Isabel Da Franca - Academia.edu (original) (raw)
Uploads
Papers by Isabel Da Franca
DOAJ (DOAJ: Directory of Open Access Journals), Jul 1, 1997
Acta Médica Portuguesa, 2005
Leishmania infantum zimodeme MON-1 foi isolado a partir de uma lesão cutânea da face de uma crian... more Leishmania infantum zimodeme MON-1 foi isolado a partir de uma lesão cutânea da face de uma criança, residente em Lisboa e que nunca saiu do país. Após biópsia excisional não houve recorrência da lesão. Este é o primeiro caso em que este agente é identificado como responsável pela leishmaniose cutânea em Portugal.
European Journal of Dermatology, 1995
This article describes 2 patients with acquired immunodeficiency syndrome (AIDS) who in the last ... more This article describes 2 patients with acquired immunodeficiency syndrome (AIDS) who in the last 6 months of their terminal phase developed painful, disseminated hyperkeratotic skin lesions, biopsies of which revealed histological aspects of verrucous epidermal hyperplasia with dyskeratotic cells and multinucleated cells of Unna. The patients had recently had disseminated herpes virus infections. The patient who presented the greater number of relapses and who had been treated with long-term oral acyclovir in prophylactic doses suffered from a skin eruption which was unresponsive to this drug, resolving only with intravenous Foscarnet. We review AIDS cases with chronic verrucous eruptions attributed to herpes varicellazoster virus (VZV) infection some of which were acyclovir resistant. We also make reference to the appearance of identical lesions secondary to other DNA viruses in these patients
![Research paper thumbnail of [Cutaneous leishmaniosis in Portugal due to Leishmania infantum MON-1]](https://attachments.academia-assets.com/108568013/thumbnails/1.jpg)
](Acta medica portuguesa, 2005
Leishmania infantum zymodeme MON-1 was isolated from a skin lesion in a child in Lisboa area (Por... more Leishmania infantum zymodeme MON-1 was isolated from a skin lesion in a child in Lisboa area (Portugal) who had never travelled abroad. Succefull therapy was achieved by excisional biopsy of the lesion. This is the first evidence that this agent is responsible by cutaneous leishmaniasis in the country.
![Research paper thumbnail of [Verrucous herpes zoster in AIDS patients]](https://attachments.academia-assets.com/108568011/thumbnails/1.jpg)
](Acta medica portuguesa, 1997
The authors describe a case of disseminated Herpes-Zoster (VZV) in an HIV 1 positive patient with... more The authors describe a case of disseminated Herpes-Zoster (VZV) in an HIV 1 positive patient with AIDS. Hyperkeratotic characteristics, acyclovir resistance and sensitivity to foscarnet of cutaneous lesions are the most important features of this example. From the casuistics of the department, the authors describe two similar cases and review the medical literature with emphasis on etiopathogenic, diagnostic and therapeutic factors of lesions caused by DNA Virus in immunocompromised hosts.
Leishmania infantum zimodeme MON-1 foi isolado a partir de uma lesão cutânea da face de uma crian... more Leishmania infantum zimodeme MON-1 foi isolado a partir de uma lesão cutânea da face de uma criança, residente em Lisboa e que nunca saiu do país. Após biópsia excisional não houve recorrência da lesão. Este é o primeiro caso em que este agente é identificado como responsável pela leishmaniose cutânea em Portugal.
... borreliose de Lyme. QUADRO CLÍNICO Em 1921, Arvid Afzelius, já com experiência de diversos ca... more ... borreliose de Lyme. QUADRO CLÍNICO Em 1921, Arvid Afzelius, já com experiência de diversos casos, caracterizou do seguinte modo o ECM(5): “[… A doença começa como uma pequena placa circular. Esta estende-se ...
