Huy Ngo - Academia.edu (original) (raw)
Papers by Huy Ngo
The current paper presents preliminary work towards the integration of the Fujisaki model into th... more The current paper presents preliminary work towards the integration of the Fujisaki model into the VnVoice Vietnamese TTS system, based on a set of rules to control the F0 contour. A speech corpus consisting of 20 sentences was compiled. Each of the sentences can have various meanings depending on the tone associated with a monosyllabic keyword which it contains. The corpus with a total of 46 sentences was recorded by a female speaker whose voice had also been used in the speech corpus for VnVoice, and labeled at the syllabic level. Tone contrast perception results and naturalness comparisons show that the Fujisaki model works well in modeling F0 contour of Vietnamese tones.
Antibiotics, 2022
Schiff bases (SBs) have extensive applications in different fields such as analytical, inorganic ... more Schiff bases (SBs) have extensive applications in different fields such as analytical, inorganic and organic chemistry. They are used as dyes, catalysts, polymer stabilizers, luminescence chemosensors, catalyzers in the fixation of CO2 biolubricant additives and have been suggested for solar energy applications as well. Further, a wide range of pharmacological and biological applications, such as antimalarial, antiproliferative, analgesic, anti-inflammatory, antiviral, antipyretic, antibacterial and antifungal uses, emphasize the need for SB synthesis. Several SBs conjugated with chitosan have been studied in order to enhance the antibacterial activity of chitosan. Moreover, the use of the nanoparticles of SBs may improve their antimicrobial effects. Herein, we provide an analytical overview of the antibacterial and antifungal properties of SBs and chitosan-based SBs as well as SBs-functionalized nanoparticles. The most relevant and recent literature was reviewed for this purpose.
Tạp chí Khoa học Điều dưỡng, 2019
Mục tiêu: Mô tả thực trạng kiến thức tự chăm sóc và đánh giá sự thay đổi kiến thức tự chăm sóc củ... more Mục tiêu: Mô tả thực trạng kiến thức tự chăm sóc và đánh giá sự thay đổi kiến thức tự chăm sóc của người bệnh suy tim mạn sau can thiệp giáo dục sức khỏe cho người bệnh suy tim mạn tại Khoa Nội tim mạch - Bệnh viện Đa khoa tỉnh Nam Định năm 2018. Đối tượng và phương pháp nghiên cứu: Can thiệp giáo dục một nhóm có so sánh trước sau cho 90 người bệnh suy tim mạn điều trị nội trú tại Khoa nội Tim mạch - Bệnh viên Đa khoa tỉnh Nam Định từ tháng 01 đến tháng 04 năm 2018. Tư vấn trực tiếp, nhóm nhỏ từ 3 - 5 người bệnh, nội dung tư vấn dựa trên Hướng dẫn tự chăm sóc trong suy tim mạn của Hội Tim mạch Hoa kỳ (2014) và Hội Tim mạch Việt Nam (2015). Bộ câu hỏi và cách đánh giá Atlanta Heart Failure Knowledge Test – AHFKT.V2 bản tiếng Việt đã được dùng trong nghiên cứu của Trần Thị Ngọc Anh tại Viện tim mạch Việt Nam 2016 và kiểm định độ tin cậy với hệ số Cronbach alpha 0,80 trước khi áp dụng cho nghiên cứu này. Kết quả: Trước can thiệp, kiến thức tự chăm sóc của người bệnh suy tim mạn trong p...
Proceedings of the Tenth International Conference on Enterprise Information Systems, 2008
Group authentication provides authentication for members of communication group between services ... more Group authentication provides authentication for members of communication group between services and users in insecure environments such as wireless networks. Most of the group authentication models do not consider the risk of compromised share secrets in the group under various security threats such as cryptanalysis. Although authentication key exchange in groups can benefit from group key management to minimise this risk, the group key management schemes are inefficient for authentication services. In this paper, a group authentication model for wireless networks services using a group key management is presented. The group key management is specially designed with forward secrecy and session keys for efficient and secure key exchange. Based on this secure session keys, a dynamic group authentication scheme provides a secure and efficient group authentication for wireless network users and services.
