Luciana Santos - Academia.edu (original) (raw)

Papers by Luciana Santos

Coastal Sediments 2019, 2019

Estudos Geológicos, 2017

Um estudo sobre a dinâmica e composição sedimentar foi realizado na barra norte do canal de santa... more Um estudo sobre a dinâmica e composição sedimentar foi realizado na barra norte do canal de santa Cruz (07°41'S/34°50'W), que separa a Ilha de Itamaracá do continente. O objetivo deste trabalho foi analisar a influência da maré na estrutura sedimentar, sendo realizadas coletas em um transecto transversal, durante um ciclo semidiurno de marés sizígia. As amostras foram coletadas em três pontos equidistantes (ST1, ST2 e ST3), durante uma baixamar e uma preamar. Foram realizadas análises de Carbonato de cálcio (CaCO 3), matéria orgânica total (MOT) e granulometria. Os resultados da análise granulométrica sofreram tratamento estatístico para obtenção do grau de seleção, diâmetro médio, classificação e composição sedimentar. Foram executadas também análises estatísticas de correlação (Spearman) com os parâmetros de CaCO3, MOT, diâmetro médio e percentual de areia. Os resultados mostraram que na estação próxima ao continente, ST1, o material sedimentar não apresentou nenhuma alteração em sua composição, aumentando apenas os teores de CaCO3 e de MOT (21% a 24%; 1,37% a 1,87% respectivamente) durante a baixa-mar. Na ST2 os teores de CaCO3 e MOT também aumentaram durante a baixa-mar (13,9% a 40,5%; 1,80% a 2,03% respectivamente), enquanto o sedimento varia apenas no grau de seleção (de moderado a pobremente selecionado). A ST3, próxima da ilha, teve um decréscimo de todos os parâmetros analisados em relação à preamar, visto que o CaCO3 caiu de 17,2% para 8,6%, a MOT caiu de 1,30% para 1,23%, assim como o grau de seleção que foi de moderado a pobremente selecionado e a granulação que foi de areia grossa para média. As análises de correlação (Spearman) indicaram relação significativa entre o teor de CaCO3 e MOT (rs= 0,72) e uma relação não significativa desses teores com o diâmetro médio e a fração areia. Conclui-se que embora a granulometria não apresente uma variação intermareal considerável, a maré e a hidrodinâmica dos estuários adjacentes atuam como agentes controladores na deposição da matéria orgânica e do carbonato. Uma vez que as correntes marinhas com direção sul-norte deslocam o material para norte durante a subida da maré e a hidrodinâmica dos rios carreiam esse material para o sul, fazendo com que a ST2 seja uma área de bypass de sedimentos, que precisamente é o eixo do canal e o ponto médio do transecto de estudo. Palavras chave: sedimentação estuarina, estuário de Barra de Catuama maré de sizígia, matéria orgânica total, carbonato de cálcio.

Regional Studies in Marine Science, 2021

Abstract Mangrove ecosystems can record biogeochemical and sedimentary signatures in their strati... more Abstract Mangrove ecosystems can record biogeochemical and sedimentary signatures in their stratigraphic column. This study examines a mangrove sediment core to evaluate the potential environmental impact of a large-scale port-industrial construction in a tropical lagoonal-estuary near Recife, NE Brazil. Here, we measure sediment accreation rate (SAR), carbon and nitrogen stable isotopes ( δ 13 C and δ 15 N), total organic matter (TOM), total nitrogen (TN), total organic carbon (TOC), and carbonate content (CaCO 3) to determine the impact of Suape’s Port-Industrial Complex in the adjacent estuarine system. We identify a high SAR (1.37 cm yr −1) and propose three main depositional phases in the 82 cm sediment core. The first phase (circa 1956–1973) corresponds to the period prior to the installation of the Suape port complex, where the sediments are characterized by containing sand and organic material derived from terrestrial sources. The second phase (c. 1976–1986) shows signatures that reflect the installation of the Suape port complex and the intensification of the sugarcane monoculture in the catchment area. This phase shows an increase of mud and carbonate content, interpreted as a predominance of marine sediment source due to the morphological changes along the estuary. The third and final phase (c. 1986-2015) contains fluctuating results, reflecting an increase of land use, but not as intense as the period after the installation of the port complex (phase 2). Our results show a biogeochemical and sediment signanature shifts direcly related to anthropogenic impacts and natural factors. Overall, this study reveals a shift in the sediment sources and composition in the Suape estuarine system as a consequence of human development adjacent to estuarine areas and the resilience of mangrove ecosystems to adapt to anthropogenic impact.

