Hilmi Ataseven - Academia.edu (original) (raw)
Papers by Hilmi Ataseven
Indian Journal of Chemistry, Feb 21, 2024
Cumhuriyet medical journal, Dec 27, 2022
Turkiye Klinikleri Medical Oncology - Special Topics, 2019
Bratislavské lekárske listy, 2021
International Journal of Scientific and Technological Research, Mar 1, 2020
Turkiye Klinikleri Gastroenterohepatology - Special Topics, 2018
Turkiye Klinikleri Gastroenterohepatology - Special Topics, 2017
Cumhuriyet Science Journal, Mar 26, 2023
Journal of Clinical Oncology, Feb 20, 2010
Cumhuriyet medical journal, Dec 29, 2021
DergiPark (Istanbul University), Mar 14, 2011
Medical Oncology, Aug 16, 2023
Turkiye Klinikleri Gastroenterohepatology - Special Topics, 2018
Inflammatory Bowel Diseases, Aug 1, 2009
Thromboembolic events are welldefined complications of inflammatory bowel disease (IBD) and it is... more Thromboembolic events are welldefined complications of inflammatory bowel disease (IBD) and it is an important cause of morbidity and mortality. The incidence of thromboembolic events in patients with IBD has been reported to be 1%-6% 1,2 and it usually affects the deep veins. Arterial embolism is infrequent in IBD and here we describe a patient with IBD complicated by arterial mesenteric ischemia. A 54-year-old man was admitted to the hospital with abdominal pain, bloody diarrhea, and weight loss of 16 kg. In his past medical history, ulcerative colitis (UC) was diagnosed 4 months previously at another center and mesalamine was administered. He did not respond to treatment and oral steroid therapy was started. Despite bloody diarrhea reduced with steroids, abdominal pain progressively increased. Physical examination was within normal limits. On laboratory analysis he had severe hypochromic anemia, with a hemoglobin level of 6.6 g/dL and a mean corpuscular volume of 72.8 fL. The erythrocyte sedimentation rate was 64 mm/h. Biochemical parameters including electrolytes and liver enzymes renal function tests were in the normal range. Microscopic examinations of stool and amebic antigen in stool were normal. Abdominal ultrasonography revealed colonic wall thickening. Colonoscopy was compatible with ulcerative pancolitis with an endoscopical activity index of 10. He was hospital
Akademik Gastroenteroloji Dergisi, Apr 1, 2009
Gastrik mukozadaki diffüz makroskopik değişiklikler gastrit olarak yorumlanır. Makroskopik değerl... more Gastrik mukozadaki diffüz makroskopik değişiklikler gastrit olarak yorumlanır. Makroskopik değerlendirmeler ile Helikobakter pilori (Hp) kaynaklı ve diğer nedenli gastritlerin ayırımını endoskopik olarak yapmak konusunda yeterli bilgi olmayıp bu konuda belirli bir konsensus sağlanamamıştır. Hp enfeksiyonu tüm dünyada görülmekle birlikte aynı ülkedeki farklı populasyon gruplarında farklı oranlara sahiptir (1). Dünya nüfusunun yaklaşık olarak %60'ının bu bakteri ile enfekte olduğu düşünülmektedir. Bu mikroorganiz-mayı taşıyanların %100'e yakınında gastrit gelişirken, ömür boyu peptik ülser olma riski ise %15-20'dir (2). Hp veya diğer nedenli gastritlerin tanısında sadece endoskopik inceleme ile biyopsiye gerek kalmadan bir hastada gastritin varlığını ve nedenini belirlemek daha pratik ve ekonomik bir yöntem olacaktır. Ülkemizde bu amaçla yapılan her endoskopik işlemde kesin tanı sağlanması amacıyla biyopsi işleminin yapılamadığı dikkate alındığında, endoskopik olarak yapılan tanımlamanın ne
Bratislavské lekárske listy, 2021
BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole world, is the most im... more BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole world, is the most important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are sought to prevent the spread of this virus. Azithromycin and clarithromycin are considered for the treatment of the SARS-CoV-2 virus, which has a high similarity to previous colonic diseases. AIM: We aimed to determine whether azithromycin and clarithromycin, the RNA-dependent RNA polymerase protein inhibitor used in the treatment of COVID-19, is effective against SARS Cov-2 in silico. RESULTS AND CONCLUSION: The 503 analogues of azithromycin and clarithromycin were studied to target SARS-CoV-2 the RNA-dependent RNA polymerase protein inhibition. Maestro program was used to compare the inhibition activities of these analogues. A detailed comparison was made using the numerical value of many parameters obtained. ADME / T properties were then examined to determine the effects and reactions of analogues on human metabolism. In this study, the SARS-CoV2 virus is 6NUR and 6NUS, which is the RNA-dependent RNA polymerase protein. Among these proteins, the best inhibitor among the 503 analogues according to the docking score parameter was 9851445 with a great difference. This analogue was an analogue of azithromycin (Tab.