Int. J. Netw. Secur., 2010
In modern security models, cryptography plays a fundamental role in protecting data integrity and... more In modern security models, cryptography plays a fundamental role in protecting data integrity and confidentiality in information systems. However, cryptography itself is subject to cryptanalysis attacks. To reduce the cryptanalysis attack risk, a dynamic key theory is presented and analyzed in this paper. Because these dynamic keys are one-time used symmetric cryptographic keys, they can significantly improve the security of cryptographic systems. The dynamic key theory generation scheme and key update mechanism are formally analyzed to demonstrate balance between security and performance. The theory can be applied to enhance the security and performance of cryptographic systems, especially those used in wireless networks communication. Two case studies using the proposed dynamic key theory are also described and analyzed to illustrate the power of the theory.
Heart, Lung and Circulation, 2018
Background: The development of minimally invasive mitral valve surgery has created the motivation... more Background: The development of minimally invasive mitral valve surgery has created the motivation for using this approach in young patients with chronic rheumatic valve disease. We report our recent experience with patients undergoing minimally mitral valve surgery in this group of patients. Methods: Between July 2014 and June 2018, 142 patients with rheumatic mitral valve dysfunction underwent minimally invasive surgery through a right thoracotomy approach at the University Medical Center of Ho Chi Minh City in Vietnam. Diagnosis was confirmed with transthoracic and transesophageal echocardiography (TTE and TEE). We analyzed the inhospital and midterm follow-up outcomes of this group. Results: The mean age was 42.6 ± 9.6 years. Sixty patients (42.3%) were male. Sixty-three patients were diagnosed with functional severe tricuspid regurgitation, 29 patients were identified with moderate tricuspid regurgitation, and tricuspid annulus was more than 21 mm/m²). Mitral valve repair was performed in 16 patients (11.3%), and 126 patients underwent mitral valve replacement. Mitral valve repair techniques included annuloplasty, leaflet peeling, and commissurotomy. Thirty-day mortality was 0.7%. Two patients had to be converted to conventional sternotomy, due to left atrial appendage laceration and mitral annular rupture. The overall survival rate was 98.6%. Freedom from reoperation was 97.1%. Conclusions: In patients with rheumatic valve disease, minimally invasive mitral surgery safely and effectively can be performed with few perioperative complications and good midterm results.
Journal of the American Medical Directors Association, 2020
IOP Conference Series: Earth and Environmental Science, 2019
The study aimed to show in a systematic way possible energy efficiency measures that would decrea... more The study aimed to show in a systematic way possible energy efficiency measures that would decrease the total energy use at the university campus in Trondheim, Norway. The entire study was developed in close collaboration with the NTNU Property and Technical Management divisions, meaning that suggested energy efficiency scenarios and other assumptions were highly relevant. Currently, the campus floor area is about 300 000 m2 and consists of buildings combining offices, lecturing halls, study halls, and laboratories. The campus building stock has been built from 1910 to 2002. To perform this study, building performance simulation and the dynamic segmented modeling were combined. A dynamic neighborhood building stock model was utilized to aggregate the outputs from the building simulation and evaluate global effects of energy efficiency measures. Reference building models for each university cohort were developed based on the methodology for defining the reference buildings. The resul...
Journal of Gynecologic Oncology, 2019
Objectives: The global obesity epidemic has great impact on the prevalence of low-grade endometri... more Objectives: The global obesity epidemic has great impact on the prevalence of low-grade endometrial carcinoma. The preoperative tumor serum marker cancer antigen 125 (CA-125) might contribute to improved identification of high-risk patients within this group. The study aimed to investigate the prognostic value of CA-125 in relation to established preoperative prognosticators, with a focus on identifying patients with poor outcome in low-grade endometrial carcinoma (EC) patients. Methods: Prospective multicenter cohort study including all consecutive patients surgically treated for endometrial carcinoma in nine collaborating hospitals from September 2011 until December 2013. All preoperative histopathological diagnoses were reviewed in a blinded manner. Associations between CA-125 and clinicopathological features were determined. Univariable and multivariable analysis by Cox regression were used. Separate analyses were performed for preoperatively designated low-grade and high-grade endometrial carcinoma patients. Results: A total of 333 patients were analyzed. CA-125 was associated with poor prognostic features including advanced International Federation of Gynecology and Obstetrics (FIGO) stage. In multivariable analysis, age, preoperative tumor and CA-125 were significantly associated with disease-free survival (DFS); preoperative grade, tumor type, FIGO and CA-125 were significantly associated with disease-specific survival (DSS). Low-grade EC patients with elevated CA-125 revealed a DFS of 80.6% and DSS of 87.1%, compared to 92.1% and 97.2% in low-grade EC patients with normal CA-125. Conclusion: Preoperative elevated CA-125 was associated with poor prognostic features and independently associated with DFS and DSS. Particularly patients with low-grade EC and elevated CA-125 represent a group with poor outcome and should be considered as high-risk endometrial carcinoma.
