Lee Perry - Academia.edu (original) (raw)

Papers by Lee Perry

International Journal of Leadership in Education, 2006

... The article raises questions about the implications of all this for staff development in gene... more ... The article raises questions about the implications of all this for staff development in general ... productivity in terms of student learning, are translated into quite precise quantitative measures that ... market are those that can shift their focus and commitment from 'distributive justice' to ...

Annals of Allergy Asthma & Immunology, 2009

Pregnancy alters the function of many body systems, including the immune system. However, little ... more Pregnancy alters the function of many body systems, including the immune system. However, little is known regarding the effect of pregnancy on maternal IgE levels or atopy.To determine whether pregnancy consistently influences serum levels of total or allergen specific IgE.Blood samples were obtained from 764 women during the third trimester of pregnancy and 1 month post partum. A third sample was obtained from 106 of these women 1 year post partum. Samples were analyzed for total and specific IgE to 8 regionally common allergens using a commercially available system. Sensitization was defined as an allergen specific IgE level of 0.35 kU of allergen per liter or higher to any allergen.Total IgE increased significantly post partum, both at 1 month (40.36 vs 35.37 IU/mL intrapartum; P = .001) and at 1 year (44.97 vs 37.00 IU/mL intrapartum; P = .005). Allergen specific IgE decreased significantly at 1 month for cat, dog, ragweed, timothy grass, and egg (P = .001 to P = .02) but not for dust mite, cockroach, or Alternaria (P = .15 to P = .90). Similar patterns of change in total and specific IgE were seen at 1 year. However, on average, only 3.5% of participants changed sensitization status to the individual allergens studied during the 1 year of observation.Compared with intrapartum levels, total IgE levels increased significantly at 1 month and 1 year post partum. Conversely, at the same time points, IgE levels specific for common allergens significantly declined to most but not all allergens. Few women changed their sensitization status over 1 year.

Neuropsychologia, 2009

We describe the case of a child (“S”) who was treated with radiation therapy at age 5 for a recur... more We describe the case of a child (“S”) who was treated with radiation therapy at age 5 for a recurrent malignant brain tumor. Radiation successfully abolished the tumor but caused radiation-induced tissue necrosis, primarily affecting cerebral white matter. S was introduced to us at age 15 because of her profound dyslexia. We assessed cognitive abilities and performed diffusion tensor imaging (DTI) to measure cerebral white matter pathways. Diffuse white matter differences were evident in T1-weighted, T2-weighted, diffusion anisotropy, and mean diffusivity measures in S compared to a group of 28 normal female controls. In addition, we found specific white matter pathway deficits by comparing tensor-orientation directions in S's brain with those of the control brains. While her principal diffusion direction maps appeared consistent with those of controls over most of the brain, there were tensor-orientation abnormalities in the fiber tracts that form the superior longitudinal fasciculus (SLF) in both hemispheres. Tractography analysis indicated that the left and right arcuate fasciculus (AF), as well as other tracts within the SLF, were missing in S. Other major white matter tracts, such as the corticospinal and inferior occipitofrontal pathways, were intact. Functional MRI measurements indicated left-hemisphere dominanance for language with a normal activation pattern. Despite the left AF abnormality, S had preserved oral language with average sentence repetition skills. In addition to profound dyslexia, S exhibited visuospatial, calculation, and rapid naming deficits and was impaired in both auditory and spatial working memory. We propose that the reading and visuospatial deficits were due to the abnormal left and right SLF pathways, respectively. These results advance our understanding of the functional significance of the SLF and are the first to link radiation necrosis with selective damage to a specific set of fiber tracts.

Journal of Neuroimmunology, 2010

Diffusion tensor imaging is widely used to evaluate the development of white matter. Information ... more Diffusion tensor imaging is widely used to evaluate the development of white matter. Information about how alterations in major neurotransmitter systems, such as the dopamine (DA) system, influence this development in healthy children, however, is lacking. Catechol-O-metyltransferase (COMT) is the major enzyme responsible for DA degradation in prefrontal brain structures, for which there is a corresponding genetic polymorphism (val158met) that confers either a more or less efficient version of this enzyme. The result of this common genetic variation is that children may have more or less available synaptic DA in prefrontal brain regions. In the present study we examined the relation between diffusion properties of frontal white matter structures and the COMT val158met polymorphism in 40 children ages 9–15. We found that the val allele was associated with significantly elevated fractional anisotropy values and reduced axial and radial diffusivities. These results indicate that the development of white matter in healthy children is related to COMT genotype and that alterations in white matter may be related to the differential availability of prefrontal DA. This investigation paves the way for further studies of how common functional variants in the genome might influence the development of brain white matter.

