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Papers by Kalpana Upadhyaya

Journal of Molecular Liquids, 2019

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

European Journal of Medicinal Chemistry, 2019

Two Zn(II) nitro porphyrin derivatives bearing combinations of meso-4-nitrophenyl and meso-4-meth... more Two Zn(II) nitro porphyrin derivatives bearing combinations of meso-4-nitrophenyl and meso-4-methylpyridinium moieties and their free-base precursors were synthesized through one-pot microwave process, purified and characterized. The biological activity of these nitroporphyrins was assessed under both photodynamic and non-photodynamic conditions to correlate their structure-activity relationship (SAR). Unlike, the free-base precursors, Zn(II) complexes of these nitroporphyrins displayed nearly complete inhibition in the entry of lentiviruses such as HIV-1 and SIVmac under non-photodynamic conditions. In addition, the Zn(II) complexes also exhibited a higher in vitro photodynamic activity towards human lung cancer cell-line A549 than their free-base precursors. Our results strongly suggest that incorporation of Zn(II) has improved the antiviral and anticancer properties of the nitroporphyrins. To the best of our knowledge, this is the first report demonstrating the dual activity of nitroporphyrin-zinc complexes as antiviral and anti-cancer, which will aid in their development as therapeutics in clinics.

Journal of Hepatology, 2016

Physica E: Low-dimensional Systems and Nanostructures, 2010

Biological synthesis of gold and silver nanoparticles of various shapes using the leaf extract of... more Biological synthesis of gold and silver nanoparticles of various shapes using the leaf extract of Hibiscus rosa sinensis is reported. This is a simple, cost-effective, stable for long time and reproducible aqueous room temperature synthesis method to obtain a self-assembly of Au and Ag nanoparticles. The size and shape of Au nanoparticles are modulated by varying the ratio of metal

Journal of Hepatology, 2012

The prevalence of fatty liver disease (FLD) has been increase, because of increase of metabolic s... more The prevalence of fatty liver disease (FLD) has been increase, because of increase of metabolic syndrome and obesity. We reported visceral adiposity was closely related to the pathogenesis of NAFLD. Alcohol is considered as one of important predictive factors for development of FLD. However, the influence by alcohol to the patients with FLD in health checkups has not been well clarified yet. The aims of this study are to examine the influence and the relationship between alcohol intake and visceral fat volume to development of FLD in health checkups in Japan. Methods: A cross-sectional study was conducted among 11404 subjects, female: 4985, male: 7294, who received health checkups from 2009 to 2010 in three health centers in Japan. Subjects with chronic hepatitis B and C were excluded. Fatty liver was detected by ultrasonography. The volume of alcohol intake was interviewed from every subject. The relationship among prevalence of FLD, influence of alcohol intake, and physiological and laboratory data were investigated. Results: The overall prevalence of FLD was 17.4%, drinkers (more than 20 g of alcohol per day) was 14.4% and non-drinkers was 17.8% in women, and overall prevalence was 39.9%, drinkers was 39.5% and non-drinkers was 40.2% in men. No statistical difference of the prevalence of FLD was recognized between drinkers and non-drinkers both in women and men. In both women and men, physiological and laboratory data other than GGT levels in drinkers were not different from that in non-drinkers. In accordance with increase of waist circumstances and BMI, the prevalence of FLD was increased both in women and men, and the distribution of FLD in drinkers was quite similar pattern with that in non-drinkers.

Beilstein Journal of Organic Chemistry, 2013

Non-symmetrically substituted four-ring achiral bent-core compounds with polar substituents, i.e.... more Non-symmetrically substituted four-ring achiral bent-core compounds with polar substituents, i.e.., chloro in the bent or transverse direction in the central core and cyano in the lateral direction at one terminal end of the molecule, are designed and synthesized. These molecules possess an alkoxy chain attached at only one end of the bent-core molecule. The molecular structure characterization is consistent with data from elemental and spectroscopic analysis. The materials thermal behaviour and phase characterization have been investigated by differential scanning calorimetry and polarizing microscopy. All the compounds exhibit a wide-ranging monotropic nematic phase.