Lisa Forsén - Academia.edu (original) (raw)
Papers by Lisa Forsén
European Journal of Ageing, 2008
The aim of the present study was to identify predictors for initial uptake and adherence with the... more The aim of the present study was to identify predictors for initial uptake and adherence with the use of hip protectors when offering hip protectors free of charge to nursing-home residents. An 18 months prospective follow up study was carried out in 18 Norwegian nursing homes. One thousand two hundred and thirty-six residents were included in the study of which 604
Bone, 2015
Background: The Norwegian population has among the highest hip fracture rates in the world. The i... more Background: The Norwegian population has among the highest hip fracture rates in the world. The incidence varies geographically, also within Norway. Calcium in drinking water has been found to be beneficially associated with bone health in some studies, but not in all. In most previous studies, other minerals in water have not been taken into account. Trace minerals, for which drinking water can be an important source and even fulfill the daily nutritional requirement, could act as effect-modifiers in the association between calcium and hip fracture risk. The aim of the present study was to investigate the association between calcium in drinking water and hip fracture, and whether other water minerals modified this association. Materials and methods: A survey of trace metals in 429 waterworks, supplying 64% of the population in Norway, was linked geographically to the home addresses of patients with incident hip fractures (1994)(1995)(1996)(1997)(1998)(1999)(2000). Drinking water mineral concentrations were divided into "low" (below and equal waterworks average) and "high" (above waterworks average). Poisson regression models were fitted, and all incidence rate ratios (IRRs) were adjusted for age, geographic region, urbanization degree, type of water source, and pH of the water. Effect modifications were examined by stratification, and interactions between calcium and magnesium, copper, zinc, iron and manganese were tested both on the multiplicative and the additive scale. Analyses were stratified on gender. Results: Among those supplied from the 429 waterworks (2,110,916 person-years in men and 2,397,217 personyears in women), 5433 men and 13,493 women aged 50-85 years suffered a hip fracture during 1994-2000. Compared to low calcium in drinking water, a high level was associated with a 15% lower hip fracture risk in men (IRR = 0.85, 95% CI: 0.78, 0.91) but no significant difference was found in women (IRR = 0.98, 95%CI: 0.93-1.02). There was interaction between calcium and copper on hip fracture risk in men (p = 0.051); the association between calcium and hip fracture risk was stronger when the copper concentration in water was high (IRR = 0.52, 95% CI: 0.35, 0.78) as opposed to when it was low (IRR = 0.88, 95% CI: 0.81, 0.94). This pattern persisted also after including potential confounding factors and other minerals in the model. No similar variation in risk was found in women. Conclusion: In this large, prospective population study covering two thirds of the Norwegian population and comprising 19,000 hip fractures, we found an inverse association between calcium in drinking water and hip fracture risk in men. The association was stronger when the copper concentration in the water was high.
![Research paper thumbnail of Randomised controlled trial of a theoretically grounded tailored intervention to diffuse evidence-based public health practice [ISRCTN23257060]](https://attachments.academia-assets.com/42054938/thumbnails/1.jpg)
](BMC medical education, Jan 13, 2003
Previous studies have shown that Norwegian public health physicians do not systematically and exp... more Previous studies have shown that Norwegian public health physicians do not systematically and explicitly use scientific evidence in their practice. They work in an environment that does not encourage the integration of this information in decision-making. In this study we investigate whether a theoretically grounded tailored intervention to diffuse evidence-based public health practice increases the physicians' use of research information. 148 self-selected public health physicians were randomised to an intervention group (n = 73) and a control group (n = 75). The intervention group received a multifaceted intervention while the control group received a letter declaring that they had access to library services. Baseline assessments before the intervention and post-testing immediately at the end of a 1.5-year intervention period were conducted. The intervention was theoretically based and consisted of a workshop in evidence-based public health, a newsletter, access to a specially...