Journal of the European Academy of Dermatology and Venereology, 2002
![Research paper thumbnail of [Cutaneous infection with the cytomegalovirus virus in AIDS patients]](https://attachments.academia-assets.com/108567893/thumbnails/1.jpg)
](Acta medica portuguesa, 1997
Cutaneous cytomegalovirus (CMV) infection has been observed in a variety of nonspecific skin lesi... more Cutaneous cytomegalovirus (CMV) infection has been observed in a variety of nonspecific skin lesions. Because of this fact, its diagnosis is rare and frequently accidental. The presence of the virus has also been observed in apparently normal skin, from both a clinical and histological point of view. In this context, skin biopsy and immunohistochemistry are often the first means of diagnosis of systemic CMV infection. In 180 skin biopsies carried out on HIV patients in the Infectious and Parasitic Diseases Unit, typical histopathological findings of CMV infection in a nonspecific skin lesion were observed in only one patient. Although the patient showed no extracutaneous manifestations at this time, she died soon after this diagnosis. Because of this fact, we review the literature and discuss the difficulties and implications of the diagnosis of cutaneous CMV infection in AIDS patients.
Journal of the European Academy of Dermatology and Venereology, 2000
... Treatment of oral condylomata acuminata in a HIV-1 patient with bleomycin. Leonor Girão 3 ,; ... more ... Treatment of oral condylomata acuminata in a HIV-1 patient with bleomycin. Leonor Girão 3 ,; Isabel Franca 1 ,; Helena Macedo 1 ,; Carmo Ornelas 2 ,; Moura Nunes 2 ,; Carlos Araújo 1 ,; Kamal Mansinho 1. Article first published online: 8 MAY 2002. ...
Wiener klinische Wochenschrift, 2005
Borrelia lusitaniae was isolated from an Ixodes ricinus tick in Portugal in 1993 for the first ti... more Borrelia lusitaniae was isolated from an Ixodes ricinus tick in Portugal in 1993 for the first time. Further, this borrelia genospecies has been found in ixodid ticks collected around the coasts of southern Portugal and North Africa. Its reservoir has not been defined yet. B. lusitaniae was isolated once until now from a patient with a long standing and expanding skin disorder. A 46-year-old Portuguese woman presented with a skin lesion on the left thigh which had evolved slowly over ten years. The patient reported limb paraesthesias, cramps, chronic headaches, and cardiac rhythm disturbances. History of tick bites was negative nor had the patient ever noticed a skin lesion comparable with erythema chronicum migrans. Skin biopsies were taken for histological evaluation, culture and DNA detection. Antibodies to borrelia were searched by indirect immunofluorescence assay and Western-blot. A bilateral carpal tunnel syndrome and local synovitis was diagnosed. Dermato-histology was normal, serology was negative. Spirochaetal organisms were cultured from a skin biopsy and identified as B. lusitaniae. The patient improved after a 2-week course of intravenous ceftriaxone; the skin lesions did not expand further. This culture confirmed skin infection by B. lusitaniae in a patient from Portugal suggests an additional human pathogen out of the B. burgdorferi sensu lato complex in Europe, particularly in Portugal.
spdv.com.pt
Page 1. CAPÍTULO 1 BORRELIOSE DE LYME: UMA INTRODUÇÃO À DOENÇA Isabel da Franca RESUMO - A borrel... more Page 1. CAPÍTULO 1 BORRELIOSE DE LYME: UMA INTRODUÇÃO À DOENÇA Isabel da Franca RESUMO - A borreliose de Lyme, causada pelo espiroquetídeo Borrelia burgdorferi sensu lato, transmitido ao homem por mordedura ...
Journal of Clinical Microbiology, 2004
The first human isolate of Borrelia lusitaniae recovered from a Portuguese patient with suspected... more The first human isolate of Borrelia lusitaniae recovered from a Portuguese patient with suspected Lyme borreliosis is described. This isolate, from a chronic skin lesion, is also the first human isolate of Borrelia in Portugal. Different phenotypic and molecular methods are used to characterize it.
