Mahfuja Rahman - Academia.edu (original) (raw)
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Papers by Mahfuja Rahman
Science Documents, 2018
Type 2 diabetes is associated with both extracellular and intracellular magnesium (Mg 2+) deficit... more Type 2 diabetes is associated with both extracellular and intracellular magnesium (Mg 2+) deficits. A chronic latent Mg 2+ deficit or an overt clinical hypomagnesemia is common in patients with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulin and glucose are important regulators of Mg 2+ metabolism. Intracellular Mg 2+ plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. The present study was undertaken to investigate the serum and erythrocyte levels of Mg 2+ , and also to examine their relationship to glycemic status in a group of type 2 diabetic of Bangladeshi patients without any complications. Thirty newly diagnosed type 2 Diabetic subjects were studied with age-and BMI (body mass index)-matched Control subjects. Fasting serum glucose and fasting serum insulin level were measured by glucose oxidase method and ELISA, respectively. Total cholesterol (TChol), triglyceride, HDL and LDL in serum were measured by enzymatic colorimetric assay. Serum and erythrocyte Mg 2+ levels were estimated by Ion Sensitive Electrode (ISE). There were no significant differences in anthropometric features of Control and Diabetic subjects. The lipid profile did not have any significant change except a significant increase in TChol in serum of Diabetic subjects. Fasting serum Mg 2+ (FSMg 2+) and two hours serum Mg 2+ after glucose load (2HSMg 2+) as well as fasting red blood cell Mg 2+ (FRBCMg 2+) and two hours red blood cell Mg 2+ after glucose load (2HRBCMg 2+) levels were significantly lower in Diabetic subjects. Diabetics subjects had 2.5 times more fasting serum glucose (FSG) levels. Although the fasting serum insulin (FSI) levels were similar between Control and Diabetic subjects, the insulin levels two hour after glucose load were 1.5 times more in Control subjects. The % of βcell secretion and insulin sensitivity were significantly decreased in Diabetic subjects. There was no correlation was found between the FSG and FSI, but a significant negative correlation was observed between FSG and FSMg 2+ or FRBCMg 2+. These data combinedly suggest that decreased serum and intraerythrocyte magnesium could be a cause of hyperglycemia and type 2 diabetes in Bangladeshi population.
Acta Scientific Medical Sciences
Science Documents, 2018
Type 2 diabetes is associated with both extracellular and intracellular magnesium (Mg 2+) deficit... more Type 2 diabetes is associated with both extracellular and intracellular magnesium (Mg 2+) deficits. A chronic latent Mg 2+ deficit or an overt clinical hypomagnesemia is common in patients with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulin and glucose are important regulators of Mg 2+ metabolism. Intracellular Mg 2+ plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. The present study was undertaken to investigate the serum and erythrocyte levels of Mg 2+ , and also to examine their relationship to glycemic status in a group of type 2 diabetic of Bangladeshi patients without any complications. Thirty newly diagnosed type 2 Diabetic subjects were studied with age-and BMI (body mass index)-matched Control subjects. Fasting serum glucose and fasting serum insulin level were measured by glucose oxidase method and ELISA, respectively. Total cholesterol (TChol), triglyceride, HDL and LDL in serum were measured by enzymatic colorimetric assay. Serum and erythrocyte Mg 2+ levels were estimated by Ion Sensitive Electrode (ISE). There were no significant differences in anthropometric features of Control and Diabetic subjects. The lipid profile did not have any significant change except a significant increase in TChol in serum of Diabetic subjects. Fasting serum Mg 2+ (FSMg 2+) and two hours serum Mg 2+ after glucose load (2HSMg 2+) as well as fasting red blood cell Mg 2+ (FRBCMg 2+) and two hours red blood cell Mg 2+ after glucose load (2HRBCMg 2+) levels were significantly lower in Diabetic subjects. Diabetics subjects had 2.5 times more fasting serum glucose (FSG) levels. Although the fasting serum insulin (FSI) levels were similar between Control and Diabetic subjects, the insulin levels two hour after glucose load were 1.5 times more in Control subjects. The % of βcell secretion and insulin sensitivity were significantly decreased in Diabetic subjects. There was no correlation was found between the FSG and FSI, but a significant negative correlation was observed between FSG and FSMg 2+ or FRBCMg 2+. These data combinedly suggest that decreased serum and intraerythrocyte magnesium could be a cause of hyperglycemia and type 2 diabetes in Bangladeshi population.
Acta Scientific Medical Sciences