Huynh Nguyen - Academia.edu (original) (raw)

Papers by Huynh Nguyen

MedPharmRes

The research aimed to increase certain HbA1c concentrations at medical decision levels for extern... more The research aimed to increase certain HbA1c concentrations at medical decision levels for external quality control samples from healthy donor blood. The in vitro study was performed from October 2019 to January 2021 at Quality Control Center for Medical Laboratory at University of Medicine and Pharmacy at Ho Chi Minh City. The study observed on the conditions including the optimal buffer solutions (BAGPM, BPS, Ringer, Saline), temperature (2°C - 8°C, 22°C - 24°C, 37°C), and glucose concentration (100 mM, 305 mM, 500 mM) affecting the HbA1c concentration in vitro to make the external quality control samples fell in normal, prediabetes, and diabetes range. At every condition, the HbA1c concentration was measured by Tina Quant method to look for the optimal procedure to increase HbA1c concentration required of the external quality control protocol. The highest HbA1c concentration (11.57±0.2%) was found in BAGPM solution with 100 mM glucose after 15 days with the baseline HbA1c 5.43±0....

Biomolecules

Reactive oxygen species (ROS) are highly reactive molecules generated in living organisms and an ... more Reactive oxygen species (ROS) are highly reactive molecules generated in living organisms and an excessive production of ROS culminates in oxidative stress and cellular damage. Notably, oxidative stress plays a critical role in the pathogenesis of a number of oral mucosal diseases, including oral mucositis, which remains one of cancer treatments’ most common side effects. We have shown previously that oral keratinocytes are remarkably sensitive to oxidative stress, and this may hinder the development and reproducibility of epithelial cell-based models of oral disease. Here, we examined the oxidative stress signatures that parallel oral toxicity by reproducing the initial events taking place during cancer treatment-induced oral mucositis. We used three oral epithelial cell lines (an immortalized normal human oral keratinocyte cell line, OKF6, and malignant oral keratinocytes, H357 and H400), as well as a mouse model of mucositis. The cells were subjected to increasing oxidative stres...

IEEE Access

This paper presents a data fusion framework to enhance the accuracy of air-pollutant forecast in ... more This paper presents a data fusion framework to enhance the accuracy of air-pollutant forecast in the state of New South Wales (NSW), Australia using deep learning (DL) as a core model. Here, we propose a long short-term memory Bayesian neural network (LSTM-BNN) to improve performance of the predictive profiles via quantifying uncertainties and adjusting model parameters. For this, we develop a new inferring technique for kernel density estimation with subdivision tuning to ensure both forecast accuracy and computational efficiency with a limited number of samples from the prediction distributions. Moreover, a novel algorithm called spatially-adjusted multivariate imputation by chained equation is also developed to take into account spatial correlations between nearby air-quality stations for correctly imputing the incoming data, and hence, to enable forecasting at a local scale. The LSTM-BNN framework is evaluated with observed datasets collected from stations and modeling outputs generated by the Conformal Cubic Atmospheric Model-Chemical Transport Model (CCAM-CTM) currently used in NSW. The airborne pollutants under investigation are PM 2.5 and ozone, which frequently exceed the standards. The results obtained from data fusion with our framework demonstrated high performance of the proposed LSTM-BNN model in air-pollutant prediction with reductions of over 30% in root mean square error compared to CCAM-CTM and over 50 % in inferring time compared to a DL model with Gaussian-based inference. Accuracy and reliability of the proposed model were also achieved with air pollution forecast in various seasons and suburbs.

Tạp chí Y học Việt Nam

Daratumumab được Cục Quản lý Thực phẩm và Dược phẩm Hoa Kỳ (Food and Drug Administration – FDA) p... more Daratumumab được Cục Quản lý Thực phẩm và Dược phẩm Hoa Kỳ (Food and Drug Administration – FDA) phê duyệt vào năm 2015 trong điều trị bệnh đa u tuỷ xương (ĐUTX) [3] với hiệu lực lâm sàng được chứng minh qua nhiều nghiên cứu trên thế giới [6]. Tuy nhiên tính chi phí – hiệu quả là yếu tố cần cân nhắc khi chỉ định thuốc trong thực hành lâm sàng, đặc biệt ở các quốc gia có ngân sách y tế giới hạn như Việt Nam. Trong phân tích chi phí – hiệu quả, xây dựng mô hình là bước quan trọng, nhất là khi chưa có nghiên cứu nào thực hiện tại Việt Nam. Thông qua các bước xây dựng mô hình hoá cơ bản, đề tài đã thiết lập được mô hình phân tích chi phí – hiệu quả dựa trên phần mềm Microsoft Excel 2013. Mô hình cho phép phân tích chi phí – hiệu quả của daratumumab so với các phác đồ chuẩn trong điều trị đa u tuỷ xương tại Việt Nam.

Tạp chí Y Dược học Cần Thơ

Đặt vấn đề: Hen phế quản là một vấn đề y tế toàn cầu nghiêm trọng ảnh hưởng đến tất cả mọi nhóm t... more Đặt vấn đề: Hen phế quản là một vấn đề y tế toàn cầu nghiêm trọng ảnh hưởng đến tất cả mọi nhóm tuổi. Mục tiêu nghiên cứu: Mô tả đặc điểm chức năng thông khí phổi bằng hô hấp ký và xác định một số yếu tố liên quan với tái phát cơn hen phế quản cấp. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên bệnh nhân hen phế quản cấp từ 6 đến 15 tuổi nhập viện tại Bệnh viện Nhi đồng Cần Thơ từ tháng 1/2021 đến tháng 5/2022. Kết quả: Có 60 bệnh nhân hen phế quản được đưa vào nghiên cứu. Tuổi trung bình là 8,8±1,9 (tuổi), giới nam chiếm 68,3%. Giá trị trung bình của FEV1 là 68,9±21,1% dự đoán; FVC là 86,5±20,9% dự đoán; FEV1/FVC là 69,9±13,0%; FEF25-75 là 44,5±21,1% dự đoán. Khi so sánh đặc điểm chức năng thông khí phổi theo độ nặng cơn hen cấp, chúng tôi ghi nhận có sự khác biệt có ý nghĩa thống kê về FEV1 (p=0,002), FVC (p=0,045), FEV1/FVC (p<0,001) và FEF25-75 (p<0,001) giữa các nhóm. Tỷ lệ tái phát cơn hen cấp là 13,3%. Nhóm bệnh nhân tái phát cơn có FEV1, FEV1/FVC,...

