Jou-Wei Lin - Academia.edu (original) (raw)

Papers by Jou-Wei Lin

Journal of Personalized Medicine, 2022

Background: This 12-year study aimed to compare the longitudinal change in left ventricular diast... more Background: This 12-year study aimed to compare the longitudinal change in left ventricular diastolic dysfunction (LVDD) between healthy elderly, coronary artery disease (CAD), and hypertension (HTN) patients. Methods: From 2008 to 2020, 1476 patients were included, and 3181 echocardiography examinations were conducted. Finally, 130 participants (36 healthy elderly (79.39 ± 9.51 years old), 51 with CAD (68.31 ± 12.09 years old), and 43 with HTN (68.31 ± 12.09 years old)) with more than a 10-year follow-up period were included in the final analysis. Results: The change in diastolic function was different among these subjects according to the integrated score index (elderly vs. HTN, p = 0.01; CAD vs. HTN, p = 0.01), septal E/e’ ratio (elderly vs. HTN, p < 0.001; CAD vs. HTN, p = 0.01), lateral E/e’ ratio (elderly vs. HTN, p < 0.001; CAD vs. HTN, p < 0.001), and NYHA functional class (elderly vs. HTN, p = 0.03; CAD vs. HTN, p < 0.001). Additionally, per one-year increase in...

International Journal of Environmental Research and Public Health, 2021

This study aimed to evaluate the medical and socioeconomic impacts of IRDs using the nationwide h... more This study aimed to evaluate the medical and socioeconomic impacts of IRDs using the nationwide health database and a large hospital-based cohort. This retrospective cross-sectional cohort study used data from the nationwide National Health Insurance Research Database (NHIRD). All patients with IRD from January 2012 to December 2016 were selected from the NHIRD and matched with the general population at a ratio of 1:4. All variables, including comorbidities, medications, service utilization, and medical costs, within 1 year from the date of the IRD diagnosis, were analyzed. Disability data were retrieved from the Taiwan Inherited retinal degeneration Project (TIP), a medical center-based database. A total of 4447 and 17,788 subjects from the nationwide database were included in the IRD and control groups, respectively. The Charlson comorbidity index score was higher in the IRD group (0.74:0.52, p < 0.001). Yearly visits to the ophthalmology clinic were more frequent in the IRD gr...

Thank you very much for reviewing our original manuscript entitled, "Integrated post-discharge tr... more Thank you very much for reviewing our original manuscript entitled, "Integrated post-discharge transitional care in a hospitalist system to improve discharge outcome" (MS No. 1678569673526672) that we submitted for possible publication. We appreciate the comments of the editors and reviewers, and we have revised the manuscript accordingly. Below please find our point-by-point responses to the reviewers' comments. Attached also is our revised manuscript. We truly appreciate the time and effort you have given our paper. We look forward to hearing from you soon.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2001

UNLABELLED Quantification of myocardial perfusion with 82Rb has been difficult to achieve because... more UNLABELLED Quantification of myocardial perfusion with 82Rb has been difficult to achieve because of the low signal-to-noise ratio of the dynamic data curves. This study evaluated the accuracy of flow estimates after the application of a novel multidimensional wavelet-based noise-reduction protocol. METHODS Myocardial perfusion was estimated using 82Rb and a two-compartment model from dynamic PET scans on 11 healthy volunteers at rest and after hyperemic stress with dipyridamole. Midventricular planes were divided into eight regions of interest, and a wavelet transform protocol was applied to images and time-activity curves. Flow estimates without and with the wavelet approach were compared with those obtained using H2(15)O. RESULTS Over a wide flow range (0.45-2.75 mL/g/min), flow achieved with the wavelet approach correlated extremely closely with values obtained with H2(15)O (y = 1.03 x -0.12; n = 23 studies, r = 0.94, P < 0.001). If the wavelet noise-reduction technique was n...

PloS one, 2017

The pathophysiology of cardio-renal syndrome (CRS) is complex. Hydronephrosis caused by urolithia... more The pathophysiology of cardio-renal syndrome (CRS) is complex. Hydronephrosis caused by urolithiasis may cause cytokine release and lead to cardiac dysfunction. The aim of this study was to evaluate cardiac function changes observed in patients who received double J placement using feasible biomarkers and echocardiography. This was a prospective, single-center study. Eighty-seven patients who presented with acute unilateral hydronephrosis and received ureteroscope stone manipulation were enrolled. Echocardiography and cytokines were measured on the day of the operation and 24 hours after the procedure. Changes before and after surgery were assessed by the paired t-test and Wilcoxon test. Correlation analyses between echocardiographic diastolic indices and cytokine levels were performed using Pearson's correlation coefficients. Patients with hydronephrosis showed a higher left atrium volume index (LAVI), decreased E', and increased E/ E' ratio, which indicated diastolic d...

