Khaled Salama - Academia.edu (original) (raw)
Papers by Khaled Salama
F1000Research, 2021
Background: Cardiac, hepatic and pancreatic T2* measured by magnetic resonance imaging (MRI) has ... more Background: Cardiac, hepatic and pancreatic T2* measured by magnetic resonance imaging (MRI) has been proven to be an accurate and non-invasive method for measuring iron overload in iron overload conditions. There is accumulating evidence that pancreatic iron can predict cardiac iron in young children because the pancreas loads earlier than the heart. The aim of our study was to assess the relationships between pancreatic T2* values and pancreatic iron loading with cardiac dysfunctions and liver and cardiac iron among patients with β-thalassaemia major (βTM) and sickle cell disease (SCD). Methods: 40 βTM and 20 transfusion-dependant SCD patients were included along with 60 healthy age and sex-matched controls. Echocardiography and Tissue Doppler Imaging were performed for all subjects as well as the control group. Hepatic, cardiac and pancreatic iron overload in cases were assessed by MRI T2*. Results: The mean age of our patients was 13.7 years with mean frequency of transfusion/...
The Egyptian Orthopaedic Journal, 2020
Background Global stenosis is any type of spinal canal stenosis with more than two levels of sten... more Background Global stenosis is any type of spinal canal stenosis with more than two levels of stenosis (three or more). The usual course of spinal stenosis is benign and chronic, and most of the patients followed up show insignificant changes over years. In addition, many patients may respond to conservative treatment and physiotherapy, but regarding the global canal stenosis, the natural history is different. Patients and methods A case series retrospective study was conducted on 64 patients who were divided into two groups. Decompression and fixation was the standard procedure, and the method of fusion in group A was lateral bilateral intertransverse processes bone grafting whereas in group B was interbody fusion using cages. Results In each group separately, statistics showed that there is a strong relationship between 1-month postoperative Oswestry disability index (ODI) improvements, which resulted in progressive improvement as long as it was improved from the baseline. Moreover, at the final follow-up, the authors found a strong significant relationship between ODI and visual analog scale improvement. Spinal canal diameter preoperatively had insignificant relationship with postoperative improvement. Fusion obtained at 6-month assessment was more than 90% of the fused levels in group B and almost the same or less in groups A, but at 12-month assessment. No significant difference was found between the two groups regarding the preoperative or postoperative results regarding the ODI or visual analog scale at 1-month follow-up or up to 2-year follow-up. The blood loss and operative time showed significant differences between the two groups (more blood loss and longer operative time in group B). Conclusion Global spinal canal stenosis is better treated with surgical decompression whatever the method of fusion used.
Background: Lung function abnormalities in patients with thalassemia major are various, complex a... more Background: Lung function abnormalities in patients with thalassemia major are various, complex and of different etiological backgrounds. Methods: To evaluate the pulmonary function changes during both rest and integrated cardiopulmonary exercise in patients with thalassemia major, we studied 30 thalassemia major cases with mean age of 18 ± 13.34 years. Nineteen healthy subjects were enrolled as a control group. Routine laboratory tests as well as assessment of pulmonary function test during both rest and integrated cardiopulmonary exercise were performed for cases and controls. Results: Both forced vital capacity (FVC) and forced expiratory flow in the first second (FEV 1) were significantly reduced in cases than in controls (p<0.01 for both), pointing to a restrictive pulmonary dysfunction. Seventy percent of cases had FVC below the normal predicted value. Functional capacity, anaerobic threshold and O 2 pulse were significantly reduced in cases than controls (p<0.05). There...
Recent Patents on Food, Nutrition & Agriculture, 2021
Background: Eggs are commonly regarded as one of the best sources of various macro and micronutri... more Background: Eggs are commonly regarded as one of the best sources of various macro and micronutrients, in particular, high biological value (BV) proteins and both saturated and unsaturated fatty acids. Apart from proteins, eggs are excellent sources of various high health value lipid components, carotenoids, minerals, and both water and lipid-soluble vitamins. However, the nutrient-rich nature of this ‘superfood’ also makes them susceptible to microbial contamination from various sources, such as fecal matter, drinking water for layer chicken, and the surrounding environment. Moreover, drinking water and chicken feed are also sources of heavy metal contamination. The presence of both factors poses serious health concerns for consumers. Objective: The main aim of this research was to proximate heavy metals and bacterial contaminants in nine different brands of brown organic and conventional white eggs available in the hypermarkets of the Eastern Province of Saudi Arabia. Methods: An ...
