Himanshu Kumar - Academia.edu (original) (raw)
Papers by Himanshu Kumar
Modern Physics Letters A, 2015
In this paper, we have tried to explore the twin paradox in the ellipsoidal coordinate system. We... more In this paper, we have tried to explore the twin paradox in the ellipsoidal coordinate system. We have investigated that the traveling twin travels away from the gravitational source in the first case while in the other it moves towards the source. We then tried to compare it with the special relativistic case where the static twin ages faster as compared to his traveling counterpart.
Journal of Biosciences, 2012
ABSTRACT In this study fecal microflora of human infants born through vaginal delivery (VB) and t... more ABSTRACT In this study fecal microflora of human infants born through vaginal delivery (VB) and through cesarean section (CB) was investigated using culture independent 16S rDNA cloning and sequencing approach. The results obtained clearly revealed that fecal microbiota of VB infants distinctly differ from their counterpart CB infants. The intestinal microbiota of infants delivered by cesarean section appears to be more diverse, in terms of bacteria species, than the microbiota of vaginally delivered infants. The most abundant bacterial species present in VB infants were Acinetobacter sp., Bifidobacterium sp. and Staphylococcus sp. However, CB infant's fecal microbiota was dominated with Citrobacter sp., Escherichia coli and Clostridium difficile. The intestinal microbiota of cesarean section delivered infants in this study was also characterized by an absence of Bifidobacteria species. An interesting finding of our study was recovery of large number of Acinetobacter sp consisting of Acinetobacter pittii (former Acinetobacter genomic species 3), Acinetobacter junii and Acinetobacter baumannii in the VB infants clone library. Among these Acinetobacter baumannii is a known nosocomial pathogen and Acinetobacter pittii (gen. sp. 3) is recently recognized as clinically important taxa within the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex. Though, none of the infants had shown any sign of clinical symptoms of disease, this observation warrant a closer look.
International Reviews of Immunology, 2013
Innate immune sensors are a family of receptors which play a pivotal role in immune surveillance ... more Innate immune sensors are a family of receptors which play a pivotal role in immune surveillance in various cellular compartments, recognizing numerous motifs derived from pathogens or associated with altered self molecules. Sensing of pathogenic components of self or nonself origin leads to a variety of integrated responses such as induction of proinflammatory and antiviral cytokines and lipid mediators, as well as upregulation of costimulatory molecules on a variety of cells. Furthermore, these sensors play a crucial role in cell survival, autophagy and pluripotency, and therefore, they are essential for the maintenance of cellular metabolic homeostasis. Finally, these sensors also play a substantial role in elicitation of specific immune responses, deploying and regulating the development of appropriate adaptive immunity against pathogens. This issue focuses on the biology of innate immune sensors, particularly Toll-like receptors and C-type lectin receptors, mutations in such sensors and/or their signaling components associated with disorders and the role of innate immune sensors in the mechanism of response to particulate vaccine adjuvants.
BMC Microbiology, 2011
Background Lactobacillus plantarum is considered as a safe and effective probiotic microorganism.... more Background Lactobacillus plantarum is considered as a safe and effective probiotic microorganism. Among various sources of isolation, traditionally fermented foods are considered to be rich in Lactobacillus spp., which can be exploited for their probiotic attribute. Antibacterial property of L. plantarum has been demonstrated against various enteric pathogens in both in vitro and in vivo systems. This study was aimed at characterizing L. plantarum isolated from Kutajarista, an ayurvedic fermented biomedicine, and assessing its antagonistic property against a common enteropathogen Aeromonas veronii. Results We report the isolation of L. plantarum (VR1) from Kutajarista, and efficacy of its cell free supernatant (CFS) in amelioration of cytotoxicity caused by Aeromonas veronii. On the part of probiotic attributes, VR1 was tolerant to pH 2, 0.3% bile salts and simulated gastric juice. Additionally, VR1 also exhibited adhesive property to human intestinal HT-29 cell line. Furthermore, C...