Bratislavské lekárske listy, 2020
BACKGROUND: COVID-19 is not fully known and causes severe infl ammation and cytokine storm. It ha... more BACKGROUND: COVID-19 is not fully known and causes severe infl ammation and cytokine storm. It has many symptoms, such as: fever, sore throat, headache, dyspnoea, and diarrhoea. Arbidol was used in the treatment of COVID19, which was the most critical health problem in the world. However, the desired recovery was not achieved with Arbidol. Many countries still use this drug in the treatment of COVID19. AIM: We aimed to determine whether Arbidol, the hemagglutinin esterase inhibitor used in the treatment of COVID-19, was effective against SARS Cov-2 in silico. RESULTS AND CONCLUSION: The similarity between hemagglutinin and spike proteins were reported due to the fact that inhibition properties of Arbidol and its 39 analogues were examined in detail against hemagglutinin esterase and spike glycoproteins. CID 1070884 and CID 1207786 were found to be more active against hemagglutinin esterase than in Arbidol, while these compounds were inactive against spike glycoproteins. The interaction mechanism was clarifi ed between arbidol and spike proteins. Phenylalanine, tyrosine, glycine, lysine, and aspartic acid were found to be the headliner amino acids in the interactions between Arbidol and binding domains of spike glycoproteins in the SARS-CoV2 (Tab.
Endocrine Research, 2003
The relationship of leptin to diminished appetite and weight loss has been investigated in many d... more The relationship of leptin to diminished appetite and weight loss has been investigated in many diseases. Diminished appetite and weight loss are the most apparent characteristics of patients with active lung tuberculosis and in this study the relation of leptin to such diminished appetite and weight loss has been investigated in patients with active lung tuberculosis before and after treatment. Twenty-five patients (7 female, 18 male) with active tuberculosis having an age range of 18-70 years (mean 47.48 AE 15.36 y) and 25 normal individuals (9 female, 16 male) having an age range of 25-71 years (mean 44.60 AE 13.80 y) were included in this study. Leptin levels, body mass index (BMI), body fat ratio (BFR), and waist hip ratio (WHR) were measured before and after 6 months of antituberculosis treatment. The same measurements were also made in the control group and the results were compared. While the pretreatment BMI (22.02 AE 4.31 kg=m 2) and BFR (16.60% AE 9.30%) values in the patient group were significantly lower than in the control group, we found no difference in their pretreatment WHR values. Pretreatment leptin levels (3.49 AE 3.34 mg=L) were significantly higher in patients with tuberculosis than in the control group (2.33 AE 1.10 mg=L). Leptin levels were found to be significantly increased at the 6th month of antituberculosis treatment (5.65 AE 5.41 mg=L) than the pretreatment values (p < 0.05).
DergiPark (Istanbul University), Aug 1, 2005
Bratislavské lekárske listy, 2021
BACKGROUND: It is the SARS-CoV-2 virus, one of the most signifi cant diseases of today's world. D... more BACKGROUND: It is the SARS-CoV-2 virus, one of the most signifi cant diseases of today's world. Due to the high transmission of this disease, studies are ongoing to discover an inhibitor drug that can stop this disease. In this study, inhibitory drugs used for many diseases were tried to stop the SARS-CoV-2 virus. AIM: In the calculations made, inhibitor molecules for the SARS-CoV-2 virus were calculated by molecular docking method. RESULTS AND CONCLUSION: Inhibitory activities of SARS-CoV-2 virus against spike glycoprotein (PDB ID: 6M0J, 6LZG), main protease (PDB ID: 5RGG, 6WTT), and RNA dependent RNA polymerase (RdRp) (PDB ID: 6YYT, 7BV2) proteins were compared. Then, docking calculations were supported by calculations by MM-PSBA of the inhibitor with the highest activity. Afterwards, it was compared with FDA approved drugs for the SARS-CoV-2 virus. It was found that the Carvedilol molecule was the best against RNA dependent RNA polymerase (RdRp) protein of SARS-CoV-2 (Tab. 4, Fig. 9, Ref. 42).
