Majid Ghassemian - Academia.edu (original) (raw)

Papers by Majid Ghassemian

Research paper thumbnail of Corrigendum: Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development

Nature, Jan 19, 2015

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Research paper thumbnail of Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development

Nature

Environmental stimuli, including elevated carbon dioxide levels, regulate stomatal development; h... more Environmental stimuli, including elevated carbon dioxide levels, regulate stomatal development; however, the key mechanisms mediating the perception and relay of the CO2 signal to the stomatal development machinery remain elusive. To adapt CO2 intake to water loss, plants regulate the development of stomatal gas exchange pores in the aerial epidermis. A diverse range of plant species show a decrease in stomatal density in response to the continuing rise in atmospheric CO2 (ref. 4). To date, one mutant that exhibits deregulation of this CO2-controlled stomatal development response, hic (which is defective in cell-wall wax biosynthesis, ref. 5), has been identified. Here we show that recently isolated Arabidopsis thaliana β-carbonic anhydrase double mutants (ca1 ca4) exhibit an inversion in their response to elevated CO2, showing increased stomatal development at elevated CO2 levels. We characterized the mechanisms mediating this response and identified an extracellular signalling pat...

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Research paper thumbnail of Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss

Science (New York, N.Y.), Jan 9, 1998

Desiccation of plants during drought can be detrimental to agricultural production. The phytohorm... more Desiccation of plants during drought can be detrimental to agricultural production. The phytohormone abscisic acid (ABA) reduces water loss by triggering stomatal pore closure in leaves, a process requiring ion-channel modulation by cytoplasmic proteins. Deletion of the Arabidopsis farnesyltransferase gene ERA1 or application of farnesyltransferase inhibitors resulted in ABA hypersensitivity of guard cell anion-channel activation and of stomatal closing. ERA1 was expressed in guard cells. Double-mutant analyses of era1 with the ABA-insensitive mutants abi1 and abi2 showed that era1 suppresses the ABA-insensitive phenotypes. Moreover, era1 plants exhibited a reduction in transpirational water loss during drought treatment.

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Research paper thumbnail of Proteomic Analysis of Highly Prevalent Amyloid A Amyloidosis Endemic to Endangered Island Foxes

PLoS ONE, 2014

Amyloid A (AA) amyloidosis is a debilitating, often fatal, systemic amyloid disease associated wi... more Amyloid A (AA) amyloidosis is a debilitating, often fatal, systemic amyloid disease associated with chronic inflammation and persistently elevated serum amyloid A (SAA). Elevated SAA is necessary but not sufficient to cause disease and the risk factors for AA amyloidosis remain poorly understood. Here we identify an extraordinarily high prevalence of AA amyloidosis (34%) in a genetically isolated population of island foxes (Urocyon littoralis) with concurrent chronic inflammatory diseases. Amyloid deposits were most common in kidney (76%), spleen (58%), oral cavity (45%), and vasculature (44%) and were composed of unbranching, 10 nm in diameter fibrils. Peptide sequencing by mass spectrometry revealed that SAA peptides were dominant in amyloid-laden kidney, together with high levels of apolipoprotein E, apolipoprotein A-IV, fibrinogen-α chain, and complement C3 and C4 (false discovery rate ≤ 0.05). Reassembled peptide sequences showed island fox SAA as an 111 amino acid protein, most similar to dog and artic fox, with 5 unique amino acid variants among carnivores. SAA peptides extended to the last two C-terminal amino acids in 5 of 9 samples, indicating that near full length SAA was often present in amyloid aggregates. These studies define a remarkably prevalent AA amyloidosis in island foxes with widespread systemic amyloid deposition, a unique SAA sequence, and the co-occurrence of AA with apolipoproteins.

