Jorge Casseb - Academia.edu (original) (raw)
Papers by Jorge Casseb
Sexually Transmitted Diseases, 1998
Wolters Kluwer Health may email you for journal alerts and information, but is committed to maint... more Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. ... Skip Navigation Links Home > July ...
Research Square (Research Square), Jun 1, 2023
The Lancet Global Health, Aug 1, 2023
International Journal of Molecular Sciences, Jun 26, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Clinical Infectious Diseases, Nov 1, 1999
We report the characterization of phenotype, genotype, and functional parameters such as CD4+ T c... more We report the characterization of phenotype, genotype, and functional parameters such as CD4+ T cell, viral load, HIV-1 genotype, class I HLA genotype, CCR5 polymorphism, and IFN-γ producing cells from a cohort of 37 people living with HIV-1 (PLWH) (viremic controllers, were compared those on antiretroviral therapy (ART) from two sites in São Paulo, Brazil. Half the PLWH (51.4%) were classified as viremic controllers (Controller group - CG), compared to 48.6% were on ART. As expected, controllers showed baseline higher levels of CD4+ T cells and nadir compared to those under ART, confirming the ability of HIV-1 controllers to preserve these cells even in the absence of ART. IFN-γ-producing cells showed greater magnitude to the HIV peptides Gag in controllers (p<0.03). Our results demonstrated that HLA protective alleles are associated with strong production of IFN-γ to Gag, Nef and RT epitopes in people living with HIV controllers.
The Lancet Global Health, May 1, 2023
Animal Diseases
Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but... more Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in dogs. Then, this letter discussed the dog susceptibility to retrovirus infection, encompassing arguments to understand why dogs may have not been infected by retroviruses thus far. The potential resistance of retrovirus in dogs enables this provocative short communication to discuss this question, looking at some evolutive aspects. The lineage of canids has shown, throughout its evolutionary history, a smaller accumulation of retroviruses in canid genomes, classified as endogenous retroviruses. In this context, the genomes of canids seem to offer obstacles, which have been evolutionarily conserved, in the face of retroviral infection.
The Journal of Infectious Diseases, Jun 30, 2023
Background Mother-to-child transmission (MTCT) of human T-lymphotropic virus type 1 (HTLV-1) is a... more Background Mother-to-child transmission (MTCT) of human T-lymphotropic virus type 1 (HTLV-1) is an important route of transmission that can cause lifelong infection. There is high morbidity and mortality due to adult T-cell leukemia/lymphoma, HTLV-1–associated myelopathy (HAM), and other inflammatory disorders. These conditions develop in nearly 10% of people with HTLV-1 infection, with a higher risk if infection occurs early in life. Identification of risk factors can inform targeted measures to reduce HTLV-1 MTCT. This study aimed to investigate the potential of cesarean delivery to prevent HTLV-1 MTCT. Methods We performed a review of the cases of women and their offspring under regular follow-up at the HTLV-1 outpatient clinic at the Institute of Infectious Diseases Emilio Ribas. Results A total of 177 HTLV-1–infected women and 369 adult offspring were investigated. Overall, 15% of the children were positive for HTLV-1 and 85% were negative. Regarding vertical transmission, we found that a breastfeeding duration of >6 months was associated with MTCT. Moreover, maternal proviral load was not associated with transmission, but high educational level and cesarean delivery were identified as protective factors. Conclusions HTLV-1 MTCT was associated with mother's age at delivery of >25 years, low educational level, prolonged breastfeeding, and vaginal delivery.
Alopecia areata é uma doença que provoca a queda de cabelos e pelos em uma única ou diversas área... more Alopecia areata é uma doença que provoca a queda de cabelos e pelos em uma única ou diversas áreas do corpo. Fatores psicológicos estão relacionados com seu início, evolução e tratamento. Este estudo verificou a frequência de depressão e ansiedade, percepção em relação à doença e impacto na qualidade de vida desses pacientes. Participantes: 59 homens e mulheres entre 20 e 65 anos. Delineamento: quantitativo transversal do tipo analítico descritivo e qualitativo.
BEPA. Boletim Epidemiológico Paulista (Online), Dec 1, 2008
A paraparesia espástica tropical (TSP/HAM) é uma doença neurológica ocasionada pelo vírus HTLV-I,... more A paraparesia espástica tropical (TSP/HAM) é uma doença neurológica ocasionada pelo vírus HTLV-I, que acomete preferencialmente os membros inferiores de forma lenta e progressiva. O objetivo deste estudo foi avaliar a freqüência dos aspectos psicológicos ( ...
The Journal of Infectious Diseases, Jul 1, 2000
Correspondence 379 of human cytomegalovirus pp67 late transcript in heart, lung, and bone marrow ... more Correspondence 379 of human cytomegalovirus pp67 late transcript in heart, lung, and bone marrow transplant recipients as determined by nucleic acid sequence-based amplification. J Clin Microbiol 1999; 37:902-11. 7. Blok MJ, Goossens VJ, Vanherle SJV, et al. Diagnostic value of monitoring human cytomegalovirus late pp67 mRNA expression in renal-allograft recipients by nucleic acid sequence-based amplification.