Indian Journal of Chemistry, Feb 21, 2024
Cumhuriyet medical journal, Dec 27, 2022
Turkiye Klinikleri Medical Oncology - Special Topics, 2019
Bratislavské lekárske listy, 2021
International Journal of Scientific and Technological Research, Mar 1, 2020
Turkiye Klinikleri Gastroenterohepatology - Special Topics, 2018
Turkiye Klinikleri Gastroenterohepatology - Special Topics, 2017
Cumhuriyet Science Journal, Mar 26, 2023
Journal of Clinical Oncology, Feb 20, 2010
Cumhuriyet medical journal, Dec 29, 2021
DergiPark (Istanbul University), Mar 14, 2011
Medical Oncology, Aug 16, 2023
Turkiye Klinikleri Gastroenterohepatology - Special Topics, 2018
Inflammatory Bowel Diseases, Aug 1, 2009
Thromboembolic events are welldefined complications of inflammatory bowel disease (IBD) and it is... more Thromboembolic events are welldefined complications of inflammatory bowel disease (IBD) and it is an important cause of morbidity and mortality. The incidence of thromboembolic events in patients with IBD has been reported to be 1%-6% 1,2 and it usually affects the deep veins. Arterial embolism is infrequent in IBD and here we describe a patient with IBD complicated by arterial mesenteric ischemia. A 54-year-old man was admitted to the hospital with abdominal pain, bloody diarrhea, and weight loss of 16 kg. In his past medical history, ulcerative colitis (UC) was diagnosed 4 months previously at another center and mesalamine was administered. He did not respond to treatment and oral steroid therapy was started. Despite bloody diarrhea reduced with steroids, abdominal pain progressively increased. Physical examination was within normal limits. On laboratory analysis he had severe hypochromic anemia, with a hemoglobin level of 6.6 g/dL and a mean corpuscular volume of 72.8 fL. The erythrocyte sedimentation rate was 64 mm/h. Biochemical parameters including electrolytes and liver enzymes renal function tests were in the normal range. Microscopic examinations of stool and amebic antigen in stool were normal. Abdominal ultrasonography revealed colonic wall thickening. Colonoscopy was compatible with ulcerative pancolitis with an endoscopical activity index of 10. He was hospital
Akademik Gastroenteroloji Dergisi, Apr 1, 2009
Gastrik mukozadaki diffüz makroskopik değişiklikler gastrit olarak yorumlanır. Makroskopik değerl... more Gastrik mukozadaki diffüz makroskopik değişiklikler gastrit olarak yorumlanır. Makroskopik değerlendirmeler ile Helikobakter pilori (Hp) kaynaklı ve diğer nedenli gastritlerin ayırımını endoskopik olarak yapmak konusunda yeterli bilgi olmayıp bu konuda belirli bir konsensus sağlanamamıştır. Hp enfeksiyonu tüm dünyada görülmekle birlikte aynı ülkedeki farklı populasyon gruplarında farklı oranlara sahiptir (1). Dünya nüfusunun yaklaşık olarak %60'ının bu bakteri ile enfekte olduğu düşünülmektedir. Bu mikroorganiz-mayı taşıyanların %100'e yakınında gastrit gelişirken, ömür boyu peptik ülser olma riski ise %15-20'dir (2). Hp veya diğer nedenli gastritlerin tanısında sadece endoskopik inceleme ile biyopsiye gerek kalmadan bir hastada gastritin varlığını ve nedenini belirlemek daha pratik ve ekonomik bir yöntem olacaktır. Ülkemizde bu amaçla yapılan her endoskopik işlemde kesin tanı sağlanması amacıyla biyopsi işleminin yapılamadığı dikkate alındığında, endoskopik olarak yapılan tanımlamanın ne
Bratislavské lekárske listy, 2021
BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole world, is the most im... more BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole world, is the most important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are sought to prevent the spread of this virus. Azithromycin and clarithromycin are considered for the treatment of the SARS-CoV-2 virus, which has a high similarity to previous colonic diseases. AIM: We aimed to determine whether azithromycin and clarithromycin, the RNA-dependent RNA polymerase protein inhibitor used in the treatment of COVID-19, is effective against SARS Cov-2 in silico. RESULTS AND CONCLUSION: The 503 analogues of azithromycin and clarithromycin were studied to target SARS-CoV-2 the RNA-dependent RNA polymerase protein inhibition. Maestro program was used to compare the inhibition activities of these analogues. A detailed comparison was made using the numerical value of many parameters obtained. ADME / T properties were then examined to determine the effects and reactions of analogues on human metabolism. In this study, the SARS-CoV2 virus is 6NUR and 6NUS, which is the RNA-dependent RNA polymerase protein. Among these proteins, the best inhibitor among the 503 analogues according to the docking score parameter was 9851445 with a great difference. This analogue was an analogue of azithromycin (Tab.