Wiener klinische Wochenschrift, 2005
Zusammenfassung. Hintergrund: Borrelia lusitaniae wurde erstmals im Jahr 1993 in Portugal von ein... more Zusammenfassung. Hintergrund: Borrelia lusitaniae wurde erstmals im Jahr 1993 in Portugal von einer Ixodes ricinus-Zecke isoliert. In der Folge wurde diese Borrelien-Art in Ixodes-Zecken von der Küste Süd-Portugals und Nordafrikas nachgewiesen. Tierische Reservoire dieser Borrelienart sind noch unbekannt. B. lusitaniae wurde bisher ein einziges Mal aus der Haut eines Patienten mit einer langdauernden progredienten Hauterkrankung isoliert. Patient und Methoden: Eine 46-jährige Portugiesin kam mit einer Hautläsion am rechten Oberschenkel, die sich langsam innerhalb von 10 Jahren entwickelt hatte. Die Patientin litt an Paraesthesien der Gliedmaßen, Krämpfen, chronischen Kopfschmerzen und Herzrhythmusstörungen. Weder war ein Zeckenstich erinnerlich, noch hatte die Patientin jemals an einer dem Erythema chronicum migrans vergleichbaren Hautläsion gelitten. Hautbiopsien wurden für histologische Untersuchungen sowie für einen direkten Erregernachweis mittels Kultur und Nukleinsäureamplifikation entnommen, Serum zum Nachweis von Antikörpern gegen Borrelien. Ergebnisse: Diagnostiziert wurde ein beidseitiges Karpaltunnelsyndrom und Synovitis. Dermato-histologisch fanden sich keine Auffälligkeiten, die Serologie war negativ. Aus einer Hautbiopsie wurden Spirochäten kultiviert und als B. lusitaniae identifiziert. Die Patientin wurde über 2 Wochen mit intravenösem Ceftriaxon behandelt. Hierauf war sie subjektiv gebessert, ein Stillstand der Expansion der Hautläsionen war zu beobachten. Schlussfolgerung: Die durch Anzüchtung von B. lusitaniae bestätigte Hautinfektion einer Patientin aus Portugal legt nahe, dass B. lusitaniae ein weiterer Krankheitserreger aus dem B. burgdorferi sensu lato-Komplex in Europa sein könnte.
DOAJ (DOAJ: Directory of Open Access Journals), Jul 1, 1997
Acta Médica Portuguesa, 2005
Leishmania infantum zimodeme MON-1 foi isolado a partir de uma lesão cutânea da face de uma crian... more Leishmania infantum zimodeme MON-1 foi isolado a partir de uma lesão cutânea da face de uma criança, residente em Lisboa e que nunca saiu do país. Após biópsia excisional não houve recorrência da lesão. Este é o primeiro caso em que este agente é identificado como responsável pela leishmaniose cutânea em Portugal.
European Journal of Dermatology, 1995
This article describes 2 patients with acquired immunodeficiency syndrome (AIDS) who in the last ... more This article describes 2 patients with acquired immunodeficiency syndrome (AIDS) who in the last 6 months of their terminal phase developed painful, disseminated hyperkeratotic skin lesions, biopsies of which revealed histological aspects of verrucous epidermal hyperplasia with dyskeratotic cells and multinucleated cells of Unna. The patients had recently had disseminated herpes virus infections. The patient who presented the greater number of relapses and who had been treated with long-term oral acyclovir in prophylactic doses suffered from a skin eruption which was unresponsive to this drug, resolving only with intravenous Foscarnet. We review AIDS cases with chronic verrucous eruptions attributed to herpes varicellazoster virus (VZV) infection some of which were acyclovir resistant. We also make reference to the appearance of identical lesions secondary to other DNA viruses in these patients
Acta medica portuguesa, 2005
Leishmania infantum zymodeme MON-1 was isolated from a skin lesion in a child in Lisboa area (Por... more Leishmania infantum zymodeme MON-1 was isolated from a skin lesion in a child in Lisboa area (Portugal) who had never travelled abroad. Succefull therapy was achieved by excisional biopsy of the lesion. This is the first evidence that this agent is responsible by cutaneous leishmaniasis in the country.