Scandinavian Journal of Public Health, 2003
This study was undertaken to estimate the effect of hip protectors on the incidence of hip fractu... more This study was undertaken to estimate the effect of hip protectors on the incidence of hip fracture when introduced into nursing homes as a regular part of the healthcare for all residents. A pre-test/test design was used. The pre-intervention period lasted 18 months from May 1996. The intervention period lasted 18 months from May 1998. During the intervention period all residents (965 beds) in nursing homes in two municipalities in Norway were offered free use of hip protectors. The project manager provided motivational activities in the nursing homes during the whole period, aimed at increasing the participation rate. The intervention period showed a 39% reduction in the hip fracture incidence when compared with the pre-intervention period (p = 0.003). The percentage of daily users of the protector varied from 35% during the first months to 22% at the end of the period. Among the 61 persons who suffered a hip fracture 31 were registered as daily users. Fourteen of the 31 users were not wearing the protector when the hip fracture occurred, while five of the 31 had the protector on their knees. Twelve of the 31 suffered a hip fracture while properly wearing the protector. This non-randomized study showed that hip protectors introduced to all residents in nursing homes considerably reduced the incidence of hip fracture. It may be possible to achieve higher compliance and a further reduction in the incidence of hip fractures if the producers of hip protectors increase the comfort of the protector without reducing its effect. In addition, it is important that health workers encourage more individuals at high risk to use the protector.
Osteoporosis International, 2005
The fracture incidence in Norway is among the highest in Europe, presumably due to osteoporosis. ... more The fracture incidence in Norway is among the highest in Europe, presumably due to osteoporosis. As part of a multipurpose health study in the county of Nord-Trøndelag, Norway (the HUNT study), a 5% randomly selected sample (n=4,646) of the population >19 years of age was invited to undergo single X-ray absorptiometry (SXA) of the forearm. A total of 1,274 men (50.5 years) and 1,505 women (49.9 years) participated (60%). The aim of the study was to describe the variation in bone mineral density (BMD) and the prevalence of forearm BMD 2.5 standard deviations (SD) below the mean value for young adults in an unselected population sample. In women the BMD remained stable until the age of 50 years, whereupon a strong decline in BMD was observed. In men, a BMD increase was observed until about the age of 40 years; the decline after the age of 65 was, however, similar to that in women. Based on age and gender-specific reference values, the age-adjusted prevalence of T-scores <)2.5 SD in women and men aged 50-69 years was 16.0% and 5.6%, respectively. In the age group of 70 years or older the prevalence was 65.8% and 30.6% for women and men, respectively. The accelerated BMD reduction in women aged 50-65 explains the higher prevalence of T-score <)2.5 SD in elderly women than in men. Further studies on bone loss and falls are required to explain the high fracture incidence in Norway.
Journal of Clinical Densitometry, 2008
The purpose of this study was to assess the agreement of in vivo hip scans on 3 densitometers (1 ... more The purpose of this study was to assess the agreement of in vivo hip scans on 3 densitometers (1 GE Lunar DPX-IQ and 2 GE Lunar Prodigy scanners) and to evaluate whether the European Spine Phantom (ESP) was able to reproduce the in vivo variability. Sixteen subjects had 3 repeated scans (with repositioning) on each densitometer, and the ESP was measured on each densitometer at least 40 times. Mean differences between hip scans on the Prodigy scanners were small and insignificant, and the in vivo results were not significantly different from the in vitro results. Bland and Altman plots showed no systematic differences between the Prodigy scanners over the range of bone mineral density (BMD). On the other hand, differences between Prodigy and DPX-IQ changed systematically over the range of BMD. The ESP did not fully reproduce the in vivo difference between Prodigy and DPX-IQ. In conclusion, the ESP is a valid substitute when assessing agreement between Prodigy scanners. However, when assessing agreement between different types of scanners, substitution of in vivo with in vitro measurements should be made with caution.
Journal of Bone and Mineral Research, 2009
European Journal of Epidemiology, 2009
The objective of the study was to examine the predictive effect of prospectively registered falls... more The objective of the study was to examine the predictive effect of prospectively registered falls on survival within a randomly selected group of elderly women. A longitudinal study, with 9 years follows up after 1 year prospective fall registration was designed. Persons age 75 or more living in the community. A total of 300 Norwegian women; mean age was 80.8 participated in the study. Baseline registrations of health, functioning and medication were made. Falls which occurred during a 1-year period after baseline were registered as well as the date of death within a 9-year period after the end of the fall registration period. Half of the women reported one or more falls (1-11). Eightysix women (28.7%) experienced only one fall and 65 (21.7%) had at least two. During the 9-year follow-up period, 41.7% died. Cox regression analyzes demonstrated that frequent falling, old age and a self-reported worsening of health were significantly associated with mortality during the follow-up period. Their relative risks of death when experiencing at least two falls was 1.6 (95% CI 1.1-2.4), P = 0.04, when compared with no falls. Older fallers appear to have markedly increased mortality. Since falls are common among elderly people, this is a relevant fact for public health policy. Increasing age, poor self-rated health and high frequency of falls predict independently mortality in our 9 years follow up study. Because women represent the largest proportion of the elderly and falls are amendable, fall preventive may have the potential for significant impact on increasing year of life.