Frontiers in microbiology, 2018
Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year... more Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year. Treatment options for tuberculosis patients are limited, expensive and characterized by severe side effects, especially in the case of multidrug-resistant forms. Uncovering novel vulnerabilities of the pathogen is crucial to generate new therapeutic strategies. Using high resolution microscopy techniques, we discovered one such vulnerability of . We demonstrate that the DNA of can condense under stressful conditions such as starvation and antibiotic treatment. The DNA condensation is reversible and specific for viable bacteria. Based on these observations, we hypothesized that blocking the recovery from the condensed state could weaken the bacteria. We showed that after inducing DNA condensation, and subsequent blocking of acetylation of DNA binding proteins, the DNA localization in the bacteria is altered. Importantly under these conditions, did not replicate and its survival was sign...
Journal of medicinal chemistry, Jan 11, 2018
The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of... more The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity concerns have resulted in an increased demand for new azole antifungal agents. Herein, we report the synthesis and antifungal activity of novel alkylated piperazines and alkylated piperazine-azole hybrids, their time-kill studies, their hemolytic activity against murine erythrocytes, as well as their cytotoxicity against mammalian cells. Many of these molecules exhibited broad-spectrum activity against all tested fungal strains, with excellent minimum inhibitory concentration (MIC) values against non-albicans Candida and Aspergillus strains. The most promising compounds were found to be less hemolytic than the FDA-approved antifungal agent voriconazole (VOR). Finally, we demonstrate that the synthetic alkylated piperazine-azole hybrids do not function by fungal membrane disruption, but instead by disruptio...
Bioorganic & medicinal chemistry, Feb 1, 2018
The fungistatic nature and toxicity concern associated with the azole drugs currently on the mark... more The fungistatic nature and toxicity concern associated with the azole drugs currently on the market have resulted in an increased demand for new azole antifungal agents for which these problematic characteristics do not exist. The extensive use of azoles has resulted in fungal strains capable of resisting the action of these drugs. Herein, we report the synthesis and antifungal activity of novel fluconazole (FLC) analogues with alkyl-, aryl-, cycloalkyl-, and dialkyl-amino substituents. We evaluated their antifungal activity by MIC determination and time-kill assay as well as their safety profile by hemolytic activity against murine erythrocytes as well as cytotoxicity against mammalian cells. The best compounds from our study exhibited broad-spectrum activity against most of the fungal strains tested, with excellent MIC values against a number of clinical isolates. The most promising compounds were found to be less hemolytic than the least hemolytic FDA-approved azole antifungal ag...
![Research paper thumbnail of Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis](https://attachments.academia-assets.com/95184150/thumbnails/1.jpg)
](ACS infectious diseases, Jan 30, 2018
A common cause of resistance to kanamycin (KAN) in tuberculosis is overexpression of the enhanced... more A common cause of resistance to kanamycin (KAN) in tuberculosis is overexpression of the enhanced intracellular survival (Eis) protein. Eis is an acetyltransferase that multiacetylates KAN and other aminoglycosides, rendering them unable to bind the bacterial ribosome. By high-throughput screening, a series of substituted 1,2,4-triazino[5,6 b]indole-3-thioether molecules were identified as effective Eis inhibitors. Herein, we purchased 17 and synthesized 22 new compounds, evaluated their potency, and characterized their steady-state kinetics. Four inhibitors were found not only to inhibit Eis in vitro, but also to act as adjuvants of KAN and partially restore KAN sensitivity in a Mycobacterium tuberculosis KAN-resistant strain in which Eis is upregulated. A crystal structure of Eis in complex with a potent inhibitor and CoA shows that the inhibitors bind in the aminoglycoside binding site snugly inserted into a hydrophobic cavity. These inhibitors will undergo preclinical developmen...
![Research paper thumbnail of Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors](https://attachments.academia-assets.com/95184144/thumbnails/1.jpg)
](ACS infectious diseases, Apr 17, 2017
Tuberculosis (TB) remains one of the leading causes of mortality worldwide. Hence, the identifica... more Tuberculosis (TB) remains one of the leading causes of mortality worldwide. Hence, the identification of highly effective antitubercular drugs with novel modes of action is crucial. In this paper, we report the discovery and development of pyrrolo[1,5-a]pyrazine-based analogues as highly potent inhibitors of the Mycobacterium tuberculosis (Mtb) acetyltransferase enhanced intracellular survival (Eis), whose up-regulation causes clinically observed resistance to the aminoglycoside (AG) antibiotic kanamycin A (KAN). We performed a structure-activity relationship (SAR) study to optimize these compounds as potent Eis inhibitors both against purified enzyme and in mycobacterial cells. A crystal structure of Eis in complex with one of the most potent inhibitors reveals that the compound is bound to Eis in the AG binding pocket, serving as the structural basis for the SAR. These Eis inhibitors have no observed cytotoxicity to mammalian cells and are promising leads for the development of in...