Acta medica portuguesa, 1997
The authors describe a case of disseminated Herpes-Zoster (VZV) in an HIV 1 positive patient with... more The authors describe a case of disseminated Herpes-Zoster (VZV) in an HIV 1 positive patient with AIDS. Hyperkeratotic characteristics, acyclovir resistance and sensitivity to foscarnet of cutaneous lesions are the most important features of this example. From the casuistics of the department, the authors describe two similar cases and review the medical literature with emphasis on etiopathogenic, diagnostic and therapeutic factors of lesions caused by DNA Virus in immunocompromised hosts.
Leishmania infantum zimodeme MON-1 foi isolado a partir de uma lesão cutânea da face de uma crian... more Leishmania infantum zimodeme MON-1 foi isolado a partir de uma lesão cutânea da face de uma criança, residente em Lisboa e que nunca saiu do país. Após biópsia excisional não houve recorrência da lesão. Este é o primeiro caso em que este agente é identificado como responsável pela leishmaniose cutânea em Portugal.
... borreliose de Lyme. QUADRO CLÍNICO Em 1921, Arvid Afzelius, já com experiência de diversos ca... more ... borreliose de Lyme. QUADRO CLÍNICO Em 1921, Arvid Afzelius, já com experiência de diversos casos, caracterizou do seguinte modo o ECM(5): “[… A doença começa como uma pequena placa circular. Esta estende-se ...
Journal of the European Academy of Dermatology and Venereology, 2002
Acta medica portuguesa, 1997
Cutaneous cytomegalovirus (CMV) infection has been observed in a variety of nonspecific skin lesi... more Cutaneous cytomegalovirus (CMV) infection has been observed in a variety of nonspecific skin lesions. Because of this fact, its diagnosis is rare and frequently accidental. The presence of the virus has also been observed in apparently normal skin, from both a clinical and histological point of view. In this context, skin biopsy and immunohistochemistry are often the first means of diagnosis of systemic CMV infection. In 180 skin biopsies carried out on HIV patients in the Infectious and Parasitic Diseases Unit, typical histopathological findings of CMV infection in a nonspecific skin lesion were observed in only one patient. Although the patient showed no extracutaneous manifestations at this time, she died soon after this diagnosis. Because of this fact, we review the literature and discuss the difficulties and implications of the diagnosis of cutaneous CMV infection in AIDS patients.
Journal of the European Academy of Dermatology and Venereology, 2000
... Treatment of oral condylomata acuminata in a HIV-1 patient with bleomycin. Leonor Girão 3 ,; ... more ... Treatment of oral condylomata acuminata in a HIV-1 patient with bleomycin. Leonor Girão 3 ,; Isabel Franca 1 ,; Helena Macedo 1 ,; Carmo Ornelas 2 ,; Moura Nunes 2 ,; Carlos Araújo 1 ,; Kamal Mansinho 1. Article first published online: 8 MAY 2002. ...
Wiener klinische Wochenschrift, 2005
Borrelia lusitaniae was isolated from an Ixodes ricinus tick in Portugal in 1993 for the first ti... more Borrelia lusitaniae was isolated from an Ixodes ricinus tick in Portugal in 1993 for the first time. Further, this borrelia genospecies has been found in ixodid ticks collected around the coasts of southern Portugal and North Africa. Its reservoir has not been defined yet. B. lusitaniae was isolated once until now from a patient with a long standing and expanding skin disorder. A 46-year-old Portuguese woman presented with a skin lesion on the left thigh which had evolved slowly over ten years. The patient reported limb paraesthesias, cramps, chronic headaches, and cardiac rhythm disturbances. History of tick bites was negative nor had the patient ever noticed a skin lesion comparable with erythema chronicum migrans. Skin biopsies were taken for histological evaluation, culture and DNA detection. Antibodies to borrelia were searched by indirect immunofluorescence assay and Western-blot. A bilateral carpal tunnel syndrome and local synovitis was diagnosed. Dermato-histology was normal, serology was negative. Spirochaetal organisms were cultured from a skin biopsy and identified as B. lusitaniae. The patient improved after a 2-week course of intravenous ceftriaxone; the skin lesions did not expand further. This culture confirmed skin infection by B. lusitaniae in a patient from Portugal suggests an additional human pathogen out of the B. burgdorferi sensu lato complex in Europe, particularly in Portugal.
