Justina Karpaviciute - Academia.edu (original) (raw)
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State University of Medicine and Pharmacy Nicolae Testemitanu in Chisinau
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Papers by Justina Karpaviciute
International Journal of Clinical Pharmacy, Apr 22, 2020
Background Potentially inappropriate prescribing is frequent among elderly patients admitted to h... more Background Potentially inappropriate prescribing is frequent among elderly patients admitted to hospitals in many countries. However, the impact of hospitalization on potentially inappropriate medications and potential prescribing omissions has not been studied in depth. Objective This study aimed to investigate the impact of hospitalization on the prevalence of potentially inappropriate medications and potential prescribing omissions among elderly patients admitted to and discharged from an acute care geriatric clinic. Setting Geriatric wards of a teaching hospital in Lithuania. Method This observational cross-sectional study included 76 subjects aged ≥ 65 years. The Beers 2015 Criteria, the EU(7)-PIM list, and the second versions of the Screening Tool of Older Person's Prescriptions and the Screening Tool to Alert doctors to Right Treatment were applied to detect potentially inappropriate medications and potential prescribing omissions. Data were extracted from patient's medical records. Main outcome measure Prevalence of potentially inappropriate medications and potential prescribing omissions on hospital admission and hospital discharge. Results Potentially inappropriate medications were identified among 44.7% to 69.7% of patients upon hospital admission and 59.2% to 72.4% upon hospital discharge. The prevalence of potentially inappropriate medications had increased upon discharge based on each set of criteria. Potential prescribing omissions were detected in 93.4% of patients at admission and 96.1% of patients at discharge. Conclusion Potentially inappropriate prescribing is highly prevalent among older patients hospitalized in the studied setting in Lithuania and hospitalization had not reduced potentially inappropriate medications and potential prescribing omissions. There is a need for interventions aiming to reduce potentially inappropriate prescribing among elderly patients.
Medicina, 2021
Background and Objectives: Fluid disbalance is associated with adverse outcomes in critically ill... more Background and Objectives: Fluid disbalance is associated with adverse outcomes in critically ill patients with acute kidney injury (AKI). In this study, we intended to assess fluid status using bioimpedance analysis (BIA) and central venous pressure (CVP) measurement and to evaluate the association between hyperhydration and hypervolemia with the outcomes of severe AKI. Materials and Methods: A prospective study was conducted in the Hospital of the Lithuanian University of Health Sciences Kauno Klinikos. Forty-seven patients treated at the Intensive Care Unit (ICU) with severe AKI and a need for renal replacement therapy (RRT) were examined. The hydration level was evaluated according to the ratio of extracellular water to total body water (ECW/TBW) of bioimpedance analysis and volemia was measured according to CVP. All of the patients were tested before the first hemodialysis (HD) procedure. Hyperhydration was defined as ECW/TBW > 0.39 and hypervolemia as CVP > 12 cm H2O. Re...
International Journal of Clinical Pharmacy, Apr 22, 2020
Background Potentially inappropriate prescribing is frequent among elderly patients admitted to h... more Background Potentially inappropriate prescribing is frequent among elderly patients admitted to hospitals in many countries. However, the impact of hospitalization on potentially inappropriate medications and potential prescribing omissions has not been studied in depth. Objective This study aimed to investigate the impact of hospitalization on the prevalence of potentially inappropriate medications and potential prescribing omissions among elderly patients admitted to and discharged from an acute care geriatric clinic. Setting Geriatric wards of a teaching hospital in Lithuania. Method This observational cross-sectional study included 76 subjects aged ≥ 65 years. The Beers 2015 Criteria, the EU(7)-PIM list, and the second versions of the Screening Tool of Older Person's Prescriptions and the Screening Tool to Alert doctors to Right Treatment were applied to detect potentially inappropriate medications and potential prescribing omissions. Data were extracted from patient's medical records. Main outcome measure Prevalence of potentially inappropriate medications and potential prescribing omissions on hospital admission and hospital discharge. Results Potentially inappropriate medications were identified among 44.7% to 69.7% of patients upon hospital admission and 59.2% to 72.4% upon hospital discharge. The prevalence of potentially inappropriate medications had increased upon discharge based on each set of criteria. Potential prescribing omissions were detected in 93.4% of patients at admission and 96.1% of patients at discharge. Conclusion Potentially inappropriate prescribing is highly prevalent among older patients hospitalized in the studied setting in Lithuania and hospitalization had not reduced potentially inappropriate medications and potential prescribing omissions. There is a need for interventions aiming to reduce potentially inappropriate prescribing among elderly patients.
Medicina, 2021
Background and Objectives: Fluid disbalance is associated with adverse outcomes in critically ill... more Background and Objectives: Fluid disbalance is associated with adverse outcomes in critically ill patients with acute kidney injury (AKI). In this study, we intended to assess fluid status using bioimpedance analysis (BIA) and central venous pressure (CVP) measurement and to evaluate the association between hyperhydration and hypervolemia with the outcomes of severe AKI. Materials and Methods: A prospective study was conducted in the Hospital of the Lithuanian University of Health Sciences Kauno Klinikos. Forty-seven patients treated at the Intensive Care Unit (ICU) with severe AKI and a need for renal replacement therapy (RRT) were examined. The hydration level was evaluated according to the ratio of extracellular water to total body water (ECW/TBW) of bioimpedance analysis and volemia was measured according to CVP. All of the patients were tested before the first hemodialysis (HD) procedure. Hyperhydration was defined as ECW/TBW > 0.39 and hypervolemia as CVP > 12 cm H2O. Re...