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Graduate Center of the City University of New York
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Papers by Jill Fisher
Large elastic arteries are a composite structure composed of cells and extracellular matrix prote... more Large elastic arteries are a composite structure composed of cells and extracellular matrix proteins. Passive arterial mechanical behavior is determined by the composition of extracellular matrix proteins, in particular elastin and collagen. Elastin provides reversible elasticity to the large elastic arteries during cyclic loading and dampens the pulsatile flow from the left ventricle, reducing the workload on the heart and protecting the end organs. Disorganization and
American journal of physiology. Heart and circulatory physiology, Jan 6, 2018
Large, elastic arteries are composed of cells and a specialized extracellular matrix that provide... more Large, elastic arteries are composed of cells and a specialized extracellular matrix that provides reversible elasticity and strength. Elastin is the matrix protein responsible for this reversible elasticity that reduces the workload on the heart and dampens pulsatile flow in distal arteries. We summarize elastin protein biochemistry, self-association behavior, crosslinking process, and multi-step elastic fiber assembly that provide large arteries with their unique mechanical properties. We present measures of passive arterial mechanics that depend on elastic fiber amounts and integrity such as the Windkessel effect, structural and material stiffness, and energy storage. We discuss supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa-1 (ADCL1), which are genetic disorders caused by mutations in the elastin gene. We present mouse models of SVAS, ADCL1, and graded elastin amounts that have been invaluable for understanding the role of elastin in arterial mechanics an...
Large elastic arteries are a composite structure composed of cells and extracellular matrix prote... more Large elastic arteries are a composite structure composed of cells and extracellular matrix proteins. Passive arterial mechanical behavior is determined by the composition of extracellular matrix proteins, in particular elastin and collagen. Elastin provides reversible elasticity to the large elastic arteries during cyclic loading and dampens the pulsatile flow from the left ventricle, reducing the workload on the heart and protecting the end organs. Disorganization and
American journal of physiology. Heart and circulatory physiology, Jan 6, 2018
Large, elastic arteries are composed of cells and a specialized extracellular matrix that provide... more Large, elastic arteries are composed of cells and a specialized extracellular matrix that provides reversible elasticity and strength. Elastin is the matrix protein responsible for this reversible elasticity that reduces the workload on the heart and dampens pulsatile flow in distal arteries. We summarize elastin protein biochemistry, self-association behavior, crosslinking process, and multi-step elastic fiber assembly that provide large arteries with their unique mechanical properties. We present measures of passive arterial mechanics that depend on elastic fiber amounts and integrity such as the Windkessel effect, structural and material stiffness, and energy storage. We discuss supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa-1 (ADCL1), which are genetic disorders caused by mutations in the elastin gene. We present mouse models of SVAS, ADCL1, and graded elastin amounts that have been invaluable for understanding the role of elastin in arterial mechanics an...