Jelica Videnovic - Ivanov - Academia.edu (original) (raw)

Papers by Jelica Videnovic - Ivanov

Research paper thumbnail of Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases, 2018

Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestatio... more Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P<0.05) and more LDL II, LDL III, LDL IVA particles (P<0.01), but low...

Research paper thumbnail of A Real-Life Observational Study on a Quality of Life in Patients with Acute Respiratory Infection Supplemented with Combination of N-Acetyl Cysteine and Propolis

Jelica Videnovic Ivanov1*, Mihailovic Vucinic V1, Filipovic Stepic S1 and Agic A2

Research paper thumbnail of Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients

Arhiv za farmaciju, 2017

Matrix metaloproteinases (MMPs) and their specific inhibitors-tissue inhibitors of matrix metallo... more Matrix metaloproteinases (MMPs) and their specific inhibitors-tissue inhibitors of matrix metalloproteinases (TIMPs) play an important role in pulmonary extracellular matrix destruction. Sarcoidosis is an inflammatory disease affecting multiple organs. It has been reported that MMP-9 and TIMP-1 levels were increased in bronchoalveolar lavage fluid and induced sputum of sarcoidosis patients. The aim of our study was to evaluate MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations and MMP-9/TIMP-1 ratio in sarcoidosis patients, their relationship with inflammatory markers and their ability do predict the existence of disease. We included 101 sarcoidosis patients and 50 healthy subjects. Serum samples were analyzed. Besides routine biochemical parameters, high-sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations were measured. MMP-9 (P<0.05), hsCRP, SAA and TIMP-1 (P<0.001) concentrations were significantly increased in patients whereas MMP-9/TIMP-1 complex was higher in patients, but with marginal significance. In sarcoidosis, TIMP-1 correlated significantly positively with inflammatory parameters (P<0.05). Uni-variate analysis showed that MMP-9, TIMP-1, hsCRP and SAA had the ability to predict the existence of sarcoidosis. In the model consisted of MMP-9, TIMP-1, hsCRP and SAA, only SAA remained significant predictor of disease (P<0.01). Results showed the significance of MMP-9 and TIMP-1 in sarcoidosis.

Research paper thumbnail of The 18F PET/CT scan in patients with chronic sarcoidosis

1.5 Diffuse Parenchymal Lung Disease, 2016

Introduction: Sarcoidosis is chronic systemic granulomatous disease most involving the lung.New m... more Introduction: Sarcoidosis is chronic systemic granulomatous disease most involving the lung.New markers of activity are important due to lack of sufficiently sensitive and specific .The aim : Performed 18F-FDG PET / CT scan in clinical problems of chronic sarcoidosis. Method: Previously histological obtained sarcoidosis are enrolled : 58 patients (mean age 54.4 ± 12 years ; 23 – 40% men and 35-60% women). PET scan performed and also after 20 months of finished therapy. Resuls: PET scan is verified inflammation in 54(93.1%)patients (SUVmax 8.84 ± 3.52). MDCT scan was positive in 49(84,48%) patients. Significant difference between the two methods not verified (p = 0.238, McNemar9s test).Spirometry findings:Ventilatory restriction is the main findings in 22 % and obstruction findings in 8 (14%) patients- age over 50 years with fibrotic chest ray findings. Markers of activity are higher in patients with positive findings on 18F-FDG PET / CT scan , compared to the group with negative results (p = 0.002, Mann-Whitney test). Specified group of 16( 28%) patients with positive PET but normal ACE and Ca in 24h urine,was obtained .Chitotriosidase levels significantly correlated with the findings of the 18F-FDG PET / CT scan in 57 patients. Logistic regression (univariate and multivariate) indicates significant correlation (p=0.001),positive PET scan findings and the modifying treatment. Control findings of PET scan after 14-22 months, obtaine reduction in SUV (8.84 vs.4.4) . Located SUV were significantly correlated with the subjective perception of the state of patients (P = 0.019). Conclusion: 18F-FDG PET / CT scan is the significant diagnostic method in determining the sites of inflammation in patients with chronic sarcoidosis.

Research paper thumbnail of The utility of 18F-FDG PET/CT in chronic sarcoidosis

European Respiratory Journal, Sep 1, 2013

Body: The analysis was performed in chronic sarcoidosis patients with persistent clinical symptom... more Body: The analysis was performed in chronic sarcoidosis patients with persistent clinical symptoms due to assess the utility of 18F-FDG PET/CT. The analysis were performed before and after the period of specific therapy for sarcoidosis due to clinical-radiographic-functional findings. Methods: We analyzed 51 patients with chronic sarcoidosis (mean age ± SD: 47 ± 12 year; 38 F/13M). After the follow up (12 ± 5 months), the clinical status,functional findings and therapy modalities were analyzed. Results: 18F-FDG PET CT detected activity s.inflammation in 37 patients (82%) (SUV: 8.1 ± 3.9).MDCT was positive in 5 additional patients (89%). The difference between this two methods was not significant.Correlation between ACE levels and 18F-FDG PET/CT results were obtaine in 25 (49%) patients (P = 0.002,Mann-Whitney test). In 26 patients (51%) with positive 18F-FDG PET/CT findings, the ACE levels were in physiological levels. The therapies were initiated or even changed in 43 (81%). Significante correlation were find out between the positive 18F-FDG PET/CT results and changes in therapies. Conclusion: the results from our study indicate that 18F-FDG PET/CT is the important diagnostic method in chronic sarcoidosis due to obtaine the activity of sarcoidosis granulomas.