Tạp chí Y Dược học Cần Thơ

Đặt vấn đề: Hen phế quản ở trẻ từ 6 tháng đến 5 tuổi có thể liên quan đến một số yếu tố, đặc biệt... more Đặt vấn đề: Hen phế quản ở trẻ từ 6 tháng đến 5 tuổi có thể liên quan đến một số yếu tố, đặc biệt là vấn đề nồng độ vitamin D không đầy đủ. Mục tiêu nghiên cứu: Xác định tỉ lệ vitamin D không đầy đủ. Khảo sát một số yếu tố liên quan và một số đặc điểm lâm sàng, cận lâm sàng, kết quả điều trị ở trẻ hen phế quản từ 6 tháng đến 5 tuổi có nồng độ vitamin D không đầy đủ. Đối tượng và phương pháp nghiên cứu: Mô tả cắt ngang có phân tích với 30 ca bệnh hen phế quản từ 6 tháng đến 5 tuổi tại khoa Nội hô hấp, Bệnh viện Nhi Đồng Cần Thơ, từ 1/4/2021 đến 1/3/2022. Bệnh nhi được xác định mức độ cơn hen cấp, phỏng vấn theo bảng câu hỏi, xét nghiệm công thức máu, định lượng vitamin D và theo dõi điều trị. Kết quả: Nồng độ vitamin D trung bình ở trẻ hen phế quản từ 6 tháng đến 5 tuổi là 34,6±11,3ng/ml. Tỷ lệ trẻ hen phế quản có vitamin D không đầy đủ là 33,3%. Một số yếu tố liên quan đến nồng độ vitamin D không đầy đủ: không tiếp xúc với ánh nắng mặt trời từ 15-30 phút ngày (75,0%), không uống bổ ...

BÁO CÁO KHOA HỌC VỀ NGHIÊN CỨU VÀ GIẢNG DẠY SINH HỌC Ở VIỆT NAM HỘI NGHỊ KHOA HỌC QUỐC GIA LẦN THỨ 5 - PROCEEDING OF THE 5TH NATIONAL SCIENTIFIC CONFERENCE ON BIOLOGICAL RESEARCH AND TEACHING IN VIETNAM

In this research, we evaluated the preimplantation development, embryo morphology, the time of ce... more In this research, we evaluated the preimplantation development, embryo morphology, the time of cell division and the cell number of the blastocyst stage of single mouse blastomeres biopsied from 8-cell embryos. One blastomere was biopsied from each 8-cell embryo using micromanipulation system with XYClone laser. After biopsy, the single blastomeres and biopsied embryos were cultured together in the in vitro development (IVD) medium until the blastocyst stage. Our data shows that, one blastomere could be developed to the blastocyst stage with approximately 6 cells ± 0.5 and the remaining embryo could be cultured normally to the blastocyst stage with 95 cells ± 4.9 (P < 0.05). However, the percentage of biopsied blastomere that have developed to the morula and blastocyst stage is lower than that of biopsied and non-biopsied embryos. The results also show that the time taken for biopsied blastomere to form morula and blastocyst was the same as that of biopsied embryos although the cell number was much lower. In conclusion, single blastomeres collected from the 8-cell stage mouse embryos can develop into morula and blastocyst with the same time. Thus, the time for embryo compaction and blastocyst formation was depended on the time of fertilization. These results provide potential benefits for preimplantation genetic diagnosis (PGD) in infertile couples at risk of genetic diseases as well as opening a novel approach for the establishment of stem cell line from biopsied blastomere combined with PGD in future research.

IEEE Access

This paper presents an Internet of Things-enabled low-cost wireless sensor network with newly-dev... more This paper presents an Internet of Things-enabled low-cost wireless sensor network with newly-developed dependable schemes to improve reliability for monitoring air quality in suburban areas. The system features sensing units for router communications with energy savings from dynamic conservation. Based on the reliability function and mean time to failure, a continuous time Markov chain model is used to analyze the monitoring performance. The proposed dependable monitoring network is shown to achieve high availability with regards to energy consumption and data assurance with the survival probability of over 80% during a minimum period of 72-hour operation for monitoring air quality in a suburb. Distributions of fine particle concentrations studied over a 6-month period demonstrate feasibility of the developed system in its high correlations to benchmark monitoring stations with the Pearson's coefficients obtained at 0.903 and 0.817 respectively for PM2.5 and PM10. Statistical analysis is conducted for performance evaluation in association with two extreme events, one with bushfires and the other with pandemic lockdown. The results obtained indicate enhancements in reliability and accuracy of the colocated dependable low-cost sensors network proposed for wireless monitoring of air quality in urban conditions. INDEX TERMS Low-cost wireless sensor networks, Internet of Things, air quality, dependability, monitoring systems.

Ministry of Science and Technology, Vietnam, 2021

This research presents the effect of heat treatment temperature on the forming ability of β-trica... more This research presents the effect of heat treatment temperature on the forming ability of β-tricalcium phosphate (β-TCP) bioceramic materials toward the bone tissue regeneration application. Ca(OH)2 and H3PO4 were mixed with a Ca/P molar ratio of 1.5, followed by hydrothermal treatment at 180oC for 24 hours to obtain the calcium phosphate hydrate (CPH) with phase composition similar to hydroxyapatite (HA). The CPH mineral was heat-treated at 700 and 1000oC for 3 hours to evaluate the ability to obtain β-TCP. The result showed that β-TCP can be obtained by the CPH calcined at 1000oC for 3 hours, with the particle size of 1~2 μm, suitable for bone tissue regeneration application.

Nâng cao sự hài lòng khách hàng được cho là giải pháp giúp phát triển các hoạt động kinh doanh dị... more Nâng cao sự hài lòng khách hàng được cho là giải pháp giúp phát triển các hoạt động kinh doanh dịch vụ, trong đó có dịch vụ ngân hàng. Vì thế, nghiên cứu này nhằm mục đích nhận diện và đo lường các nhân tố tác động đến sự hài lòng khách hàng tại các ngân hàng thương mại ở Việt Nam. Để đạt được mục tiêu nghiên cứu, tác giả tiến hành khảo sát 461 khách hàng đã và đang giao dịch tại các ngân hàng thương mại và sử dụng mô hình cấu trúc tuyến tính (SEM) để kiểm định các giả thuyết nghiên cứu. Kết quả nghiên cứu cho thấy có bốn nhân tố tác động đến sự hài lòng khách hàng gồm: năng lực đáp ứng, cơ sở vật chất, giá dịch vụ, và bảo mật thông tin khách hàng. Dựa vào kết quả nghiên cứu, tác giả đề xuất một số hàm ý quản trị nhằm nâng cao sự hài lòng khách hàng. Bên cạnh các kết quả đạt được, nghiên cứu này còn một số hạn chế về phương pháp chọn mẫu, nên cần các nghiên cứu khác bổ sung.

