Jesper Smeenk - Academia.edu (original) (raw)
Papers by Jesper Smeenk
Fertility and Sterility, 2013
To evaluate whether ovarian reserve tests (ORTs) add prognostic value to patient characteristics,... more To evaluate whether ovarian reserve tests (ORTs) add prognostic value to patient characteristics, such as female age, in the prediction of excessive response to ovarian hyperstimulation in patients undergoing IVF, and whether their performance differs across clinical subgroups. Authors of studies reporting on basal FSH, antimüllerian hormone (AMH), or antral follicle count (AFC) in relation to ovarian response to ovarian hyperstimulation were invited to share original data. Random intercept logistic regression models were used to estimate added value of ORTs on patient characteristics, while accounting for between-study heterogeneity. Receiver operating characteristic regression analyses were performed to study the effect of patient characteristics on ORT accuracy. In vitro fertilization clinics. A total of 4,786 women for the main analysis, with a subgroup of 1,023 women with information on all three ORTs. None. Excessive response prediction. We included 57 studies reporting on 32 databases. Female age had an area under the receiver operating characteristic curve of 0.61 for excessive response prediction. Antral follicle count and AMH significantly added prognostic value to this. A model with female age, AFC, and AMH had an area under the receiver operating characteristic curve of 0.85. The combination of AMH and AFC, without age, had similar accuracy. Subgroup analysis indicated that FSH performed significantly worse in predicting excessive response in higher age groups, AFC did significantly better, and AMH performed the same. We demonstrate that AFC and AMH add value to female age in the prediction of excessive response and that, for AFC and FSH, the discriminatory performance is affected by female age.
BACKGROUND: The aim of this study was to examine the associations between urinary levels of the s... more BACKGROUND: The aim of this study was to examine the associations between urinary levels of the stress hormones adrenaline, noradrenaline and cortisol during treatment with self reported stress, in order to investigate the mechanism for the previously observed negative association of anxiety and depression with the outcome of IVF/ICSI. METHODS: In a multicentre prospective cohort study, women entering their first cycle of IVF/ICSI treatment were asked to participate. From each participant nocturnal urine samples were collected; pre-treatment, before oocyte retrieval and before embryo-transfer (ET), to assess hormonal concentrations. Additionally, two questionnaires were administered before the start of the treatment to measure anxiety and depression. RESULTS: 168 women completed the questionnaires and collected at least two urine specimens. A significant positive correlation between urinary adrenaline concentrations at baseline and ET and the scores on depression at baseline were found. In women with successful treatment, lower concentrations of adrenaline at oocyte retrieval and lower concentrations of adrenaline and noradrenaline at ET, compared with unsuccessful women, were found. CONCLUSIONS: The significant positive association of adrenaline concentration with pregnancy and with depression suggested that this adrenal hormone could be one of the links in the complex relationship between psychosocial stress and outcome after IVF/ICSI.
BACKGROUND: The study aim was to clarify the role of anxiety and depression on the outcome in ass... more BACKGROUND: The study aim was to clarify the role of anxiety and depression on the outcome in assisted reproductive treatment. Previous studies on this topic have shown contradicting results, which may have been caused by population characteristics, the design of the study, or small sample sizes. METHODS: In a multicentre prospective study, 291 out of 359 (81%) consecutively invited women agreed to participate. Before down-regulation by means of gonadotrophin-releasing hormone (GnRH) analogues in a long IVF protocol, patients were asked to complete the Dutch version of the State and Trait Anxiety Inventory to measure anxiety, and the Dutch version of the Beck Depression Inventory (BDI) to measure depression. Multiple logistic regression analysis was used to analyse known predictors of pregnancy and psychological factors and their relationship with treatment outcome. RESULTS: A significant relationship was shown between baseline psychological factors and the probability to become pregnant after IVF/intracytoplasmic sperm injection (ICSI) treatment, controlling for other factors. State anxiety had a slightly stronger correlation (P 0.01) with treatment outcome than depression (P 0.03). CONCLUSIONS: Pre-existing psychological factors are independently related to treatment outcome in IVF/ICSI, and should therefore be taken into account in patient counselling. Psychological factors may be improved by intervention, whereas demographic and gynaecological factors cannot. Future studies should be directed towards underlying mechanisms involved and the role of evidence-based distress reduction in order to improve treatment results.