European Journal of Epidemiology, 2008
The aims were to compare the precision (reliability) in single X-ray (SXA) and dual X-ray (DXA) a... more The aims were to compare the precision (reliability) in single X-ray (SXA) and dual X-ray (DXA) absorptiometry, and to compare smallest detectable difference (SDD). An additional aim was to examine determinants for precision in bone mineral density (BMD). BMD was measured by SXA (DTX-100, Osteometer) in the forearm and by DXA (Lunar Expert) in the forearm and in the hip. Two measurements were performed at each site/method, and 195 of 207 participants had complete datasets. Participants were aged 47-49 and 71-74 years. The precision was estimated by Root Mean Square Standard Deviation (RMS SD) with 95% Confidence Interval (95%CI) and the corresponding coefficients of variation (CV%). Determinants (age, gender, BMD) were analysed by multiple linear regression with log (SD) and log (CV) as dependent variables. RMS SD tended to be largest in older women and in those with low BMD. RMS SD for SXA and DXA forearm was 4.6 (4.2-5.1) and 6.8 (6.1-7.4) and the corresponding CVs 1.0% and 1.4%. RMS SD for DXA hip was 11.0 (9.9-12.0) with CV 1.2%. To detect a 3% change in BMD one would need two repeated measurements by DXA in the distal forearm at each of two consultations, but only one measurement by SXA in the distal forearm and also only one measurement by DXA in the hip. Precision differed by type of densitometer affecting the number of repeated measurements needed to detect a given BMD difference.
Bulletin of the World Health Organization, 2006
Objective To study the levels and causes of maternal mortality in St. Petersburg, Russian Federat... more Objective To study the levels and causes of maternal mortality in St. Petersburg, Russian Federation.
American Journal of Obstetrics and Gynecology, 2009
OBJECTIVE: Our purpose was to study the impact of labor onset and delivery mode on the risk of se... more OBJECTIVE: Our purpose was to study the impact of labor onset and delivery mode on the risk of severe postpartum hemorrhage.
American Journal of Epidemiology, 2002
Maximizing attainment of optimal peak bone mineral density (BMD) is a potential osteoporosis prev... more Maximizing attainment of optimal peak bone mineral density (BMD) is a potential osteoporosis prevention strategy. The main objective of this study was to identify correlates of forearm BMD in young adult women. Population-based data derived from standardized questionnaires administered to healthy women aged 19-35 years in Nord-Trøndelag, Norway (n = 963), were collected in 1995-1997. Forearm BMD was assessed by single x-ray absorptiometry. Multiple linear and logistic regression analyses were used to determine correlates of BMD (g/cm 2 ) and lowest quintile of BMD, respectively, at the ultradistal and distal sites. The mean age and weight of the cohort were 29.7 years (standard deviation 4.7) and 68.6 kg (standard deviation 12.5), respectively. Age and weight were positively associated with BMD at both forearm sites. When data were controlled for age and weight, later age at menarche and lack of milk consumption were associated with lower BMD values. In both linear models and logistic models, none of the factors vitamin D intake, physical activity, smoking, alcohol consumption, amenorrhea, oral contraceptive use, number of pregnancies, history of breastfeeding, and family history of osteoporosis were found to be significantly associated with BMD. Prior studies have suggested that calcium supplementation in children is useful for optimizing peak BMD. Further studies exploring the relation between lifestyle factors and BMD are warranted to search for ways to maximize attainment of peak BMD. Am J Epidemiol 2002;156:418-27. bone density; cross-sectional studies; forearm; osteoporosis; women's health Abbreviation: BMD, bone mineral density.