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Research paper thumbnail of Analysis of mRNA recognition by human thymidylate synthase

Bioscience Reports, 2014

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Research paper thumbnail of Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development

Nature, Jan 11, 2014

Environmental stimuli, including elevated carbon dioxide levels, regulate stomatal development; h... more Environmental stimuli, including elevated carbon dioxide levels, regulate stomatal development; however, the key mechanisms mediating the perception and relay of the CO2 signal to the stomatal development machinery remain elusive. To adapt CO2 intake to water loss, plants regulate the development of stomatal gas exchange pores in the aerial epidermis. A diverse range of plant species show a decrease in stomatal density in response to the continuing rise in atmospheric CO2 (ref. 4). To date, one mutant that exhibits deregulation of this CO2-controlled stomatal development response, hic (which is defective in cell-wall wax biosynthesis, ref. 5), has been identified. Here we show that recently isolated Arabidopsis thaliana β-carbonic anhydrase double mutants (ca1 ca4) exhibit an inversion in their response to elevated CO2, showing increased stomatal development at elevated CO2 levels. We characterized the mechanisms mediating this response and identified an extracellular signalling pat...

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Research paper thumbnail of Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jan 24, 2014

Pathologic amyloid accumulates in the CNS or in peripheral organs, yet the mechanism underlying t... more Pathologic amyloid accumulates in the CNS or in peripheral organs, yet the mechanism underlying the targeting of systemic amyloid deposits is unclear. Serum amyloid A (SAA) 1 and 2 are produced predominantly by the liver and form amyloid most commonly in the spleen, liver, and kidney. In contrast, SAA3 is produced primarily extrahepatically and has no causal link to amyloid formation. Here, we identified 8 amyloidosis cases with amyloid composed of SAA3 expanding the uterine wall of goats with near-term fetuses. Uterine amyloid accumulated in the endometrium, only at the site of placental attachment, compromising maternal-fetal gas and nutrient exchange and leading to fetal ischemia and death. No other organ contained amyloid. SAA3 mRNA levels in the uterine endometrium were as high as SAA2 in the liver, yet mass spectrometry of the insoluble uterine peptides identified SAA3 as the predominant protein, and not SAA1 or SAA2. These findings suggest that high local SAA3 production led ...

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Research paper thumbnail of An integrated Arabidopsis annotation database for Affymetrix Genechip® data analysis, and tools for regulatory motif searches

Trends in Plant Science, 2001

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Research paper thumbnail of Regulation of Abscisic Acid Signaling by the Ethylene Response Pathway in Arabidopsis

THE PLANT CELL ONLINE, 2000

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Research paper thumbnail of Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

The Journal of Cell Biology, 2014

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Research paper thumbnail of Tyrosine Phosphorylation of the G -Interacting Protein GIV Promotes Activation of Phosphoinositide 3-Kinase During Cell Migration

Science Signaling, 2011

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Research paper thumbnail of A Protein Farnesyl Transferase Involved in Abscisic Acid Signal Transduction in Arabidopsis

Science, 1996

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Research paper thumbnail of Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1

PROTEOMICS, 2009

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Research paper thumbnail of Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners

Proceedings of the National Academy of Sciences, 2013

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Research paper thumbnail of Cortactin as a Target for FAK in the Regulation of Focal Adhesion Dynamics

PLoS ONE, 2012

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Research paper thumbnail of Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite

Nature, 2007

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Research paper thumbnail of Automated Querying and Identification of Novel Peptides using MALDI Mass Spectrometric Imaging

Journal of Proteome Research, 2011

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Research paper thumbnail of Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism

Plant molecular biology, 2003

The isoprenoid biosynthetic pathway provides intermediates for the synthesis of a multitude of na... more The isoprenoid biosynthetic pathway provides intermediates for the synthesis of a multitude of natural products which serve numerous biochemical functions in plants: sterols (isoprenoids with a C30 backbone) are essential components of membranes; carotenoids (C40) and chlorophylls (which contain a C20 isoprenoid side-chain) act as photosynthetic pigments; plastoquinone, phylloquinone and ubiquinone (all of which contain long isoprenoid side-chains) participate in electron transport chains; gibberellins (C20), brassinosteroids (C30) and abscisic acid (C15) are phytohormones derived from isoprenoid intermediates; prenylation of proteins (with C15 or C20 isoprenoid moieties) may mediate subcellular targeting and regulation of activity; and several monoterpenes (C10), sesquiterpenes (C15) and diterpenes (C20) have been demonstrated to be involved in plant defense. Here we present a comprehensive analysis of genes coding for enzymes involved in the metabolism of isoprenoid-derived compou...