Objective: To determine differences in emotional status (anxiety and depression) and marital sati... more Objective: To determine differences in emotional status (anxiety and depression) and marital satisfaction in pregnant and nonpregnant women before and after their first cycle of IVF and intracytoplasmic sperm injection (ICSI). Design: Repeated measurement. Setting: Fertility department at a university and a regional hospital. Patient(s): Women entering their first treatment cycle of IVF or ICSI. Intervention(s): Questionnaires on psychological factors were administered 3 to 12 days before the start of their first treatment cycle and repeated 3 weeks after the pregnancy test. Main Outcome Measure(s): State anxiety, depression, mood, and marital satisfaction. Result(s): At pretreatment, the women who became pregnant showed lower levels of depression than those who did not. Higher levels of depression in the pregnant women after the first cycle were due to higher scores on vital aspects of depression, related to signs of early pregnancy. Higher levels of depression in the nonpregnant women were due to a higher score on cognitive aspects of depression. Conclusion(s): Differences in emotional status between pregnant and nonpregnant women were present before treatment and became more apparent after the first IVF and ICSI cycle. There were no differences in emotional status between the women who underwent IVF and those who underwent ICSI. (Fertil Steril 2001; 76:525–31.
Fertility and Sterility, 2001
Objective: To determine differences in emotional status (anxiety and depression) and marital sati... more Objective: To determine differences in emotional status (anxiety and depression) and marital satisfaction in pregnant and nonpregnant women before and after their first cycle of IVF and intracytoplasmic sperm injection (ICSI). Design: Repeated measurement. Setting: Fertility department at a university and a regional hospital. Patient(s): Women entering their first treatment cycle of IVF or ICSI. Intervention(s): Questionnaires on psychological factors were administered 3 to 12 days before the start of their first treatment cycle and repeated 3 weeks after the pregnancy test. Main Outcome Measure(s): State anxiety, depression, mood, and marital satisfaction. Result(s): At pretreatment, the women who became pregnant showed lower levels of depression than those who did not. Higher levels of depression in the pregnant women after the first cycle were due to higher scores on vital aspects of depression, related to signs of early pregnancy. Higher levels of depression in the nonpregnant women were due to a higher score on cognitive aspects of depression. Conclusion(s): Differences in emotional status between pregnant and nonpregnant women were present before treatment and became more apparent after the first IVF and ICSI cycle. There were no differences in emotional status between the women who underwent IVF and those who underwent ICSI. (Fertil Steril 2001; 76:525-31.
Personality and Individual Differences, 2003
This study was designed to prospectively investigate the role of neuroticism, trait anxiety and a... more This study was designed to prospectively investigate the role of neuroticism, trait anxiety and attentional biases towards threat in the development of anxiety after a failed IVF or ICSI treatment. A subliminal and supraliminal Stroop task was administered to 49 women entering IVF or ICSI treatment as well as self-report measures of neuroticism, trait anxiety and state anxiety. The assessment of state anxiety was repeated after failed treatment. Results of concurrent analyses have indicated that there was no relationship between Stroop factors and state anxiety. As hypothesised, prospective analyses showed a significant effect for neuroticism and Stroop interference on anxiety response to failed IVF or ICSI treatment. This effect was only apparent for interference on stressor related words and not for words related to general threat. The effect of subliminal Stroop interference was more pronounced in a subsample of women showing an increase in anxiety as a result of failed treatment. It can be concluded that, in addition to neuroticism, subliminal Stroop interference is a predictor for emotional response to an aversive stressor, such as failed IVF or ICSI treatment. #
Personality and Individual Differences, 2004
This study was designed to prospectively investigate the role of neuroticism, trait anxiety and a... more This study was designed to prospectively investigate the role of neuroticism, trait anxiety and attentional biases towards threat in the development of anxiety after a failed IVF or ICSI treatment. A subliminal and supraliminal Stroop task was administered to 49 women entering IVF or ICSI treatment as well as self-report measures of neuroticism, trait anxiety and state anxiety. The assessment of state anxiety was repeated after failed treatment. Results of concurrent analyses have indicated that there was no relationship between Stroop factors and state anxiety. As hypothesised, prospective analyses showed a significant effect for neuroticism and Stroop interference on anxiety response to failed IVF or ICSI treatment. This effect was only apparent for interference on stressor related words and not for words related to general threat. The effect of subliminal Stroop interference was more pronounced in a subsample of women showing an increase in anxiety as a result of failed treatment. It can be concluded that, in addition to neuroticism, subliminal Stroop interference is a predictor for emotional response to an aversive stressor, such as failed IVF or ICSI treatment. #
Human Reproduction, 2001
BACKGROUND: The study aim was to clarify the role of anxiety and depression on the outcome in ass... more BACKGROUND: The study aim was to clarify the role of anxiety and depression on the outcome in assisted reproductive treatment. Previous studies on this topic have shown contradicting results, which may have been caused by population characteristics, the design of the study, or small sample sizes. METHODS: In a multicentre prospective study, 291 out of 359 (81%) consecutively invited women agreed to participate. Before down-regulation by means of gonadotrophin-releasing hormone (GnRH) analogues in a long IVF protocol, patients were asked to complete the Dutch version of the State and Trait Anxiety Inventory to measure anxiety, and the Dutch version of the Beck Depression Inventory (BDI) to measure depression. Multiple logistic regression analysis was used to analyse known predictors of pregnancy and psychological factors and their relationship with treatment outcome.