Aging Clinical and Experimental Research, 2011
To determine the diagnostic accuracy of three different methods for identifying individuals at hi... more To determine the diagnostic accuracy of three different methods for identifying individuals at high risk of falling. The St- Thomas Risk Assessment tool (STRATIFY- modified for nursing homes), staff judgment of fall risk, and previous falls remembered by the staff were evaluated. We also examined whether a combination of two of the methods would increase accuracy. A prospective observational cohort study was carried out for 18 months. One thousand one hundred and forty-eight participants were included and assessed for fall risk. Falls among these residents were recorded from the date of inclusion to the date of death, transfer, or end of observation time. Diagnostic accuracy was evaluated in terms of sensitivity, specificity, predictive values and likelihood ratios, as well as Kaplan-Meier estimates and the Cox proportional hazard model, with time to the first fall as the dependent variable. Sensitivity, specificity, predictive value and likelihood ratios were calculated for falls within 30, 90 and 180 days of assessment for fall risk. Five hundred and seventy (49.6%) of the 1148 residents had one or more falls during the observation period. One thousand one hundred had more than 30 days of observation, 987 more than 90 days, and 867 more than 180 days. For falls within 30 days of assessment for fall risk, sensitivity varied from 65% to 72%, specificity from 69% to 75%, positive predictive value from 31% to 35% and negative predictive value from 91% to 92%. Sensitivity and negative predictive value decreased for falls within 90 days and decreased further for falls within 180 days, whereas specificity and positive predictive value increased for all three assessment methods. Staff judgment of fall risk was the single method having the highest sensitivity but the lowest specificity. A combination of either two of them increased sensitivity to more than 80%, but decreased specificity. The positive Likelihood ratio varied from 2.24 to 2.70 and the negative Likelihood ratio from 0.41 to 0.49 for falls within 30 days. The relative risk of sustaining a fall was 2.4, 2.9 and 3.0 times higher for those assessed to be at high risk of falls compared with those assessed to be at low risk, according to STRATIFY, staff judgment of fall risk and previous falls remembered by the staff, respectively. The diagnostic accuracy of the three methods did not differ markedly. However, staff judgment had the highest sensitivity and the lowest specificity after 30, 90 and 180 days. A combination of either two of the methods showed the highest sensitivity but the lowest specificity.
Acta Obstetricia et Gynecologica Scandinavica, 2013
To validate uterine rupture registration in the Medical Birth Registry of Norway (MBRN) between 1... more To validate uterine rupture registration in the Medical Birth Registry of Norway (MBRN) between 1999 and 2008, and to identify rupture type and causes of incorrect or missed registration during 1967-2008. Population-based study. The validation sample was 392,958 maternities from 21 maternity units registered in MBRN and local Patient Administration Systems in 1999-2008. In addition we identified type of rupture and causes of incorrect registration among 2,422,934 maternities from 48 units, and 1,449,201 maternities from 21 units during 1967-2008. Information about uterine rupture in MBRN was compared with information in medical records. Sensitivity, specificity, positive and negative predictive value of uterine rupture registration in MBRN. In 1999-2008, there were 10 false positive cases among 151 uterine ruptures registered in MBRN. In addition, 82 ruptures not registered in MBRN, were identified through Patient Administration Systems. The sensitivity, specificity, positive and negative predictive value of the MBRN to detect uterine rupture was 63.2, 99.99, 93.4 and 99.98%, respectively. The incidence of uterine rupture changed after correction from 0.38 to 0.56/1000. During 1967-2008, false positive cases (125) were mainly due to wrong coding by MBRN. Around 60% of 141 false negative cases were due to lack of reporting by maternity units. Complete rupture accounted for 63.9% of ruptures registered in MBRN. The validity of MBRN data on uterine rupture is not optimal, diagnosis being under-reported by around 37%. Ticked boxes may improve the quality of registration.
Sports Medicine, 2010
Objective: To systematically review and appraise studies examining selfadministered physical acti... more Objective: To systematically review and appraise studies examining selfadministered physical activity questionnaires (PAQ) for the elderly. This article is one of a group of four articles in Sports Medicine on the content and measurement properties of PAQs. Literature Search Methodology: Searches in PubMed. EMBASE and SportDiscus® (until May 2009) on self-administered PAQ. Inclusion criteria were as follows: (i) the study examined (at least one oQ the measurement properties of a self-administered PAQ; (ii) the questionnaire aimed to measure physical activity (PA) in older people; (iii) the average age of the study population was >55 years; (iv) the article was written in English. We excluded PA interviews, diaries and studies that evaluated the measurement properties of a self-administered PAQ in a specific population, such as patients. We used a standard checklist (qualitative attributes and measurement properties of PA questionnaires [QAPAQ]) for appraising the measurement properties of PAQs. Findings: Eighteen articles on 13 PAQs were reviewed, including 16 reliability analyses and 25 validity analyses (of which 15 were on construct validity, seven on health/functioning associations, two on known-groups validity and one on responsiveness). Many studies suffered from methodological Haws, e.g. too small sample size or Inadequate time interval between test and retest. Three PAQs received a positive rating on reliability: IPAQ-C (International Physical Aetivity Questionnaire-Chinese), intraclass correlation coefficient (ICC) >0.81; WHI-PAQ (Women's Health Initiative-PAQ), ICC = 0.76; and PASE (Physical Activity Scale for the Elderly), Pearson correlation