Physical Review B, 2020
We combine theories of scattering for linearized water waves and flexural waves in thin plates to... more We combine theories of scattering for linearized water waves and flexural waves in thin plates to characterize and achieve control of water wave scattering using floating plates. This requires manipulating a sixth-order partial differential equation with appropriate boundary conditions of the velocity potential. Making use of multipole expansions, we reduce the scattering problem to a linear algebraic system. The response of a floating plate in the quasistatic limit simplifies, considering a distinct behavior for water and flexural waves. Unlike similar studies in electromagnetics and acoustics, scattering of gravity-flexural waves is
IEEE Transactions on Biomedical Circuits and Systems, 2019
In this paper, a low power support vector machine (SVM) training, feature extraction, and classif... more In this paper, a low power support vector machine (SVM) training, feature extraction, and classification algorithm are hardware implemented in a neural seizure detection application. The training algorithm used is the sequential minimal optimization (SMO) algorithm. The system is implemented on different platforms: such as field programmable gate array (FPGA), Xilinx Virtex-7 and application specific integrated circuit (ASIC) using hardware-calibrated UMC 65 nm CMOS technology. The implemented training hardware is introduced as an accelerator intellectual property (IP), especially in the case of large number of training sets, such as neural seizure detection. Feature extraction and classification blocks are implemented to achieve the best trade-off between sensitivity and power consumption. The proposed seizure detection system achieves a sensitivity around 96.77% when tested with the implemented linear kernel classifier. A power consumption evaluation is performed on both the ASIC and FPGA platforms showing that the ASIC power consumption is improved by a factor of 2X when compared with the FPGA counterpart.
International Surgery Journal, 2016
Background: Stabilizing unstable pelvic fractures with rapidly applied pelvic binder or the garme... more Background: Stabilizing unstable pelvic fractures with rapidly applied pelvic binder or the garment has long been a standard practice in patients suspected to be bleeding from their pelvic injuries. External fixation is believed to provide better tamponade, by decreasing the pelvic volume and, thereby, the space for blood loss. Methods: Prospective case control randomized study. A total of 30 patients were enrolled in this study. They were recruited from Suez Canal University hospital (Ismailia). They were categorized into two groups. They were selected by simple randomization method using the table of random number. Group I: patients were subjected to antishock garment (15 patients). Group II: patients were subjected to external pelvic fixation (15 patients). Results: Data analysis of the 30 patients showed that symphysis pubis diastasis was decreased from (3.2 to 2.8 cm) in binder group in comparison to (3.8 to 2.2cm) in EX-FIX group with statistically significant different (p value = P = 0.04). But there were no marked difference in the degree of shock index improvement between the two groups (pvalue >0.05). Conclusions: Although EX-FIX is showing significant improvement in pelvic stability and more decreasing diastasis in comparison with binder, there was no difference in improving the haemodynamic state between both maneuvers.
International Journal of Surgery and Medicine, 2016
Background:Heart failure (HF) has become one of the most significant problems in healthcare in th... more Background:Heart failure (HF) has become one of the most significant problems in healthcare in the western world. There are over 26 million people who suffer from heart failure in the world. Half of all patients diagnosed with heart failure die within four years. It is critical to predicting if a patient will die soon so that an effective prevention can be employed. However, characteristics and outcome of HF patients are not well investigated in developing countries like Egypt. Methods: Was to assess the short-term predictive value of simple biomarkers (such as d-dimer, CRP& ESR) regarding cardiovascular mortality and major cardiovascular events in patients with severe heart failure. This is a cross-sectional study which included 141 patients. Results: According to ESR, CRP and d-dimer as predictors of hospital admission within one-month follow-up: 45.9% of the patients had moderately elevated ESR, 72.1% of the patients had high CRP and 13.1% of the patients had positive d-dimer. According to ESR, CRP, d-dimer as predictors of mortality within one month follow up: 83.3% of the patients had moderately elevated ESR within the first hour, 83.3% of the patients had high CRP, and 33.3% of the patients had positive d-dimer. Conclusion: ESR may be a good predictor of mortality within one month follow-up, while CRP, d-dimer are not.