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2019

A facomatose pigmentoqueratósica é uma rara variante da síndrome do nevo epidérmico. Esta doença ... more A facomatose pigmentoqueratósica é uma rara variante da síndrome do nevo epidérmico. Esta doença caracteriza-se pela associação de nevo epidérmico com diferenciação sebácea, nevos spilus e anomalias extracutâneas que envolvem sistemas nervoso central, esquelético e renal. Neste relato, discutimos o caso de uma paciente que apresentava desde o nascimento nevo sebáceo extenso na região cefálica, seguindo as linhas de Blaschko, e múltiplos nevos melanocíticos no hemicorpo direito, bem como alterações esqueléticas decorrentes de raquitismo hipofosfatémico. Ressaltamos a importância de se reconhecer a síndrome do nevo epidérmico e suas diferentes formas de apresentação, bem como manifestações cutâneas associadas a doenças osteometabólicas.

Obstetric Medicine, 2017

Background This study had sought to assess the seroreactivity to the fish nematode Anisakis spp. ... more Background This study had sought to assess the seroreactivity to the fish nematode Anisakis spp. in a puerperal population, as well as to ascertain whether a correlation exists between maternal and cord blood levels. Methods Blood samples were obtained from puerperal women and cord blood to measure specific anti- Anisakis antigen IgG and IgE by ELISA. Non-parametric tests were used to compare two or more independent and related samples. Results Of the 99 maternal serum samples assessed, 21 were positive on ELISA (21.2%). There were no significant differences in the mean ranks of IgG optical density levels between women who ate fish and those who did not (p = 0.456), those who ate raw fish and those who did not (p = 0.479), or between those who had allergic complaints and those who did not (p = 0.431). Conclusion Transplacental passage of antibodies occurred, leading to moderate correlation between maternal and cord blood serum levels.

Neuroscience, Aug 30, 2016

Anodal transcranial direct current stimulation (tDCS) is known to increase the force-generating c... more Anodal transcranial direct current stimulation (tDCS) is known to increase the force-generating capacity of the skeletal muscles. However, when tDCS is concurrently combined with a motor task, interference may occur that hinders tDCS effects. Here, we tested the interaction and time course of tDCS effects on force production when paired with a low-level force-matching task. Twenty-two subjects were randomized into two groups: tDCS-Matching and tDCS-Resting. Each group received tDCS and a sham stimulation, separated by one week. Maximal knee extensor and flexor torques were measured before and up to twenty-five minutes following the stimulation. The tDCS-Matching group produced greater knee extension torques relative to sham when compared with the tDCS-Resting group. There was no significant effect for knee flexion. This suggests that interference does not occur for force production tasks when tDCS is combined with a motor task. Rather, the task appears to aid and isolate the effects...

2015 International Conference on Solar Energy and Building (ICSoEB), 2015

Biomass-based energy represents an increasing relevance in the Brazilian energy matrix, represent... more Biomass-based energy represents an increasing relevance in the Brazilian energy matrix, representing 24 % of the Brazilian overall energy production in 2012. Besides the amount of the energy obtained, its qualitative aspect is as much as important, as it is accounted in the renewable energy share. Considering the Brazilian agricultural activity, the energy production from biomass can be still significantly increased and energy cogeneration from biomass burning is one of the process that contributes to support this grow. As an example, almost all of the more than 500 sugar cane mills in Brazil burn the sugar cane bagasse to generate electrical energy. The main waste from the energy cogeneration is the biomass ash, a mix of mineral compounds and remained carbon-based components. Portland cements and concretes are the most widely used manufactured materials in the world, consuming large quantities of raw materials and energy and being responsible for a significant share of the CO2 emissions. One of the main strategies to reduce the environmental impacts from cement production is to combine the cement clinker to supplementary cement materials (SCM), resulting in blended cements. This paper focus on the potential of biomass ashes resulted from the energy cogeneration as SCM in cement-based materials. There are presented results from research in which sugarcane bagasse ash (SCBA) are used as SCM, resulted in cement composites and concretes with improved properties.