Gynecological Surgery, 2010
At present, there are only few data on the surgical outcomes of laparoscopic hysterectomy (LH). U... more At present, there are only few data on the surgical outcomes of laparoscopic hysterectomy (LH). Up till now, it has been unclear whether there is a difference in number of complications among the subcategories of laparoscopic total hysterectomy and laparoscopic subtotal hysterectomy (LSH). Therefore, we have performed a retrospective analysis to evaluate the peri- and postoperative outcomes in women undergoing LSH versus LH. This multi-centre retrospective cohort study (Canadian Task Force classification II-2) was conducted in multi-centres (two teaching hospitals and one university medical centre) in the Netherlands, all experienced in minimally invasive gynaecology. In a multi-centre retrospective cohort study we compared the long-term outcomes of laparoscopic subtotal hysterectomy and laparoscopic total hysterectomy (including laparoscopic assisted vaginal hysterectomy, laparoscopic hysterectomy and total laparoscopic hysterectomy). All laparoscopic hysterectomies from the last 10 years (January 1998 till December 2007) were included. Patient characteristics, intra- and postoperative complications, operating time and duration of hospital stay were recorded. The minimum follow-up was 6 months. A total of 390 cases of laparoscopic hysterectomies were included in the analysis: 192 laparoscopic subtotal hysterectomies and 198 laparoscopic total hysterectomies. Patient characteristics such as age and parity were equal in the groups. The overall number of short-term and long-term complications was comparable in both groups: 17% and 15%. Short-term complications (bleeding, fever) were 3% in the LSH group and 12% in the LH group. Long-term complications were (tubal prolapse and cervical stump reoperations) 15% in the LSH group and 3% in the LH group. Laparoscopic subtotal hysterectomy as compared with the different types of laparoscopic total hysterectomy is associated with more long-term postoperative complications, whereas laparoscopic total hysterectomy is associated with more short-term complications.
Fertility and Sterility, 2004
Because several studies indicate that psychological factors play a role in dropping out of IVF tr... more Because several studies indicate that psychological factors play a role in dropping out of IVF treatment, the question arises as to whether psychological interference is indicated. (Fertil Steril 2004;81:277.
British Journal of Clinical Psychology, 2005
Objectives. In the present prospective study, the relationship between autobiographical memory sp... more Objectives. In the present prospective study, the relationship between autobiographical memory specificity and the emotional reactions to a stressful event was investigated.
BMC Women's Health, 2012
Background: Costs of in vitro fertilisation (IVF) are high, which is partly due to the use of fol... more Background: Costs of in vitro fertilisation (IVF) are high, which is partly due to the use of follicle stimulating hormone (FSH). FSH is usually administered in a standard dose. However, due to differences in ovarian reserve between women, ovarian response also differs with potential negative consequences on pregnancy rates. A Markov decision-analytic model showed that FSH dose individualisation according to ovarian reserve is likely to be cost-effective in women who are eligible for IVF. However, this has never been confirmed in a large randomised controlled trial (RCT). The aim of the present study is to assess whether an individualised FSH dose regime based on an ovarian reserve test (ORT) is more cost-effective than a standard dose regime. Methods/Design: Multicentre RCT in subfertile women indicated for a first IVF or intracytoplasmic sperm injection cycle, who are aged < 44 years, have a regular menstrual cycle and no major abnormalities at transvaginal sonography. Women with polycystic ovary syndrome, endocrine or metabolic abnormalities and women undergoing IVF with oocyte donation, will not be included. Ovarian reserve will be assessed by measuring the antral follicle count. Women with a predicted poor response or hyperresponse will be randomised for a standard versus an individualised FSH regime (150 IU/day, 225-450 IU/day and 100 IU/day, respectively). Participants will undergo a maximum of three stimulation cycles during maximally 18 months. The primary study outcome is the cumulative ongoing pregnancy rate resulting in live birth achieved within 18 months after randomisation. Secondary outcomes are parameters for ovarian response, multiple pregnancies, number of cycles needed per live birth, total IU of FSH per stimulation cycle, and costs. All data will be analysed according to the intention-to-treat principle. Cost-effectiveness analysis will be performed to assess whether the health and associated economic benefits of individualised treatment of subfertile women outweigh the additional costs of an ORT.