Al-Azhar Assiut Medical Journal, 2016
Objective and aim Hepatitis C virus (HCV) can cause both acute and chronic hepatitis. Antiviral t... more Objective and aim Hepatitis C virus (HCV) can cause both acute and chronic hepatitis. Antiviral therapy is the cornerstone for the treatment of chronic HCV infection once diagnosis is confirmed by PCR. The goal of antiviral therapy is to eradicate HCV RNA or attain sustained virological response (SVR). In many countries worldwide, including Egypt, HCV infection is treated with a combination of pegylated interferon α and ribavirin (RBV). Liver fibrosis/cirrhosis stage influences the response to pegylated interferon α and RBV. Even with new oral therapies such as Sovaldi many patients have to continue to be on combination regimens of interferon/RBV or RBV alone. In the current study, we aimed to use data mining analysis to determine sonographic pictures that can successfully predict SVR in HCV-4 patients before the antiviral therapy. Methods Eighty-two patients were enrolled in this study and they underwent two-dimensional ultrasound examination before the antiviral therapy. The sonographic data obtained were analyzed with Rapidminer version 4.6 to create a decision tree algorithm for the prediction of SVR. Results The absence of significant liver fibrosis was a predictive parameter of SVR mainly in those patients without a sonographic picture of cirrhosis. The resulting tree yielded an accuracy, sensitivity, and specificity of 85.82 ± 10.79, 68.75, and 96.00%, respectively, upon 10-fold cross-validation. Conclusion In the current study we used decision tree algorithm, one of the most important computational methods and tools for data analysis and predictive modeling in applied medicine, to predict SVR in HCV-infected patients. Two-dimensional ultrasound can give predictive information regarding the treatment outcome before interferon therapy for HCV-4.
Medicine, 2015
In countries endemic for liver and GIT diseases, frequent emergency department (ED) patients cont... more In countries endemic for liver and GIT diseases, frequent emergency department (ED) patients contribute to a disproportionate number of visits consuming substantial amount of medical resources. One of the most frequent ED visits is patients who present with hypovolemic shock, abdominal pain, or confusion with or without signs of upper gastrointestinal bleeding (UGIB). The use of conventional twodimensional ultrasound (2D-U/S) may provide immediate and useful information on the presence of esophageal varices, gastrointestinal tumors, and other GIT abnormalities. The current study investigated the feasibility of using (2D-U/S) to predict the source of UGIB in ED and to determine patients' priority for UGE. Between February 2003 and March 2013, we retrospectively reviewed the profiles of 38,551 Egyptian patients, aged 2 to 75 years old, who presented with a history of GI/liver diseases and no alcohol consumption. We assessed the value of 2D-U/S technology in predicting the source of UGIB. Of 38,551 patients presenting to ED, 900 patients (2.3%), 534 male (59.3%) and 366 female (40.7%) developed UGIB. Analyzing results obtained from U/S examinations by data mining for emergent UGE were patients with liver cirrhosis (LC), splenomegaly, and ascites (42.6% incidence of UGIB), followed by LC and splenomegaly (14.6%), LC only (9.4%), and was only 0.5% who had no morbidity finding by 2D-U/S. Ultrasonographic instrumentation increases the feasibility of predictive emergency medicine. The area has recently not only gained a fresh impulse, but also a new set of complex problems that needs to be addressed in the emergency medicine setting according to each priority.
Medicine, 2015
Children obesity has become one of the most important public health problems in many countries wo... more Children obesity has become one of the most important public health problems in many countries worldwide. Although the awareness of childhood obesity as a modifiable health risk is high, but many societies do not prioritize this issue as a health care problem, which may lead to comorbidities and even premature death. Despite the rising interest in bariatric surgery for children, only laparoscopic sleeve gastrectomy (LSG) is being considered in resolving childhood obesity who failed other dietary or drug therapies; however many of LSG procedures failed to reduce the weight in children or resulted in complications postsurgery. Here, we present a novel bariatric procedure to clue out a female child 13 years old presented with Legg-Calvé-Perthes disease-associated morbid obesity. The surgical bariatric technique applied both fundal resection and surgical bypass in pediatric obesity using the Elbanna novel bariatric technique. Bariatric surgical bypass may be considered in complicated-childhood cases who failed all other options.
International Journal of Medical Science and Public Health, 2015
AIMR Conference Proceedings, 1995
2007 Digest of the IEEE/LEOS Summer Topical Meetings, 2007
This paper presents an enhanced design of Opto-Fluidic Microscopy (OFM) with significant improvem... more This paper presents an enhanced design of Opto-Fluidic Microscopy (OFM) with significant improvement over the first reported OFM design 1. OFM is a novel optical imaging device that can be directly integrated into a microfluidic network, and can therefore enable high resolution and on-chip imaging of biological samples that are flowing in microfluidic channels. The main advantages of OFM are its very compact miniaturized design, low cost, high throughput, and its non destructive nature of optical probing. But the key advantage of this optical imaging device is its ability to capture high resolution (750 nm) images although it is free from any bulk optics (lenses). Instead of bulk optics, OFM is based on a nanohole array defined in an opaque metallic layer that is patterned onto the floor of the microfluidic channel and then mounted on top of a one dimensional CCD or photodiode array.