Neuroreport, Jan 5, 2015

Noninvasive brain stimulation has recently been used to augment motor training-induced plasticity... more Noninvasive brain stimulation has recently been used to augment motor training-induced plasticity. However, the exact time during which noninvasive brain stimulation can be combined with motor therapy to maximize neuroplasticity and behavioral changes is unknown. We conducted a randomized sham-controlled crossover trial to examine when (before, during, or after training) transcranial direct current stimulation (tDCS) should be applied to best reinforce motor training-induced plasticity in 12 healthy right-handed participants (mean age: 21.8±1.6) who underwent active or sham tDCS combined with motor training. Transcranial magnetic stimulation-elicited motor-evoked potentials from the right first dorsal interosseous muscle were recorded before (baseline) and immediately after each session. The training task comprised four practice trials - 3 min each (30 s pause between trials) - of repetitive finger movements (thumb abduction/adduction) with the right hand. Anodal tDCS (1 mA, 13 min,...

Clinics, 2007

Anemia is one of the most common abnormal findings in critically ill patients, and many of these ... more Anemia is one of the most common abnormal findings in critically ill patients, and many of these patients will receive a blood transfusion during their intensive care unit stay. However, the determinants of exactly which patients do receive transfusions remains to be defined and have been the subject of considerable debate in recent years. Concerns and doubts have emerged regarding the benefits and safety of blood transfusion, in part due to the lack of evidence of better outcomes resulting from randomized studies and in part related to the observations that transfusion may increase the risk of infection. As a result of these concerns and of several studies suggesting better or similar outcomes with a lower transfusion trigger, there has been a general tendency to decrease the transfusion threshold from the classic 10 g/dL to lower values. In this review, we focus on some of the key studies providing insight into current transfusion practices and fueling the current debate on the ideal transfusion trigger.

Psicologia: Reflexão e Crítica, 1999

Resumo Considerando que dificuldades de aprendizagem são fator de vulnerabilidade no desenvolvime... more Resumo Considerando que dificuldades de aprendizagem são fator de vulnerabilidade no desenvolvimento, intensificadas quando presentes outras condições adversas, buscou-se verificar a associação entre condições antecedentes e ajustamento atual, em adolescentes que quando crianças foram atendidos em um ambulatório de psicologia por dificuldades de aprendizagem. Os adolescentes e suas mães foram entrevistados. Dados referentes às condições de vida na época do atendimento foram obtidos em prontuários. Avaliados 41 adolescentes de ambos os sexos, com idade média de 13 anos e nove meses, foram constituídos dois grupos: G1, com nove adolescentes encaminhados a serviços de Saúde Mental por apresentarem atualmente dificuldades severas de ajustamento; G2, com dez adolescentes apresentando dificuldades mínimas de ajustamento. Comparando os grupos, observou-se maior acúmulo de fatores negativos antecedentes, familiares e pessoais, no grupo de adolescentes com pior ajustamento atual. Torna-se clara a necessidade de acompanhamento psicológico das crianças com dificuldade de aprendizagem associada a outras condições de vulnerabilidade. Palavras-chave: Dificuldade de aprendizagem; ajustamento sócio-emocional.

International Archives of Otorhinolaryngology, 2014

Introduction High-level noise exposure in dentists' workplaces may cause damages to the auditory ... more Introduction High-level noise exposure in dentists' workplaces may cause damages to the auditory systems. High-frequency audiometry is an important tool in the investigation in the early diagnosis of hearing loss. Objectives To analyze the auditory thresholds at frequencies from 500 to 16,000 Hz of dentists in the city of Curitiba. Methods This historic cohort study retrospectively tested hearing thresholds from 500 to 16,000 Hz with a group of dentists from Curitiba, in the state of Paraná, Brazil. Eighty subjects participated in the study, separated into a dentist group and a control group, with the same age range and gender across groups but with no history of occupational exposure to high levels of sound pressure in the control group. Subjects were tested with conventional audiometry and high-frequency audiometry and answered a questionnaire about exposure to noise. Results Results showed that 81% of dentists did not receive any information regarding noise at university; 6 (15%) dentists had sensorineural hearing impairment; significant differences were observed between the groups only at frequencies of 500 Hz and 1,000, 6,000 and 8,000 Hz in the right ear. There was no significant difference between the groups after analysis of mean hearing thresholds of high frequencies with the average hearing thresholds in conventional frequencies; subjects who had been working as dentists for longer than 10 years had worse tonal hearing thresholds at high frequencies. Conclusions In this study, we observed that dentists are at risk for the development of sensorineural hearing loss especially after 10 years of service.