Bioorganic & medicinal chemistry, Dec 31, 2016
Antibiotic resistance is a worldwide problem that needs to be addressed. Staphylococcus aureus is... more Antibiotic resistance is a worldwide problem that needs to be addressed. Staphylococcus aureus is one of the dangerous "ESKAPE" pathogens that rapidly evolve and evade many current FDA-approved antibiotics. Thus, there is an urgent need for new anti-MRSA compounds. Ebselen (also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one) has shown promising activity in clinical trials for cerebral ischemia, bipolar disorder, and noise-induced hearing loss. Recently, there has been a renewed interest in exploring the antibacterial properties of ebselen. In this study, we synthesized an ebselen-inspired library of 33 compounds where the selenium atom has been replaced by sulfur (ebsulfur derivatives) and evaluated them against a panel of drug-sensitive and drug-resistant S. aureus and non-S. aureus strains. Within our library, we identified three outstanding analogues with potent activity against all S. aureus strains tested (MIC values mostly ⩽2μg/mL), and numerous additional ones wi...
Digest of Papers. COMPCON Spring 88 Thirty-Third IEEE Computer Society International Conference, 1988
In the remote control of distant robots by a human operator, even if the robotic manipulator and/... more In the remote control of distant robots by a human operator, even if the robotic manipulator and/or mobility device has vision or other senses, problems arise involving control, communications, and display. The communication restrictions and especially severe bandwidth limitations suggest that transmitting large numbers of videocamera pictures frame by frame may not be the most expeditious means of providing display
Proceedings of the IEEE 2003 Custom Integrated Circuits Conference, 2003.
The SoPC (System on a Programmable Chip) aspects of the Stratix GX™ FPGA with 3.125Gbps SERDES ar... more The SoPC (System on a Programmable Chip) aspects of the Stratix GX™ FPGA with 3.125Gbps SERDES are described. The FPGA was fabricated on a 0.13um, 9-layer metal process. The 16 high-speed serial transceiver channels with Clock Data Recovery (CDR) provides 622megabits per second (Mbps) to 3.125-Gbps full-duplex transceiver operation per channel. Another challenge described, is the implementation of 39 source-synchronous channels at 100Mbps to 1Gbps, utilizing Dynamic Phase Alignment (DPA). The implementation and integration of the FPGA logic array (with its own Hard IP) with the CDR and DPA channels involved grappling with SoC design issues and methodologies.
2012 IEEE RIVF International Conference on Computing & Communication Technologies, Research, Innovation, and Vision for the Future, 2012
This paper introduces a library which supports programmers to write parallel programs on GPU arch... more This paper introduces a library which supports programmers to write parallel programs on GPU architecture, especially with a system consisting of multi-GPUs. The library is designed from the idea of skeletons, which helps us to make parallel programs easily and quickly as if writing sequential programs. Skeletons usually are described by functional language which supports high-order function totally. Because of the performance and popularity of C++ language, we try to re-annotate C++ language to support high-order functions completely, hence, it is convenience for us to create general-purpose skeletons.
The Journal of Physical Chemistry B, 2011
![Research paper thumbnail of An oxacalix[2]arene[2]pyrimidine-bis(Zn-porphyrin) tweezer as a selective receptor towards fullerene C70](https://attachments.academia-assets.com/95184142/thumbnails/1.jpg)
](Tetrahedron Letters, 2010
An oxacalix[2]arene[2]pyrimidine-bis(Zn II-porphyrin) conjugate was readily prepared via nucleoph... more An oxacalix[2]arene[2]pyrimidine-bis(Zn II-porphyrin) conjugate was readily prepared via nucleophilic aromatic substitution of a phenolic AB 3-Zn-porphyrin on the upper rim of a (1,3-alternate) 5,17-bis(methylsulfonyl)oxacalix[4]arene precursor. Efficient 1:1 complex formation between the 'jaws' bisporphyrin tweezer and fullerene C 70 was evidenced by 1 H NMR titrations (K = 3.0 Â 10 4 M À1), while no detectable complexation could be observed with C 60. On the other hand, an analogous oxacalix[4]arene-bis(Cu-corrole) conjugate did not show any measurable (C 60 or C 70) fullerene binding.