Human Reproduction Update, 2007
This review provides an overview of how women adjust emotionally to the various phases of IVF tre... more This review provides an overview of how women adjust emotionally to the various phases of IVF treatment in terms of anxiety, depression or general distress before, during and after different treatment cycles. A systematic scrutiny of the literature yielded 706 articles that paid attention to emotional aspects of IVF treatment of which 27 investigated the women's emotional adjustment with standardized
Diamond GA. What price perfection? Calibration and discrimination of clinical prediction models. ... more Diamond GA. What price perfection? Calibration and discrimination of clinical prediction models. J Clin Epidemiol 1992;45:85-89. Mol BWJ, Coppus SF, Van der Veen F, Bossuyt PMM. Evaluating predictors for the outcome of assisted reproductive technology: Roc-curves are misleading; calibration is not. (Abstract). Fertil Steril 2005;84: s253-s254. Steures P, van der Steeg JW, Hompes PGA, Habbema JDF, Eijkemans MJC, Broekmans FJ, Verhoeve HR, Bossuyt PM, Van der Veen F, Mol BWJ. Intrauterine insemination with controlled ovarian hyperstimulation versus expectant management for couples with unexplained subfertility and an intermediate prognosis: a randomised clinical trial.
Nederlands tijdschrift voor geneeskunde
Determination of the emotional burden of the first IVF or ICSI treatment cycle, the effect of the... more Determination of the emotional burden of the first IVF or ICSI treatment cycle, the effect of the treatment on the marital relationship, and the course of the treatment following a failed and a successful first attempt. Descriptive longitudinal study with repeated measures before and after the first treatment cycle. 240 women and 219 men filled in questionnaires both before and after the first treatment cycle in the area of anxiety, depression, and the marital relationship (as measured with the 'Spielberger state trait anxiety inventory' (STAI), the 'Beck depression inventory for primary care' (BDI-PC) and the 'Maudsley marital questionnaire' (MMQ), respectively), as well as their plans for further treatment. After a first failed treatment cycle, both women and men showed an increase in depression, while women also showed increased anxiety. No differences were found between pre- and post-treatment levels of anxiety and depression after a successful treatment....
Fertility and Sterility
To determine differences in emotional status (anxiety and depression) and marital satisfaction in... more To determine differences in emotional status (anxiety and depression) and marital satisfaction in pregnant and nonpregnant women before and after their first cycle of IVF and intracytoplasmic sperm injection (ICSI). Repeated measurement. Fertility department at a university and a regional hospital. Women entering their first treatment cycle of IVF or ICSI. Questionnaires on psychological factors were administered 3 to 12 days before the start of their first treatment cycle and repeated 3 weeks after the pregnancy test. MAIN OUTCOME MEASURE(s): State anxiety, depression, mood, and marital satisfaction. At pretreatment, the women who became pregnant showed lower levels of depression than those who did not. Higher levels of depression in the pregnant women after the first cycle were due to higher scores on vital aspects of depression, related to signs of early pregnancy. Higher levels of depression in the nonpregnant women were due to a higher score on cognitive aspects of depression. ...
Human reproduction (Oxford, England), Jan 18, 2015
Does the prewash total motile sperm count (TMSC) have a better predictive value for spontaneous o... more Does the prewash total motile sperm count (TMSC) have a better predictive value for spontaneous ongoing pregnancy (SOP) than the World Health Organization (WHO) classification system? The prewash TMSC shows a better correlation with the spontaneous ongoing pregnancy rate (SOPR) than the WHO 2010 classification system. According to the WHO classification system, an abnormal semen analysis can be diagnosed as oligozoospermia, astenozoospermia, teratozoospermia or combinations of these and azoospermia. This classification is based on the fifth percentile cut-off values of a cohort of 1953 men with proven fertility. Although this classification suggests accuracy, the relevance for the prognosis of an infertile couple and the choice of treatment is questionable. The TMSC is obtained by multiplying the sample volume by the density and the percentage of A and B motility spermatozoa. We analyzed data from a longitudinal cohort study among unselected infertile couples who were referred to th...