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Research paper thumbnail of Abscisic acid-induced modulation of metabolic and redox control pathways in Arabidopsis thaliana

Phytochemistry, 2008

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Research paper thumbnail of Comprehensive post-genomic data analysis approaches integrating biochemical pathway maps

Phytochemistry, 2005

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Research paper thumbnail of Corrigendum: Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development

Nature, Jan 19, 2015

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Research paper thumbnail of Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development

Nature

Environmental stimuli, including elevated carbon dioxide levels, regulate stomatal development; h... more Environmental stimuli, including elevated carbon dioxide levels, regulate stomatal development; however, the key mechanisms mediating the perception and relay of the CO2 signal to the stomatal development machinery remain elusive. To adapt CO2 intake to water loss, plants regulate the development of stomatal gas exchange pores in the aerial epidermis. A diverse range of plant species show a decrease in stomatal density in response to the continuing rise in atmospheric CO2 (ref. 4). To date, one mutant that exhibits deregulation of this CO2-controlled stomatal development response, hic (which is defective in cell-wall wax biosynthesis, ref. 5), has been identified. Here we show that recently isolated Arabidopsis thaliana β-carbonic anhydrase double mutants (ca1 ca4) exhibit an inversion in their response to elevated CO2, showing increased stomatal development at elevated CO2 levels. We characterized the mechanisms mediating this response and identified an extracellular signalling pat...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Role of farnesyltransferase in ABA regulation of guard cell anion channels and plant water loss

Science (New York, N.Y.), Jan 9, 1998

Desiccation of plants during drought can be detrimental to agricultural production. The phytohorm... more Desiccation of plants during drought can be detrimental to agricultural production. The phytohormone abscisic acid (ABA) reduces water loss by triggering stomatal pore closure in leaves, a process requiring ion-channel modulation by cytoplasmic proteins. Deletion of the Arabidopsis farnesyltransferase gene ERA1 or application of farnesyltransferase inhibitors resulted in ABA hypersensitivity of guard cell anion-channel activation and of stomatal closing. ERA1 was expressed in guard cells. Double-mutant analyses of era1 with the ABA-insensitive mutants abi1 and abi2 showed that era1 suppresses the ABA-insensitive phenotypes. Moreover, era1 plants exhibited a reduction in transpirational water loss during drought treatment.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Proteomic Analysis of Highly Prevalent Amyloid A Amyloidosis Endemic to Endangered Island Foxes

PLoS ONE, 2014

Amyloid A (AA) amyloidosis is a debilitating, often fatal, systemic amyloid disease associated wi... more Amyloid A (AA) amyloidosis is a debilitating, often fatal, systemic amyloid disease associated with chronic inflammation and persistently elevated serum amyloid A (SAA). Elevated SAA is necessary but not sufficient to cause disease and the risk factors for AA amyloidosis remain poorly understood. Here we identify an extraordinarily high prevalence of AA amyloidosis (34%) in a genetically isolated population of island foxes (Urocyon littoralis) with concurrent chronic inflammatory diseases. Amyloid deposits were most common in kidney (76%), spleen (58%), oral cavity (45%), and vasculature (44%) and were composed of unbranching, 10 nm in diameter fibrils. Peptide sequencing by mass spectrometry revealed that SAA peptides were dominant in amyloid-laden kidney, together with high levels of apolipoprotein E, apolipoprotein A-IV, fibrinogen-α chain, and complement C3 and C4 (false discovery rate ≤ 0.05). Reassembled peptide sequences showed island fox SAA as an 111 amino acid protein, most similar to dog and artic fox, with 5 unique amino acid variants among carnivores. SAA peptides extended to the last two C-terminal amino acids in 5 of 9 samples, indicating that near full length SAA was often present in amyloid aggregates. These studies define a remarkably prevalent AA amyloidosis in island foxes with widespread systemic amyloid deposition, a unique SAA sequence, and the co-occurrence of AA with apolipoproteins.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Analysis of mRNA recognition by human thymidylate synthase

Bioscience Reports, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development