Proceedings of the 37th International Symposium on Automation and Robotics in Construction (ISARC), 2020

This paper proposes an IoT-enabled network of low-cost sensors that are co-located for constructi... more This paper proposes an IoT-enabled network of low-cost sensors that are co-located for construction site monitoring. The network performance enhancement is achieved via its system dependability in terms of improved availability, integrity, reliability, maintainability, security and safety in real-time monitoring of environment parameters. The sensor motes of various sensing modules form a reliable wireless in-situ cluster for gathering on-site information of air temperature, soil moisture, air pressure, humidity, particulate matters (PM), emissions and weather variables. They are useful for the site management, improving safety and effective operation of construction equipment. The components for the development include inexpensive microcontrollers ESP32 embedded with wireless gateway function and energy-efficient motes featuring cost-effective sensors. Here, the adoption of the dependability concept for collocated sensor motes aims to introduce a level of redundancy to allow for improving fault-tolerance and reliability. Extensive field tests have been conducted in different environments. Experimental results as well as statistical analysis are provided to verify the merits of the proposed approach.

Journal of Food Processing and Preservation, 2021

Rosmarinic acid (RA) is an ester of caffeic acid, which is a water-soluble phenolic compound and ... more Rosmarinic acid (RA) is an ester of caffeic acid, which is a water-soluble phenolic compound and is present in most species of the Lamiaceae family (Sik et al., 2020). RA is a strong natural antioxidant (Bernatoniene et al., 2016) and exhibits potential antibacterial, antiviral, antidiabetic, antiallergic, immunosuppressive, and anti-inflammatory activities (Anwar et al., 2020; Nadeem et al., 2019). Because of such remarkable biological activities, RA has gained considerable attention for use in pharmaceutical and functional food industries (Amoah et al., 2016). Consequently, the demand for RA has increased considerably, which has motivated the development of effective extraction methods from its natural sources. Rosemary (Rosmarinus officinalis L.) is an aromatic evergreen herb belonging to the Lamiaceae family (Karataş et al., 2020).

NEWS of National Academy of Sciences of the Republic of Kazakhstan, 2020

In modern organisations, personnel are not at their workplace permanently and, accordingly, in ca... more In modern organisations, personnel are not at their workplace permanently and, accordingly, in case of emergency, they are at risk. There are a number of situations in which the access of even emergency services to the premises is very difficult to organise due to the regime of secrecy and the desire to preserve trade secrets. Additionally, the system of restricting the movement of workers in their places can be very limited on the part of management in order to maintain production discipline. The novelty of the study is determined by the fact that when using the detection system in case of fire or other emergency, its integration with the access verification and distribution system can be based on the use of integrated access systems. The authors show that the use of conditional access systems makes it possible to get employee lists at a faster pace and identify threats if certain technological complexes are used in their work. The practical significance of the study is determined ...

Scientific Reports, 2020

The increasing risk of infectious pathogens, especially in the under-developed countries, is dema... more The increasing risk of infectious pathogens, especially in the under-developed countries, is demanding the development of point-of-care (POC) nucleic acid testing in the low-resource setting conditions. Here, we describe a methodology for colorimetric quantitative analysis of nucleic acid using an easy-to-build smartphone-based platform, offering low-cost, portability, simplicity in operation, and user-friendliness. The whole system consists of a hand-held box equipped with a smartphone, a film heater, a white LED, a loop-mediated isothermal amplification (LAMP) chip, and a DC converter, and all the processes were powered by a portable battery of 5 V. Upon the amplification of the target gene by an Eriochrome Black T-mediated LAMP reaction, the color of the LAMP reaction was changed from violet to blue that was real-time recorded by a smartphone camera. To keep track of the progress of the color change, we developed a novel mobile app in which a hue value was accepted as an indicato...

Palaeontologia Electronica, 2014

This study introduces a standardized framework for the holistic analysis of cortical and trabecul... more This study introduces a standardized framework for the holistic analysis of cortical and trabecular bone structure. This method, although applicable to all bones of the skeleton, is particularly useful for irregular-shaped or small bones for which the application of traditional methods has been especially challenging. Traditional analyses have quantified cortical or trabecular structure in only selected regions of a bone, such as single cross-sections of cortical bone or volumes of interest of trabecular structure in epiphyses. The proposed method improves on these traditional methods by visualizing and quantifying the internal bony structure throughout the entire bone and in userdefined anatomical subregions. Here, we describe and demonstrate the method using high-resolution microtomographic scans of a first metacarpal of an orangutan, gorilla, chimpanzee and human. Using automated morphological filters, the cortical bone is defined and extracted from the underlying trabecular structure to create two 3D models, one of the cortex and one of the trabecular bone that can be analysed separately. We test the sensitivity of the morphological parameters used to create these 3D models, demonstrating that the parameters defined here are robust and can provide accurate measures of cortical thickness, relative bone density, trabecular orientation, trabecular thickness and degree of anisotropy. This new, holistic method is able to reveal morphological and functional information about bone loading that is obscured or ignored using traditional methods, thus providing more informed interpretations of behaviour in extant and fossil taxa.

Forests, 2019

This study analyzed the perceptions of four stakeholder groups (forest landowners, private forest... more This study analyzed the perceptions of four stakeholder groups (forest landowners, private forest consultants, forest management researchers or educators, and federal or state agency foresters), regarding their management practices and preferred geographic growing conditions of loblolly pine in Virginia by combining AHP (analytical hierarchy process) and regression modeling. By ranking the importance of different geographical conditions for managing loblolly pine, we aimed to identify ways to support loblolly growth as a potential feedstock for biofuel generation. We achieved this through collecting survey responses from 43 stakeholders during the 2019 Virginia Forestry Summit. The results showed that the landowner, researcher/educator, and federal/state agency stakeholder groups all indicated that proximity to a mill was the most important criteria, whereas the consultant stakeholder group indicated that proximity to a road was the most important criteria. All the stakeholder groups indicated that distance from protected land was the least important criteria, followed by proximity to a water body and flat land. The regression model revealed that acres of land managed and loblolly rotation age were correlated to the weight given to the distance to a mill criterion, where increased acreage and increased rotation age were associated with an increased prioritization of proximity to a mill. Distance from protected land, the lowest-ranking criteria, was shown to have an association with the level of experience with loblolly, where more experience was associated with a lower prioritization of proximity from protected land. A contingency analysis of the self-identified level of experience with loblolly in each stakeholder group revealed that federal/state agency foresters had the most experience, followed by consultants, landowners, and researchers/educators. The research supports the importance of understanding the variation of perceptions between and within stakeholder groups in order to develop the necessary infrastructural and policy support for the sustainable development of bioenergy.