Endocrine, 2014
Background: Both insulin like growth factor-1(IGF-1) and oral contraceptive (OC) use have been li... more Background: Both insulin like growth factor-1(IGF-1) and oral contraceptive (OC) use have been linked to premenopausal breast and colorectal cancers, osteoporosis and cardiovascular disease. Understanding the effects of different patterns of use of OC on IGF-1 levels and bone mineral density (BMD) may offer insight into its influence on osteoporosis. Methods: We conducted a cross-sectional study of 135 women who were included into 3 groups (Group A= OC users, 43 women; Group B who never use OC, 51 women; and Group C who were past users, 41 women). Each patient completed a questionnaire on demographic parameters, marital state history, and contraception history including duration of use and type of contraceptive pills or used method. Lower end radius, proximal femur and lumbar spine BMD were measured by dual-energy X-ray absorptiometry. IGF-1 was assessed with chemiluminescent immunometric assay. Results: The 3 groups were matched for age and BMI, and nearly similar in total body T-value of BMD (with slight better results in past-users than the other 2 groups but it was statistically insignificant difference), but the other BMD values shows significant difference between the studied groups regarding the measurement at lumbar spine and femur which were statistically significantly better results in Group C (past users). Among past-users women the mean level of circulating IGF-1 was higher than the other 2 groups, and that difference was statistically significant. Conclusion: Lower IGF-1 level among current users may also potentially lead to decreased BMD, while the higher levels we observed in older past users may decrease the osteoporosis risk, reflecting observed relationship between IGF-1, BMD, and oral contraceptives.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
... Issue Date: 30-Sep-2007. Citation: Salama K, El-Koofy N, El-Hawary M, El-Raziky M, Abou-El El... more ... Issue Date: 30-Sep-2007. Citation: Salama K, El-Koofy N, El-Hawary M, El-Raziky M, Abou-El Ela M, Ali H, El-Karaksy H. Thrombophilic factors in Egyptian children with portal vein thrombosis. Indian Journal of Gastroenterology. 2007 Sep-Oct; 26(5): 252-3. Language: eng. ...
Image Quality and System Performance II, 2005
This paper evaluates the operation of self-correcting active pixel sensors presented in [6] using... more This paper evaluates the operation of self-correcting active pixel sensors presented in [6] using Signal-to-Noise Ratio. The evaluation is based on a simplified Active Pixel Sensing (APS) model. We show that in the absence of stuck faults (i.e., no errors) the performance of the system suffers from considerable degradation especially at low illumination (i.e., typical indoor scenes). We use the same model to quantify the number of defective pixels under which self correction is beneficial.
Egyptian Pediatric Association Gazette, 2013
Background: Treatment of anemia in children with predialysis chronic kidney disease (CKD) has bee... more Background: Treatment of anemia in children with predialysis chronic kidney disease (CKD) has been facilitated by the administration of recombinant human erythropoietin (rHuEpo). The aim of this study was to evaluate the effect of rHuEpo on the correction of anemia and to study its effect on the progression of CKD in predialysis patients. Methods: This study was done at the New Children's Hospital, Cairo University, included 40 patients with CKD and renal anemia on conservative management. The patients were divided into two groups; group I (received rHuEpo) and group II (did not receive rHuEpo). For all patients, clinical assessment and routine laboratory investigation were recorded every 2 weeks, in addition to iron indices and ultrasonography. Glomerular filtration rate (GFR) was calculated every 2 weeks and the rate of decline of GFR (DGFR) was determined over 6 months preceding starting follow up. GFR was also determined over a follow up period of 12 months. Results: There was a statistically significant difference between the initial and final levels of hemoglobin (Hb) and hematocrit (Hct) in group I. Also, there was a statistically significant difference between the two groups as regards Hb and Hct levels at the end of the study. The progression of CKD is already slower before T0 (the time of starting rHuEpo administration) in group I and also decreased after T0, with highly statistically significant difference. Conclusion: The study concluded that rHuEpo therapy is beneficial for correction of renal anemia and its early treatment is a useful intervention for slowing the progression in patients with CKD.