Research paper thumbnail of Characteristic of gender distribution in sarcoidosis

European Respiratory Journal, Sep 1, 2012

Research paper thumbnail of Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases, 2018

Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestatio... more Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P<0.05) and more LDL II, LDL III, LDL IVA particles (P<0.01), but low...

Research paper thumbnail of A Real-Life Observational Study on a Quality of Life in Patients with Acute Respiratory Infection Supplemented with Combination of N-Acetyl Cysteine and Propolis

Jelica Videnovic Ivanov1*, Mihailovic Vucinic V1, Filipovic Stepic S1 and Agic A2

Research paper thumbnail of Manifestations of malignancies during the course of sarcoidosis

European Respiratory Journal, Sep 1, 2011

Introduction: Sarcoidosis is the granulomatous disorder with chronic course which can involve any... more Introduction: Sarcoidosis is the granulomatous disorder with chronic course which can involve any organ in human body. Coexistance of two disorders is potential. Method of the work: Analysis were restrospective.All patients with histologically proved sarcoidosis were obtained. Patients were ambulatory or hospitaly treated in the Clinic for lung diseases and tuberculosis. Malignincies were also histologycally proved. Results: Among 1307 patients with sarcoidosis (ACCES group, ERS) only 15 patients with malignicies were obtained.Mean ages were 47.3 years, and 11 F/4 M ratio was find out.In 5 patients malignicies were the first obtained diagnosis in patients life as followed: carcinoma mammae (2 patients), carcinoma renis, fibrosarcoma and chronic laeucemia.The mean time in which sarcoidosis were manifested - 3,1 years. All patients were treated for carcinoma, till nowdays. In 11 patients, malignincies followed the sarcoidosis in mean time of 7.7 years: M. Hodgkin, adenocarcinoma ovarii, melanoma malignum, carcinoma cutis (3 female patients), adenocarcinoma intestine, carcinoma recti (2 patients), carcinoma mammae.Mean time of sarcoidosis duration were 8.3 years. All patients with sarcoidosis were mediacally treated even for relapses. In this group 3 lethal outcomes were obtained. Conclusion: Comorbidities exists even in sarcoidosis.The question is what is the cause for manifesting sarcoidosis and malignincies. Is immunodefitientia one of the potential factors in manifesting sarcoidosis and in manifesting malignincies. Another question is due to cytostatic drugs delivering during the treatment from malignincies. One of the known cytostatics which can cause granulomatous disorders is vinblastin.

Research paper thumbnail of Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients

Arhiv za farmaciju, 2017

Matrix metaloproteinases (MMPs) and their specific inhibitors-tissue inhibitors of matrix metallo... more Matrix metaloproteinases (MMPs) and their specific inhibitors-tissue inhibitors of matrix metalloproteinases (TIMPs) play an important role in pulmonary extracellular matrix destruction. Sarcoidosis is an inflammatory disease affecting multiple organs. It has been reported that MMP-9 and TIMP-1 levels were increased in bronchoalveolar lavage fluid and induced sputum of sarcoidosis patients. The aim of our study was to evaluate MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations and MMP-9/TIMP-1 ratio in sarcoidosis patients, their relationship with inflammatory markers and their ability do predict the existence of disease. We included 101 sarcoidosis patients and 50 healthy subjects. Serum samples were analyzed. Besides routine biochemical parameters, high-sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations were measured. MMP-9 (P<0.05), hsCRP, SAA and TIMP-1 (P<0.001) concentrations were significantly increased in patients whereas MMP-9/TIMP-1 complex was higher in patients, but with marginal significance. In sarcoidosis, TIMP-1 correlated significantly positively with inflammatory parameters (P<0.05). Uni-variate analysis showed that MMP-9, TIMP-1, hsCRP and SAA had the ability to predict the existence of sarcoidosis. In the model consisted of MMP-9, TIMP-1, hsCRP and SAA, only SAA remained significant predictor of disease (P<0.01). Results showed the significance of MMP-9 and TIMP-1 in sarcoidosis.

Research paper thumbnail of The 18F PET/CT scan in patients with chronic sarcoidosis

1.5 Diffuse Parenchymal Lung Disease, 2016

Introduction: Sarcoidosis is chronic systemic granulomatous disease most involving the lung.New m... more Introduction: Sarcoidosis is chronic systemic granulomatous disease most involving the lung.New markers of activity are important due to lack of sufficiently sensitive and specific .The aim : Performed 18F-FDG PET / CT scan in clinical problems of chronic sarcoidosis. Method: Previously histological obtained sarcoidosis are enrolled : 58 patients (mean age 54.4 ± 12 years ; 23 – 40% men and 35-60% women). PET scan performed and also after 20 months of finished therapy. Resuls: PET scan is verified inflammation in 54(93.1%)patients (SUVmax 8.84 ± 3.52). MDCT scan was positive in 49(84,48%) patients. Significant difference between the two methods not verified (p = 0.238, McNemar9s test).Spirometry findings:Ventilatory restriction is the main findings in 22 % and obstruction findings in 8 (14%) patients- age over 50 years with fibrotic chest ray findings. Markers of activity are higher in patients with positive findings on 18F-FDG PET / CT scan , compared to the group with negative results (p = 0.002, Mann-Whitney test). Specified group of 16( 28%) patients with positive PET but normal ACE and Ca in 24h urine,was obtained .Chitotriosidase levels significantly correlated with the findings of the 18F-FDG PET / CT scan in 57 patients. Logistic regression (univariate and multivariate) indicates significant correlation (p=0.001),positive PET scan findings and the modifying treatment. Control findings of PET scan after 14-22 months, obtaine reduction in SUV (8.84 vs.4.4) . Located SUV were significantly correlated with the subjective perception of the state of patients (P = 0.019). Conclusion: 18F-FDG PET / CT scan is the significant diagnostic method in determining the sites of inflammation in patients with chronic sarcoidosis.