AIDS Research and Human Retroviruses, Jul 6, 2023
Journal of medical microbiology and infectious diseases, Sep 1, 2021
Introduction: HIV-1 gp120 V3 GPGR motif has an essential role in viral invasion, cell fusion, and... more Introduction: HIV-1 gp120 V3 GPGR motif has an essential role in viral invasion, cell fusion, and pathogenesis but presents a significant variability that can implicate neutralizing antibodies and antiretroviral drug resistance. Methods: We performed a comprehensive analysis based on 259,288 HIV-1 gp120 amino acid sequences obtained from the Los Alamos National Laboratory (LANL) HIV Sequence Database to infer the global distribution of V3 tetrapeptide motifs. We calculated the frequencies and presented the main variants according to continents and countries. Furthermore, the clinical importance of the most distributed V3 motifs was detailed. Results: Our results showed GPGR and GPGQ as the most commonly found V3 motifs among more than five hundred V3 variant motifs. Motifs with clinical implications are widely distributed around the world. Within the most frequent V3 tetrapeptide motifs set, some variants enable the escape from fusion inhibitor drugs and neutralizing antibodies. Conclusion: Considering that an effective vaccine candidate should elicit broadly neutralizing antibodies while fusion inhibitor drug interaction requires conserved amino acids, the diversity of V3 motifs implicates a great challenge in developing an effective HIV-1 vaccine.
Medicine and Science in Sports and Exercise, May 1, 2006
Journal of AIDS and Clinical Research, Jun 15, 2013
Medical Hypotheses, Jun 1, 2002
The loss of T CD4 cells leading to impairment of the immune system is the major cause of disease ... more The loss of T CD4 cells leading to impairment of the immune system is the major cause of disease progression during HIV infection. More recently, the use of highly active anti-retroviral therapy (HAART) has raised important questions regarding the immune system restoration. Idiopathic CD4 T lymphocytopenia syndrome (ICL) is similar to AIDS, except for the presence of HIV. Despite this similarity, ICL patients have a longer survival time than AIDS cases without HAART. The impairment of TCR/CD3-directed CD4 T cell immune responses may be responsible for HIV disease progression. We think that the reduction of opportunistic infections which lead to death after HAART, is due to the ability of these memory clones to restore enough clones of the TCR/CD3 complex with fair capacity and diversity to confront frequent pathogens.
Sexually Transmitted Diseases, 1998
Wolters Kluwer Health may email you for journal alerts and information, but is committed to maint... more Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. ... Skip Navigation Links Home > July ...
Research Square (Research Square), Jun 1, 2023
The Lancet Global Health, Aug 1, 2023
International Journal of Molecular Sciences, Jun 26, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Clinical Infectious Diseases, Nov 1, 1999
We report the characterization of phenotype, genotype, and functional parameters such as CD4+ T c... more We report the characterization of phenotype, genotype, and functional parameters such as CD4+ T cell, viral load, HIV-1 genotype, class I HLA genotype, CCR5 polymorphism, and IFN-γ producing cells from a cohort of 37 people living with HIV-1 (PLWH) (viremic controllers, were compared those on antiretroviral therapy (ART) from two sites in São Paulo, Brazil. Half the PLWH (51.4%) were classified as viremic controllers (Controller group - CG), compared to 48.6% were on ART. As expected, controllers showed baseline higher levels of CD4+ T cells and nadir compared to those under ART, confirming the ability of HIV-1 controllers to preserve these cells even in the absence of ART. IFN-γ-producing cells showed greater magnitude to the HIV peptides Gag in controllers (p<0.03). Our results demonstrated that HLA protective alleles are associated with strong production of IFN-γ to Gag, Nef and RT epitopes in people living with HIV controllers.
The Lancet Global Health, May 1, 2023
Animal Diseases
Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but... more Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in dogs. Then, this letter discussed the dog susceptibility to retrovirus infection, encompassing arguments to understand why dogs may have not been infected by retroviruses thus far. The potential resistance of retrovirus in dogs enables this provocative short communication to discuss this question, looking at some evolutive aspects. The lineage of canids has shown, throughout its evolutionary history, a smaller accumulation of retroviruses in canid genomes, classified as endogenous retroviruses. In this context, the genomes of canids seem to offer obstacles, which have been evolutionarily conserved, in the face of retroviral infection.