Fertility and Sterility, 2013
To evaluate whether ovarian reserve tests (ORTs) add prognostic value to patient characteristics,... more To evaluate whether ovarian reserve tests (ORTs) add prognostic value to patient characteristics, such as female age, in the prediction of excessive response to ovarian hyperstimulation in patients undergoing IVF, and whether their performance differs across clinical subgroups. Authors of studies reporting on basal FSH, antimüllerian hormone (AMH), or antral follicle count (AFC) in relation to ovarian response to ovarian hyperstimulation were invited to share original data. Random intercept logistic regression models were used to estimate added value of ORTs on patient characteristics, while accounting for between-study heterogeneity. Receiver operating characteristic regression analyses were performed to study the effect of patient characteristics on ORT accuracy. In vitro fertilization clinics. A total of 4,786 women for the main analysis, with a subgroup of 1,023 women with information on all three ORTs. None. Excessive response prediction. We included 57 studies reporting on 32 databases. Female age had an area under the receiver operating characteristic curve of 0.61 for excessive response prediction. Antral follicle count and AMH significantly added prognostic value to this. A model with female age, AFC, and AMH had an area under the receiver operating characteristic curve of 0.85. The combination of AMH and AFC, without age, had similar accuracy. Subgroup analysis indicated that FSH performed significantly worse in predicting excessive response in higher age groups, AFC did significantly better, and AMH performed the same. We demonstrate that AFC and AMH add value to female age in the prediction of excessive response and that, for AFC and FSH, the discriminatory performance is affected by female age.
BACKGROUND: The aim of this study was to examine the associations between urinary levels of the s... more BACKGROUND: The aim of this study was to examine the associations between urinary levels of the stress hormones adrenaline, noradrenaline and cortisol during treatment with self reported stress, in order to investigate the mechanism for the previously observed negative association of anxiety and depression with the outcome of IVF/ICSI. METHODS: In a multicentre prospective cohort study, women entering their first cycle of IVF/ICSI treatment were asked to participate. From each participant nocturnal urine samples were collected; pre-treatment, before oocyte retrieval and before embryo-transfer (ET), to assess hormonal concentrations. Additionally, two questionnaires were administered before the start of the treatment to measure anxiety and depression. RESULTS: 168 women completed the questionnaires and collected at least two urine specimens. A significant positive correlation between urinary adrenaline concentrations at baseline and ET and the scores on depression at baseline were found. In women with successful treatment, lower concentrations of adrenaline at oocyte retrieval and lower concentrations of adrenaline and noradrenaline at ET, compared with unsuccessful women, were found. CONCLUSIONS: The significant positive association of adrenaline concentration with pregnancy and with depression suggested that this adrenal hormone could be one of the links in the complex relationship between psychosocial stress and outcome after IVF/ICSI.
BACKGROUND: The study aim was to clarify the role of anxiety and depression on the outcome in ass... more BACKGROUND: The study aim was to clarify the role of anxiety and depression on the outcome in assisted reproductive treatment. Previous studies on this topic have shown contradicting results, which may have been caused by population characteristics, the design of the study, or small sample sizes. METHODS: In a multicentre prospective study, 291 out of 359 (81%) consecutively invited women agreed to participate. Before down-regulation by means of gonadotrophin-releasing hormone (GnRH) analogues in a long IVF protocol, patients were asked to complete the Dutch version of the State and Trait Anxiety Inventory to measure anxiety, and the Dutch version of the Beck Depression Inventory (BDI) to measure depression. Multiple logistic regression analysis was used to analyse known predictors of pregnancy and psychological factors and their relationship with treatment outcome. RESULTS: A significant relationship was shown between baseline psychological factors and the probability to become pregnant after IVF/intracytoplasmic sperm injection (ICSI) treatment, controlling for other factors. State anxiety had a slightly stronger correlation (P 0.01) with treatment outcome than depression (P 0.03). CONCLUSIONS: Pre-existing psychological factors are independently related to treatment outcome in IVF/ICSI, and should therefore be taken into account in patient counselling. Psychological factors may be improved by intervention, whereas demographic and gynaecological factors cannot. Future studies should be directed towards underlying mechanisms involved and the role of evidence-based distress reduction in order to improve treatment results.