The neurotrophin, brain-derived neurotrophic factor (BDNF) promotes central nervous system (CNS) ... more The neurotrophin, brain-derived neurotrophic factor (BDNF) promotes central nervous system (CNS) myelination during development and after injury. This is achieved via activation of oligodendrocyte-expressed tropomyosin-related kinase (Trk) B receptors. However, while administration of BDNF has shown beneficial effects, BDNF itself has a poor pharmacokinetic profile. Here, we compare two TrkB-targeted BDNF-mimetics, the structural-mimetic, tricyclic dimeric peptide-6 (TDP6) and the non-peptide small molecule TrkB agonist LM22A-4 in the cuprizone model of central demyelination in female mice. Both mimetics promoted remyelination, increasing myelin sheath thickness and oligodendrocyte densities after one-week recovery. Importantly, LM22A-4 exerts these effects in an oligodendroglial TrkB-dependent manner. However, analysis of TrkB signaling by LM22A-4 suggests rather than direct activation of TrkB, LM22A-4 exerts its effects via indirect transactivation of Trk receptors. Overall, these...

La Houille Blanche, 2012

An experimental program was set up to study the suffusion process by using a triaxial erodimeter ... more An experimental program was set up to study the suffusion process by using a triaxial erodimeter developed in our laboratory. This device is equipped with a multichannel optical sensor in order to characterize precisely the initiation and development of suffusion process. With the objective to characterize the erodibility of clayey sand, tests were performed under either flow-rate-controlled or hydraulic-gradient-controlled conditions. The test analysis allows distinguishing three steps. First, suffusion of a small quantity of clay is detected on downstream. In flow-rate-controlled conditions, this suffusion is immediately followed by a high increase of the hydraulic gradient which continues during the second step. The second step is characterized by very low amount of particles in the effluent. During the third step, high suffusion of clay appears and induces erosion of clay and sand. The results reveal the necessity to take into account the evolutions of hydraulic gradient (or pressure gradient) and also the evolutions of velocity (or flow rate) to represent the hydraulic loading. The analysis based on energy expended by fluid flow and eroded mass permits to characterize the soil sensitivity to clay suffusion and clayey sand erosion for tests under the two types of hydraulic loading.

Advances in Natural Sciences: Nanoscience and Nanotechnology, 2014

In the present research work we evaluate the in vivo distribution of gold nanoparticles (AuNPs) a... more In the present research work we evaluate the in vivo distribution of gold nanoparticles (AuNPs) at different time durations after intravenous administration in mice. AuNPs with size of about 20 nm and concentration of 1 mM were synthesized by gamma irradiation method using 0.5% alginate as a stabilizer. AuNPs were characterized by UV-Vis spectrum and transmission electron microscope (TEM) image. The as-synthesized AuNPs solution was centrifuged to concentrate to 2 mg AuNPs/1 ml solution. Intravenous administration of AuNPs in mice was done at the tail with 1 mg AuNPs (0.5 ml). After 1, 3, 6 and 12 h of injection, blood was collected, mice were sacrificed and various tissues/organs were removed. The blood haematology and serum clinical chemistry indexes of mice intravenously injected with AuNPs were not significantly different compared to those of the control ones. In addition, gold content in the samples was quantitatively determined by k 0-neutron activation analysis (k 0-NAA) at nuclear research reactor, Da Lat Vietnam. Results showed that after 1 h of administration, AuNPs were mainly accumulated in blood (41.56%), in liver (51.60.%), in lung (6.16%) and in kidney (0.53%). After that the content of AuNPs in blood was decreased to nearly normal at 6 h while the content of AuNPs in liver, lung and kidney was accumulatively increased. After 6 h of administration AuNPs were mainly accumulated in organs like liver (76.33%), lung (11.86%) and kidney (2.23%). Thus, the obtained results are practically useful for using AuNPs as x-ray contrast agent, especially for blood and liver.

PLoS ONE, 2013

Bone is capable of adapting during life in response to stress. Therefore, variation in locomotor ... more Bone is capable of adapting during life in response to stress. Therefore, variation in locomotor and manipulative behaviours across extant hominoids may be reflected in differences in trabecular bone structure. The hand is a promising region for trabecular analysis, as it is the direct contact between the individual and the environment and joint positions at peak loading vary amongst extant hominoids. Building upon traditional volume of interest-based analyses, we apply a wholeepiphysis analytical approach using high-resolution microtomographic scans of the hominoid third metacarpal to investigate whether trabecular structure reflects differences in hand posture and loading in knuckle-walking (Gorilla, Pan), suspensory (Pongo, Hylobates and Symphalangus) and manipulative (Homo) taxa. Additionally, a comparative phylogenetic method was used to analyse rates of evolutionary changes in trabecular parameters. Results demonstrate that trabecular bone volume distribution and regions of greatest stiffness (i.e., Young's modulus) correspond with predicted loading of the hand in each behavioural category. In suspensory and manipulative taxa, regions of high bone volume and greatest stiffness are concentrated on the palmar or distopalmar regions of the metacarpal head, whereas knuckle-walking taxa show greater bone volume and stiffness throughout the head, and particularly in the dorsal region; patterns that correspond with the highest predicted joint reaction forces. Trabecular structure in knuckle-walking taxa is characterised by high bone volume fraction and a high degree of anisotropy in contrast to the suspensory brachiators. Humans, in which the hand is used primarily for manipulation, have a low bone volume fraction and a variable degree of anisotropy. Finally, when trabecular parameters are mapped onto a molecular-based phylogeny, we show that the rates of change in trabecular structure vary across the hominoid clade. Our results support a link between inferred behaviour and trabecular structure in extant hominoids that can be informative for reconstructing behaviour in fossil primates.