European Journal of Ageing, 2008
The aim of the present study was to identify predictors for initial uptake and adherence with the... more The aim of the present study was to identify predictors for initial uptake and adherence with the use of hip protectors when offering hip protectors free of charge to nursing-home residents. An 18 months prospective follow up study was carried out in 18 Norwegian nursing homes. One thousand two hundred and thirty-six residents were included in the study of which 604
Bone, 2015
Background: The Norwegian population has among the highest hip fracture rates in the world. The i... more Background: The Norwegian population has among the highest hip fracture rates in the world. The incidence varies geographically, also within Norway. Calcium in drinking water has been found to be beneficially associated with bone health in some studies, but not in all. In most previous studies, other minerals in water have not been taken into account. Trace minerals, for which drinking water can be an important source and even fulfill the daily nutritional requirement, could act as effect-modifiers in the association between calcium and hip fracture risk. The aim of the present study was to investigate the association between calcium in drinking water and hip fracture, and whether other water minerals modified this association. Materials and methods: A survey of trace metals in 429 waterworks, supplying 64% of the population in Norway, was linked geographically to the home addresses of patients with incident hip fractures (1994)(1995)(1996)(1997)(1998)(1999)(2000). Drinking water mineral concentrations were divided into "low" (below and equal waterworks average) and "high" (above waterworks average). Poisson regression models were fitted, and all incidence rate ratios (IRRs) were adjusted for age, geographic region, urbanization degree, type of water source, and pH of the water. Effect modifications were examined by stratification, and interactions between calcium and magnesium, copper, zinc, iron and manganese were tested both on the multiplicative and the additive scale. Analyses were stratified on gender. Results: Among those supplied from the 429 waterworks (2,110,916 person-years in men and 2,397,217 personyears in women), 5433 men and 13,493 women aged 50-85 years suffered a hip fracture during 1994-2000. Compared to low calcium in drinking water, a high level was associated with a 15% lower hip fracture risk in men (IRR = 0.85, 95% CI: 0.78, 0.91) but no significant difference was found in women (IRR = 0.98, 95%CI: 0.93-1.02). There was interaction between calcium and copper on hip fracture risk in men (p = 0.051); the association between calcium and hip fracture risk was stronger when the copper concentration in water was high (IRR = 0.52, 95% CI: 0.35, 0.78) as opposed to when it was low (IRR = 0.88, 95% CI: 0.81, 0.94). This pattern persisted also after including potential confounding factors and other minerals in the model. No similar variation in risk was found in women. Conclusion: In this large, prospective population study covering two thirds of the Norwegian population and comprising 19,000 hip fractures, we found an inverse association between calcium in drinking water and hip fracture risk in men. The association was stronger when the copper concentration in the water was high.
BMC medical education, Jan 13, 2003
Previous studies have shown that Norwegian public health physicians do not systematically and exp... more Previous studies have shown that Norwegian public health physicians do not systematically and explicitly use scientific evidence in their practice. They work in an environment that does not encourage the integration of this information in decision-making. In this study we investigate whether a theoretically grounded tailored intervention to diffuse evidence-based public health practice increases the physicians' use of research information. 148 self-selected public health physicians were randomised to an intervention group (n = 73) and a control group (n = 75). The intervention group received a multifaceted intervention while the control group received a letter declaring that they had access to library services. Baseline assessments before the intervention and post-testing immediately at the end of a 1.5-year intervention period were conducted. The intervention was theoretically based and consisted of a workshop in evidence-based public health, a newsletter, access to a specially...
Scandinavian Journal of Public Health, 2003
This study was undertaken to estimate the effect of hip protectors on the incidence of hip fractu... more This study was undertaken to estimate the effect of hip protectors on the incidence of hip fracture when introduced into nursing homes as a regular part of the healthcare for all residents. A pre-test/test design was used. The pre-intervention period lasted 18 months from May 1996. The intervention period lasted 18 months from May 1998. During the intervention period all residents (965 beds) in nursing homes in two municipalities in Norway were offered free use of hip protectors. The project manager provided motivational activities in the nursing homes during the whole period, aimed at increasing the participation rate. The intervention period showed a 39% reduction in the hip fracture incidence when compared with the pre-intervention period (p = 0.003). The percentage of daily users of the protector varied from 35% during the first months to 22% at the end of the period. Among the 61 persons who suffered a hip fracture 31 were registered as daily users. Fourteen of the 31 users were not wearing the protector when the hip fracture occurred, while five of the 31 had the protector on their knees. Twelve of the 31 suffered a hip fracture while properly wearing the protector. This non-randomized study showed that hip protectors introduced to all residents in nursing homes considerably reduced the incidence of hip fracture. It may be possible to achieve higher compliance and a further reduction in the incidence of hip fractures if the producers of hip protectors increase the comfort of the protector without reducing its effect. In addition, it is important that health workers encourage more individuals at high risk to use the protector.