Objective: To determine differences in emotional status (anxiety and depression) and marital sati... more Objective: To determine differences in emotional status (anxiety and depression) and marital satisfaction in pregnant and nonpregnant women before and after their first cycle of IVF and intracytoplasmic sperm injection (ICSI). Design: Repeated measurement. Setting: Fertility department at a university and a regional hospital. Patient(s): Women entering their first treatment cycle of IVF or ICSI. Intervention(s): Questionnaires on psychological factors were administered 3 to 12 days before the start of their first treatment cycle and repeated 3 weeks after the pregnancy test. Main Outcome Measure(s): State anxiety, depression, mood, and marital satisfaction. Result(s): At pretreatment, the women who became pregnant showed lower levels of depression than those who did not. Higher levels of depression in the pregnant women after the first cycle were due to higher scores on vital aspects of depression, related to signs of early pregnancy. Higher levels of depression in the nonpregnant women were due to a higher score on cognitive aspects of depression. Conclusion(s): Differences in emotional status between pregnant and nonpregnant women were present before treatment and became more apparent after the first IVF and ICSI cycle. There were no differences in emotional status between the women who underwent IVF and those who underwent ICSI. (Fertil Steril 2001; 76:525–31.
Fertility and Sterility, 2001
Objective: To determine differences in emotional status (anxiety and depression) and marital sati... more Objective: To determine differences in emotional status (anxiety and depression) and marital satisfaction in pregnant and nonpregnant women before and after their first cycle of IVF and intracytoplasmic sperm injection (ICSI). Design: Repeated measurement. Setting: Fertility department at a university and a regional hospital. Patient(s): Women entering their first treatment cycle of IVF or ICSI. Intervention(s): Questionnaires on psychological factors were administered 3 to 12 days before the start of their first treatment cycle and repeated 3 weeks after the pregnancy test. Main Outcome Measure(s): State anxiety, depression, mood, and marital satisfaction. Result(s): At pretreatment, the women who became pregnant showed lower levels of depression than those who did not. Higher levels of depression in the pregnant women after the first cycle were due to higher scores on vital aspects of depression, related to signs of early pregnancy. Higher levels of depression in the nonpregnant women were due to a higher score on cognitive aspects of depression. Conclusion(s): Differences in emotional status between pregnant and nonpregnant women were present before treatment and became more apparent after the first IVF and ICSI cycle. There were no differences in emotional status between the women who underwent IVF and those who underwent ICSI. (Fertil Steril 2001; 76:525-31.
Personality and Individual Differences, 2003
This study was designed to prospectively investigate the role of neuroticism, trait anxiety and a... more This study was designed to prospectively investigate the role of neuroticism, trait anxiety and attentional biases towards threat in the development of anxiety after a failed IVF or ICSI treatment. A subliminal and supraliminal Stroop task was administered to 49 women entering IVF or ICSI treatment as well as self-report measures of neuroticism, trait anxiety and state anxiety. The assessment of state anxiety was repeated after failed treatment. Results of concurrent analyses have indicated that there was no relationship between Stroop factors and state anxiety. As hypothesised, prospective analyses showed a significant effect for neuroticism and Stroop interference on anxiety response to failed IVF or ICSI treatment. This effect was only apparent for interference on stressor related words and not for words related to general threat. The effect of subliminal Stroop interference was more pronounced in a subsample of women showing an increase in anxiety as a result of failed treatment. It can be concluded that, in addition to neuroticism, subliminal Stroop interference is a predictor for emotional response to an aversive stressor, such as failed IVF or ICSI treatment. #
Personality and Individual Differences, 2004
This study was designed to prospectively investigate the role of neuroticism, trait anxiety and a... more This study was designed to prospectively investigate the role of neuroticism, trait anxiety and attentional biases towards threat in the development of anxiety after a failed IVF or ICSI treatment. A subliminal and supraliminal Stroop task was administered to 49 women entering IVF or ICSI treatment as well as self-report measures of neuroticism, trait anxiety and state anxiety. The assessment of state anxiety was repeated after failed treatment. Results of concurrent analyses have indicated that there was no relationship between Stroop factors and state anxiety. As hypothesised, prospective analyses showed a significant effect for neuroticism and Stroop interference on anxiety response to failed IVF or ICSI treatment. This effect was only apparent for interference on stressor related words and not for words related to general threat. The effect of subliminal Stroop interference was more pronounced in a subsample of women showing an increase in anxiety as a result of failed treatment. It can be concluded that, in addition to neuroticism, subliminal Stroop interference is a predictor for emotional response to an aversive stressor, such as failed IVF or ICSI treatment. #
Human Reproduction, 2001
BACKGROUND: The study aim was to clarify the role of anxiety and depression on the outcome in ass... more BACKGROUND: The study aim was to clarify the role of anxiety and depression on the outcome in assisted reproductive treatment. Previous studies on this topic have shown contradicting results, which may have been caused by population characteristics, the design of the study, or small sample sizes. METHODS: In a multicentre prospective study, 291 out of 359 (81%) consecutively invited women agreed to participate. Before down-regulation by means of gonadotrophin-releasing hormone (GnRH) analogues in a long IVF protocol, patients were asked to complete the Dutch version of the State and Trait Anxiety Inventory to measure anxiety, and the Dutch version of the Beck Depression Inventory (BDI) to measure depression. Multiple logistic regression analysis was used to analyse known predictors of pregnancy and psychological factors and their relationship with treatment outcome.