Research paper thumbnail of Assessment of Health-Related Quality of Life in Patients With Chronic Sarcoidosis

Chest Journal, Oct 1, 2003

Research paper thumbnail of The utility of 18F-FDG PET/CT in chronic sarcoidosis

European Respiratory Journal, Sep 1, 2013

Body: The analysis was performed in chronic sarcoidosis patients with persistent clinical symptom... more Body: The analysis was performed in chronic sarcoidosis patients with persistent clinical symptoms due to assess the utility of 18F-FDG PET/CT. The analysis were performed before and after the period of specific therapy for sarcoidosis due to clinical-radiographic-functional findings. Methods: We analyzed 51 patients with chronic sarcoidosis (mean age ± SD: 47 ± 12 year; 38 F/13M). After the follow up (12 ± 5 months), the clinical status,functional findings and therapy modalities were analyzed. Results: 18F-FDG PET CT detected activity s.inflammation in 37 patients (82%) (SUV: 8.1 ± 3.9).MDCT was positive in 5 additional patients (89%). The difference between this two methods was not significant.Correlation between ACE levels and 18F-FDG PET/CT results were obtaine in 25 (49%) patients (P = 0.002,Mann-Whitney test). In 26 patients (51%) with positive 18F-FDG PET/CT findings, the ACE levels were in physiological levels. The therapies were initiated or even changed in 43 (81%). Significante correlation were find out between the positive 18F-FDG PET/CT results and changes in therapies. Conclusion: the results from our study indicate that 18F-FDG PET/CT is the important diagnostic method in chronic sarcoidosis due to obtaine the activity of sarcoidosis granulomas.

Research paper thumbnail of Obstructive findings in sarcoidosis, diagnosis and therapies modalities

European Respiratory Journal, Sep 1, 2012

Introduction: Symptoms of respiratory disturbances are common during the course of sarcoidosis. T... more Introduction: Symptoms of respiratory disturbances are common during the course of sarcoidosis. The aim of analysis is to notifie obstructive findings in sarcoidosis. Method: The analyses is restrospective in all incominig patients to the Clinic for lung diseases and tuberculosis CC of Serbia in Belgrade. Results: 127 (8,7%) patients with dry cough and occasionaly dyspnea had the impairent of lung function. The main findings were: FEVl / VC 63,1% in 57- 44,8% patients; in 27-21,1% patients – FEVl / FVC were 55,7% , in 3-2,3% patients FEVl / FVC were 68.7 %. Gender distribution were as followed: 264 (66,2%)Female- Male 135 (33,8%); average ages were 43,32 years. Extrathoracis sarcoidosis involvement were find out in 3 (2.3%) patients (skin, lymph nodes,).Lung and nonpulmonary sarcoidosis is notify in 27 pts and in 97 pts lung were the only sarcoidosis manifestation. Radiographic stadium of lung involvement: I-87(68.5%), II-31(24,4%), III-7%(5,%), IV-1 (0,78%). Acute onset of sarcoidosis is predominatly with average level of ACE: 75.3 U / L. After obtaining the diagnosis of sarcoidosis, inhaled corticosteroides were administered, 160 mcg-daily through 3 months with controls which meansa :ACE and UCa/24h levels, lung function, chest X ray. Regression of symptoms such as dry cough were obtained in 55% patients after the period of 2 months; 45% patients were excluded due to persistence of symptoms seeking prednisone. Conclusion – inhaled corticosteroid have the role in sarcoidosis treatment resolving symptoms such as cough, improvement of FEV1, but the main therapy in most of the patients is still orally administired prednisone.

Research paper thumbnail of Characteristic of gender distribution in sarcoidosis

European Respiratory Journal, Sep 1, 2012

Research paper thumbnail of Manifestations of malignancies during the course of sarcoidosis

