Irfan Tasoglu - Academia.edu (original) (raw)

Papers by Irfan Tasoglu

... Türkiye Yüksek İhtisas Hastanesi, Kalp ve Damar Cerrahisi Kliniği, #Kardiyoloji Kliniği, Anka... more ... Türkiye Yüksek İhtisas Hastanesi, Kalp ve Damar Cerrahisi Kliniği, #Kardiyoloji Kliniği, Ankara Dr. Gökhan Lafçı, Dr. Adem İlkay Diken, Dr. Hikmet Selçuk Gedik, Dr. Kemal Korkmaz, Dr. Fırat Özcan,# Dr. İrfan Taşoğlu, Dr. Garip Altıntaş, Dr. Kerim Çağlı ...

Aim: The aim of this study is to retrospectively evaluate the results of patients who underwent b... more Aim: The aim of this study is to retrospectively evaluate the results of patients who underwent bedside surgical PDA ligation that did not respond to the hemodynamic significant patent ductus arteriosus (HAPDA) medical closure therapy. Material And Methods: Twelve infants diagnosed with HAPDA in the Neonatal Intensive Care Unit and treated with bedside surgical pda ligation were included in the study. Demographic features, pre- and postoperative respiratory support, oxygen demand and duration, intraventricular hemorrhage, bronchopulmonary dysplasia, hospital stay duration and mortality data were recorded. Results: The mean age at surgery was 38 (19-78) days. About 40 days after the operation one patient (8%) was lost (syndromic infant) and 11 patients were discharged. There was no complication due to surgical treatment in our patients. All patients who were discharged were saved from oxygen after 15 days (19-60 days) postoperatively. Conclusion: PDA ligation in bedside surgery shoul...

We describe the treatment of an extremely rare case of interrupted aortic arch, annuloaortic ecta... more We describe the treatment of an extremely rare case of interrupted aortic arch, annuloaortic ectasia, and aortic regurgitation in a 34-year-old man who presented with dyspnea and palpitation. We performed a single-stage operation involving aortic root reconstruction and valve repair with concomitant extra-anatomic bypass from the ascending to the descending aorta with a Dacron tube graft. The patient made a full recovery. To the best of our knowledge, this is the first such report in the English medical literature.

The Journal of Spinal Cord Medicine

Context: Both copper and betanin have been implicated as having significant bioactivity against i... more Context: Both copper and betanin have been implicated as having significant bioactivity against ischemic damage in a variety of experimental and clinical settings. The aim of this study is to investigate whether betanin and copper have any protective effect on spinal cord in an ischemia–reperfusion (I/R) model in rats. Design: Spraque-Dawley rats were used in four groups: Sham group (n = 7), control group (laparotomy and cross-clamping of aorta, n = 7), betanin treatment group (dosage of 100 mg/kg of betanin administered intraperitoneally (i.p.) 60 min before laparotomy, n = 7), copper sulfate treatment group (administered copper sulfate i.p. at a dose of 0.1 mg/kg/day for 7 days before laparotomy, n = 7). Malondialdehyde (MDA), glutathione (GSH) levels, myeloperoxidase (MPO) and superoxide dismutase (SOD) activity were measured. Terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling (TUNEL) assay was also performed to evaluate apoptosis. Setting: Kafkas University, Faculty of Medicine, Kars, Turkey. Results: I/R injury was successfully demonstrated with the surgical model. Betanin and copper treatment significantly decreased MDA levels, MPO activity and the number of apoptotic cells in the spinal cord. Betanin and copper treatment significantly increased GSH levels. Copper treatment significantly increased SOD activity, whereas betanin was not as effective. Apoptotic cells were significantly decreased in both treatment groups. Conclusion: I/R injury of the spinal cord can be successfully demonstrated by aortic clamping in this surgical model. Betanin/Copper sulphate has ameliorative effects against operative I/R injury. Low toxicity of those agents makes them ideal targets for clinical research for this purpose.

Journal of Vascular Medicine & Surgery

Primary end point was determined as amputation (limb survival) and all-cause death were performed... more Primary end point was determined as amputation (limb survival) and all-cause death were performed. The effect of PLR on outcome was studied by constructing a receiver operating characteristic curve. Using a PLR cutoff of ≥ 160, the area under the receiver operating characteristic curve was 0.65 (95% confidence interval [CI] 0.55-0.75) (Figure 1).