The current paper presents preliminary work towards the integration of the Fujisaki model into th... more The current paper presents preliminary work towards the integration of the Fujisaki model into the VnVoice Vietnamese TTS system, based on a set of rules to control the F0 contour. A speech corpus consisting of 20 sentences was compiled. Each of the sentences can have various meanings depending on the tone associated with a monosyllabic keyword which it contains. The corpus with a total of 46 sentences was recorded by a female speaker whose voice had also been used in the speech corpus for VnVoice, and labeled at the syllabic level. Tone contrast perception results and naturalness comparisons show that the Fujisaki model works well in modeling F0 contour of Vietnamese tones.
Antibiotics, 2022
Schiff bases (SBs) have extensive applications in different fields such as analytical, inorganic ... more Schiff bases (SBs) have extensive applications in different fields such as analytical, inorganic and organic chemistry. They are used as dyes, catalysts, polymer stabilizers, luminescence chemosensors, catalyzers in the fixation of CO2 biolubricant additives and have been suggested for solar energy applications as well. Further, a wide range of pharmacological and biological applications, such as antimalarial, antiproliferative, analgesic, anti-inflammatory, antiviral, antipyretic, antibacterial and antifungal uses, emphasize the need for SB synthesis. Several SBs conjugated with chitosan have been studied in order to enhance the antibacterial activity of chitosan. Moreover, the use of the nanoparticles of SBs may improve their antimicrobial effects. Herein, we provide an analytical overview of the antibacterial and antifungal properties of SBs and chitosan-based SBs as well as SBs-functionalized nanoparticles. The most relevant and recent literature was reviewed for this purpose.
Tạp chí Khoa học Điều dưỡng, 2019
Mục tiêu: Mô tả thực trạng kiến thức tự chăm sóc và đánh giá sự thay đổi kiến thức tự chăm sóc củ... more Mục tiêu: Mô tả thực trạng kiến thức tự chăm sóc và đánh giá sự thay đổi kiến thức tự chăm sóc của người bệnh suy tim mạn sau can thiệp giáo dục sức khỏe cho người bệnh suy tim mạn tại Khoa Nội tim mạch - Bệnh viện Đa khoa tỉnh Nam Định năm 2018. Đối tượng và phương pháp nghiên cứu: Can thiệp giáo dục một nhóm có so sánh trước sau cho 90 người bệnh suy tim mạn điều trị nội trú tại Khoa nội Tim mạch - Bệnh viên Đa khoa tỉnh Nam Định từ tháng 01 đến tháng 04 năm 2018. Tư vấn trực tiếp, nhóm nhỏ từ 3 - 5 người bệnh, nội dung tư vấn dựa trên Hướng dẫn tự chăm sóc trong suy tim mạn của Hội Tim mạch Hoa kỳ (2014) và Hội Tim mạch Việt Nam (2015). Bộ câu hỏi và cách đánh giá Atlanta Heart Failure Knowledge Test – AHFKT.V2 bản tiếng Việt đã được dùng trong nghiên cứu của Trần Thị Ngọc Anh tại Viện tim mạch Việt Nam 2016 và kiểm định độ tin cậy với hệ số Cronbach alpha 0,80 trước khi áp dụng cho nghiên cứu này. Kết quả: Trước can thiệp, kiến thức tự chăm sóc của người bệnh suy tim mạn trong p...
Proceedings of the Tenth International Conference on Enterprise Information Systems, 2008
Group authentication provides authentication for members of communication group between services ... more Group authentication provides authentication for members of communication group between services and users in insecure environments such as wireless networks. Most of the group authentication models do not consider the risk of compromised share secrets in the group under various security threats such as cryptanalysis. Although authentication key exchange in groups can benefit from group key management to minimise this risk, the group key management schemes are inefficient for authentication services. In this paper, a group authentication model for wireless networks services using a group key management is presented. The group key management is specially designed with forward secrecy and session keys for efficient and secure key exchange. Based on this secure session keys, a dynamic group authentication scheme provides a secure and efficient group authentication for wireless network users and services.