MedPharmRes

The research aimed to increase certain HbA1c concentrations at medical decision levels for extern... more The research aimed to increase certain HbA1c concentrations at medical decision levels for external quality control samples from healthy donor blood. The in vitro study was performed from October 2019 to January 2021 at Quality Control Center for Medical Laboratory at University of Medicine and Pharmacy at Ho Chi Minh City. The study observed on the conditions including the optimal buffer solutions (BAGPM, BPS, Ringer, Saline), temperature (2°C - 8°C, 22°C - 24°C, 37°C), and glucose concentration (100 mM, 305 mM, 500 mM) affecting the HbA1c concentration in vitro to make the external quality control samples fell in normal, prediabetes, and diabetes range. At every condition, the HbA1c concentration was measured by Tina Quant method to look for the optimal procedure to increase HbA1c concentration required of the external quality control protocol. The highest HbA1c concentration (11.57±0.2%) was found in BAGPM solution with 100 mM glucose after 15 days with the baseline HbA1c 5.43±0....

Biomolecules

Reactive oxygen species (ROS) are highly reactive molecules generated in living organisms and an ... more Reactive oxygen species (ROS) are highly reactive molecules generated in living organisms and an excessive production of ROS culminates in oxidative stress and cellular damage. Notably, oxidative stress plays a critical role in the pathogenesis of a number of oral mucosal diseases, including oral mucositis, which remains one of cancer treatments’ most common side effects. We have shown previously that oral keratinocytes are remarkably sensitive to oxidative stress, and this may hinder the development and reproducibility of epithelial cell-based models of oral disease. Here, we examined the oxidative stress signatures that parallel oral toxicity by reproducing the initial events taking place during cancer treatment-induced oral mucositis. We used three oral epithelial cell lines (an immortalized normal human oral keratinocyte cell line, OKF6, and malignant oral keratinocytes, H357 and H400), as well as a mouse model of mucositis. The cells were subjected to increasing oxidative stres...

IEEE Access

This paper presents a data fusion framework to enhance the accuracy of air-pollutant forecast in ... more This paper presents a data fusion framework to enhance the accuracy of air-pollutant forecast in the state of New South Wales (NSW), Australia using deep learning (DL) as a core model. Here, we propose a long short-term memory Bayesian neural network (LSTM-BNN) to improve performance of the predictive profiles via quantifying uncertainties and adjusting model parameters. For this, we develop a new inferring technique for kernel density estimation with subdivision tuning to ensure both forecast accuracy and computational efficiency with a limited number of samples from the prediction distributions. Moreover, a novel algorithm called spatially-adjusted multivariate imputation by chained equation is also developed to take into account spatial correlations between nearby air-quality stations for correctly imputing the incoming data, and hence, to enable forecasting at a local scale. The LSTM-BNN framework is evaluated with observed datasets collected from stations and modeling outputs generated by the Conformal Cubic Atmospheric Model-Chemical Transport Model (CCAM-CTM) currently used in NSW. The airborne pollutants under investigation are PM 2.5 and ozone, which frequently exceed the standards. The results obtained from data fusion with our framework demonstrated high performance of the proposed LSTM-BNN model in air-pollutant prediction with reductions of over 30% in root mean square error compared to CCAM-CTM and over 50 % in inferring time compared to a DL model with Gaussian-based inference. Accuracy and reliability of the proposed model were also achieved with air pollution forecast in various seasons and suburbs.

Tạp chí Y học Việt Nam

Daratumumab được Cục Quản lý Thực phẩm và Dược phẩm Hoa Kỳ (Food and Drug Administration – FDA) p... more Daratumumab được Cục Quản lý Thực phẩm và Dược phẩm Hoa Kỳ (Food and Drug Administration – FDA) phê duyệt vào năm 2015 trong điều trị bệnh đa u tuỷ xương (ĐUTX) [3] với hiệu lực lâm sàng được chứng minh qua nhiều nghiên cứu trên thế giới [6]. Tuy nhiên tính chi phí – hiệu quả là yếu tố cần cân nhắc khi chỉ định thuốc trong thực hành lâm sàng, đặc biệt ở các quốc gia có ngân sách y tế giới hạn như Việt Nam. Trong phân tích chi phí – hiệu quả, xây dựng mô hình là bước quan trọng, nhất là khi chưa có nghiên cứu nào thực hiện tại Việt Nam. Thông qua các bước xây dựng mô hình hoá cơ bản, đề tài đã thiết lập được mô hình phân tích chi phí – hiệu quả dựa trên phần mềm Microsoft Excel 2013. Mô hình cho phép phân tích chi phí – hiệu quả của daratumumab so với các phác đồ chuẩn trong điều trị đa u tuỷ xương tại Việt Nam.

Tạp chí Y Dược học Cần Thơ

Đặt vấn đề: Hen phế quản là một vấn đề y tế toàn cầu nghiêm trọng ảnh hưởng đến tất cả mọi nhóm t... more Đặt vấn đề: Hen phế quản là một vấn đề y tế toàn cầu nghiêm trọng ảnh hưởng đến tất cả mọi nhóm tuổi. Mục tiêu nghiên cứu: Mô tả đặc điểm chức năng thông khí phổi bằng hô hấp ký và xác định một số yếu tố liên quan với tái phát cơn hen phế quản cấp. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên bệnh nhân hen phế quản cấp từ 6 đến 15 tuổi nhập viện tại Bệnh viện Nhi đồng Cần Thơ từ tháng 1/2021 đến tháng 5/2022. Kết quả: Có 60 bệnh nhân hen phế quản được đưa vào nghiên cứu. Tuổi trung bình là 8,8±1,9 (tuổi), giới nam chiếm 68,3%. Giá trị trung bình của FEV1 là 68,9±21,1% dự đoán; FVC là 86,5±20,9% dự đoán; FEV1/FVC là 69,9±13,0%; FEF25-75 là 44,5±21,1% dự đoán. Khi so sánh đặc điểm chức năng thông khí phổi theo độ nặng cơn hen cấp, chúng tôi ghi nhận có sự khác biệt có ý nghĩa thống kê về FEV1 (p=0,002), FVC (p=0,045), FEV1/FVC (p<0,001) và FEF25-75 (p<0,001) giữa các nhóm. Tỷ lệ tái phát cơn hen cấp là 13,3%. Nhóm bệnh nhân tái phát cơn có FEV1, FEV1/FVC,...