F1000Research, 2021
Background: Cardiac, hepatic and pancreatic T2* measured by magnetic resonance imaging (MRI) has ... more Background: Cardiac, hepatic and pancreatic T2* measured by magnetic resonance imaging (MRI) has been proven to be an accurate and non-invasive method for measuring iron overload in iron overload conditions. There is accumulating evidence that pancreatic iron can predict cardiac iron in young children because the pancreas loads earlier than the heart. The aim of our study was to assess the relationships between pancreatic T2* values and pancreatic iron loading with cardiac dysfunctions and liver and cardiac iron among patients with β-thalassaemia major (βTM) and sickle cell disease (SCD). Methods: 40 βTM and 20 transfusion-dependant SCD patients were included along with 60 healthy age and sex-matched controls. Echocardiography and Tissue Doppler Imaging were performed for all subjects as well as the control group. Hepatic, cardiac and pancreatic iron overload in cases were assessed by MRI T2*. Results: The mean age of our patients was 13.7 years with mean frequency of transfusion/...
The Egyptian Orthopaedic Journal, 2020
Background Global stenosis is any type of spinal canal stenosis with more than two levels of sten... more Background Global stenosis is any type of spinal canal stenosis with more than two levels of stenosis (three or more). The usual course of spinal stenosis is benign and chronic, and most of the patients followed up show insignificant changes over years. In addition, many patients may respond to conservative treatment and physiotherapy, but regarding the global canal stenosis, the natural history is different. Patients and methods A case series retrospective study was conducted on 64 patients who were divided into two groups. Decompression and fixation was the standard procedure, and the method of fusion in group A was lateral bilateral intertransverse processes bone grafting whereas in group B was interbody fusion using cages. Results In each group separately, statistics showed that there is a strong relationship between 1-month postoperative Oswestry disability index (ODI) improvements, which resulted in progressive improvement as long as it was improved from the baseline. Moreover, at the final follow-up, the authors found a strong significant relationship between ODI and visual analog scale improvement. Spinal canal diameter preoperatively had insignificant relationship with postoperative improvement. Fusion obtained at 6-month assessment was more than 90% of the fused levels in group B and almost the same or less in groups A, but at 12-month assessment. No significant difference was found between the two groups regarding the preoperative or postoperative results regarding the ODI or visual analog scale at 1-month follow-up or up to 2-year follow-up. The blood loss and operative time showed significant differences between the two groups (more blood loss and longer operative time in group B). Conclusion Global spinal canal stenosis is better treated with surgical decompression whatever the method of fusion used.
Background: Lung function abnormalities in patients with thalassemia major are various, complex a... more Background: Lung function abnormalities in patients with thalassemia major are various, complex and of different etiological backgrounds. Methods: To evaluate the pulmonary function changes during both rest and integrated cardiopulmonary exercise in patients with thalassemia major, we studied 30 thalassemia major cases with mean age of 18 ± 13.34 years. Nineteen healthy subjects were enrolled as a control group. Routine laboratory tests as well as assessment of pulmonary function test during both rest and integrated cardiopulmonary exercise were performed for cases and controls. Results: Both forced vital capacity (FVC) and forced expiratory flow in the first second (FEV 1) were significantly reduced in cases than in controls (p<0.01 for both), pointing to a restrictive pulmonary dysfunction. Seventy percent of cases had FVC below the normal predicted value. Functional capacity, anaerobic threshold and O 2 pulse were significantly reduced in cases than controls (p<0.05). There...
Recent Patents on Food, Nutrition & Agriculture, 2021
Background: Eggs are commonly regarded as one of the best sources of various macro and micronutri... more Background: Eggs are commonly regarded as one of the best sources of various macro and micronutrients, in particular, high biological value (BV) proteins and both saturated and unsaturated fatty acids. Apart from proteins, eggs are excellent sources of various high health value lipid components, carotenoids, minerals, and both water and lipid-soluble vitamins. However, the nutrient-rich nature of this ‘superfood’ also makes them susceptible to microbial contamination from various sources, such as fecal matter, drinking water for layer chicken, and the surrounding environment. Moreover, drinking water and chicken feed are also sources of heavy metal contamination. The presence of both factors poses serious health concerns for consumers. Objective: The main aim of this research was to proximate heavy metals and bacterial contaminants in nine different brands of brown organic and conventional white eggs available in the hypermarkets of the Eastern Province of Saudi Arabia. Methods: An ...
