west Bogor district with samples of 34 Pre-elderly and elderly respondents. Design of pre-experiment One Group Pre-Post Test Design by working combination intervention. Analysis of T-dependent tests and simple linear regression correlation. RESULTS: There is an influence of combination intervention on the second measurement of the day of intervention of the Systolic BP (p-value 0.006), a mean of 6.56 mmHg decrease, against diastole BP (p-value Vauile) is disclosed difference of 3.82 mmHg. In the post-intervention measurement of the Systolic BP (p-value 0.000) is a mean 8.86 mmHg, of diastole BP not the influence (p-value 0.103) with a decrease of 2.60 mmHg, there is an age correlation to the average of the decision of BP of the system of the Systole (p-value 0.006) shows the relationship and patterned positive. CONCLUSION: They recommended research results to alternative, complementary therapy effectively lowering BP in the community.

Open Access Macedonian Journal of Medical Sciences, Jan 3, 2022

BACKGROUND: Foods consumed with fiber sources will be different from foods not consumed with fibe... more BACKGROUND: Foods consumed with fiber sources will be different from foods not consumed with fiber sources because fiber has a mechanism to lower blood sugar levels. However, the difference or the correlation factor is not yet known. AIM: This study aims to determine the differences in changes in blood sugar levels in the fruit or vegetable intervention and to determine the correction factor for changes in blood sugar levels and the glycemic index (GI) of food. METHODS: The research design used was experimental with a pre-post design; the sampling technique used purposive sampling totaling 13 people divided into two groups, namely, the fruit and vegetable group. The sample was selected under normal circumstances and had no history of diabetes mellitus. Blood sugar levels taken were fasting blood sugar levels at 0', 30', 60', 90', and 120' after the intervention to see a graph of changes in blood sugar levels. The statistical analysis used is ANOVA/Kruskal-Wallis. RESULTS: The results showed a significant difference (p < 0.005) in comparing standard bread with bread and avocado and bread and beans at 30' after the intervention. After the intervention, bread with watermelon showed significant results at 120' and bread with carrots at 90'. The highest GI and the lowest correction factor for changes in blood sugar levels were shown in watermelon. In contrast, the lowest GI and the highest correction factor were shown in avocado. CONCLUSION: When compared between the four interventions, giving avocados were more able to lower blood sugar levels.

Disaster and Emergency Medicine Journal, Dec 30, 2022

This article is available in open access under Creative Common Attribution-Non-Commercial-No Deri... more This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.

JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, 2019

The safe ice cream which is consumed by Diabetes Mellitus sufferers is made by subtituting skim m... more The safe ice cream which is consumed by Diabetes Mellitus sufferers is made by subtituting skim milk, cream and sugar with kefir, pure pumpkin, cornstarch, vegetable oil, and artificial sweetener special gor Diabetes Mellitus. The aim of this research is knowing predilection level test to ice cream pumpkin kefir, microbes total, beta-caroten levels, and antioxidant levels. This research is conducted with experimental method. The research method used hedonic test to determine the level of preference, total plate count method to determine the number of microbes, UV-Vis spectrophotometry method for testing beta-carotene levels, and DPPH method for testing antioxidant levels. The results of the Kruskal Wallis test showed differences in the level of texture preference and there were no differences that appreciated the level of taste, color, and aroma. Ice cream pumpkin kefir that is liked most are from texture, taste, color and aroma side exists in balance F2 with the ratio of kefir and ...

Potravinarstvo, Sep 1, 2022

In disaster conditions, the elderly are vulnerable groups that require special attention. With in... more In disaster conditions, the elderly are vulnerable groups that require special attention. With increasing age, there is a decrease in biological function and psychological disorders. The elderly tend to have anxiety, especially during disaster conditions. This anxiety has an impact on the diet and health of the elderly. Soybean (Glycine max L.) flour biscuits and Ambon banana (Musa paradisiaca var. sapientum L.) flour is a food product that meets disaster emergency food requirements and food requirements for the elderly. It is appropriate to be used as an alternative disaster emergency food for the elderly. This study aims to determine the effect of the balance of the soybean flour biscuit formula Ambon banana flour on the organoleptic and protein properties. The research design used is an experimental study, with the research method used is a hedonic test for testing organoleptic properties and the Kjeldahl procedure for testing protein content. The formula of Ambon banana and soybean flour biscuits consisted of three balances, with the ratio of Ambon banana flour soybean flour (%) F1 (45:55), F2 (35:65), and F3 (25:75). From the study results, it can be concluded that there is a significant difference in the test results of organoleptic properties only for colour. Moreover, there are no significant differences in the test results of organoleptic properties, including aroma, taste, texture, and overall. In the test results of organoleptic properties, the balance (25:75) was declared superior overall. The 45:55 balance contains 8.01% protein, the 35:65 balance contains 7.23% protein, and the 25:75 balance includes 7.42%.