Schizophrenia Research, 2014

Revista de Enfermagem Referência, 2012

* Doutora em enfermagem. Docente do curso de enfermagem da Universidade Federal de São João del R... more * Doutora em enfermagem. Docente do curso de enfermagem da Universidade Federal de São João del Rei, área enfermagem materno-infantil, coordenadora do curso de enfermagem [marciachristinacs@gmail.com]. ** Mestre em enfermagem. Docente do curso de enfermagem da Universidade Federal de São João del Rei, área enfermagem fundamental, coordenadora adjunta do curso de enfermagem [

Brain Stimulation, 2015

Background-Noninvasive brain stimulation (NIBS) techniques such as transcranial magnetic stimulat... more Background-Noninvasive brain stimulation (NIBS) techniques such as transcranial magnetic stimulation (TMS) and transcranial current stimulation (tCS) have the potential to mitigate a variety of symptoms associated with neurological and psychiatric conditions, including stroke, cerebral palsy, autism, depression, and Tourette syndrome. While the safety of these modalities has been established in adults, there is a paucity of research assessing the safety of NIBS among children. Objective-To examine the existing literature regarding the safety of NIBS techniques in children and adolescents with neurologic and neuropsychiatric disorders. Methods-An electronic search was performed on online databases for studies using NIBS in individuals less than 18 years of age. Non-English publications, diagnostic studies, electroconvulsive therapy, single/dual pulse TMS studies, and reviews were excluded. Adverse events reported in the studies were carefully examined and synthesized to understand the safety and tolerability of NIBS among children and adolescents. Results-The data from 48 studies involving more than 513 children/adolescents (2.5-17.8 years of age) indicate that the side-effects of NIBS were, in general, mild and transient [TMS: headache (11.5%), scalp discomfort (2.5%), twitching (1.2%), mood changes (1.2%), fatigue (0.9%), tinnitus (0.6%); tCS: tingling (11.5%), itching (5.8%), redness (4.7%), scalp discomfort (3.1%)] with relatively few serious adverse events. Conclusion-Our findings indicate that both repetitive TMS and tCS are safe modalities in children and adolescents with various neurological conditions, especially when safety guidelines are followed. The incidence of adverse events appears to be similar to that observed in adults;

Psychiatry Research: Neuroimaging, 2012

The occurrence of white matter (WM) abnormalities in psychotic disorders has been suggested by se... more The occurrence of white matter (WM) abnormalities in psychotic disorders has been suggested by several studies investigating brain pathology and diffusion tensor measures, but evidence assessing regional WM morphometry is still scarce and conflicting. In the present study, 122 individuals with first-episode psychosis (FEP) (62 fulfilling criteria for schizophrenia/schizophreniform disorder, 26 psychotic bipolar I disorder, and 20 psychotic major depressive disorder) underwent magnetic resonance imaging, as well as 94 epidemiologically recruited controls. Images were processed with the Statistical Parametric Mapping (SPM2) package, and voxel-based morphometry was used to compare groups (t-test) and subgroups (ANOVA). Initially, no regional WM abnormalities were observed when both groups (overall FEP group versus controls) and subgroups (i.e., schizophrenia/schizophreniform, psychotic bipolar I disorder, psychotic depression, and controls) were compared. However, when the voxelwise analyses were repeated excluding subjects with comorbid substance abuse or dependence, the resulting statistical maps revealed a focal volumetric reduction in right frontal WM, corresponding to the right middle frontal gyral WM/third subcomponent of the superior longitudinal fasciculus, in subjects with schizophrenia/schizophreniform disorder (n = 40) relative to controls (n = 89). Our results suggest that schizophrenia/schizophreniform disorder is associated with right frontal WM volume decrease at an early course of the illness.

Ocean & Coastal Management, 2014

Neuroscience Letters, 2008

The purpose of this study was to investigate regional structural abnormalities in the brains of f... more The purpose of this study was to investigate regional structural abnormalities in the brains of five patients with refractory obsessive-compulsive disorder (OCD) submitted to gamma ventral capsulotomy. Methods: We acquired morphometric magnetic resonance imaging (MRI) data before and after 1 year of radiosurgery using a 1.5-T MRI scanner. Images were spatially normalized and segmented using optimized voxel-based morphometry (VBM) methods. Voxelwise statistical comparisons between preand post-surgery MRI scans were performed using a general linear model. Findings in regions predicted a priori to show volumetric changes (orbitofrontal cortex, anterior cingulate gyrus, basal ganglia and thalamus) were reported as significant if surpassing a statistical threshold of p < 0.001 (uncorrected for multiple comparisons). Results: We detected a significant regional postoperative increase in gray matter volume in the right inferior frontal gyri (Brodmann area 47, BA47) when comparing all patients pre and postoperatively. Conclusions: Our results support the current theory of frontal-striatal-thalamiccortical (FSTC) circuitry involvement in OCD pathogenesis. Gamma ventral capsulotomy is associated with neurobiological changes in the inferior orbitofrontal cortex in refractory OCD patients.