Physical Review B, 2020
We combine theories of scattering for linearized water waves and flexural waves in thin plates to... more We combine theories of scattering for linearized water waves and flexural waves in thin plates to characterize and achieve control of water wave scattering using floating plates. This requires manipulating a sixth-order partial differential equation with appropriate boundary conditions of the velocity potential. Making use of multipole expansions, we reduce the scattering problem to a linear algebraic system. The response of a floating plate in the quasistatic limit simplifies, considering a distinct behavior for water and flexural waves. Unlike similar studies in electromagnetics and acoustics, scattering of gravity-flexural waves is
IEEE Transactions on Biomedical Circuits and Systems, 2019
In this paper, a low power support vector machine (SVM) training, feature extraction, and classif... more In this paper, a low power support vector machine (SVM) training, feature extraction, and classification algorithm are hardware implemented in a neural seizure detection application. The training algorithm used is the sequential minimal optimization (SMO) algorithm. The system is implemented on different platforms: such as field programmable gate array (FPGA), Xilinx Virtex-7 and application specific integrated circuit (ASIC) using hardware-calibrated UMC 65 nm CMOS technology. The implemented training hardware is introduced as an accelerator intellectual property (IP), especially in the case of large number of training sets, such as neural seizure detection. Feature extraction and classification blocks are implemented to achieve the best trade-off between sensitivity and power consumption. The proposed seizure detection system achieves a sensitivity around 96.77% when tested with the implemented linear kernel classifier. A power consumption evaluation is performed on both the ASIC and FPGA platforms showing that the ASIC power consumption is improved by a factor of 2X when compared with the FPGA counterpart.
International Surgery Journal, 2016
Background: Stabilizing unstable pelvic fractures with rapidly applied pelvic binder or the garme... more Background: Stabilizing unstable pelvic fractures with rapidly applied pelvic binder or the garment has long been a standard practice in patients suspected to be bleeding from their pelvic injuries. External fixation is believed to provide better tamponade, by decreasing the pelvic volume and, thereby, the space for blood loss. Methods: Prospective case control randomized study. A total of 30 patients were enrolled in this study. They were recruited from Suez Canal University hospital (Ismailia). They were categorized into two groups. They were selected by simple randomization method using the table of random number. Group I: patients were subjected to antishock garment (15 patients). Group II: patients were subjected to external pelvic fixation (15 patients). Results: Data analysis of the 30 patients showed that symphysis pubis diastasis was decreased from (3.2 to 2.8 cm) in binder group in comparison to (3.8 to 2.2cm) in EX-FIX group with statistically significant different (p value = P = 0.04). But there were no marked difference in the degree of shock index improvement between the two groups (pvalue >0.05). Conclusions: Although EX-FIX is showing significant improvement in pelvic stability and more decreasing diastasis in comparison with binder, there was no difference in improving the haemodynamic state between both maneuvers.
International Journal of Surgery and Medicine, 2016
Background:Heart failure (HF) has become one of the most significant problems in healthcare in th... more Background:Heart failure (HF) has become one of the most significant problems in healthcare in the western world. There are over 26 million people who suffer from heart failure in the world. Half of all patients diagnosed with heart failure die within four years. It is critical to predicting if a patient will die soon so that an effective prevention can be employed. However, characteristics and outcome of HF patients are not well investigated in developing countries like Egypt. Methods: Was to assess the short-term predictive value of simple biomarkers (such as d-dimer, CRP& ESR) regarding cardiovascular mortality and major cardiovascular events in patients with severe heart failure. This is a cross-sectional study which included 141 patients. Results: According to ESR, CRP and d-dimer as predictors of hospital admission within one-month follow-up: 45.9% of the patients had moderately elevated ESR, 72.1% of the patients had high CRP and 13.1% of the patients had positive d-dimer. According to ESR, CRP, d-dimer as predictors of mortality within one month follow up: 83.3% of the patients had moderately elevated ESR within the first hour, 83.3% of the patients had high CRP, and 33.3% of the patients had positive d-dimer. Conclusion: ESR may be a good predictor of mortality within one month follow-up, while CRP, d-dimer are not.