Osteoporosis International, 2005
The fracture incidence in Norway is among the highest in Europe, presumably due to osteoporosis. ... more The fracture incidence in Norway is among the highest in Europe, presumably due to osteoporosis. As part of a multipurpose health study in the county of Nord-Trøndelag, Norway (the HUNT study), a 5% randomly selected sample (n=4,646) of the population >19 years of age was invited to undergo single X-ray absorptiometry (SXA) of the forearm. A total of 1,274 men (50.5 years) and 1,505 women (49.9 years) participated (60%). The aim of the study was to describe the variation in bone mineral density (BMD) and the prevalence of forearm BMD 2.5 standard deviations (SD) below the mean value for young adults in an unselected population sample. In women the BMD remained stable until the age of 50 years, whereupon a strong decline in BMD was observed. In men, a BMD increase was observed until about the age of 40 years; the decline after the age of 65 was, however, similar to that in women. Based on age and gender-specific reference values, the age-adjusted prevalence of T-scores <)2.5 SD in women and men aged 50-69 years was 16.0% and 5.6%, respectively. In the age group of 70 years or older the prevalence was 65.8% and 30.6% for women and men, respectively. The accelerated BMD reduction in women aged 50-65 explains the higher prevalence of T-score <)2.5 SD in elderly women than in men. Further studies on bone loss and falls are required to explain the high fracture incidence in Norway.
Journal of Clinical Densitometry, 2008
The purpose of this study was to assess the agreement of in vivo hip scans on 3 densitometers (1 ... more The purpose of this study was to assess the agreement of in vivo hip scans on 3 densitometers (1 GE Lunar DPX-IQ and 2 GE Lunar Prodigy scanners) and to evaluate whether the European Spine Phantom (ESP) was able to reproduce the in vivo variability. Sixteen subjects had 3 repeated scans (with repositioning) on each densitometer, and the ESP was measured on each densitometer at least 40 times. Mean differences between hip scans on the Prodigy scanners were small and insignificant, and the in vivo results were not significantly different from the in vitro results. Bland and Altman plots showed no systematic differences between the Prodigy scanners over the range of bone mineral density (BMD). On the other hand, differences between Prodigy and DPX-IQ changed systematically over the range of BMD. The ESP did not fully reproduce the in vivo difference between Prodigy and DPX-IQ. In conclusion, the ESP is a valid substitute when assessing agreement between Prodigy scanners. However, when assessing agreement between different types of scanners, substitution of in vivo with in vitro measurements should be made with caution.
Journal of Bone and Mineral Research, 2009
European Journal of Epidemiology, 2009
The objective of the study was to examine the predictive effect of prospectively registered falls... more The objective of the study was to examine the predictive effect of prospectively registered falls on survival within a randomly selected group of elderly women. A longitudinal study, with 9 years follows up after 1 year prospective fall registration was designed. Persons age 75 or more living in the community. A total of 300 Norwegian women; mean age was 80.8 participated in the study. Baseline registrations of health, functioning and medication were made. Falls which occurred during a 1-year period after baseline were registered as well as the date of death within a 9-year period after the end of the fall registration period. Half of the women reported one or more falls (1-11). Eightysix women (28.7%) experienced only one fall and 65 (21.7%) had at least two. During the 9-year follow-up period, 41.7% died. Cox regression analyzes demonstrated that frequent falling, old age and a self-reported worsening of health were significantly associated with mortality during the follow-up period. Their relative risks of death when experiencing at least two falls was 1.6 (95% CI 1.1-2.4), P = 0.04, when compared with no falls. Older fallers appear to have markedly increased mortality. Since falls are common among elderly people, this is a relevant fact for public health policy. Increasing age, poor self-rated health and high frequency of falls predict independently mortality in our 9 years follow up study. Because women represent the largest proportion of the elderly and falls are amendable, fall preventive may have the potential for significant impact on increasing year of life.