Indian Pediatrics

Vasoactive-inotropic Score (VIS) was developed to quantify the amount of inotropic support provid... more Vasoactive-inotropic Score (VIS) was developed to quantify the amount of inotropic support provided in the postoperative period. We investigated the predictive value of (VIS) for mortality in neonates with congenital heart disease (CHD). Prospective cohort. 119 newborns who underwent cardiac surgery. Tertiary NICU-CHD center of Ankara from November 2016 to January 2019. VIS values were calculated by a standard formula for the first 72 postoperative hours, and the maximum score was recorded. Duration of mechanical ventilation, NICU length of stay, and mortality. At surgery, the median (IQR) age was 15 d (9–31). The patients were divided into two groups according to mortality; Group 1 (Non-survivors) (n=36) and Group 2 (Survivors) (n=83). Higher VIS score was correlated to longer duration of mechanical ventilation (P=0.009, r=0.33), and was higher among patients who died (P=0.003). Area under the curve (AUC) was 0,83 (P<.001, CI: 95% 0.7–0.9) for VIS to identify mortality. At a cut-off value of 15.5, sensitivity and negative predictive values of VIS for mortality were 73.6% and 85.3%, respectively. The higher VIS (>15.5) was independently associated with increased odds for mortality (OR: 8.1, 95% CI: 1.8–35.7, P=0.005). In newborns with CHD, a higher VIS within 72 hours after cardiac surgery is associated with increased duration of mechanical ventilation, and mortality. VIS may be useful for prediction of mortality at early postoperative period.

Cardiology in the Young

BackgroundOptimal management strategy for native aortic coarctation in neonates and young infants... more BackgroundOptimal management strategy for native aortic coarctation in neonates and young infants is still a matter of debate. The surgical procedure, histopathologic research, and clinical outcome in 15 neonates who underwent surgery after successful balloon angioplasty is the basis of this study.MethodBetween 01 October, 2014 and 01 August, 2017, we enrolled 15 patients with native aortic coarctation for this study. These patients had complications regarding recoarctation, following balloon angioplasty intervention at our institute and other centres. Surgically extracted parts were examined histopathologically and patient’s data were collected retrospectively.ResultThe reasons for recurrence of recoarctation after balloon angioplasty are as follows: patients with higher preoperative echocardiographic gradients had recoarctation earlier, neointimal proliferation, aortic intimal fibrosis at the region of ductal insertion, and ductal residual tissue debris after balloon angioplasty. ...

Cardiology in the young, 2018

Pulmonary valvular stenosis is a relatively common disorder, accounting for approximately 10% of ... more Pulmonary valvular stenosis is a relatively common disorder, accounting for approximately 10% of all CHDs. Pulmonic valvular disease can get clinically detected at different ages of life. The more severe the obstruction, the earlier detected the valvular abnormality. Surgical pulmonary valvotomy has been available as a treatment since 1956. This article is about a case of pulmonary annular and valvular stenosis in a 1-year-old child, and it also explores surgical operation of this condition. Transannular patches are usually used within the 1st year of age in pulmonary annular and valvular stenosis. In recent years, anterior leaflet augmentation has been preferred for annulus enlargements. In our 1-year-old case, we expanded the annulus by the anterior leaflet expansion technique and we also augmented other leaflets by polytetrafluoroethylene patch.

The American Journal of Cardiology, 2016

Texas Heart Institute Journal from the Texas Heart Institute of St Luke S Episcopal Hospital Texas Children S Hospital, 2012

Pulmonary endarterectomy is the treatment of choice in suitable patients who have chronic thrombo... more Pulmonary endarterectomy is the treatment of choice in suitable patients who have chronic thromboembolic pulmonary hypertension. The most common surgical technique involves the use of deep hypothermic circulatory arrest. Herein, we describe a modified aortic clamping technique with selective antegrade cerebral perfusion, performed with moderate hypothermia but without circulatory arrest. This technique avoids the adverse effects of deep hypothermic circulatory arrest and also establishes a bloodless surgical field. We achieved good surgical results and acceptable long-term outcomes in 3 patients with use of this technique, which we recommend as a feasible alternative to the standard operative practice.