Parkinson's disease, 2016

Background. Several guidelines for Parkinson's disease (PD) management were recently updated.... more Background. Several guidelines for Parkinson's disease (PD) management were recently updated. We examined temporal trends for antiparkinsonism drugs in Taiwan. Methods. Antiparkinsonism prescriptions, including levodopa, ergot/nonergot dopamine agonists (DAs), amantadine, selegiline, entacapone, and anticholinergics, were identified in the Taiwan National Health Insurance Database from 2004 to 2011. Time trend analyses were estimated assuming Poisson distribution. Results. A total of 19,302 PD patients in 2004 and 41,606 PD patients in 2011 were analyzed. Antiparkinsonism prescriptions increased significantly from 187,137 in 2004 to 414,587 in 2011. Levodopa monotherapy or combination therapy was the mainstay. Levodopa monotherapy comprised 37.4% of prescriptions in 2004 and 44.2% in 2011, with an annual increase rate of 18.14%. There was a substantially increasing trend of DA prescriptions, which were higher in younger-aged patients (<60 years) than in older-aged group (p = ...

Scientific reports, Jan 15, 2015

The impact of ribavirin (RBV) dosage on sustained virologic response (SVR) rates remains elusive ... more The impact of ribavirin (RBV) dosage on sustained virologic response (SVR) rates remains elusive in hepatitis C virus genotype 2 (HCV-2) rapid responders receiving 16 weeks of peginterferon (Peg-IFN) plus RBV. Treatment-naïve HCV-2 patients with rapid virologic response (RVR) received Peg-IFN alfa-2a 180 μg/week plus weight-based RBV (1,000 or 1,200 mg/day; cut-off body weight: 75 kg) for 6 weeks, and then randomly received Peg-IFN alfa-2a 180 μg/week plus weight-based (1,000 or 1,200 mg/day; n = 247) or flat-dose (800 mg/day; n = 246) RBV for additional 10 weeks. The primary endpoint was SVR24. Patients receiving weight-based and flat-dose RBV therapies had comparable SVR24 rates (93.5% versus 91.9%, P = 0.49). The risk differences (RDs) of SVR24 receiving weight-based and flat-dose RBV arms were 7.1% [95% CI: 0.7% to 13.6%] in males, and -5.8% [95% CI: -12.1% to 0.5%] in females (interaction P = 0.01). The SVR24 rate was higher in males receiving ≥13 mg/kg/day than those receiving...

Journal of the Formosan Medical Association, 2016

Background/purpose: Identifying trends in the prevalence and incidence of Parkinson's disease (PD... more Background/purpose: Identifying trends in the prevalence and incidence of Parkinson's disease (PD) may yield information that supports public health goals. Our aim was to evaluate timetrend changes in the prevalence and incidence of PD in Taiwan between 2004 and 2011. Methods: This retrospective, nationwide, longitudinal study used the Taiwan National Health Insurance Research Database to identify patients with PD from 2004 to 2011 based on having ICD-9-CM diagnostic codes, which were assigned by neurologists, and being prescribed PD medication. Annual incidence and prevalence were calculated, and time-trend analyses were estimated assuming a Poisson distribution. Results: Over the study period, 19,302 patients in 2004 and 41,606 patients in 2011 fulfilling the study criteria for PD were included in the analysis. The average age-standardized prevalence of PD per 100,000 of population was 84.8 in 2004 and 147.7 in 2011, with a 7.9% yearly increase. Increasing prevalence trends of PD were statistically significant (p < 0.001) in all age groups, with the steepest rate among those aged 80 years. In contrast, the average age-standardized incidence of PD decreased steadily from 35.3 per 100,000 in 2005 to 28.8 per 100,000 in 2011. The incidence rate was higher in men than in women, and increased with age.