European Respiratory Journal, Sep 1, 2011

Introduction: Sarcoidosis is the granulomatous disorder with chronic course which can involve any... more Introduction: Sarcoidosis is the granulomatous disorder with chronic course which can involve any organ in human body. Coexistance of two disorders is potential. Method of the work: Analysis were restrospective.All patients with histologically proved sarcoidosis were obtained. Patients were ambulatory or hospitaly treated in the Clinic for lung diseases and tuberculosis. Malignincies were also histologycally proved. Results: Among 1307 patients with sarcoidosis (ACCES group, ERS) only 15 patients with malignicies were obtained.Mean ages were 47.3 years, and 11 F/4 M ratio was find out.In 5 patients malignicies were the first obtained diagnosis in patients life as followed: carcinoma mammae (2 patients), carcinoma renis, fibrosarcoma and chronic laeucemia.The mean time in which sarcoidosis were manifested - 3,1 years. All patients were treated for carcinoma, till nowdays. In 11 patients, malignincies followed the sarcoidosis in mean time of 7.7 years: M. Hodgkin, adenocarcinoma ovarii, melanoma malignum, carcinoma cutis (3 female patients), adenocarcinoma intestine, carcinoma recti (2 patients), carcinoma mammae.Mean time of sarcoidosis duration were 8.3 years. All patients with sarcoidosis were mediacally treated even for relapses. In this group 3 lethal outcomes were obtained. Conclusion: Comorbidities exists even in sarcoidosis.The question is what is the cause for manifesting sarcoidosis and malignincies. Is immunodefitientia one of the potential factors in manifesting sarcoidosis and in manifesting malignincies. Another question is due to cytostatic drugs delivering during the treatment from malignincies. One of the known cytostatics which can cause granulomatous disorders is vinblastin.

Research paper thumbnail of Assessment of Health-Related Quality of Life in Patients With Chronic Sarcoidosis

Chest Journal, Oct 1, 2003

BACKGROUND. In pediatric settings, measures of health-related quality of life (HRQL) are often ob... more BACKGROUND. In pediatric settings, measures of health-related quality of life (HRQL) are often obtained by proxy, especially from parents, but the correlation between parental report and patient report has not been clearly established. In the current study, the authors examined the agreement between child and parent reports of HRQL in children with cancer (both those receiving treatment and those off treatment) and healthy controls. METHODS. Two groups of children with cancer who differed with regard to treatment status (n ϭ 199) and a group of healthy control children (n ϭ 108) were assessed using a standardized measure of HRQL. Both children and parents reported on the child's HRQL using parallel forms of the Children's Health Questionnaire. RESULTS. Significant parent-child correlations were found for all 10 HRQL scales, and these correlations were higher in the cancer groups compared with controls. Parents in the cancer groups tended to underestimate the HRQL of their children compared with the child report, although there were no significant parent-child mean differences in the group of patients who were off treatment and only 2 significant differences in the group of children receiving treatment. In contrast, parents in the control group tended to overestimate the HRQL of their children, and the parent-child differences were found to be larger, achieving statistical significance on 8 of 10 scales. CONCLUSIONS. Parents and children tend to report comparable child HRQL outcomes, and this is particularly true in oncology populations. In cases in which the child is either too young or too ill to provide a self-report, parent-reported HRQL can be viewed as a reliable substitute.

Research paper thumbnail of Oxidative Stress Markers During The Course Of Sarcoidosis-corelation Of Measured Values And Different Phase And Stages Of Sarcoidosis

D47. INTERSTITIAL LUNG DISEASE: COLLAGEN-VASCULAR DISEASE, SARCOIDOSIS AND OTHER DIFFUSE LUNG DISEASES, 2010

Research paper thumbnail of Obstructive findings in sarcoidosis, diagnosis and therapies modalities

European Respiratory Journal, Sep 1, 2012

Introduction: Symptoms of respiratory disturbances are common during the course of sarcoidosis. T... more Introduction: Symptoms of respiratory disturbances are common during the course of sarcoidosis. The aim of analysis is to notifie obstructive findings in sarcoidosis. Method: The analyses is restrospective in all incominig patients to the Clinic for lung diseases and tuberculosis CC of Serbia in Belgrade. Results: 127 (8,7%) patients with dry cough and occasionaly dyspnea had the impairent of lung function. The main findings were: FEVl / VC 63,1% in 57- 44,8% patients; in 27-21,1% patients – FEVl / FVC were 55,7% , in 3-2,3% patients FEVl / FVC were 68.7 %. Gender distribution were as followed: 264 (66,2%)Female- Male 135 (33,8%); average ages were 43,32 years. Extrathoracis sarcoidosis involvement were find out in 3 (2.3%) patients (skin, lymph nodes,).Lung and nonpulmonary sarcoidosis is notify in 27 pts and in 97 pts lung were the only sarcoidosis manifestation. Radiographic stadium of lung involvement: I-87(68.5%), II-31(24,4%), III-7%(5,%), IV-1 (0,78%). Acute onset of sarcoidosis is predominatly with average level of ACE: 75.3 U / L. After obtaining the diagnosis of sarcoidosis, inhaled corticosteroides were administered, 160 mcg-daily through 3 months with controls which meansa :ACE and UCa/24h levels, lung function, chest X ray. Regression of symptoms such as dry cough were obtained in 55% patients after the period of 2 months; 45% patients were excluded due to persistence of symptoms seeking prednisone. Conclusion – inhaled corticosteroid have the role in sarcoidosis treatment resolving symptoms such as cough, improvement of FEV1, but the main therapy in most of the patients is still orally administired prednisone.

Research paper thumbnail of The Role Of FDG PET/CT In The Clinical Evaluation Of Chronic Sarcoidosis

B44. ADVANCES IN THE DIAGNOSIS AND TREATMENT OF SARCOIDOSIS, 2012

Research paper thumbnail of Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases, 2018

Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestatio... more Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P<0.05) and more LDL II, LDL III, LDL IVA particles (P<0.01), but low...