spdv.com.pt
Page 1. CAPÍTULO 1 BORRELIOSE DE LYME: UMA INTRODUÇÃO À DOENÇA Isabel da Franca RESUMO - A borrel... more Page 1. CAPÍTULO 1 BORRELIOSE DE LYME: UMA INTRODUÇÃO À DOENÇA Isabel da Franca RESUMO - A borreliose de Lyme, causada pelo espiroquetídeo Borrelia burgdorferi sensu lato, transmitido ao homem por mordedura ...
Journal of Clinical Microbiology, 2004
The first human isolate of Borrelia lusitaniae recovered from a Portuguese patient with suspected... more The first human isolate of Borrelia lusitaniae recovered from a Portuguese patient with suspected Lyme borreliosis is described. This isolate, from a chronic skin lesion, is also the first human isolate of Borrelia in Portugal. Different phenotypic and molecular methods are used to characterize it.
Wiener klinische Wochenschrift, 2005
Zusammenfassung. Hintergrund: Borrelia lusitaniae wurde erstmals im Jahr 1993 in Portugal von ein... more Zusammenfassung. Hintergrund: Borrelia lusitaniae wurde erstmals im Jahr 1993 in Portugal von einer Ixodes ricinus-Zecke isoliert. In der Folge wurde diese Borrelien-Art in Ixodes-Zecken von der Küste Süd-Portugals und Nordafrikas nachgewiesen. Tierische Reservoire dieser Borrelienart sind noch unbekannt. B. lusitaniae wurde bisher ein einziges Mal aus der Haut eines Patienten mit einer langdauernden progredienten Hauterkrankung isoliert. Patient und Methoden: Eine 46-jährige Portugiesin kam mit einer Hautläsion am rechten Oberschenkel, die sich langsam innerhalb von 10 Jahren entwickelt hatte. Die Patientin litt an Paraesthesien der Gliedmaßen, Krämpfen, chronischen Kopfschmerzen und Herzrhythmusstörungen. Weder war ein Zeckenstich erinnerlich, noch hatte die Patientin jemals an einer dem Erythema chronicum migrans vergleichbaren Hautläsion gelitten. Hautbiopsien wurden für histologische Untersuchungen sowie für einen direkten Erregernachweis mittels Kultur und Nukleinsäureamplifikation entnommen, Serum zum Nachweis von Antikörpern gegen Borrelien. Ergebnisse: Diagnostiziert wurde ein beidseitiges Karpaltunnelsyndrom und Synovitis. Dermato-histologisch fanden sich keine Auffälligkeiten, die Serologie war negativ. Aus einer Hautbiopsie wurden Spirochäten kultiviert und als B. lusitaniae identifiziert. Die Patientin wurde über 2 Wochen mit intravenösem Ceftriaxon behandelt. Hierauf war sie subjektiv gebessert, ein Stillstand der Expansion der Hautläsionen war zu beobachten. Schlussfolgerung: Die durch Anzüchtung von B. lusitaniae bestätigte Hautinfektion einer Patientin aus Portugal legt nahe, dass B. lusitaniae ein weiterer Krankheitserreger aus dem B. burgdorferi sensu lato-Komplex in Europa sein könnte.