Int. J. Netw. Secur., 2010
In modern security models, cryptography plays a fundamental role in protecting data integrity and... more In modern security models, cryptography plays a fundamental role in protecting data integrity and confidentiality in information systems. However, cryptography itself is subject to cryptanalysis attacks. To reduce the cryptanalysis attack risk, a dynamic key theory is presented and analyzed in this paper. Because these dynamic keys are one-time used symmetric cryptographic keys, they can significantly improve the security of cryptographic systems. The dynamic key theory generation scheme and key update mechanism are formally analyzed to demonstrate balance between security and performance. The theory can be applied to enhance the security and performance of cryptographic systems, especially those used in wireless networks communication. Two case studies using the proposed dynamic key theory are also described and analyzed to illustrate the power of the theory.
Heart, Lung and Circulation, 2018
Background: The development of minimally invasive mitral valve surgery has created the motivation... more Background: The development of minimally invasive mitral valve surgery has created the motivation for using this approach in young patients with chronic rheumatic valve disease. We report our recent experience with patients undergoing minimally mitral valve surgery in this group of patients. Methods: Between July 2014 and June 2018, 142 patients with rheumatic mitral valve dysfunction underwent minimally invasive surgery through a right thoracotomy approach at the University Medical Center of Ho Chi Minh City in Vietnam. Diagnosis was confirmed with transthoracic and transesophageal echocardiography (TTE and TEE). We analyzed the inhospital and midterm follow-up outcomes of this group. Results: The mean age was 42.6 ± 9.6 years. Sixty patients (42.3%) were male. Sixty-three patients were diagnosed with functional severe tricuspid regurgitation, 29 patients were identified with moderate tricuspid regurgitation, and tricuspid annulus was more than 21 mm/m²). Mitral valve repair was performed in 16 patients (11.3%), and 126 patients underwent mitral valve replacement. Mitral valve repair techniques included annuloplasty, leaflet peeling, and commissurotomy. Thirty-day mortality was 0.7%. Two patients had to be converted to conventional sternotomy, due to left atrial appendage laceration and mitral annular rupture. The overall survival rate was 98.6%. Freedom from reoperation was 97.1%. Conclusions: In patients with rheumatic valve disease, minimally invasive mitral surgery safely and effectively can be performed with few perioperative complications and good midterm results.
Journal of the American Medical Directors Association, 2020
IOP Conference Series: Earth and Environmental Science, 2019
The study aimed to show in a systematic way possible energy efficiency measures that would decrea... more The study aimed to show in a systematic way possible energy efficiency measures that would decrease the total energy use at the university campus in Trondheim, Norway. The entire study was developed in close collaboration with the NTNU Property and Technical Management divisions, meaning that suggested energy efficiency scenarios and other assumptions were highly relevant. Currently, the campus floor area is about 300 000 m2 and consists of buildings combining offices, lecturing halls, study halls, and laboratories. The campus building stock has been built from 1910 to 2002. To perform this study, building performance simulation and the dynamic segmented modeling were combined. A dynamic neighborhood building stock model was utilized to aggregate the outputs from the building simulation and evaluate global effects of energy efficiency measures. Reference building models for each university cohort were developed based on the methodology for defining the reference buildings. The resul...
Journal of Gynecologic Oncology, 2019
Objectives: The global obesity epidemic has great impact on the prevalence of low-grade endometri... more Objectives: The global obesity epidemic has great impact on the prevalence of low-grade endometrial carcinoma. The preoperative tumor serum marker cancer antigen 125 (CA-125) might contribute to improved identification of high-risk patients within this group. The study aimed to investigate the prognostic value of CA-125 in relation to established preoperative prognosticators, with a focus on identifying patients with poor outcome in low-grade endometrial carcinoma (EC) patients. Methods: Prospective multicenter cohort study including all consecutive patients surgically treated for endometrial carcinoma in nine collaborating hospitals from September 2011 until December 2013. All preoperative histopathological diagnoses were reviewed in a blinded manner. Associations between CA-125 and clinicopathological features were determined. Univariable and multivariable analysis by Cox regression were used. Separate analyses were performed for preoperatively designated low-grade and high-grade endometrial carcinoma patients. Results: A total of 333 patients were analyzed. CA-125 was associated with poor prognostic features including advanced International Federation of Gynecology and Obstetrics (FIGO) stage. In multivariable analysis, age, preoperative tumor and CA-125 were significantly associated with disease-free survival (DFS); preoperative grade, tumor type, FIGO and CA-125 were significantly associated with disease-specific survival (DSS). Low-grade EC patients with elevated CA-125 revealed a DFS of 80.6% and DSS of 87.1%, compared to 92.1% and 97.2% in low-grade EC patients with normal CA-125. Conclusion: Preoperative elevated CA-125 was associated with poor prognostic features and independently associated with DFS and DSS. Particularly patients with low-grade EC and elevated CA-125 represent a group with poor outcome and should be considered as high-risk endometrial carcinoma.