Open Access Macedonian Journal of Medical Sciences, Mar 25, 2022

BACKGROUND: Older toddlers period (children aged 6-23 months) is often referred to as the "golden... more BACKGROUND: Older toddlers period (children aged 6-23 months) is often referred to as the "golden age," "critical period." The World Bank (2006) refers to it as the "window of opportunity" because it is one of the periods of dealing with stunted and severe stunted the most effective. The immediate cause of stunting is a lack of food intake and infectious diseases. Therefore, maternal knowledge about nutrition influences behavior and attitudes in choosing food. Ignorance of foods with good nutrition will cause the selection of the wrong food, and poor nutrition will cause the child's nutritional status to be poor and lacking. AIM: This study aimed to determine the relationship of nutritional knowledge to the nutritional status of the height/age index in older toddlers in Sumbang District, Banyumas Regency, Central Java. METHODS: This descriptive-analytic study was taken from secondary data using a cross-sectional design conducted on 736 mothers who have older toddlers in Sumbang District, Banyumas Regency, Central Java. RESULTS: There is no relationship between the nutritional status of children under 2 years old (H/A) with maternal age (p = 0.441), mother's education (p = 0.232), and mother's occupation (p = 0.284). There is a relationship between the nutritional status of children under 2 years (H/A) and mother's knowledge (p = 0.002). CONCLUSION: This study aimed to determine the relationship of nutritional knowledge to the nutritional status of the height/age index in older toddlers in Sumbang District, Banyumas Regency, Central Java. There is no relationship between the nutritional status of children under 2 years old (H/A) with maternal age (p = 0.441), mother's education (p = 0.232), and mother's occupation (p = 0.284). There is a relationship between the nutritional status of children under 2 years (H/A) and mother's knowledge (p = 0.002).

Jurnal Riset Kesehatan Poltekkes Depkes Bandung, 2014

Open Access Macedonian Journal of Medical Sciences, 2022

BACKGROUND: Sexually transmitted infections (STIs) are preventable and treatable diseases. Female... more BACKGROUND: Sexually transmitted infections (STIs) are preventable and treatable diseases. Female sex workers are more susceptible to contracting STIs. Successful prevention of STIs will not be achieved without community involvement and patient compliance in implementing prevention programs. AIM: The study aimed to analyze the effect of integrative counseling on knowledge and attitudes about STIs. METHODS: This type of research is a quasi-experiment with a pre-post test two-group design. The population was female sexual workers (FSW) at the Mawar PKBI clinic in Bandung City. The number of samples per group was 28 people. The sampling technique was the purposive sampling technique. The knowledge and attitude instruments used a questionnaire. Differences in knowledge and attitudes pre and post-test in the treatment and control groups used the dependent t-test. The effect of integrative counseling on knowledge and attitudes was used in the independent t-test. RESULTS: This study showed...

Open Access Macedonian Journal of Medical Sciences, 2022

BACKGROUND: Exclusive breastfeeding is the cornerstone of a child’s survival and health because i... more BACKGROUND: Exclusive breastfeeding is the cornerstone of a child’s survival and health because it provides essential and irreplaceable nutrients for their growth and development. The coverage rate for exclusive breastfeeding for infants 0–6 months in West Java in 2017 was 55.4%, below the national figure of 61.33%. AIM: The purpose of this article is to identify the failure factors for exclusive breastfeeding. METHODS: The study began with a quasi-experimental period with a pre- and post-test group design approach through a health education process about exclusive breastfeeding in the third trimester of pregnancy, followed by a prospective study on breastfeeding practice in infants in the first 6 months of life. The analysis used was Chi-square analysis (χ2) and Paired t-test. Then, followed by a qualitative study to explore the supports and barriers to exclusive breastfeeding through in-depth interviews and carried out an analysis with modified Aronso’s qualitative analysis steps....

Open Access Macedonian Journal of Medical Sciences, 2021

The strategy for reducing maternal mortality is through increasing empowerment of women, families... more The strategy for reducing maternal mortality is through increasing empowerment of women, families, and communities. Families are expected to play an active role in knowing and making efforts to prevent maternal and infant morbidity and mortality—the number of cases of maternal death in Kab. Karawang in 2015 and 2016, respectively, as many as 68 cases and 61 cases, the main causes are preeclampsia, bleeding, and comorbidities. The aim is to determine the effect of Warneng’s booklet on increasing knowledge and attitudes of pregnant women towards early detection of pregnancy complications. The research design used a quasi-experimental design, non-equivalent control group. The research location was carried out in the areas of Purwasari Health Center and Rengasdengklok Health Center. The population is pregnant women in trimester I-III, with a total sample of 70 respondents. The analysis test used t-test and Mann Whitney U. The sampling technique used purposive random sampling. Degree of ...