European Journal of Epidemiology, 2008
The aims were to compare the precision (reliability) in single X-ray (SXA) and dual X-ray (DXA) a... more The aims were to compare the precision (reliability) in single X-ray (SXA) and dual X-ray (DXA) absorptiometry, and to compare smallest detectable difference (SDD). An additional aim was to examine determinants for precision in bone mineral density (BMD). BMD was measured by SXA (DTX-100, Osteometer) in the forearm and by DXA (Lunar Expert) in the forearm and in the hip. Two measurements were performed at each site/method, and 195 of 207 participants had complete datasets. Participants were aged 47-49 and 71-74 years. The precision was estimated by Root Mean Square Standard Deviation (RMS SD) with 95% Confidence Interval (95%CI) and the corresponding coefficients of variation (CV%). Determinants (age, gender, BMD) were analysed by multiple linear regression with log (SD) and log (CV) as dependent variables. RMS SD tended to be largest in older women and in those with low BMD. RMS SD for SXA and DXA forearm was 4.6 (4.2-5.1) and 6.8 (6.1-7.4) and the corresponding CVs 1.0% and 1.4%. RMS SD for DXA hip was 11.0 (9.9-12.0) with CV 1.2%. To detect a 3% change in BMD one would need two repeated measurements by DXA in the distal forearm at each of two consultations, but only one measurement by SXA in the distal forearm and also only one measurement by DXA in the hip. Precision differed by type of densitometer affecting the number of repeated measurements needed to detect a given BMD difference.
Bulletin of the World Health Organization, 2006
Objective To study the levels and causes of maternal mortality in St. Petersburg, Russian Federat... more Objective To study the levels and causes of maternal mortality in St. Petersburg, Russian Federation.
American Journal of Obstetrics and Gynecology, 2009
OBJECTIVE: Our purpose was to study the impact of labor onset and delivery mode on the risk of se... more OBJECTIVE: Our purpose was to study the impact of labor onset and delivery mode on the risk of severe postpartum hemorrhage.
American Journal of Epidemiology, 2002
Maximizing attainment of optimal peak bone mineral density (BMD) is a potential osteoporosis prev... more Maximizing attainment of optimal peak bone mineral density (BMD) is a potential osteoporosis prevention strategy. The main objective of this study was to identify correlates of forearm BMD in young adult women. Population-based data derived from standardized questionnaires administered to healthy women aged 19-35 years in Nord-Trøndelag, Norway (n = 963), were collected in 1995-1997. Forearm BMD was assessed by single x-ray absorptiometry. Multiple linear and logistic regression analyses were used to determine correlates of BMD (g/cm 2 ) and lowest quintile of BMD, respectively, at the ultradistal and distal sites. The mean age and weight of the cohort were 29.7 years (standard deviation 4.7) and 68.6 kg (standard deviation 12.5), respectively. Age and weight were positively associated with BMD at both forearm sites. When data were controlled for age and weight, later age at menarche and lack of milk consumption were associated with lower BMD values. In both linear models and logistic models, none of the factors vitamin D intake, physical activity, smoking, alcohol consumption, amenorrhea, oral contraceptive use, number of pregnancies, history of breastfeeding, and family history of osteoporosis were found to be significantly associated with BMD. Prior studies have suggested that calcium supplementation in children is useful for optimizing peak BMD. Further studies exploring the relation between lifestyle factors and BMD are warranted to search for ways to maximize attainment of peak BMD. Am J Epidemiol 2002;156:418-27. bone density; cross-sectional studies; forearm; osteoporosis; women's health Abbreviation: BMD, bone mineral density.