Al-Azhar Assiut Medical Journal, 2016
Objective and aim Hepatitis C virus (HCV) can cause both acute and chronic hepatitis. Antiviral t... more Objective and aim Hepatitis C virus (HCV) can cause both acute and chronic hepatitis. Antiviral therapy is the cornerstone for the treatment of chronic HCV infection once diagnosis is confirmed by PCR. The goal of antiviral therapy is to eradicate HCV RNA or attain sustained virological response (SVR). In many countries worldwide, including Egypt, HCV infection is treated with a combination of pegylated interferon α and ribavirin (RBV). Liver fibrosis/cirrhosis stage influences the response to pegylated interferon α and RBV. Even with new oral therapies such as Sovaldi many patients have to continue to be on combination regimens of interferon/RBV or RBV alone. In the current study, we aimed to use data mining analysis to determine sonographic pictures that can successfully predict SVR in HCV-4 patients before the antiviral therapy. Methods Eighty-two patients were enrolled in this study and they underwent two-dimensional ultrasound examination before the antiviral therapy. The sonographic data obtained were analyzed with Rapidminer version 4.6 to create a decision tree algorithm for the prediction of SVR. Results The absence of significant liver fibrosis was a predictive parameter of SVR mainly in those patients without a sonographic picture of cirrhosis. The resulting tree yielded an accuracy, sensitivity, and specificity of 85.82 ± 10.79, 68.75, and 96.00%, respectively, upon 10-fold cross-validation. Conclusion In the current study we used decision tree algorithm, one of the most important computational methods and tools for data analysis and predictive modeling in applied medicine, to predict SVR in HCV-infected patients. Two-dimensional ultrasound can give predictive information regarding the treatment outcome before interferon therapy for HCV-4.
Medicine, 2015
In countries endemic for liver and GIT diseases, frequent emergency department (ED) patients cont... more In countries endemic for liver and GIT diseases, frequent emergency department (ED) patients contribute to a disproportionate number of visits consuming substantial amount of medical resources. One of the most frequent ED visits is patients who present with hypovolemic shock, abdominal pain, or confusion with or without signs of upper gastrointestinal bleeding (UGIB). The use of conventional twodimensional ultrasound (2D-U/S) may provide immediate and useful information on the presence of esophageal varices, gastrointestinal tumors, and other GIT abnormalities. The current study investigated the feasibility of using (2D-U/S) to predict the source of UGIB in ED and to determine patients' priority for UGE. Between February 2003 and March 2013, we retrospectively reviewed the profiles of 38,551 Egyptian patients, aged 2 to 75 years old, who presented with a history of GI/liver diseases and no alcohol consumption. We assessed the value of 2D-U/S technology in predicting the source of UGIB. Of 38,551 patients presenting to ED, 900 patients (2.3%), 534 male (59.3%) and 366 female (40.7%) developed UGIB. Analyzing results obtained from U/S examinations by data mining for emergent UGE were patients with liver cirrhosis (LC), splenomegaly, and ascites (42.6% incidence of UGIB), followed by LC and splenomegaly (14.6%), LC only (9.4%), and was only 0.5% who had no morbidity finding by 2D-U/S. Ultrasonographic instrumentation increases the feasibility of predictive emergency medicine. The area has recently not only gained a fresh impulse, but also a new set of complex problems that needs to be addressed in the emergency medicine setting according to each priority.
Medicine, 2015
Children obesity has become one of the most important public health problems in many countries wo... more Children obesity has become one of the most important public health problems in many countries worldwide. Although the awareness of childhood obesity as a modifiable health risk is high, but many societies do not prioritize this issue as a health care problem, which may lead to comorbidities and even premature death. Despite the rising interest in bariatric surgery for children, only laparoscopic sleeve gastrectomy (LSG) is being considered in resolving childhood obesity who failed other dietary or drug therapies; however many of LSG procedures failed to reduce the weight in children or resulted in complications postsurgery. Here, we present a novel bariatric procedure to clue out a female child 13 years old presented with Legg-Calvé-Perthes disease-associated morbid obesity. The surgical bariatric technique applied both fundal resection and surgical bypass in pediatric obesity using the Elbanna novel bariatric technique. Bariatric surgical bypass may be considered in complicated-childhood cases who failed all other options.
International Journal of Medical Science and Public Health, 2015
AIMR Conference Proceedings, 1995
2007 Digest of the IEEE/LEOS Summer Topical Meetings, 2007
This paper presents an enhanced design of Opto-Fluidic Microscopy (OFM) with significant improvem... more This paper presents an enhanced design of Opto-Fluidic Microscopy (OFM) with significant improvement over the first reported OFM design 1. OFM is a novel optical imaging device that can be directly integrated into a microfluidic network, and can therefore enable high resolution and on-chip imaging of biological samples that are flowing in microfluidic channels. The main advantages of OFM are its very compact miniaturized design, low cost, high throughput, and its non destructive nature of optical probing. But the key advantage of this optical imaging device is its ability to capture high resolution (750 nm) images although it is free from any bulk optics (lenses). Instead of bulk optics, OFM is based on a nanohole array defined in an opaque metallic layer that is patterned onto the floor of the microfluidic channel and then mounted on top of a one dimensional CCD or photodiode array.