Tạp chí Y Dược học Cần Thơ

Đặt vấn đề: Hen phế quản ở trẻ từ 6 tháng đến 5 tuổi có thể liên quan đến một số yếu tố, đặc biệt... more Đặt vấn đề: Hen phế quản ở trẻ từ 6 tháng đến 5 tuổi có thể liên quan đến một số yếu tố, đặc biệt là vấn đề nồng độ vitamin D không đầy đủ. Mục tiêu nghiên cứu: Xác định tỉ lệ vitamin D không đầy đủ. Khảo sát một số yếu tố liên quan và một số đặc điểm lâm sàng, cận lâm sàng, kết quả điều trị ở trẻ hen phế quản từ 6 tháng đến 5 tuổi có nồng độ vitamin D không đầy đủ. Đối tượng và phương pháp nghiên cứu: Mô tả cắt ngang có phân tích với 30 ca bệnh hen phế quản từ 6 tháng đến 5 tuổi tại khoa Nội hô hấp, Bệnh viện Nhi Đồng Cần Thơ, từ 1/4/2021 đến 1/3/2022. Bệnh nhi được xác định mức độ cơn hen cấp, phỏng vấn theo bảng câu hỏi, xét nghiệm công thức máu, định lượng vitamin D và theo dõi điều trị. Kết quả: Nồng độ vitamin D trung bình ở trẻ hen phế quản từ 6 tháng đến 5 tuổi là 34,6±11,3ng/ml. Tỷ lệ trẻ hen phế quản có vitamin D không đầy đủ là 33,3%. Một số yếu tố liên quan đến nồng độ vitamin D không đầy đủ: không tiếp xúc với ánh nắng mặt trời từ 15-30 phút ngày (75,0%), không uống bổ ...

BÁO CÁO KHOA HỌC VỀ NGHIÊN CỨU VÀ GIẢNG DẠY SINH HỌC Ở VIỆT NAM HỘI NGHỊ KHOA HỌC QUỐC GIA LẦN THỨ 5 - PROCEEDING OF THE 5TH NATIONAL SCIENTIFIC CONFERENCE ON BIOLOGICAL RESEARCH AND TEACHING IN VIETNAM

In this research, we evaluated the preimplantation development, embryo morphology, the time of ce... more In this research, we evaluated the preimplantation development, embryo morphology, the time of cell division and the cell number of the blastocyst stage of single mouse blastomeres biopsied from 8-cell embryos. One blastomere was biopsied from each 8-cell embryo using micromanipulation system with XYClone laser. After biopsy, the single blastomeres and biopsied embryos were cultured together in the in vitro development (IVD) medium until the blastocyst stage. Our data shows that, one blastomere could be developed to the blastocyst stage with approximately 6 cells ± 0.5 and the remaining embryo could be cultured normally to the blastocyst stage with 95 cells ± 4.9 (P < 0.05). However, the percentage of biopsied blastomere that have developed to the morula and blastocyst stage is lower than that of biopsied and non-biopsied embryos. The results also show that the time taken for biopsied blastomere to form morula and blastocyst was the same as that of biopsied embryos although the cell number was much lower. In conclusion, single blastomeres collected from the 8-cell stage mouse embryos can develop into morula and blastocyst with the same time. Thus, the time for embryo compaction and blastocyst formation was depended on the time of fertilization. These results provide potential benefits for preimplantation genetic diagnosis (PGD) in infertile couples at risk of genetic diseases as well as opening a novel approach for the establishment of stem cell line from biopsied blastomere combined with PGD in future research.

IEEE Access

This paper presents an Internet of Things-enabled low-cost wireless sensor network with newly-dev... more This paper presents an Internet of Things-enabled low-cost wireless sensor network with newly-developed dependable schemes to improve reliability for monitoring air quality in suburban areas. The system features sensing units for router communications with energy savings from dynamic conservation. Based on the reliability function and mean time to failure, a continuous time Markov chain model is used to analyze the monitoring performance. The proposed dependable monitoring network is shown to achieve high availability with regards to energy consumption and data assurance with the survival probability of over 80% during a minimum period of 72-hour operation for monitoring air quality in a suburb. Distributions of fine particle concentrations studied over a 6-month period demonstrate feasibility of the developed system in its high correlations to benchmark monitoring stations with the Pearson's coefficients obtained at 0.903 and 0.817 respectively for PM2.5 and PM10. Statistical analysis is conducted for performance evaluation in association with two extreme events, one with bushfires and the other with pandemic lockdown. The results obtained indicate enhancements in reliability and accuracy of the colocated dependable low-cost sensors network proposed for wireless monitoring of air quality in urban conditions. INDEX TERMS Low-cost wireless sensor networks, Internet of Things, air quality, dependability, monitoring systems.

Ministry of Science and Technology, Vietnam, 2021

This research presents the effect of heat treatment temperature on the forming ability of β-trica... more This research presents the effect of heat treatment temperature on the forming ability of β-tricalcium phosphate (β-TCP) bioceramic materials toward the bone tissue regeneration application. Ca(OH)2 and H3PO4 were mixed with a Ca/P molar ratio of 1.5, followed by hydrothermal treatment at 180oC for 24 hours to obtain the calcium phosphate hydrate (CPH) with phase composition similar to hydroxyapatite (HA). The CPH mineral was heat-treated at 700 and 1000oC for 3 hours to evaluate the ability to obtain β-TCP. The result showed that β-TCP can be obtained by the CPH calcined at 1000oC for 3 hours, with the particle size of 1~2 μm, suitable for bone tissue regeneration application.

Nâng cao sự hài lòng khách hàng được cho là giải pháp giúp phát triển các hoạt động kinh doanh dị... more Nâng cao sự hài lòng khách hàng được cho là giải pháp giúp phát triển các hoạt động kinh doanh dịch vụ, trong đó có dịch vụ ngân hàng. Vì thế, nghiên cứu này nhằm mục đích nhận diện và đo lường các nhân tố tác động đến sự hài lòng khách hàng tại các ngân hàng thương mại ở Việt Nam. Để đạt được mục tiêu nghiên cứu, tác giả tiến hành khảo sát 461 khách hàng đã và đang giao dịch tại các ngân hàng thương mại và sử dụng mô hình cấu trúc tuyến tính (SEM) để kiểm định các giả thuyết nghiên cứu. Kết quả nghiên cứu cho thấy có bốn nhân tố tác động đến sự hài lòng khách hàng gồm: năng lực đáp ứng, cơ sở vật chất, giá dịch vụ, và bảo mật thông tin khách hàng. Dựa vào kết quả nghiên cứu, tác giả đề xuất một số hàm ý quản trị nhằm nâng cao sự hài lòng khách hàng. Bên cạnh các kết quả đạt được, nghiên cứu này còn một số hạn chế về phương pháp chọn mẫu, nên cần các nghiên cứu khác bổ sung.