Frontiers in microbiology, 2018
Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year... more Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year. Treatment options for tuberculosis patients are limited, expensive and characterized by severe side effects, especially in the case of multidrug-resistant forms. Uncovering novel vulnerabilities of the pathogen is crucial to generate new therapeutic strategies. Using high resolution microscopy techniques, we discovered one such vulnerability of . We demonstrate that the DNA of can condense under stressful conditions such as starvation and antibiotic treatment. The DNA condensation is reversible and specific for viable bacteria. Based on these observations, we hypothesized that blocking the recovery from the condensed state could weaken the bacteria. We showed that after inducing DNA condensation, and subsequent blocking of acetylation of DNA binding proteins, the DNA localization in the bacteria is altered. Importantly under these conditions, did not replicate and its survival was sign...
Journal of medicinal chemistry, Jan 11, 2018
The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of... more The extensive use of fluconazole (FLC) and other azole drugs has caused the emergence and rise of azole-resistant fungi. The fungistatic nature of FLC in combination with toxicity concerns have resulted in an increased demand for new azole antifungal agents. Herein, we report the synthesis and antifungal activity of novel alkylated piperazines and alkylated piperazine-azole hybrids, their time-kill studies, their hemolytic activity against murine erythrocytes, as well as their cytotoxicity against mammalian cells. Many of these molecules exhibited broad-spectrum activity against all tested fungal strains, with excellent minimum inhibitory concentration (MIC) values against non-albicans Candida and Aspergillus strains. The most promising compounds were found to be less hemolytic than the FDA-approved antifungal agent voriconazole (VOR). Finally, we demonstrate that the synthetic alkylated piperazine-azole hybrids do not function by fungal membrane disruption, but instead by disruptio...
Bioorganic & medicinal chemistry, Feb 1, 2018
The fungistatic nature and toxicity concern associated with the azole drugs currently on the mark... more The fungistatic nature and toxicity concern associated with the azole drugs currently on the market have resulted in an increased demand for new azole antifungal agents for which these problematic characteristics do not exist. The extensive use of azoles has resulted in fungal strains capable of resisting the action of these drugs. Herein, we report the synthesis and antifungal activity of novel fluconazole (FLC) analogues with alkyl-, aryl-, cycloalkyl-, and dialkyl-amino substituents. We evaluated their antifungal activity by MIC determination and time-kill assay as well as their safety profile by hemolytic activity against murine erythrocytes as well as cytotoxicity against mammalian cells. The best compounds from our study exhibited broad-spectrum activity against most of the fungal strains tested, with excellent MIC values against a number of clinical isolates. The most promising compounds were found to be less hemolytic than the least hemolytic FDA-approved azole antifungal ag...
ACS infectious diseases, Jan 30, 2018
A common cause of resistance to kanamycin (KAN) in tuberculosis is overexpression of the enhanced... more A common cause of resistance to kanamycin (KAN) in tuberculosis is overexpression of the enhanced intracellular survival (Eis) protein. Eis is an acetyltransferase that multiacetylates KAN and other aminoglycosides, rendering them unable to bind the bacterial ribosome. By high-throughput screening, a series of substituted 1,2,4-triazino[5,6 b]indole-3-thioether molecules were identified as effective Eis inhibitors. Herein, we purchased 17 and synthesized 22 new compounds, evaluated their potency, and characterized their steady-state kinetics. Four inhibitors were found not only to inhibit Eis in vitro, but also to act as adjuvants of KAN and partially restore KAN sensitivity in a Mycobacterium tuberculosis KAN-resistant strain in which Eis is upregulated. A crystal structure of Eis in complex with a potent inhibitor and CoA shows that the inhibitors bind in the aminoglycoside binding site snugly inserted into a hydrophobic cavity. These inhibitors will undergo preclinical developmen...