Scientific reports, 2015

Hepatitis C virus genotype 2 (HCV-2) slow responders poorly respond to 24 weeks of peginterferon ... more Hepatitis C virus genotype 2 (HCV-2) slow responders poorly respond to 24 weeks of peginterferon (Peg-IFN) plus ribavirin (RBV). We evaluated the efficacy of extended 48-week regimen and the role of interleukin-28B (IL-28B) genotype in this clinical setting. Treatment-naïve HCV-2 patients not achieving rapid virologic response (RVR) by Peg-IFN alfa-2a 180 μg/week plus weight-based RBV (1,000-1,200 mg/day, cutoff body weight of 75 kg) were randomly assigned to receive a total duration of 48 (n = 94) or 24 (n = 93) weeks of therapy. The primary endpoint was sustained virologic response (SVR). Baseline patient characteristics to predict SVR were analyzed. Patients receiving 48 weeks of treatment had a greater SVR rate than those receiving 24 weeks of treatment (70.2% versus 46.2%, P = 0.001). Compared to patients treated for 24 weeks, the SVR rate in those treated for 48 weeks increased by 10.9% [95% CI: -5.9% to 27.7%] and 65.6% [95% CI: 44.5% to 86.7%] if they had IL-28B rs8099917 TT...

Background: Carotid angioplasty and stent (CAS) placement has emerged as an attractive revascular... more Background: Carotid angioplasty and stent (CAS) placement has emerged as an attractive revascularization strategy for patients with internal carotid artery stenosis. However, the effectiveness and safety of CAS were not fully evaluated, mainly because of methodological difficulties in finding an appropriate comparison group. Methods: Patients who underwent CAS were identified from Taiwan's National Health Insurance claims database between 2005 and 2008. The incidence rate of ischemic stroke after CAS was compared with that of the year prior to the procedure using a self-controlled case series analysis and a conditional Poisson regression model. Logistic regression was conducted to identify factors associated with poor outcome. Results: A total of 1258 patients who had undergone CAS were included, and 73 cases (5.8%) of death or ischemic stroke occurred during the index hospitalization. Within 1 year after CAS, 74 patients died and 80 experienced an ischemic stroke. Of the 1184 patients who were followed for 360 days, the rate ratio for ischemic stroke decreased to 0.21 (95% CI: 0.08e0.51) between 31 and 180 days, and 0.10 (95% CI: 0.03e0.32) between 181 and 360 days. Statin therapy was associated with a reduced risk of death or ischemic stroke in the 1 st month (odds ratio of 0.53; 95% CI: 0.32e0.90). Conversely, the use of nonsteroidal anti-inflammatory agents, possibly histamine-2 receptor blockers, and CAS performed by low-volume operators were associated with a twofold increased risk.

PLoS ONE, 2011

Background: Preclinical and observational studies raise the concern about the safety of insulin g... more Background: Preclinical and observational studies raise the concern about the safety of insulin glargine in terms of cancer initiation and promotion. This study is designed to examine cancer incidence associated with use of insulin glargine vs. intermediate/long-acting human insulin (HI). Methodology: A retrospective cohort study using the Taiwan National Health Insurance claims database was conducted to identify adult patients with type 2 diabetes mellitus and without a history of cancer who initiated insulin glargine (n = 10,190) or intermediate/long-acting HI (n = 49,253) during 2004-2007. Exclusive users were followed from the date of insulin initiation to the earliest of cancer diagnosis, death, disenrollment, or December 31 2007. We estimated adjusted hazard ratios and 95% confidence intervals (CIs) with Cox proportional hazards models adjusting for baseline propensity score. Findings: The incidence rate of all cancer per 1,000 person-years was 13.8 for insulin glargine initiators (179 cases) and 16.0 for intermediate/long-acting HI initiators (1,445 cases) during an average follow-up of 2 years. No significant difference in overall cancer risk between insulin glargine initiators and HI initiators was found. For men, however, the adjusted hazard ratio of insulin glargine use as compared with intermediate/long-acting HI was 2.15 (95% CI 1.01-4.59) for pancreatic cancer, and 2.42 (95% CI 1.50-8.40) for prostate cancer. The increased risk was not observed among women. Conclusions: Insulin glargine use did not increase the risk of overall cancer incidence as compared with HI. The positive associations with pancreatic and prostate cancer need further evaluation and validation.