Proceedings of the 37th International Symposium on Automation and Robotics in Construction (ISARC), 2020

This paper proposes an IoT-enabled network of low-cost sensors that are co-located for constructi... more This paper proposes an IoT-enabled network of low-cost sensors that are co-located for construction site monitoring. The network performance enhancement is achieved via its system dependability in terms of improved availability, integrity, reliability, maintainability, security and safety in real-time monitoring of environment parameters. The sensor motes of various sensing modules form a reliable wireless in-situ cluster for gathering on-site information of air temperature, soil moisture, air pressure, humidity, particulate matters (PM), emissions and weather variables. They are useful for the site management, improving safety and effective operation of construction equipment. The components for the development include inexpensive microcontrollers ESP32 embedded with wireless gateway function and energy-efficient motes featuring cost-effective sensors. Here, the adoption of the dependability concept for collocated sensor motes aims to introduce a level of redundancy to allow for improving fault-tolerance and reliability. Extensive field tests have been conducted in different environments. Experimental results as well as statistical analysis are provided to verify the merits of the proposed approach.

Journal of Food Processing and Preservation, 2021

Rosmarinic acid (RA) is an ester of caffeic acid, which is a water-soluble phenolic compound and ... more Rosmarinic acid (RA) is an ester of caffeic acid, which is a water-soluble phenolic compound and is present in most species of the Lamiaceae family (Sik et al., 2020). RA is a strong natural antioxidant (Bernatoniene et al., 2016) and exhibits potential antibacterial, antiviral, antidiabetic, antiallergic, immunosuppressive, and anti-inflammatory activities (Anwar et al., 2020; Nadeem et al., 2019). Because of such remarkable biological activities, RA has gained considerable attention for use in pharmaceutical and functional food industries (Amoah et al., 2016). Consequently, the demand for RA has increased considerably, which has motivated the development of effective extraction methods from its natural sources. Rosemary (Rosmarinus officinalis L.) is an aromatic evergreen herb belonging to the Lamiaceae family (Karataş et al., 2020).

NEWS of National Academy of Sciences of the Republic of Kazakhstan, 2020

In modern organisations, personnel are not at their workplace permanently and, accordingly, in ca... more In modern organisations, personnel are not at their workplace permanently and, accordingly, in case of emergency, they are at risk. There are a number of situations in which the access of even emergency services to the premises is very difficult to organise due to the regime of secrecy and the desire to preserve trade secrets. Additionally, the system of restricting the movement of workers in their places can be very limited on the part of management in order to maintain production discipline. The novelty of the study is determined by the fact that when using the detection system in case of fire or other emergency, its integration with the access verification and distribution system can be based on the use of integrated access systems. The authors show that the use of conditional access systems makes it possible to get employee lists at a faster pace and identify threats if certain technological complexes are used in their work. The practical significance of the study is determined ...

Scientific Reports, 2020

The increasing risk of infectious pathogens, especially in the under-developed countries, is dema... more The increasing risk of infectious pathogens, especially in the under-developed countries, is demanding the development of point-of-care (POC) nucleic acid testing in the low-resource setting conditions. Here, we describe a methodology for colorimetric quantitative analysis of nucleic acid using an easy-to-build smartphone-based platform, offering low-cost, portability, simplicity in operation, and user-friendliness. The whole system consists of a hand-held box equipped with a smartphone, a film heater, a white LED, a loop-mediated isothermal amplification (LAMP) chip, and a DC converter, and all the processes were powered by a portable battery of 5 V. Upon the amplification of the target gene by an Eriochrome Black T-mediated LAMP reaction, the color of the LAMP reaction was changed from violet to blue that was real-time recorded by a smartphone camera. To keep track of the progress of the color change, we developed a novel mobile app in which a hue value was accepted as an indicato...

Palaeontologia Electronica, 2014

This study introduces a standardized framework for the holistic analysis of cortical and trabecul... more This study introduces a standardized framework for the holistic analysis of cortical and trabecular bone structure. This method, although applicable to all bones of the skeleton, is particularly useful for irregular-shaped or small bones for which the application of traditional methods has been especially challenging. Traditional analyses have quantified cortical or trabecular structure in only selected regions of a bone, such as single cross-sections of cortical bone or volumes of interest of trabecular structure in epiphyses. The proposed method improves on these traditional methods by visualizing and quantifying the internal bony structure throughout the entire bone and in userdefined anatomical subregions. Here, we describe and demonstrate the method using high-resolution microtomographic scans of a first metacarpal of an orangutan, gorilla, chimpanzee and human. Using automated morphological filters, the cortical bone is defined and extracted from the underlying trabecular structure to create two 3D models, one of the cortex and one of the trabecular bone that can be analysed separately. We test the sensitivity of the morphological parameters used to create these 3D models, demonstrating that the parameters defined here are robust and can provide accurate measures of cortical thickness, relative bone density, trabecular orientation, trabecular thickness and degree of anisotropy. This new, holistic method is able to reveal morphological and functional information about bone loading that is obscured or ignored using traditional methods, thus providing more informed interpretations of behaviour in extant and fossil taxa.

Forests, 2019

This study analyzed the perceptions of four stakeholder groups (forest landowners, private forest... more This study analyzed the perceptions of four stakeholder groups (forest landowners, private forest consultants, forest management researchers or educators, and federal or state agency foresters), regarding their management practices and preferred geographic growing conditions of loblolly pine in Virginia by combining AHP (analytical hierarchy process) and regression modeling. By ranking the importance of different geographical conditions for managing loblolly pine, we aimed to identify ways to support loblolly growth as a potential feedstock for biofuel generation. We achieved this through collecting survey responses from 43 stakeholders during the 2019 Virginia Forestry Summit. The results showed that the landowner, researcher/educator, and federal/state agency stakeholder groups all indicated that proximity to a mill was the most important criteria, whereas the consultant stakeholder group indicated that proximity to a road was the most important criteria. All the stakeholder groups indicated that distance from protected land was the least important criteria, followed by proximity to a water body and flat land. The regression model revealed that acres of land managed and loblolly rotation age were correlated to the weight given to the distance to a mill criterion, where increased acreage and increased rotation age were associated with an increased prioritization of proximity to a mill. Distance from protected land, the lowest-ranking criteria, was shown to have an association with the level of experience with loblolly, where more experience was associated with a lower prioritization of proximity from protected land. A contingency analysis of the self-identified level of experience with loblolly in each stakeholder group revealed that federal/state agency foresters had the most experience, followed by consultants, landowners, and researchers/educators. The research supports the importance of understanding the variation of perceptions between and within stakeholder groups in order to develop the necessary infrastructural and policy support for the sustainable development of bioenergy.