Endocrine, 2014
Background: Both insulin like growth factor-1(IGF-1) and oral contraceptive (OC) use have been li... more Background: Both insulin like growth factor-1(IGF-1) and oral contraceptive (OC) use have been linked to premenopausal breast and colorectal cancers, osteoporosis and cardiovascular disease. Understanding the effects of different patterns of use of OC on IGF-1 levels and bone mineral density (BMD) may offer insight into its influence on osteoporosis. Methods: We conducted a cross-sectional study of 135 women who were included into 3 groups (Group A= OC users, 43 women; Group B who never use OC, 51 women; and Group C who were past users, 41 women). Each patient completed a questionnaire on demographic parameters, marital state history, and contraception history including duration of use and type of contraceptive pills or used method. Lower end radius, proximal femur and lumbar spine BMD were measured by dual-energy X-ray absorptiometry. IGF-1 was assessed with chemiluminescent immunometric assay. Results: The 3 groups were matched for age and BMI, and nearly similar in total body T-value of BMD (with slight better results in past-users than the other 2 groups but it was statistically insignificant difference), but the other BMD values shows significant difference between the studied groups regarding the measurement at lumbar spine and femur which were statistically significantly better results in Group C (past users). Among past-users women the mean level of circulating IGF-1 was higher than the other 2 groups, and that difference was statistically significant. Conclusion: Lower IGF-1 level among current users may also potentially lead to decreased BMD, while the higher levels we observed in older past users may decrease the osteoporosis risk, reflecting observed relationship between IGF-1, BMD, and oral contraceptives.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
... Issue Date: 30-Sep-2007. Citation: Salama K, El-Koofy N, El-Hawary M, El-Raziky M, Abou-El El... more ... Issue Date: 30-Sep-2007. Citation: Salama K, El-Koofy N, El-Hawary M, El-Raziky M, Abou-El Ela M, Ali H, El-Karaksy H. Thrombophilic factors in Egyptian children with portal vein thrombosis. Indian Journal of Gastroenterology. 2007 Sep-Oct; 26(5): 252-3. Language: eng. ...
Image Quality and System Performance II, 2005
This paper evaluates the operation of self-correcting active pixel sensors presented in [6] using... more This paper evaluates the operation of self-correcting active pixel sensors presented in [6] using Signal-to-Noise Ratio. The evaluation is based on a simplified Active Pixel Sensing (APS) model. We show that in the absence of stuck faults (i.e., no errors) the performance of the system suffers from considerable degradation especially at low illumination (i.e., typical indoor scenes). We use the same model to quantify the number of defective pixels under which self correction is beneficial.
Egyptian Pediatric Association Gazette, 2013
Background: Treatment of anemia in children with predialysis chronic kidney disease (CKD) has bee... more Background: Treatment of anemia in children with predialysis chronic kidney disease (CKD) has been facilitated by the administration of recombinant human erythropoietin (rHuEpo). The aim of this study was to evaluate the effect of rHuEpo on the correction of anemia and to study its effect on the progression of CKD in predialysis patients. Methods: This study was done at the New Children's Hospital, Cairo University, included 40 patients with CKD and renal anemia on conservative management. The patients were divided into two groups; group I (received rHuEpo) and group II (did not receive rHuEpo). For all patients, clinical assessment and routine laboratory investigation were recorded every 2 weeks, in addition to iron indices and ultrasonography. Glomerular filtration rate (GFR) was calculated every 2 weeks and the rate of decline of GFR (DGFR) was determined over 6 months preceding starting follow up. GFR was also determined over a follow up period of 12 months. Results: There was a statistically significant difference between the initial and final levels of hemoglobin (Hb) and hematocrit (Hct) in group I. Also, there was a statistically significant difference between the two groups as regards Hb and Hct levels at the end of the study. The progression of CKD is already slower before T0 (the time of starting rHuEpo administration) in group I and also decreased after T0, with highly statistically significant difference. Conclusion: The study concluded that rHuEpo therapy is beneficial for correction of renal anemia and its early treatment is a useful intervention for slowing the progression in patients with CKD.