Gynecological Surgery, 2010
At present, there are only few data on the surgical outcomes of laparoscopic hysterectomy (LH). U... more At present, there are only few data on the surgical outcomes of laparoscopic hysterectomy (LH). Up till now, it has been unclear whether there is a difference in number of complications among the subcategories of laparoscopic total hysterectomy and laparoscopic subtotal hysterectomy (LSH). Therefore, we have performed a retrospective analysis to evaluate the peri- and postoperative outcomes in women undergoing LSH versus LH. This multi-centre retrospective cohort study (Canadian Task Force classification II-2) was conducted in multi-centres (two teaching hospitals and one university medical centre) in the Netherlands, all experienced in minimally invasive gynaecology. In a multi-centre retrospective cohort study we compared the long-term outcomes of laparoscopic subtotal hysterectomy and laparoscopic total hysterectomy (including laparoscopic assisted vaginal hysterectomy, laparoscopic hysterectomy and total laparoscopic hysterectomy). All laparoscopic hysterectomies from the last 10 years (January 1998 till December 2007) were included. Patient characteristics, intra- and postoperative complications, operating time and duration of hospital stay were recorded. The minimum follow-up was 6 months. A total of 390 cases of laparoscopic hysterectomies were included in the analysis: 192 laparoscopic subtotal hysterectomies and 198 laparoscopic total hysterectomies. Patient characteristics such as age and parity were equal in the groups. The overall number of short-term and long-term complications was comparable in both groups: 17% and 15%. Short-term complications (bleeding, fever) were 3% in the LSH group and 12% in the LH group. Long-term complications were (tubal prolapse and cervical stump reoperations) 15% in the LSH group and 3% in the LH group. Laparoscopic subtotal hysterectomy as compared with the different types of laparoscopic total hysterectomy is associated with more long-term postoperative complications, whereas laparoscopic total hysterectomy is associated with more short-term complications.
Fertility and Sterility, 2004
Because several studies indicate that psychological factors play a role in dropping out of IVF tr... more Because several studies indicate that psychological factors play a role in dropping out of IVF treatment, the question arises as to whether psychological interference is indicated. (Fertil Steril 2004;81:277.
British Journal of Clinical Psychology, 2005
Objectives. In the present prospective study, the relationship between autobiographical memory sp... more Objectives. In the present prospective study, the relationship between autobiographical memory specificity and the emotional reactions to a stressful event was investigated.
BMC Women's Health, 2012
Background: Costs of in vitro fertilisation (IVF) are high, which is partly due to the use of fol... more Background: Costs of in vitro fertilisation (IVF) are high, which is partly due to the use of follicle stimulating hormone (FSH). FSH is usually administered in a standard dose. However, due to differences in ovarian reserve between women, ovarian response also differs with potential negative consequences on pregnancy rates. A Markov decision-analytic model showed that FSH dose individualisation according to ovarian reserve is likely to be cost-effective in women who are eligible for IVF. However, this has never been confirmed in a large randomised controlled trial (RCT). The aim of the present study is to assess whether an individualised FSH dose regime based on an ovarian reserve test (ORT) is more cost-effective than a standard dose regime. Methods/Design: Multicentre RCT in subfertile women indicated for a first IVF or intracytoplasmic sperm injection cycle, who are aged < 44 years, have a regular menstrual cycle and no major abnormalities at transvaginal sonography. Women with polycystic ovary syndrome, endocrine or metabolic abnormalities and women undergoing IVF with oocyte donation, will not be included. Ovarian reserve will be assessed by measuring the antral follicle count. Women with a predicted poor response or hyperresponse will be randomised for a standard versus an individualised FSH regime (150 IU/day, 225-450 IU/day and 100 IU/day, respectively). Participants will undergo a maximum of three stimulation cycles during maximally 18 months. The primary study outcome is the cumulative ongoing pregnancy rate resulting in live birth achieved within 18 months after randomisation. Secondary outcomes are parameters for ovarian response, multiple pregnancies, number of cycles needed per live birth, total IU of FSH per stimulation cycle, and costs. All data will be analysed according to the intention-to-treat principle. Cost-effectiveness analysis will be performed to assess whether the health and associated economic benefits of individualised treatment of subfertile women outweigh the additional costs of an ORT.