Turk Kardiyoloji Dernegi Arsivi Turk Kardiyoloji Derneginin Yayin Organidir, 2008

Several studies have shown an association between elevated serum uric acid (SUA) levels and coron... more Several studies have shown an association between elevated serum uric acid (SUA) levels and coronary heart disease and cardiovascular mortality. We investigated the relationship between SUA levels and the patency of saphenous vein grafts (SVG) after coronary artery bypass graft (CABG) surgery. Study design: The study included 192 patients (152 men, 40 women) who underwent elective coronary angiography after a mean of 5.6 years following CABG surgery, which involved the use of at least one SVG. The patients were divided into two groups depending on the extent of SVG patency. Stenosis of 50% or greater within the SVG was accepted as hemodynamically significant. Serum uric acid levels were determined with the enzymatic colorimetric method. Results: Ninety patients (71 men, 19 women; mean age 62±8 years) were found to have patent SVG. Stenotic SVGs were detected in 102 patients (81 men, 21 women; mean age 62±10 years). The time interval between surgery and angiography was significantly longer in the stenotic group (p<0.001). Compared to patients without SVG disease, the mean SUA level was significantly higher in patients with SVG disease (4.9±1.2 mg/dl vs 5.8±1.4 mg/ dl; p=0.02). Serum uric acid levels were similar in patients having stenosis in a single vein graft or multiple vein grafts (p=0.224). In multiple regression analysis, SVG disease was independently associated with SUA (p<0.001), diabetes mellitus (p=0.028), and smoking (p=0.039). Conclusion: Our results show that there is a significant association between increased SUA levels and SVG disease in patients undergoing CABG, which may justify the need for early screening for hyperuricemia and antiuricemic treatment.

Clinical Rheumatology, 2016

Knee osteoarthritis (OA) is one of the most common forms of joint disease, affecting an increasin... more Knee osteoarthritis (OA) is one of the most common forms of joint disease, affecting an increasing number of people worldwide. Latest data suggests that inflammation plays a critical role in the pathogenesis of OA. There are a number of inflammatory markers like cytokins and cartilage degradation products that can be used as indicators in OA. Blood neutrophil-lymphocyte ratio (NLR) is a simple non-invasive and cost-effective marker of inflammation in various systemic diseases, but it has not been investigated in OA yet. The aim of the present study was to compare blood NLR levels in patients with severe - Kellgren and Lawrence (KL) grade 4 - knee OA and mild to moderate - KL grades 1-3 - knee OA. A total of 176 patients with knee OA were included in this cross-sectional study. KL grading was done according to the two-view (antero-posterior and lateral) plain radiography of both knees. Demographic characteristics, blood neutrophil, lymphocyte and platelet counts, erythrocyte sedimentation rate, and C-reactive protein were recorded. Blood NLR levels were calculated. In the severe knee OA group, blood NLR levels were found to be elevated as compared to the mild to moderate knee OA group. A blood NLR of ≥2.1 was taken as the cutoff based upon the receiver operating characteristics (roc). In the roc curve analysis, blood NLR ≥ 2.1 had 50 % sensitivity and 77 % specificity in predicting severe knee OA. In multivariate analysis, age and blood NLR ≥ 2.1 emerged as independent predictors of severe knee OA. The results of the present study, for the first time in the literature, suggests blood NLR as a novel and promising inflammatory marker indicating the severity of knee OA.

Turkish Journal of Thoracic and Cardiovascular Surgery, 2011

Bu çalışmada, ortotopik kalp nakli yapılan hastaların mortalite ve morbiditesini etkileyen risk f... more Bu çalışmada, ortotopik kalp nakli yapılan hastaların mortalite ve morbiditesini etkileyen risk faktörleri değerlendirildi ve kısa ve uzun dönem sağkalım oranları araştırıldı.

Annals of Vascular Surgery, 2015

Primary venous aneurysm, especially in pediatric population, is a very rare clinical entity. We r... more Primary venous aneurysm, especially in pediatric population, is a very rare clinical entity. We report a case of primary great saphenous vein aneurysm in a 4-year-old boy. He was initially suspected of suffering from inguinal hernia because the soft mass was detected at the inguinal region when the patient was in the standing position, but color Doppler ultrasonography demonstrated the swelling to be a great saphenous vein aneurysm. We decided that surgery was the best option because of potential risk for thromboembolism.