Molecular Biology Reports, 2012
Modern Physics Letters A, 2015
In this paper, we have tried to explore the twin paradox in the ellipsoidal coordinate system. We... more In this paper, we have tried to explore the twin paradox in the ellipsoidal coordinate system. We have investigated that the traveling twin travels away from the gravitational source in the first case while in the other it moves towards the source. We then tried to compare it with the special relativistic case where the static twin ages faster as compared to his traveling counterpart.
Journal of Biosciences, 2012
ABSTRACT In this study fecal microflora of human infants born through vaginal delivery (VB) and t... more ABSTRACT In this study fecal microflora of human infants born through vaginal delivery (VB) and through cesarean section (CB) was investigated using culture independent 16S rDNA cloning and sequencing approach. The results obtained clearly revealed that fecal microbiota of VB infants distinctly differ from their counterpart CB infants. The intestinal microbiota of infants delivered by cesarean section appears to be more diverse, in terms of bacteria species, than the microbiota of vaginally delivered infants. The most abundant bacterial species present in VB infants were Acinetobacter sp., Bifidobacterium sp. and Staphylococcus sp. However, CB infant's fecal microbiota was dominated with Citrobacter sp., Escherichia coli and Clostridium difficile. The intestinal microbiota of cesarean section delivered infants in this study was also characterized by an absence of Bifidobacteria species. An interesting finding of our study was recovery of large number of Acinetobacter sp consisting of Acinetobacter pittii (former Acinetobacter genomic species 3), Acinetobacter junii and Acinetobacter baumannii in the VB infants clone library. Among these Acinetobacter baumannii is a known nosocomial pathogen and Acinetobacter pittii (gen. sp. 3) is recently recognized as clinically important taxa within the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) complex. Though, none of the infants had shown any sign of clinical symptoms of disease, this observation warrant a closer look.
International Reviews of Immunology, 2013
Innate immune sensors are a family of receptors which play a pivotal role in immune surveillance ... more Innate immune sensors are a family of receptors which play a pivotal role in immune surveillance in various cellular compartments, recognizing numerous motifs derived from pathogens or associated with altered self molecules. Sensing of pathogenic components of self or nonself origin leads to a variety of integrated responses such as induction of proinflammatory and antiviral cytokines and lipid mediators, as well as upregulation of costimulatory molecules on a variety of cells. Furthermore, these sensors play a crucial role in cell survival, autophagy and pluripotency, and therefore, they are essential for the maintenance of cellular metabolic homeostasis. Finally, these sensors also play a substantial role in elicitation of specific immune responses, deploying and regulating the development of appropriate adaptive immunity against pathogens. This issue focuses on the biology of innate immune sensors, particularly Toll-like receptors and C-type lectin receptors, mutations in such sensors and/or their signaling components associated with disorders and the role of innate immune sensors in the mechanism of response to particulate vaccine adjuvants.
BMC Microbiology, 2011
Background Lactobacillus plantarum is considered as a safe and effective probiotic microorganism.... more Background Lactobacillus plantarum is considered as a safe and effective probiotic microorganism. Among various sources of isolation, traditionally fermented foods are considered to be rich in Lactobacillus spp., which can be exploited for their probiotic attribute. Antibacterial property of L. plantarum has been demonstrated against various enteric pathogens in both in vitro and in vivo systems. This study was aimed at characterizing L. plantarum isolated from Kutajarista, an ayurvedic fermented biomedicine, and assessing its antagonistic property against a common enteropathogen Aeromonas veronii. Results We report the isolation of L. plantarum (VR1) from Kutajarista, and efficacy of its cell free supernatant (CFS) in amelioration of cytotoxicity caused by Aeromonas veronii. On the part of probiotic attributes, VR1 was tolerant to pH 2, 0.3% bile salts and simulated gastric juice. Additionally, VR1 also exhibited adhesive property to human intestinal HT-29 cell line. Furthermore, C...
Molecular Biology Reports, 2012