The neurotrophin, brain-derived neurotrophic factor (BDNF) promotes central nervous system (CNS) ... more The neurotrophin, brain-derived neurotrophic factor (BDNF) promotes central nervous system (CNS) myelination during development and after injury. This is achieved via activation of oligodendrocyte-expressed tropomyosin-related kinase (Trk) B receptors. However, while administration of BDNF has shown beneficial effects, BDNF itself has a poor pharmacokinetic profile. Here, we compare two TrkB-targeted BDNF-mimetics, the structural-mimetic, tricyclic dimeric peptide-6 (TDP6) and the non-peptide small molecule TrkB agonist LM22A-4 in the cuprizone model of central demyelination in female mice. Both mimetics promoted remyelination, increasing myelin sheath thickness and oligodendrocyte densities after one-week recovery. Importantly, LM22A-4 exerts these effects in an oligodendroglial TrkB-dependent manner. However, analysis of TrkB signaling by LM22A-4 suggests rather than direct activation of TrkB, LM22A-4 exerts its effects via indirect transactivation of Trk receptors. Overall, these...

La Houille Blanche, 2012

An experimental program was set up to study the suffusion process by using a triaxial erodimeter ... more An experimental program was set up to study the suffusion process by using a triaxial erodimeter developed in our laboratory. This device is equipped with a multichannel optical sensor in order to characterize precisely the initiation and development of suffusion process. With the objective to characterize the erodibility of clayey sand, tests were performed under either flow-rate-controlled or hydraulic-gradient-controlled conditions. The test analysis allows distinguishing three steps. First, suffusion of a small quantity of clay is detected on downstream. In flow-rate-controlled conditions, this suffusion is immediately followed by a high increase of the hydraulic gradient which continues during the second step. The second step is characterized by very low amount of particles in the effluent. During the third step, high suffusion of clay appears and induces erosion of clay and sand. The results reveal the necessity to take into account the evolutions of hydraulic gradient (or pressure gradient) and also the evolutions of velocity (or flow rate) to represent the hydraulic loading. The analysis based on energy expended by fluid flow and eroded mass permits to characterize the soil sensitivity to clay suffusion and clayey sand erosion for tests under the two types of hydraulic loading.

Advances in Natural Sciences: Nanoscience and Nanotechnology, 2014

In the present research work we evaluate the in vivo distribution of gold nanoparticles (AuNPs) a... more In the present research work we evaluate the in vivo distribution of gold nanoparticles (AuNPs) at different time durations after intravenous administration in mice. AuNPs with size of about 20 nm and concentration of 1 mM were synthesized by gamma irradiation method using 0.5% alginate as a stabilizer. AuNPs were characterized by UV-Vis spectrum and transmission electron microscope (TEM) image. The as-synthesized AuNPs solution was centrifuged to concentrate to 2 mg AuNPs/1 ml solution. Intravenous administration of AuNPs in mice was done at the tail with 1 mg AuNPs (0.5 ml). After 1, 3, 6 and 12 h of injection, blood was collected, mice were sacrificed and various tissues/organs were removed. The blood haematology and serum clinical chemistry indexes of mice intravenously injected with AuNPs were not significantly different compared to those of the control ones. In addition, gold content in the samples was quantitatively determined by k 0-neutron activation analysis (k 0-NAA) at nuclear research reactor, Da Lat Vietnam. Results showed that after 1 h of administration, AuNPs were mainly accumulated in blood (41.56%), in liver (51.60.%), in lung (6.16%) and in kidney (0.53%). After that the content of AuNPs in blood was decreased to nearly normal at 6 h while the content of AuNPs in liver, lung and kidney was accumulatively increased. After 6 h of administration AuNPs were mainly accumulated in organs like liver (76.33%), lung (11.86%) and kidney (2.23%). Thus, the obtained results are practically useful for using AuNPs as x-ray contrast agent, especially for blood and liver.

PLoS ONE, 2013

Bone is capable of adapting during life in response to stress. Therefore, variation in locomotor ... more Bone is capable of adapting during life in response to stress. Therefore, variation in locomotor and manipulative behaviours across extant hominoids may be reflected in differences in trabecular bone structure. The hand is a promising region for trabecular analysis, as it is the direct contact between the individual and the environment and joint positions at peak loading vary amongst extant hominoids. Building upon traditional volume of interest-based analyses, we apply a wholeepiphysis analytical approach using high-resolution microtomographic scans of the hominoid third metacarpal to investigate whether trabecular structure reflects differences in hand posture and loading in knuckle-walking (Gorilla, Pan), suspensory (Pongo, Hylobates and Symphalangus) and manipulative (Homo) taxa. Additionally, a comparative phylogenetic method was used to analyse rates of evolutionary changes in trabecular parameters. Results demonstrate that trabecular bone volume distribution and regions of greatest stiffness (i.e., Young's modulus) correspond with predicted loading of the hand in each behavioural category. In suspensory and manipulative taxa, regions of high bone volume and greatest stiffness are concentrated on the palmar or distopalmar regions of the metacarpal head, whereas knuckle-walking taxa show greater bone volume and stiffness throughout the head, and particularly in the dorsal region; patterns that correspond with the highest predicted joint reaction forces. Trabecular structure in knuckle-walking taxa is characterised by high bone volume fraction and a high degree of anisotropy in contrast to the suspensory brachiators. Humans, in which the hand is used primarily for manipulation, have a low bone volume fraction and a variable degree of anisotropy. Finally, when trabecular parameters are mapped onto a molecular-based phylogeny, we show that the rates of change in trabecular structure vary across the hominoid clade. Our results support a link between inferred behaviour and trabecular structure in extant hominoids that can be informative for reconstructing behaviour in fossil primates.