The Journal of Neuroscience, Apr 11, 2012

Frontostriatal circuits have been implicated in reward learning, and emerging findings suggest th... more Frontostriatal circuits have been implicated in reward learning, and emerging findings suggest that frontal white matter structural integrity and probabilistic reward learning are reduced in older age. This cross-sectional study examined whether age differences in frontostriatal white matter integrity could account for age differences in reward learning in a community life span sample of human adults. By combining diffusion tensor imaging with a probabilistic reward learning task, we found that older age was associated with decreased reward learning and decreased white matter integrity in specific pathways running from the thalamus to the medial prefrontal cortex and from the medial prefrontal cortex to the ventral striatum. Further, white matter integrity in these thalamocorticostriatal paths could statistically account for age differences in learning. These findings suggest that the integrity of frontostriatal white matter pathways critically supports reward learning. The findings also raise the possibility that interventions that bolster frontostriatal integrity might improve reward learning and decision making.

Academy of Management Executive, 1988

G eneral George F. Doriot, an early venture capitalist, founded American Research and Development... more G eneral George F. Doriot, an early venture capitalist, founded American Research and Development Cor-poration (ARD) in 1946. Doriot, a professor at the Harvard Graduate School of Business Administration, was concerned that the business climate around Boston lacked vitality. He ...

Strategic Management Journal, 2004

... Received 2 March 2003 Final revision received 7 June 2004 Page 2. 1280 MH Hansen, LT Perry an... more ... Received 2 March 2003 Final revision received 7 June 2004 Page 2. 1280 MH Hansen, LT Perry and CS Reese ... Page 4. 1282 MH Hansen, LT Perry and CS Reese research is the RBV, it is precisely this distinc-tion that makes the focus on administrative deci-sions sensible. ...

Organizational Dynamics, 1986

The demand for services provided by a telecommunications firm dropped sharply during the 1979 rec... more The demand for services provided by a telecommunications firm dropped sharply during the 1979 recession. The company had no history of layoffs. Because it was in a regulated industry and its rate-of-return was guaranteed, the firm was buffered from many of the usual ...

Organizational Dynamics, 1981

... Professor Barney received his training in Sociology and Administrative Sciences at Yale Unive... more ... Professor Barney received his training in Sociology and Administrative Sciences at Yale University. ... If a family is experiencing financial difficulties, for example, a home visitor will inform his or her department manager, who in turn will inform the branch manager. ...

Strategic Management Journal, 1982

Strategic Management Journal, 2004

This paper argues that the gap between the theoretical utility and the practical utility of the r... more This paper argues that the gap between the theoretical utility and the practical utility of the resource-based view (RBV) may be narrowed by operationalizing the theory more consistently with Penrose's original framework. The operationalization proposed here is a twofold approach. First, the RBV may be enhanced by the explicit recognition of Penrose's two classes of resources, namely, administrative resources and productive resources. This distinction suggests a focus on the administrative decisions of managers that lead to economic performance. Second, we argue that the RBV is a theory about extraordinary performers or outliers—not averages. Therefore, the statistical methods used in applying the theory must account for individual firm differences, and not be based on means, which statistically neutralize firm differences. We propose a novel Bayesian hierarchical methodology to examine the relationship between administrative decisions and economic performance over time. We develop and explain a measure of competitive advantage that goes beyond comparisons of economic performance. This Bayesian methodology allows us to make meaningful probability statements about specific, individual firms and the effects of the administrative decisions examined in this study. Copyright © 2004 John Wiley & Sons, Ltd.

Human Resource Management, 1984

increasingly e n , executives are being called upon to manage arganizations through downturns. Of... more increasingly e n , executives are being called upon to manage arganizations through downturns. Of critical importance to the long-term health ofa firm is how its employees are treated during these stresfid periods. Human m u r c e strutegies must minimize the loss of key personnel newied fbr organizutional survival and turnaround. The purpose of this article is to discuss why key empl oyees lemte organizations following a daunturn. We propose two reasons: Either employees alnmdon a sinking ship or upon considtrng a lack of career oppmtunities, they take weil-timed exits. Thep, by consideting individual career issues that arise from an osganirption downturn, ways to c a i M ill-timed employee exit are ident@ed. ' Ilrese h u m n resource strategies eitker reduce organizational uncertainty or increase w e e r opportunity.

Human Resource Management, 1996

NezIer liefore 110s there O e o i so n i u h orpriizatiorial restrircfirriti<y, in spite of consi... more NezIer liefore 110s there O e o i so n i u h orpriizatiorial restrircfirriti<y, in spite of consisten t /y mixed rcs u/ts, T/I is a rt iclc argues that t/ic reas0 ti o r p n iznt io t la/ rest ruct 11 rin<y so often fails to iricrrase productiz~ity arid profit is that it is not guided by business stratc<yy. While rriost rriatiacyers agree that structure sliould fdlow stratf<y.y, ~L W J haue a process for rnozIiiig from strategy to restructuring at the business lezd, uhrre rnost restructuring occurs. A nurritw of businesses, Iiozoez~er, 1ime Iiased restritcturir~g decisions on a clear arid ziJell-iiridsrstood strategy. This article descrities zdiat is coninion to t/ic7 [irocesscs t h s c businesses hazv followed. Hurnari resou ice i r i a r i a p w , zohose role and conipetcnce sh~itld include thc nligritnent of c/iari~yc processes zi~ith liirsitiess needs, hazic often alidicatcd rrsporisitiility for ensuring that restructuring ifforts are strate'yic orid are coinpctcntly iinpletncntrd.