Research paper thumbnail of A Real-Life Observational Study on a Quality of Life in Patients with Acute Respiratory Infection Supplemented with Combination of N-Acetyl Cysteine and Propolis

Jelica Videnovic Ivanov1*, Mihailovic Vucinic V1, Filipovic Stepic S1 and Agic A2

Research paper thumbnail of Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients

Arhiv za farmaciju, 2017

Matrix metaloproteinases (MMPs) and their specific inhibitors-tissue inhibitors of matrix metallo... more Matrix metaloproteinases (MMPs) and their specific inhibitors-tissue inhibitors of matrix metalloproteinases (TIMPs) play an important role in pulmonary extracellular matrix destruction. Sarcoidosis is an inflammatory disease affecting multiple organs. It has been reported that MMP-9 and TIMP-1 levels were increased in bronchoalveolar lavage fluid and induced sputum of sarcoidosis patients. The aim of our study was to evaluate MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations and MMP-9/TIMP-1 ratio in sarcoidosis patients, their relationship with inflammatory markers and their ability do predict the existence of disease. We included 101 sarcoidosis patients and 50 healthy subjects. Serum samples were analyzed. Besides routine biochemical parameters, high-sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations were measured. MMP-9 (P<0.05), hsCRP, SAA and TIMP-1 (P<0.001) concentrations were significantly increased in patients whereas MMP-9/TIMP-1 complex was higher in patients, but with marginal significance. In sarcoidosis, TIMP-1 correlated significantly positively with inflammatory parameters (P<0.05). Uni-variate analysis showed that MMP-9, TIMP-1, hsCRP and SAA had the ability to predict the existence of sarcoidosis. In the model consisted of MMP-9, TIMP-1, hsCRP and SAA, only SAA remained significant predictor of disease (P<0.01). Results showed the significance of MMP-9 and TIMP-1 in sarcoidosis.

Research paper thumbnail of The 18F PET/CT scan in patients with chronic sarcoidosis

1.5 Diffuse Parenchymal Lung Disease, 2016

Introduction: Sarcoidosis is chronic systemic granulomatous disease most involving the lung.New m... more Introduction: Sarcoidosis is chronic systemic granulomatous disease most involving the lung.New markers of activity are important due to lack of sufficiently sensitive and specific .The aim : Performed 18F-FDG PET / CT scan in clinical problems of chronic sarcoidosis. Method: Previously histological obtained sarcoidosis are enrolled : 58 patients (mean age 54.4 ± 12 years ; 23 – 40% men and 35-60% women). PET scan performed and also after 20 months of finished therapy. Resuls: PET scan is verified inflammation in 54(93.1%)patients (SUVmax 8.84 ± 3.52). MDCT scan was positive in 49(84,48%) patients. Significant difference between the two methods not verified (p = 0.238, McNemar9s test).Spirometry findings:Ventilatory restriction is the main findings in 22 % and obstruction findings in 8 (14%) patients- age over 50 years with fibrotic chest ray findings. Markers of activity are higher in patients with positive findings on 18F-FDG PET / CT scan , compared to the group with negative results (p = 0.002, Mann-Whitney test). Specified group of 16( 28%) patients with positive PET but normal ACE and Ca in 24h urine,was obtained .Chitotriosidase levels significantly correlated with the findings of the 18F-FDG PET / CT scan in 57 patients. Logistic regression (univariate and multivariate) indicates significant correlation (p=0.001),positive PET scan findings and the modifying treatment. Control findings of PET scan after 14-22 months, obtaine reduction in SUV (8.84 vs.4.4) . Located SUV were significantly correlated with the subjective perception of the state of patients (P = 0.019). Conclusion: 18F-FDG PET / CT scan is the significant diagnostic method in determining the sites of inflammation in patients with chronic sarcoidosis.

Research paper thumbnail of The utility of 18F-FDG PET/CT in chronic sarcoidosis

European Respiratory Journal, Sep 1, 2013

Body: The analysis was performed in chronic sarcoidosis patients with persistent clinical symptom... more Body: The analysis was performed in chronic sarcoidosis patients with persistent clinical symptoms due to assess the utility of 18F-FDG PET/CT. The analysis were performed before and after the period of specific therapy for sarcoidosis due to clinical-radiographic-functional findings. Methods: We analyzed 51 patients with chronic sarcoidosis (mean age ± SD: 47 ± 12 year; 38 F/13M). After the follow up (12 ± 5 months), the clinical status,functional findings and therapy modalities were analyzed. Results: 18F-FDG PET CT detected activity s.inflammation in 37 patients (82%) (SUV: 8.1 ± 3.9).MDCT was positive in 5 additional patients (89%). The difference between this two methods was not significant.Correlation between ACE levels and 18F-FDG PET/CT results were obtaine in 25 (49%) patients (P = 0.002,Mann-Whitney test). In 26 patients (51%) with positive 18F-FDG PET/CT findings, the ACE levels were in physiological levels. The therapies were initiated or even changed in 43 (81%). Significante correlation were find out between the positive 18F-FDG PET/CT results and changes in therapies. Conclusion: the results from our study indicate that 18F-FDG PET/CT is the important diagnostic method in chronic sarcoidosis due to obtaine the activity of sarcoidosis granulomas.