Obesity, 2010

nature publishing group Bariatric surgery IntroductIon Obesity is associated with abnormalities i... more nature publishing group Bariatric surgery IntroductIon Obesity is associated with abnormalities in cardiac structure and function, including increased left ventricular (LV) wall thickness, chamber size, LV mass, and systolic and diastolic dysfunction (1-5). These structural and functional changes, especially LV hypertrophy, are independent risk factors for cardiovascular disease (6). Studies have shown that weight reduction by diet and exercise programs may induce regression of LV mass; however, the magnitude of weight reduction and changes in cardiac structure and function were subtle (7). Bariatric surgery is a more effective and rapid method for weight reduction (8,9). Studies evaluating the effect of surgical weight reduction demonstrated significant improvements in LV mass and some demonstrated improvements on diastolic function (10-15). Nonetheless, little is known about the determinants for improvement in LV structure and function after this procedure. We, therefore, conducted a prospective study in severely obese patients receiving bariatric surgery to evaluate the effect of surgical weight reduction on LV structure, systolic and diastolic function, to examine the association of weight reduction with changes in hemodynamics, LV geometry and function, and, most importantly, to seek the predictors of these changes. Methods and Procedures study population From May 2007 to August 2008, all severely obese (BMI ≥40 kg/m 2 or ≥35 kg/m 2 with comorbidities) adults (≥20 years of age), being scheduled for bariatric surgery (laparoscopic Roux-en-Y gastric bypass or laparoscopic sleeve gastrectomy) at a single medical center in the southern part of Taiwan after evaluation by a multidisciplinary team, were assessed for eligibility. Studied patients received echocardiographic evaluations before and 3 months after surgery. Patients with heart failure, valvular heart disease, coronary artery disease, regional wall motion abnormality, congenital heart disease, left bundle branch block or atrial fibrillation determined on the basis of previous history, physical examination, electrocardiography, and echocardiography were excluded from this study. Patients with an image inadequate for analysis were also excluded. The study protocol was approved by the hospital ethics committee, and all studied patients gave informed consent. clinical and demographic data Before surgery, studied patients' age, sex, and medical history were obtained. A detailed physical examination and 12-lead electrocardiography were performed. Weight, height, waist circumference, and blood pressure (BP) were measured before and 3 months after surgery by a well-trained nurse. BMI was calculated as weight (Kg)/height × height (m 2). Percent of excess BMI lost was calculated as (preoperative BMI−current BMI)/(preoperative BMI−23) × 100

Neuroepidemiology, 2009

Background: Recent interest in antihypertensive agents, especially calcium channel blockers, has ... more Background: Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson’s disease (PD) or dementia. There are no data for essential tremor (ET). Objective: To examine the association between antihypertensive use (defined broadly and by individual subclasses) and ET, PD and dementia. For each disorder, we used cross-sectional data (association with prevalent disease) and prospective data (association with incident disease). Methods: Prospective population-based study in Spain enrolling 5,278 participants at baseline. Results: Use of antihypertensive medications (aside from β-blockers) was similar in prevalent ET cases and controls. Baseline use of antihypertensive agents was not associated with reduced risk of incident ET. Antihypertensive medication use was not asso...

Kidney International, 2010

Journal of the American College of Cardiology, 2013

Background: Extracorporeal cardiopulmonary resuscitation (ECPR) had been considered adjuvant ther... more Background: Extracorporeal cardiopulmonary resuscitation (ECPR) had been considered adjuvant therapy for in-hospital cardiac arrest (IHCA). It was previously applied to out-of-hospital cardiac arrest (OHCA) with unsatisfactory result.

International Journal of Cancer, 2006

Jyh-Ming Liou, Jou-Wei Lin, Shih-Pei Huang, Jaw-Town Lin and Ming-Shiang Wu* Department of Intern... more Jyh-Ming Liou, Jou-Wei Lin, Shih-Pei Huang, Jaw-Town Lin and Ming-Shiang Wu* Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, College of Medicine, Taipei, Taiwan Department of Internal Medicine, Yun-Lin Branch, National Taiwan University Hospital, National Taiwan University, College of Medicine, Yun-Lin, Taiwan Department of Primary Care Medicine, National Taiwan University Hospital, National Taiwan University, College of Medicine, Taipei, Taiwan

IEEE Transactions on Biomedical Engineering, 2001

IEEE Transactions on Biomedical Circuits and Systems, 2011

A low-power, wireless, and implantable microstimulator system on chip with smart powering managem... more A low-power, wireless, and implantable microstimulator system on chip with smart powering management, immediate neural signal acquisition, and wireless rechargeable system is proposed. A system controller with parity checking handles the adjustable stimulus parameters for the stimulated objective. In the current paper, the rat's intra-cardiac electrogram is employed as the stimulated model in the animal study, and it is sensed by a lowvoltage and low-power monitoring analog front end. The power management unit, which includes a rectifier, battery charging and detection, and a regulator, is used for the power control of the internal circuits. The stimulation data and required clock are extracted by a phase-locked-loop-based phase shift keying demodulator from an inductive AC signal. The full chip, which consumes 48 W only, is fabricated in a TSMC 0.35 m 2P4M standard CMOS process to perform the monitoring and pacing functions with inductively powered communication in the in vivo study.