Aging Clinical and Experimental Research, 2011
To determine the diagnostic accuracy of three different methods for identifying individuals at hi... more To determine the diagnostic accuracy of three different methods for identifying individuals at high risk of falling. The St- Thomas Risk Assessment tool (STRATIFY- modified for nursing homes), staff judgment of fall risk, and previous falls remembered by the staff were evaluated. We also examined whether a combination of two of the methods would increase accuracy. A prospective observational cohort study was carried out for 18 months. One thousand one hundred and forty-eight participants were included and assessed for fall risk. Falls among these residents were recorded from the date of inclusion to the date of death, transfer, or end of observation time. Diagnostic accuracy was evaluated in terms of sensitivity, specificity, predictive values and likelihood ratios, as well as Kaplan-Meier estimates and the Cox proportional hazard model, with time to the first fall as the dependent variable. Sensitivity, specificity, predictive value and likelihood ratios were calculated for falls within 30, 90 and 180 days of assessment for fall risk. Five hundred and seventy (49.6%) of the 1148 residents had one or more falls during the observation period. One thousand one hundred had more than 30 days of observation, 987 more than 90 days, and 867 more than 180 days. For falls within 30 days of assessment for fall risk, sensitivity varied from 65% to 72%, specificity from 69% to 75%, positive predictive value from 31% to 35% and negative predictive value from 91% to 92%. Sensitivity and negative predictive value decreased for falls within 90 days and decreased further for falls within 180 days, whereas specificity and positive predictive value increased for all three assessment methods. Staff judgment of fall risk was the single method having the highest sensitivity but the lowest specificity. A combination of either two of them increased sensitivity to more than 80%, but decreased specificity. The positive Likelihood ratio varied from 2.24 to 2.70 and the negative Likelihood ratio from 0.41 to 0.49 for falls within 30 days. The relative risk of sustaining a fall was 2.4, 2.9 and 3.0 times higher for those assessed to be at high risk of falls compared with those assessed to be at low risk, according to STRATIFY, staff judgment of fall risk and previous falls remembered by the staff, respectively. The diagnostic accuracy of the three methods did not differ markedly. However, staff judgment had the highest sensitivity and the lowest specificity after 30, 90 and 180 days. A combination of either two of the methods showed the highest sensitivity but the lowest specificity.
Acta Obstetricia et Gynecologica Scandinavica, 2013
To validate uterine rupture registration in the Medical Birth Registry of Norway (MBRN) between 1... more To validate uterine rupture registration in the Medical Birth Registry of Norway (MBRN) between 1999 and 2008, and to identify rupture type and causes of incorrect or missed registration during 1967-2008. Population-based study. The validation sample was 392,958 maternities from 21 maternity units registered in MBRN and local Patient Administration Systems in 1999-2008. In addition we identified type of rupture and causes of incorrect registration among 2,422,934 maternities from 48 units, and 1,449,201 maternities from 21 units during 1967-2008. Information about uterine rupture in MBRN was compared with information in medical records. Sensitivity, specificity, positive and negative predictive value of uterine rupture registration in MBRN. In 1999-2008, there were 10 false positive cases among 151 uterine ruptures registered in MBRN. In addition, 82 ruptures not registered in MBRN, were identified through Patient Administration Systems. The sensitivity, specificity, positive and negative predictive value of the MBRN to detect uterine rupture was 63.2, 99.99, 93.4 and 99.98%, respectively. The incidence of uterine rupture changed after correction from 0.38 to 0.56/1000. During 1967-2008, false positive cases (125) were mainly due to wrong coding by MBRN. Around 60% of 141 false negative cases were due to lack of reporting by maternity units. Complete rupture accounted for 63.9% of ruptures registered in MBRN. The validity of MBRN data on uterine rupture is not optimal, diagnosis being under-reported by around 37%. Ticked boxes may improve the quality of registration.
Sports Medicine, 2010
Objective: To systematically review and appraise studies examining selfadministered physical acti... more Objective: To systematically review and appraise studies examining selfadministered physical activity questionnaires (PAQ) for the elderly. This article is one of a group of four articles in Sports Medicine on the content and measurement properties of PAQs. Literature Search Methodology: Searches in PubMed. EMBASE and SportDiscus® (until May 2009) on self-administered PAQ. Inclusion criteria were as follows: (i) the study examined (at least one oQ the measurement properties of a self-administered PAQ; (ii) the questionnaire aimed to measure physical activity (PA) in older people; (iii) the average age of the study population was >55 years; (iv) the article was written in English. We excluded PA interviews, diaries and studies that evaluated the measurement properties of a self-administered PAQ in a specific population, such as patients. We used a standard checklist (qualitative attributes and measurement properties of PA questionnaires [QAPAQ]) for appraising the measurement properties of PAQs. Findings: Eighteen articles on 13 PAQs were reviewed, including 16 reliability analyses and 25 validity analyses (of which 15 were on construct validity, seven on health/functioning associations, two on known-groups validity and one on responsiveness). Many studies suffered from methodological Haws, e.g. too small sample size or Inadequate time interval between test and retest. Three PAQs received a positive rating on reliability: IPAQ-C (International Physical Aetivity Questionnaire-Chinese), intraclass correlation coefficient (ICC) >0.81; WHI-PAQ (Women's Health Initiative-PAQ), ICC = 0.76; and PASE (Physical Activity Scale for the Elderly), Pearson correlation