Jesica Vazquez - Academia.edu (original) (raw)

Jesica Vazquez

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Papers by Jesica Vazquez

Research paper thumbnail of IMPROVEMENT IN INFORMAL SETTLEMENTS: Integration proposals in Ibagué

Research paper thumbnail of Sensory Input Directs Spatial and Temporal Plasticity in Primary Auditory Cortex

Journal of Neurophysiology, 2001

The cortical representation of the sensory environment is continuously modified by experience. Ch... more The cortical representation of the sensory environment is continuously modified by experience. Changes in spatial (receptive field) and temporal response properties of cortical neurons underlie many forms of natural learning. The scale and direction of these changes appear to be determined by specific features of the behavioral tasks that evoke cortical plasticity. The neural mechanisms responsible for this differential plasticity remain unclear partly because important sensory and cognitive parameters differ among these tasks. In this report, we demonstrate that differential sensory experience directs differential plasticity using a single paradigm that eliminates the task-specific variables that have confounded direct comparison of previous studies. Electrical activation of the basal forebrain (BF) was used to gate cortical plasticity mechanisms. The auditory stimulus paired with BF stimulation was systematically varied to determine how several basic features of the sensory input ...

Research paper thumbnail of TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

Immunity, 2008

Upon detection of viral RNA, the helicases RIG-I and/ or MDA5 trigger, via their adaptor Cardif (... more Upon detection of viral RNA, the helicases RIG-I and/ or MDA5 trigger, via their adaptor Cardif (also known as IPS-1, MAVS, or VISA), the activation of the transcription factors NF-kB and IRF3, which collaborate to induce an antiviral type I interferon (IFN) response. FADD and RIP1, known as mediators of death-receptor signaling, are implicated in this antiviral pathway; however, the link between death-receptor and antiviral signaling is not known. Here we showed that TRADD, a crucial adaptor of tumor necrosis factor receptor (TNFRI), was important in RIG-like helicase (RLH)-mediated signal transduction. TRADD is recruited to Cardif and orchestrated complex formation with the E3 ubiquitin ligase TRAF3 and TANK and with FADD and RIP1, leading to the activation of IRF3 and NF-kB. Loss of TRADD prevented Cardif-dependent activation of IFN-b, reduced the production of IFN-b in response to RNA viruses, and enhanced vesicular stomatitis virus replication. Thus, TRADD is not only an essential component of proinflammatory TNFRI signaling, but is also required for RLH-Cardif-dependent antiviral immune responses.

Research paper thumbnail of Asynchronous inputs alter excitability, spike timing, and topography in primary auditory cortex

Research paper thumbnail of IMPROVEMENT IN INFORMAL SETTLEMENTS: Integration proposals in Ibagué

Research paper thumbnail of Sensory Input Directs Spatial and Temporal Plasticity in Primary Auditory Cortex

Journal of Neurophysiology, 2001

The cortical representation of the sensory environment is continuously modified by experience. Ch... more The cortical representation of the sensory environment is continuously modified by experience. Changes in spatial (receptive field) and temporal response properties of cortical neurons underlie many forms of natural learning. The scale and direction of these changes appear to be determined by specific features of the behavioral tasks that evoke cortical plasticity. The neural mechanisms responsible for this differential plasticity remain unclear partly because important sensory and cognitive parameters differ among these tasks. In this report, we demonstrate that differential sensory experience directs differential plasticity using a single paradigm that eliminates the task-specific variables that have confounded direct comparison of previous studies. Electrical activation of the basal forebrain (BF) was used to gate cortical plasticity mechanisms. The auditory stimulus paired with BF stimulation was systematically varied to determine how several basic features of the sensory input ...

Research paper thumbnail of TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

Immunity, 2008

Upon detection of viral RNA, the helicases RIG-I and/ or MDA5 trigger, via their adaptor Cardif (... more Upon detection of viral RNA, the helicases RIG-I and/ or MDA5 trigger, via their adaptor Cardif (also known as IPS-1, MAVS, or VISA), the activation of the transcription factors NF-kB and IRF3, which collaborate to induce an antiviral type I interferon (IFN) response. FADD and RIP1, known as mediators of death-receptor signaling, are implicated in this antiviral pathway; however, the link between death-receptor and antiviral signaling is not known. Here we showed that TRADD, a crucial adaptor of tumor necrosis factor receptor (TNFRI), was important in RIG-like helicase (RLH)-mediated signal transduction. TRADD is recruited to Cardif and orchestrated complex formation with the E3 ubiquitin ligase TRAF3 and TANK and with FADD and RIP1, leading to the activation of IRF3 and NF-kB. Loss of TRADD prevented Cardif-dependent activation of IFN-b, reduced the production of IFN-b in response to RNA viruses, and enhanced vesicular stomatitis virus replication. Thus, TRADD is not only an essential component of proinflammatory TNFRI signaling, but is also required for RLH-Cardif-dependent antiviral immune responses.

Research paper thumbnail of Asynchronous inputs alter excitability, spike timing, and topography in primary auditory cortex

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