Research paper thumbnail of Characteristic of gender distribution in sarcoidosis

European Respiratory Journal, Sep 1, 2012

Research paper thumbnail of Associations of lipoprotein subclasses and oxidative stress status in pulmonary and pulmonary plus extrapulmonary sarcoidosis

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases, 2018

Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestatio... more Background: Sarcoidosis is an inflammatory disease with pulmonary and extrapulmonary manifestations. In such pathologic conditions, increased oxidative stress and rearrangement of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) may occur. Objective: This study evaluated association of oxidative stress and lipoprotein subclasses in severe forms of pulmonary and pulmonary plus extrapulmonary sarcoidosis. Methods: Lipid parameters, LDL and HDL subclass distributions, high-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), paraoxonase 1 (PON1), malondialdehyde (MDA), total-oxidant status (TOS), sulfhydryl (SH) groups, pro-oxidant anti-oxidant balance (PAB) were determined in 77 patients (53 isolated pulmonary and 24 pulmonary plus extrapulmonary) and 139 controls. Results: Both pulmonary and extrapulmonary sarcoidosis patients had significantly higher levels of triglycerides and TOS (P<0.05) and more LDL II, LDL III, LDL IVA particles (P<0.01), but low...

Research paper thumbnail of A Real-Life Observational Study on a Quality of Life in Patients with Acute Respiratory Infection Supplemented with Combination of N-Acetyl Cysteine and Propolis

Jelica Videnovic Ivanov1*, Mihailovic Vucinic V1, Filipovic Stepic S1 and Agic A2

Research paper thumbnail of Manifestations of malignancies during the course of sarcoidosis

European Respiratory Journal, Sep 1, 2011

Introduction: Sarcoidosis is the granulomatous disorder with chronic course which can involve any... more Introduction: Sarcoidosis is the granulomatous disorder with chronic course which can involve any organ in human body. Coexistance of two disorders is potential. Method of the work: Analysis were restrospective.All patients with histologically proved sarcoidosis were obtained. Patients were ambulatory or hospitaly treated in the Clinic for lung diseases and tuberculosis. Malignincies were also histologycally proved. Results: Among 1307 patients with sarcoidosis (ACCES group, ERS) only 15 patients with malignicies were obtained.Mean ages were 47.3 years, and 11 F/4 M ratio was find out.In 5 patients malignicies were the first obtained diagnosis in patients life as followed: carcinoma mammae (2 patients), carcinoma renis, fibrosarcoma and chronic laeucemia.The mean time in which sarcoidosis were manifested - 3,1 years. All patients were treated for carcinoma, till nowdays. In 11 patients, malignincies followed the sarcoidosis in mean time of 7.7 years: M. Hodgkin, adenocarcinoma ovarii, melanoma malignum, carcinoma cutis (3 female patients), adenocarcinoma intestine, carcinoma recti (2 patients), carcinoma mammae.Mean time of sarcoidosis duration were 8.3 years. All patients with sarcoidosis were mediacally treated even for relapses. In this group 3 lethal outcomes were obtained. Conclusion: Comorbidities exists even in sarcoidosis.The question is what is the cause for manifesting sarcoidosis and malignincies. Is immunodefitientia one of the potential factors in manifesting sarcoidosis and in manifesting malignincies. Another question is due to cytostatic drugs delivering during the treatment from malignincies. One of the known cytostatics which can cause granulomatous disorders is vinblastin.

Research paper thumbnail of Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients

Arhiv za farmaciju, 2017

Matrix metaloproteinases (MMPs) and their specific inhibitors-tissue inhibitors of matrix metallo... more Matrix metaloproteinases (MMPs) and their specific inhibitors-tissue inhibitors of matrix metalloproteinases (TIMPs) play an important role in pulmonary extracellular matrix destruction. Sarcoidosis is an inflammatory disease affecting multiple organs. It has been reported that MMP-9 and TIMP-1 levels were increased in bronchoalveolar lavage fluid and induced sputum of sarcoidosis patients. The aim of our study was to evaluate MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations and MMP-9/TIMP-1 ratio in sarcoidosis patients, their relationship with inflammatory markers and their ability do predict the existence of disease. We included 101 sarcoidosis patients and 50 healthy subjects. Serum samples were analyzed. Besides routine biochemical parameters, high-sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations were measured. MMP-9 (P<0.05), hsCRP, SAA and TIMP-1 (P<0.001) concentrations were significantly increased in patients whereas MMP-9/TIMP-1 complex was higher in patients, but with marginal significance. In sarcoidosis, TIMP-1 correlated significantly positively with inflammatory parameters (P<0.05). Uni-variate analysis showed that MMP-9, TIMP-1, hsCRP and SAA had the ability to predict the existence of sarcoidosis. In the model consisted of MMP-9, TIMP-1, hsCRP and SAA, only SAA remained significant predictor of disease (P<0.01). Results showed the significance of MMP-9 and TIMP-1 in sarcoidosis.