The Journal of Infectious Diseases, Jun 30, 2023
Background Mother-to-child transmission (MTCT) of human T-lymphotropic virus type 1 (HTLV-1) is a... more Background Mother-to-child transmission (MTCT) of human T-lymphotropic virus type 1 (HTLV-1) is an important route of transmission that can cause lifelong infection. There is high morbidity and mortality due to adult T-cell leukemia/lymphoma, HTLV-1–associated myelopathy (HAM), and other inflammatory disorders. These conditions develop in nearly 10% of people with HTLV-1 infection, with a higher risk if infection occurs early in life. Identification of risk factors can inform targeted measures to reduce HTLV-1 MTCT. This study aimed to investigate the potential of cesarean delivery to prevent HTLV-1 MTCT. Methods We performed a review of the cases of women and their offspring under regular follow-up at the HTLV-1 outpatient clinic at the Institute of Infectious Diseases Emilio Ribas. Results A total of 177 HTLV-1–infected women and 369 adult offspring were investigated. Overall, 15% of the children were positive for HTLV-1 and 85% were negative. Regarding vertical transmission, we found that a breastfeeding duration of >6 months was associated with MTCT. Moreover, maternal proviral load was not associated with transmission, but high educational level and cesarean delivery were identified as protective factors. Conclusions HTLV-1 MTCT was associated with mother's age at delivery of >25 years, low educational level, prolonged breastfeeding, and vaginal delivery.
Alopecia areata é uma doença que provoca a queda de cabelos e pelos em uma única ou diversas área... more Alopecia areata é uma doença que provoca a queda de cabelos e pelos em uma única ou diversas áreas do corpo. Fatores psicológicos estão relacionados com seu início, evolução e tratamento. Este estudo verificou a frequência de depressão e ansiedade, percepção em relação à doença e impacto na qualidade de vida desses pacientes. Participantes: 59 homens e mulheres entre 20 e 65 anos. Delineamento: quantitativo transversal do tipo analítico descritivo e qualitativo.
BEPA. Boletim Epidemiológico Paulista (Online), Dec 1, 2008
A paraparesia espástica tropical (TSP/HAM) é uma doença neurológica ocasionada pelo vírus HTLV-I,... more A paraparesia espástica tropical (TSP/HAM) é uma doença neurológica ocasionada pelo vírus HTLV-I, que acomete preferencialmente os membros inferiores de forma lenta e progressiva. O objetivo deste estudo foi avaliar a freqüência dos aspectos psicológicos ( ...
The Journal of Infectious Diseases, Jul 1, 2000
Correspondence 379 of human cytomegalovirus pp67 late transcript in heart, lung, and bone marrow ... more Correspondence 379 of human cytomegalovirus pp67 late transcript in heart, lung, and bone marrow transplant recipients as determined by nucleic acid sequence-based amplification. J Clin Microbiol 1999; 37:902-11. 7. Blok MJ, Goossens VJ, Vanherle SJV, et al. Diagnostic value of monitoring human cytomegalovirus late pp67 mRNA expression in renal-allograft recipients by nucleic acid sequence-based amplification.
AIDS Research and Human Retroviruses, Jul 6, 2023
Journal of medical microbiology and infectious diseases, Sep 1, 2021
Introduction: HIV-1 gp120 V3 GPGR motif has an essential role in viral invasion, cell fusion, and... more Introduction: HIV-1 gp120 V3 GPGR motif has an essential role in viral invasion, cell fusion, and pathogenesis but presents a significant variability that can implicate neutralizing antibodies and antiretroviral drug resistance. Methods: We performed a comprehensive analysis based on 259,288 HIV-1 gp120 amino acid sequences obtained from the Los Alamos National Laboratory (LANL) HIV Sequence Database to infer the global distribution of V3 tetrapeptide motifs. We calculated the frequencies and presented the main variants according to continents and countries. Furthermore, the clinical importance of the most distributed V3 motifs was detailed. Results: Our results showed GPGR and GPGQ as the most commonly found V3 motifs among more than five hundred V3 variant motifs. Motifs with clinical implications are widely distributed around the world. Within the most frequent V3 tetrapeptide motifs set, some variants enable the escape from fusion inhibitor drugs and neutralizing antibodies. Conclusion: Considering that an effective vaccine candidate should elicit broadly neutralizing antibodies while fusion inhibitor drug interaction requires conserved amino acids, the diversity of V3 motifs implicates a great challenge in developing an effective HIV-1 vaccine.
Medicine and Science in Sports and Exercise, May 1, 2006
Journal of AIDS and Clinical Research, Jun 15, 2013
Medical Hypotheses, Jun 1, 2002
The loss of T CD4 cells leading to impairment of the immune system is the major cause of disease ... more The loss of T CD4 cells leading to impairment of the immune system is the major cause of disease progression during HIV infection. More recently, the use of highly active anti-retroviral therapy (HAART) has raised important questions regarding the immune system restoration. Idiopathic CD4 T lymphocytopenia syndrome (ICL) is similar to AIDS, except for the presence of HIV. Despite this similarity, ICL patients have a longer survival time than AIDS cases without HAART. The impairment of TCR/CD3-directed CD4 T cell immune responses may be responsible for HIV disease progression. We think that the reduction of opportunistic infections which lead to death after HAART, is due to the ability of these memory clones to restore enough clones of the TCR/CD3 complex with fair capacity and diversity to confront frequent pathogens.