Lila Summer - Academia.edu (original) (raw)
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Islamic Azad University, Hamedan Branch - Hamedan
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... Rapid testing is best done using EM to identify actual virions and real-time PCR assays to de... more ... Rapid testing is best done using EM to identify actual virions and real-time PCR assays to detect viral DNA. These tests are highly sensitive if adequate specimens are provided to the laboratory (Kulesh et al., 2004; Ropp et al., 1995; Sofi et al., 2003). ...
Smallpox, the only disease ever eradicated, is one of the six pathogens considered a serious thre... more Smallpox, the only disease ever eradicated, is one of the six pathogens considered a serious threat for biological terrorism (Henderson et al., 1999; Mahy, 2003; Whitley, 2003). Smallpox has several attributes that make it a potential threat. It can be grown in large amounts. It spreads via the respiratory route. It has a 30% mortality rate. The potential for an attack using smallpox motivated President Bush to call for phased vaccination of a substantial number of American health care and public health workers (Grabenstein and Winkenwerder, 2003; Stevenson and Stolberg, 2002). Following September 11, 2001, the United States rebuilt its supplies of vaccine and Vaccinia Immune Globulin (VIG), expanded the network of laboratories capable of testing for variola virus, and engaged in a broad education campaign to help health care workers and the general public understand the disease (Centers for Disease Control and Prevention, 2003a). This chapter summarizes the scientific and theoretical bases for use of smallpox as a bioweapon and options for preparation for defense against it.
... Rapid testing is best done using EM to identify actual virions and real-time PCR assays to de... more ... Rapid testing is best done using EM to identify actual virions and real-time PCR assays to detect viral DNA. These tests are highly sensitive if adequate specimens are provided to the laboratory (Kulesh et al., 2004; Ropp et al., 1995; Sofi et al., 2003). ...
Smallpox, the only disease ever eradicated, is one of the six pathogens considered a serious thre... more Smallpox, the only disease ever eradicated, is one of the six pathogens considered a serious threat for biological terrorism (Henderson et al., 1999; Mahy, 2003; Whitley, 2003). Smallpox has several attributes that make it a potential threat. It can be grown in large amounts. It spreads via the respiratory route. It has a 30% mortality rate. The potential for an attack using smallpox motivated President Bush to call for phased vaccination of a substantial number of American health care and public health workers (Grabenstein and Winkenwerder, 2003; Stevenson and Stolberg, 2002). Following September 11, 2001, the United States rebuilt its supplies of vaccine and Vaccinia Immune Globulin (VIG), expanded the network of laboratories capable of testing for variola virus, and engaged in a broad education campaign to help health care workers and the general public understand the disease (Centers for Disease Control and Prevention, 2003a). This chapter summarizes the scientific and theoretical bases for use of smallpox as a bioweapon and options for preparation for defense against it.