Research paper thumbnail of The 18F PET/CT scan in patients with chronic sarcoidosis

1.5 Diffuse Parenchymal Lung Disease, 2016

Introduction: Sarcoidosis is chronic systemic granulomatous disease most involving the lung.New m... more Introduction: Sarcoidosis is chronic systemic granulomatous disease most involving the lung.New markers of activity are important due to lack of sufficiently sensitive and specific .The aim : Performed 18F-FDG PET / CT scan in clinical problems of chronic sarcoidosis. Method: Previously histological obtained sarcoidosis are enrolled : 58 patients (mean age 54.4 ± 12 years ; 23 – 40% men and 35-60% women). PET scan performed and also after 20 months of finished therapy. Resuls: PET scan is verified inflammation in 54(93.1%)patients (SUVmax 8.84 ± 3.52). MDCT scan was positive in 49(84,48%) patients. Significant difference between the two methods not verified (p = 0.238, McNemar9s test).Spirometry findings:Ventilatory restriction is the main findings in 22 % and obstruction findings in 8 (14%) patients- age over 50 years with fibrotic chest ray findings. Markers of activity are higher in patients with positive findings on 18F-FDG PET / CT scan , compared to the group with negative results (p = 0.002, Mann-Whitney test). Specified group of 16( 28%) patients with positive PET but normal ACE and Ca in 24h urine,was obtained .Chitotriosidase levels significantly correlated with the findings of the 18F-FDG PET / CT scan in 57 patients. Logistic regression (univariate and multivariate) indicates significant correlation (p=0.001),positive PET scan findings and the modifying treatment. Control findings of PET scan after 14-22 months, obtaine reduction in SUV (8.84 vs.4.4) . Located SUV were significantly correlated with the subjective perception of the state of patients (P = 0.019). Conclusion: 18F-FDG PET / CT scan is the significant diagnostic method in determining the sites of inflammation in patients with chronic sarcoidosis.

Research paper thumbnail of Assessment of Health-Related Quality of Life in Patients With Chronic Sarcoidosis

Chest Journal, Oct 1, 2003

Research paper thumbnail of The utility of 18F-FDG PET/CT in chronic sarcoidosis

European Respiratory Journal, Sep 1, 2013

Body: The analysis was performed in chronic sarcoidosis patients with persistent clinical symptom... more Body: The analysis was performed in chronic sarcoidosis patients with persistent clinical symptoms due to assess the utility of 18F-FDG PET/CT. The analysis were performed before and after the period of specific therapy for sarcoidosis due to clinical-radiographic-functional findings. Methods: We analyzed 51 patients with chronic sarcoidosis (mean age ± SD: 47 ± 12 year; 38 F/13M). After the follow up (12 ± 5 months), the clinical status,functional findings and therapy modalities were analyzed. Results: 18F-FDG PET CT detected activity s.inflammation in 37 patients (82%) (SUV: 8.1 ± 3.9).MDCT was positive in 5 additional patients (89%). The difference between this two methods was not significant.Correlation between ACE levels and 18F-FDG PET/CT results were obtaine in 25 (49%) patients (P = 0.002,Mann-Whitney test). In 26 patients (51%) with positive 18F-FDG PET/CT findings, the ACE levels were in physiological levels. The therapies were initiated or even changed in 43 (81%). Significante correlation were find out between the positive 18F-FDG PET/CT results and changes in therapies. Conclusion: the results from our study indicate that 18F-FDG PET/CT is the important diagnostic method in chronic sarcoidosis due to obtaine the activity of sarcoidosis granulomas.

Research paper thumbnail of Obstructive findings in sarcoidosis, diagnosis and therapies modalities

European Respiratory Journal, Sep 1, 2012

Introduction: Symptoms of respiratory disturbances are common during the course of sarcoidosis. T... more Introduction: Symptoms of respiratory disturbances are common during the course of sarcoidosis. The aim of analysis is to notifie obstructive findings in sarcoidosis. Method: The analyses is restrospective in all incominig patients to the Clinic for lung diseases and tuberculosis CC of Serbia in Belgrade. Results: 127 (8,7%) patients with dry cough and occasionaly dyspnea had the impairent of lung function. The main findings were: FEVl / VC 63,1% in 57- 44,8% patients; in 27-21,1% patients – FEVl / FVC were 55,7% , in 3-2,3% patients FEVl / FVC were 68.7 %. Gender distribution were as followed: 264 (66,2%)Female- Male 135 (33,8%); average ages were 43,32 years. Extrathoracis sarcoidosis involvement were find out in 3 (2.3%) patients (skin, lymph nodes,).Lung and nonpulmonary sarcoidosis is notify in 27 pts and in 97 pts lung were the only sarcoidosis manifestation. Radiographic stadium of lung involvement: I-87(68.5%), II-31(24,4%), III-7%(5,%), IV-1 (0,78%). Acute onset of sarcoidosis is predominatly with average level of ACE: 75.3 U / L. After obtaining the diagnosis of sarcoidosis, inhaled corticosteroides were administered, 160 mcg-daily through 3 months with controls which meansa :ACE and UCa/24h levels, lung function, chest X ray. Regression of symptoms such as dry cough were obtained in 55% patients after the period of 2 months; 45% patients were excluded due to persistence of symptoms seeking prednisone. Conclusion – inhaled corticosteroid have the role in sarcoidosis treatment resolving symptoms such as cough, improvement of FEV1, but the main therapy in most of the patients is still orally administired prednisone.