ACS infectious diseases, Apr 17, 2017
Tuberculosis (TB) remains one of the leading causes of mortality worldwide. Hence, the identifica... more Tuberculosis (TB) remains one of the leading causes of mortality worldwide. Hence, the identification of highly effective antitubercular drugs with novel modes of action is crucial. In this paper, we report the discovery and development of pyrrolo[1,5-a]pyrazine-based analogues as highly potent inhibitors of the Mycobacterium tuberculosis (Mtb) acetyltransferase enhanced intracellular survival (Eis), whose up-regulation causes clinically observed resistance to the aminoglycoside (AG) antibiotic kanamycin A (KAN). We performed a structure-activity relationship (SAR) study to optimize these compounds as potent Eis inhibitors both against purified enzyme and in mycobacterial cells. A crystal structure of Eis in complex with one of the most potent inhibitors reveals that the compound is bound to Eis in the AG binding pocket, serving as the structural basis for the SAR. These Eis inhibitors have no observed cytotoxicity to mammalian cells and are promising leads for the development of in...
Bioorganic & medicinal chemistry, Dec 31, 2016
Antibiotic resistance is a worldwide problem that needs to be addressed. Staphylococcus aureus is... more Antibiotic resistance is a worldwide problem that needs to be addressed. Staphylococcus aureus is one of the dangerous "ESKAPE" pathogens that rapidly evolve and evade many current FDA-approved antibiotics. Thus, there is an urgent need for new anti-MRSA compounds. Ebselen (also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one) has shown promising activity in clinical trials for cerebral ischemia, bipolar disorder, and noise-induced hearing loss. Recently, there has been a renewed interest in exploring the antibacterial properties of ebselen. In this study, we synthesized an ebselen-inspired library of 33 compounds where the selenium atom has been replaced by sulfur (ebsulfur derivatives) and evaluated them against a panel of drug-sensitive and drug-resistant S. aureus and non-S. aureus strains. Within our library, we identified three outstanding analogues with potent activity against all S. aureus strains tested (MIC values mostly ⩽2μg/mL), and numerous additional ones wi...
Digest of Papers. COMPCON Spring 88 Thirty-Third IEEE Computer Society International Conference, 1988
In the remote control of distant robots by a human operator, even if the robotic manipulator and/... more In the remote control of distant robots by a human operator, even if the robotic manipulator and/or mobility device has vision or other senses, problems arise involving control, communications, and display. The communication restrictions and especially severe bandwidth limitations suggest that transmitting large numbers of videocamera pictures frame by frame may not be the most expeditious means of providing display
Proceedings of the IEEE 2003 Custom Integrated Circuits Conference, 2003.
The SoPC (System on a Programmable Chip) aspects of the Stratix GX™ FPGA with 3.125Gbps SERDES ar... more The SoPC (System on a Programmable Chip) aspects of the Stratix GX™ FPGA with 3.125Gbps SERDES are described. The FPGA was fabricated on a 0.13um, 9-layer metal process. The 16 high-speed serial transceiver channels with Clock Data Recovery (CDR) provides 622megabits per second (Mbps) to 3.125-Gbps full-duplex transceiver operation per channel. Another challenge described, is the implementation of 39 source-synchronous channels at 100Mbps to 1Gbps, utilizing Dynamic Phase Alignment (DPA). The implementation and integration of the FPGA logic array (with its own Hard IP) with the CDR and DPA channels involved grappling with SoC design issues and methodologies.
2012 IEEE RIVF International Conference on Computing & Communication Technologies, Research, Innovation, and Vision for the Future, 2012
This paper introduces a library which supports programmers to write parallel programs on GPU arch... more This paper introduces a library which supports programmers to write parallel programs on GPU architecture, especially with a system consisting of multi-GPUs. The library is designed from the idea of skeletons, which helps us to make parallel programs easily and quickly as if writing sequential programs. Skeletons usually are described by functional language which supports high-order function totally. Because of the performance and popularity of C++ language, we try to re-annotate C++ language to support high-order functions completely, hence, it is convenience for us to create general-purpose skeletons.
The Journal of Physical Chemistry B, 2011
Tetrahedron Letters, 2010
An oxacalix[2]arene[2]pyrimidine-bis(Zn II-porphyrin) conjugate was readily prepared via nucleoph... more An oxacalix[2]arene[2]pyrimidine-bis(Zn II-porphyrin) conjugate was readily prepared via nucleophilic aromatic substitution of a phenolic AB 3-Zn-porphyrin on the upper rim of a (1,3-alternate) 5,17-bis(methylsulfonyl)oxacalix[4]arene precursor. Efficient 1:1 complex formation between the 'jaws' bisporphyrin tweezer and fullerene C 70 was evidenced by 1 H NMR titrations (K = 3.0 Â 10 4 M À1), while no detectable complexation could be observed with C 60. On the other hand, an analogous oxacalix[4]arene-bis(Cu-corrole) conjugate did not show any measurable (C 60 or C 70) fullerene binding.