Journal of Clinical and Analytical Medicine, 2014

1 İrfan Taşoğlu1, Aslı Demir2, Emre Kubat1, Metin Yılmaz1, Gökhan Lafçı1, Adnan Yalçınkaya1, Ümit... more 1 İrfan Taşoğlu1, Aslı Demir2, Emre Kubat1, Metin Yılmaz1, Gökhan Lafçı1, Adnan Yalçınkaya1, Ümit Kervan1, Necmettin Çolak3 1Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Hospital, 2Department of Anesthesiology, Turkiye Yuksek Ihtisas Hospital, 3Department of Cardiovascular Surgery, Fatih Unıversty Medical Faculty, Ankara, Turkey Seksen Yaş Üstünde Aort Kapak / Aortic Valve in Octogenarian Mechanical Aortic Valve Replacement in Octogenarian

Türkiye Fiziksel Tip ve Rehabilitasyon Dergisi, 2015

Objective: In recent years, discussions regarding the possibility of vitamin D deficiency playing... more Objective: In recent years, discussions regarding the possibility of vitamin D deficiency playing a role in statin myopathy development have started. The purpose of this study is to determine whether or not there is a significant difference with respect to vitamin D levels and objective muscle strength measures in males with or without statin-induced myalgia. Material and Methods: This study includes 17 male patients with statin-induced myalgia and 23 male patients without statin-induced myalgia; the latter being matched with the former. 25-OH vitamin D levels of all patients were recorded. Body fat rates of the patients were studied with bio-impedance analysis. Visual analog scale and McGill-Melzack pain questionnaire were applied to the patients with myalgia. Grip strength and isometric and isokinetic measurements on the biceps and quadriceps muscles of all patients were performed. Results: Mean vitamin D levels were above the sufficiency level in both of the groups, and there was no significant difference between them. When the measurements with the hand dynamometer and the isometric and isokinetic muscular strength analyses for both groups were compared, there was no statistically significant difference between them. Conclusion: In this study, it is demonstrated that vitamin D deficiency may not be a risk factor for the development of statin-induced myalgia; furthermore, there is no statistical difference between the objective muscle strength measures of male patients with or without statin-induced myalgia.

Surgical Endoscopy, 2015

In the present study, changes in hemodynamic parameters and cerebral oxygen saturation (rSO2) ass... more In the present study, changes in hemodynamic parameters and cerebral oxygen saturation (rSO2) associated with 10 cm H2O PEEP application were investigated, which is assumed beneficial for the respiratory functions and oxygenation during laparoscopic cholecystectomy (LC) applied at 30° head-up left side position. Data gathered via two devices, namely INVOS and FORESIGHT, were compared. After both the ethics committee approval from the hospital and patients&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; written consents were obtained, patients undergoing elective laparoscopic surgery (only ASA I-II) were randomly divided into two groups (Clinical trials protocol NCT02071550). Sensors of INVOS and FORESIGHT devices were placed on the right side at the forehead region. In total, 11 evaluation periods were formed, namely pre-induction (1st period), post-induction (2nd period), abdominal insufflation outset (3rd period), post-insufflation at 5-min intervals (4th, 5th, 6th, 7th, and 8th period), at the end of insufflation (9th period), at the end of operation (10th period), and at the end of anesthesia (11th period). While one of the groups did not receive PEEP (ZEEP group), the other group received 10 cm H2O along with abdominal insufflation (PEEP group). Demographic data, hemodynamic values, and rSO2 values were recorded for both groups at all 11 periods. A total of 44 patients in two groups, each group containing 22 individuals, were included in the study. Systolic, diastolic, and mean arterial pressures, etCO2 and SO2 values, and demographic data were found to be similar in both groups. Heart rate was observed to be higher in the PEEP group starting with the PEEP administration. INVOS rSO2 values were found similar in both groups. However, FORESIGHT rSO2 values were found to be higher in the PEEP group compared to the ZEEP group. No patient had cerebral desaturation in both groups throughout the study. Application of PEEP with 10 cm H2O during abdominal insufflation could increase the rSO2 value and heart rate in patients undergoing laparoscopic cholecystectomy. However, all changes observed were within normal limits. FORESIGHT device yielded more compatible results with hemodynamic data compared to INVOS.