Nature, Jan 11, 2014

Environmental stimuli, including elevated carbon dioxide levels, regulate stomatal development; h... more Environmental stimuli, including elevated carbon dioxide levels, regulate stomatal development; however, the key mechanisms mediating the perception and relay of the CO2 signal to the stomatal development machinery remain elusive. To adapt CO2 intake to water loss, plants regulate the development of stomatal gas exchange pores in the aerial epidermis. A diverse range of plant species show a decrease in stomatal density in response to the continuing rise in atmospheric CO2 (ref. 4). To date, one mutant that exhibits deregulation of this CO2-controlled stomatal development response, hic (which is defective in cell-wall wax biosynthesis, ref. 5), has been identified. Here we show that recently isolated Arabidopsis thaliana β-carbonic anhydrase double mutants (ca1 ca4) exhibit an inversion in their response to elevated CO2, showing increased stomatal development at elevated CO2 levels. We characterized the mechanisms mediating this response and identified an extracellular signalling pat...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jan 24, 2014

Pathologic amyloid accumulates in the CNS or in peripheral organs, yet the mechanism underlying t... more Pathologic amyloid accumulates in the CNS or in peripheral organs, yet the mechanism underlying the targeting of systemic amyloid deposits is unclear. Serum amyloid A (SAA) 1 and 2 are produced predominantly by the liver and form amyloid most commonly in the spleen, liver, and kidney. In contrast, SAA3 is produced primarily extrahepatically and has no causal link to amyloid formation. Here, we identified 8 amyloidosis cases with amyloid composed of SAA3 expanding the uterine wall of goats with near-term fetuses. Uterine amyloid accumulated in the endometrium, only at the site of placental attachment, compromising maternal-fetal gas and nutrient exchange and leading to fetal ischemia and death. No other organ contained amyloid. SAA3 mRNA levels in the uterine endometrium were as high as SAA2 in the liver, yet mass spectrometry of the insoluble uterine peptides identified SAA3 as the predominant protein, and not SAA1 or SAA2. These findings suggest that high local SAA3 production led ...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of An integrated Arabidopsis annotation database for Affymetrix Genechip® data analysis, and tools for regulatory motif searches

Trends in Plant Science, 2001

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Regulation of Abscisic Acid Signaling by the Ethylene Response Pathway in Arabidopsis

THE PLANT CELL ONLINE, 2000

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

The Journal of Cell Biology, 2014

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Tyrosine Phosphorylation of the G -Interacting Protein GIV Promotes Activation of Phosphoinositide 3-Kinase During Cell Migration

Science Signaling, 2011

Bookmarks Related papers MentionsView impact

Research paper thumbnail of A Protein Farnesyl Transferase Involved in Abscisic Acid Signal Transduction in Arabidopsis

Science, 1996

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1

PROTEOMICS, 2009

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Phosphorylation of the Rab exchange factor Sec2p directs a switch in regulatory binding partners

Proceedings of the National Academy of Sciences, 2013

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Cortactin as a Target for FAK in the Regulation of Focal Adhesion Dynamics

PLoS ONE, 2012

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite

Nature, 2007

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Automated Querying and Identification of Novel Peptides using MALDI Mass Spectrometric Imaging

Journal of Proteome Research, 2011

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism

Plant molecular biology, 2003

The isoprenoid biosynthetic pathway provides intermediates for the synthesis of a multitude of na... more The isoprenoid biosynthetic pathway provides intermediates for the synthesis of a multitude of natural products which serve numerous biochemical functions in plants: sterols (isoprenoids with a C30 backbone) are essential components of membranes; carotenoids (C40) and chlorophylls (which contain a C20 isoprenoid side-chain) act as photosynthetic pigments; plastoquinone, phylloquinone and ubiquinone (all of which contain long isoprenoid side-chains) participate in electron transport chains; gibberellins (C20), brassinosteroids (C30) and abscisic acid (C15) are phytohormones derived from isoprenoid intermediates; prenylation of proteins (with C15 or C20 isoprenoid moieties) may mediate subcellular targeting and regulation of activity; and several monoterpenes (C10), sesquiterpenes (C15) and diterpenes (C20) have been demonstrated to be involved in plant defense. Here we present a comprehensive analysis of genes coding for enzymes involved in the metabolism of isoprenoid-derived compou...

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Abscisic acid-induced modulation of metabolic and redox control pathways in Arabidopsis thaliana

Phytochemistry, 2008

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Comprehensive post-genomic data analysis approaches integrating biochemical pathway maps

Phytochemistry, 2005

Bookmarks Related papers MentionsView impact