Anesthesia & Analgesia, 2008

The arterial pulse pressure variation induced by mechanical ventilation (deltaPP) has been shown ... more The arterial pulse pressure variation induced by mechanical ventilation (deltaPP) has been shown to be a predictor of fluid responsiveness. Until now, deltaPP has had to be calculated offline (from a computer recording or a paper printing of the arterial pressure curve), or to be derived from specific cardiac output monitors, limiting the widespread use of this parameter. Recently, a method has been developed for the automatic calculation and real-time monitoring of deltaPP using standard bedside monitors. Whether this method is to predict reliable predictor of fluid responsiveness remains to be determined. We conducted a prospective clinical study in 59 mechanically ventilated patients in the postoperative period of cardiac surgery. Patients studied were considered at low risk for complications related to fluid administration (pulmonary artery occlusion pressure &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 20 mm Hg, left ventricular ejection fraction &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt; or = 40%). All patients were instrumented with an arterial line and a pulmonary artery catheter. Cardiac filling pressures and cardiac output were measured before and after intravascular fluid administration (20 mL/kg of lactated Ringer&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s solution over 20 min), whereas deltaPP was automatically calculated and continuously monitored. Fluid administration increased cardiac output by at least 15% in 39 patients (66% = responders). Before fluid administration, responders and nonresponders were comparable with regard to right atrial and pulmonary artery occlusion pressures. In contrast, deltaPP was significantly greater in responders than in nonresponders (17% +/- 3% vs 9% +/- 2%, P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001). The deltaPP cut-off value of 12% allowed identification of responders with a sensitivity of 97% and a specificity of 95%. Automatic real-time monitoring of deltaPP is possible using a standard bedside monitor and was found to be a reliable method to predict fluid responsiveness after cardiac surgery. Additional studies are needed to determine if this technique can be used to avoid the complications of fluid administration in high-risk patients.

American Journal of Neuroradiology, 2009

BACKGROUND AND PURPOSE: Several morphometric MR imaging studies have investigated age-and sex-rel... more BACKGROUND AND PURPOSE: Several morphometric MR imaging studies have investigated age-and sex-related cerebral volume changes in healthy human brains, most often by using samples spanning several decades of life and linear correlation methods. This study aimed to map the normal pattern of regional age-related volumetric reductions specifically in the elderly population. MATERIALS AND METHODS: One hundred thirty-two eligible individuals (67-75 years of age) were selected from a community-based sample recruited for the Sã o Paulo Ageing and Health (SPAH) study, and a cross-sectional MR imaging investigation was performed concurrently with the second SPAH wave. We used voxel-based morphometry (VBM) to conduct a voxelwise search for significant linear correlations between gray matter (GM) volumes and age. In addition, region-of-interest masks were used to investigate whether the relationship between regional GM (rGM) volumes and age would be best predicted by a nonlinear model. RESULTS: VBM and region-of-interest analyses revealed selective foci of accelerated rGM loss exclusively in men, involving the temporal neocortex, prefrontal cortex, and medial temporal region. The only structure in which GM volumetric changes were best predicted by a nonlinear model was the left parahippocampal gyrus. CONCLUSIONS: The variable patterns of age-related GM loss across separate neocortical and temporolimbic regions highlight the complexity of degenerative processes that affect the healthy human brain across the life span. The detection of age-related limbic GM decrease in men supports the view that atrophy in such regions should be seen as compatible with normal aging.

Alzheimer's & Dementia, 2013

for significance using a bootstrapping method (Preacher & Kelley, 2010) with 10000 iterations... more for significance using a bootstrapping method (Preacher & Kelley, 2010) with 10000 iterations. Results: Both HC (P<0.005) and ERC (P<0.0001) were significantly related to DMN connectivity while controlling for age and total grey matter. HC (Figure 1A) and ERC (Figure 1B) show similar patters of relationship with the DMN at the map level. ERCmediates the relationship between HC and DMN connectivity as assessed by a bootstrapping method (mediation ratio1⁄40.42, indirect effect1⁄41.03*10 -4, confidence interval1⁄4[3.35*10 -5 to 1.83*10 -5], p<0.001). Amyloid burden did not modify this effect. Conclusions: First, we find that structural measures of the MTL affect DMN connectivity above and beyond the effects of nonspecific greymatter and age. Second,we find further evidence for a structural/functional pathway between hippocampus and the DMN that is mediated by entorhinal cortex. Longitudinal analyses will elucidate the order in which these regions are impacted during AD development.