Human Reproduction Update, 2007
This review provides an overview of how women adjust emotionally to the various phases of IVF tre... more This review provides an overview of how women adjust emotionally to the various phases of IVF treatment in terms of anxiety, depression or general distress before, during and after different treatment cycles. A systematic scrutiny of the literature yielded 706 articles that paid attention to emotional aspects of IVF treatment of which 27 investigated the women's emotional adjustment with standardized
Diamond GA. What price perfection? Calibration and discrimination of clinical prediction models. ... more Diamond GA. What price perfection? Calibration and discrimination of clinical prediction models. J Clin Epidemiol 1992;45:85-89. Mol BWJ, Coppus SF, Van der Veen F, Bossuyt PMM. Evaluating predictors for the outcome of assisted reproductive technology: Roc-curves are misleading; calibration is not. (Abstract). Fertil Steril 2005;84: s253-s254. Steures P, van der Steeg JW, Hompes PGA, Habbema JDF, Eijkemans MJC, Broekmans FJ, Verhoeve HR, Bossuyt PM, Van der Veen F, Mol BWJ. Intrauterine insemination with controlled ovarian hyperstimulation versus expectant management for couples with unexplained subfertility and an intermediate prognosis: a randomised clinical trial.
Nederlands tijdschrift voor geneeskunde
Determination of the emotional burden of the first IVF or ICSI treatment cycle, the effect of the... more Determination of the emotional burden of the first IVF or ICSI treatment cycle, the effect of the treatment on the marital relationship, and the course of the treatment following a failed and a successful first attempt. Descriptive longitudinal study with repeated measures before and after the first treatment cycle. 240 women and 219 men filled in questionnaires both before and after the first treatment cycle in the area of anxiety, depression, and the marital relationship (as measured with the 'Spielberger state trait anxiety inventory' (STAI), the 'Beck depression inventory for primary care' (BDI-PC) and the 'Maudsley marital questionnaire' (MMQ), respectively), as well as their plans for further treatment. After a first failed treatment cycle, both women and men showed an increase in depression, while women also showed increased anxiety. No differences were found between pre- and post-treatment levels of anxiety and depression after a successful treatment....
Fertility and Sterility
To determine differences in emotional status (anxiety and depression) and marital satisfaction in... more To determine differences in emotional status (anxiety and depression) and marital satisfaction in pregnant and nonpregnant women before and after their first cycle of IVF and intracytoplasmic sperm injection (ICSI). Repeated measurement. Fertility department at a university and a regional hospital. Women entering their first treatment cycle of IVF or ICSI. Questionnaires on psychological factors were administered 3 to 12 days before the start of their first treatment cycle and repeated 3 weeks after the pregnancy test. MAIN OUTCOME MEASURE(s): State anxiety, depression, mood, and marital satisfaction. At pretreatment, the women who became pregnant showed lower levels of depression than those who did not. Higher levels of depression in the pregnant women after the first cycle were due to higher scores on vital aspects of depression, related to signs of early pregnancy. Higher levels of depression in the nonpregnant women were due to a higher score on cognitive aspects of depression. ...
Human reproduction (Oxford, England), Jan 18, 2015
Does the prewash total motile sperm count (TMSC) have a better predictive value for spontaneous o... more Does the prewash total motile sperm count (TMSC) have a better predictive value for spontaneous ongoing pregnancy (SOP) than the World Health Organization (WHO) classification system? The prewash TMSC shows a better correlation with the spontaneous ongoing pregnancy rate (SOPR) than the WHO 2010 classification system. According to the WHO classification system, an abnormal semen analysis can be diagnosed as oligozoospermia, astenozoospermia, teratozoospermia or combinations of these and azoospermia. This classification is based on the fifth percentile cut-off values of a cohort of 1953 men with proven fertility. Although this classification suggests accuracy, the relevance for the prognosis of an infertile couple and the choice of treatment is questionable. The TMSC is obtained by multiplying the sample volume by the density and the percentage of A and B motility spermatozoa. We analyzed data from a longitudinal cohort study among unselected infertile couples who were referred to th...