Research paper thumbnail of Characteristic of gender distribution in sarcoidosis

European Respiratory Journal, Sep 1, 2012

Research paper thumbnail of Manifestations of malignancies during the course of sarcoidosis

European Respiratory Journal, Sep 1, 2011

Introduction: Sarcoidosis is the granulomatous disorder with chronic course which can involve any... more Introduction: Sarcoidosis is the granulomatous disorder with chronic course which can involve any organ in human body. Coexistance of two disorders is potential. Method of the work: Analysis were restrospective.All patients with histologically proved sarcoidosis were obtained. Patients were ambulatory or hospitaly treated in the Clinic for lung diseases and tuberculosis. Malignincies were also histologycally proved. Results: Among 1307 patients with sarcoidosis (ACCES group, ERS) only 15 patients with malignicies were obtained.Mean ages were 47.3 years, and 11 F/4 M ratio was find out.In 5 patients malignicies were the first obtained diagnosis in patients life as followed: carcinoma mammae (2 patients), carcinoma renis, fibrosarcoma and chronic laeucemia.The mean time in which sarcoidosis were manifested - 3,1 years. All patients were treated for carcinoma, till nowdays. In 11 patients, malignincies followed the sarcoidosis in mean time of 7.7 years: M. Hodgkin, adenocarcinoma ovarii, melanoma malignum, carcinoma cutis (3 female patients), adenocarcinoma intestine, carcinoma recti (2 patients), carcinoma mammae.Mean time of sarcoidosis duration were 8.3 years. All patients with sarcoidosis were mediacally treated even for relapses. In this group 3 lethal outcomes were obtained. Conclusion: Comorbidities exists even in sarcoidosis.The question is what is the cause for manifesting sarcoidosis and malignincies. Is immunodefitientia one of the potential factors in manifesting sarcoidosis and in manifesting malignincies. Another question is due to cytostatic drugs delivering during the treatment from malignincies. One of the known cytostatics which can cause granulomatous disorders is vinblastin.

Research paper thumbnail of Assessment of Health-Related Quality of Life in Patients With Chronic Sarcoidosis

Chest Journal, Oct 1, 2003

BACKGROUND. In pediatric settings, measures of health-related quality of life (HRQL) are often ob... more BACKGROUND. In pediatric settings, measures of health-related quality of life (HRQL) are often obtained by proxy, especially from parents, but the correlation between parental report and patient report has not been clearly established. In the current study, the authors examined the agreement between child and parent reports of HRQL in children with cancer (both those receiving treatment and those off treatment) and healthy controls. METHODS. Two groups of children with cancer who differed with regard to treatment status (n ϭ 199) and a group of healthy control children (n ϭ 108) were assessed using a standardized measure of HRQL. Both children and parents reported on the child's HRQL using parallel forms of the Children's Health Questionnaire. RESULTS. Significant parent-child correlations were found for all 10 HRQL scales, and these correlations were higher in the cancer groups compared with controls. Parents in the cancer groups tended to underestimate the HRQL of their children compared with the child report, although there were no significant parent-child mean differences in the group of patients who were off treatment and only 2 significant differences in the group of children receiving treatment. In contrast, parents in the control group tended to overestimate the HRQL of their children, and the parent-child differences were found to be larger, achieving statistical significance on 8 of 10 scales. CONCLUSIONS. Parents and children tend to report comparable child HRQL outcomes, and this is particularly true in oncology populations. In cases in which the child is either too young or too ill to provide a self-report, parent-reported HRQL can be viewed as a reliable substitute.

Research paper thumbnail of Oxidative Stress Markers During The Course Of Sarcoidosis-corelation Of Measured Values And Different Phase And Stages Of Sarcoidosis

D47. INTERSTITIAL LUNG DISEASE: COLLAGEN-VASCULAR DISEASE, SARCOIDOSIS AND OTHER DIFFUSE LUNG DISEASES, 2010

Research paper thumbnail of Obstructive findings in sarcoidosis, diagnosis and therapies modalities

European Respiratory Journal, Sep 1, 2012

Introduction: Symptoms of respiratory disturbances are common during the course of sarcoidosis. T... more Introduction: Symptoms of respiratory disturbances are common during the course of sarcoidosis. The aim of analysis is to notifie obstructive findings in sarcoidosis. Method: The analyses is restrospective in all incominig patients to the Clinic for lung diseases and tuberculosis CC of Serbia in Belgrade. Results: 127 (8,7%) patients with dry cough and occasionaly dyspnea had the impairent of lung function. The main findings were: FEVl / VC 63,1% in 57- 44,8% patients; in 27-21,1% patients – FEVl / FVC were 55,7% , in 3-2,3% patients FEVl / FVC were 68.7 %. Gender distribution were as followed: 264 (66,2%)Female- Male 135 (33,8%); average ages were 43,32 years. Extrathoracis sarcoidosis involvement were find out in 3 (2.3%) patients (skin, lymph nodes,).Lung and nonpulmonary sarcoidosis is notify in 27 pts and in 97 pts lung were the only sarcoidosis manifestation. Radiographic stadium of lung involvement: I-87(68.5%), II-31(24,4%), III-7%(5,%), IV-1 (0,78%). Acute onset of sarcoidosis is predominatly with average level of ACE: 75.3 U / L. After obtaining the diagnosis of sarcoidosis, inhaled corticosteroides were administered, 160 mcg-daily through 3 months with controls which meansa :ACE and UCa/24h levels, lung function, chest X ray. Regression of symptoms such as dry cough were obtained in 55% patients after the period of 2 months; 45% patients were excluded due to persistence of symptoms seeking prednisone. Conclusion – inhaled corticosteroid have the role in sarcoidosis treatment resolving symptoms such as cough, improvement of FEV1, but the main therapy in most of the patients is still orally administired prednisone.

Research paper thumbnail of The Role Of FDG PET/CT In The Clinical Evaluation Of Chronic Sarcoidosis

B44. ADVANCES IN THE DIAGNOSIS AND TREATMENT OF SARCOIDOSIS, 2012