Bratislavské lekárske listy, 2020
BACKGROUND: COVID-19 is not fully known and causes severe infl ammation and cytokine storm. It ha... more BACKGROUND: COVID-19 is not fully known and causes severe infl ammation and cytokine storm. It has many symptoms, such as: fever, sore throat, headache, dyspnoea, and diarrhoea. Arbidol was used in the treatment of COVID19, which was the most critical health problem in the world. However, the desired recovery was not achieved with Arbidol. Many countries still use this drug in the treatment of COVID19. AIM: We aimed to determine whether Arbidol, the hemagglutinin esterase inhibitor used in the treatment of COVID-19, was effective against SARS Cov-2 in silico. RESULTS AND CONCLUSION: The similarity between hemagglutinin and spike proteins were reported due to the fact that inhibition properties of Arbidol and its 39 analogues were examined in detail against hemagglutinin esterase and spike glycoproteins. CID 1070884 and CID 1207786 were found to be more active against hemagglutinin esterase than in Arbidol, while these compounds were inactive against spike glycoproteins. The interaction mechanism was clarifi ed between arbidol and spike proteins. Phenylalanine, tyrosine, glycine, lysine, and aspartic acid were found to be the headliner amino acids in the interactions between Arbidol and binding domains of spike glycoproteins in the SARS-CoV2 (Tab.
Endocrine Research, 2003
The relationship of leptin to diminished appetite and weight loss has been investigated in many d... more The relationship of leptin to diminished appetite and weight loss has been investigated in many diseases. Diminished appetite and weight loss are the most apparent characteristics of patients with active lung tuberculosis and in this study the relation of leptin to such diminished appetite and weight loss has been investigated in patients with active lung tuberculosis before and after treatment. Twenty-five patients (7 female, 18 male) with active tuberculosis having an age range of 18-70 years (mean 47.48 AE 15.36 y) and 25 normal individuals (9 female, 16 male) having an age range of 25-71 years (mean 44.60 AE 13.80 y) were included in this study. Leptin levels, body mass index (BMI), body fat ratio (BFR), and waist hip ratio (WHR) were measured before and after 6 months of antituberculosis treatment. The same measurements were also made in the control group and the results were compared. While the pretreatment BMI (22.02 AE 4.31 kg=m 2) and BFR (16.60% AE 9.30%) values in the patient group were significantly lower than in the control group, we found no difference in their pretreatment WHR values. Pretreatment leptin levels (3.49 AE 3.34 mg=L) were significantly higher in patients with tuberculosis than in the control group (2.33 AE 1.10 mg=L). Leptin levels were found to be significantly increased at the 6th month of antituberculosis treatment (5.65 AE 5.41 mg=L) than the pretreatment values (p < 0.05).
DergiPark (Istanbul University), Aug 1, 2005
Bratislavské lekárske listy, 2021
BACKGROUND: It is the SARS-CoV-2 virus, one of the most signifi cant diseases of today's world. D... more BACKGROUND: It is the SARS-CoV-2 virus, one of the most signifi cant diseases of today's world. Due to the high transmission of this disease, studies are ongoing to discover an inhibitor drug that can stop this disease. In this study, inhibitory drugs used for many diseases were tried to stop the SARS-CoV-2 virus. AIM: In the calculations made, inhibitor molecules for the SARS-CoV-2 virus were calculated by molecular docking method. RESULTS AND CONCLUSION: Inhibitory activities of SARS-CoV-2 virus against spike glycoprotein (PDB ID: 6M0J, 6LZG), main protease (PDB ID: 5RGG, 6WTT), and RNA dependent RNA polymerase (RdRp) (PDB ID: 6YYT, 7BV2) proteins were compared. Then, docking calculations were supported by calculations by MM-PSBA of the inhibitor with the highest activity. Afterwards, it was compared with FDA approved drugs for the SARS-CoV-2 virus. It was found that the Carvedilol molecule was the best against RNA dependent RNA polymerase (RdRp) protein of SARS-CoV-2 (Tab. 4, Fig. 9, Ref. 42).