Manilal Gada - Academia.edu (original) (raw)
Papers by Manilal Gada
PubMed, Feb 1, 2005
Despite the availability of several antidepressants, low patient compliance with medication, main... more Despite the availability of several antidepressants, low patient compliance with medication, mainly due to adverse effects remains a major problem. The aim of this study was to evaluate the efficacy and compliance of tianeptine, a selective serotonin reuptake enhancer (SSRE), for the treatment of major depression in primary care setting of India. In a prospective observational multicentric study, 320 outpatients with major depression were treated with tianeptine 12.5 mg thrice daily for 60 days. Outcome measures were change in Hamilton depression rating scale (HDRS) score, frequency of side-effects, and compliance with medication. After treatment, mean HDRS score decreased from 10.9 +/- 3.2 at baseline to 6.9 +/- 2.7 at day 60 (p < 0.01), with more than half the patients showing > 50% improvement in HDRS score. No patient withdrew due to side-effects, which were reported in 23 patients (7.2%). Mean compliance with the medication was 91%. This study demonstrates the efficacy and acceptability of tianeptine in the management of major depression in Indian clinical practice.
PubMed, Jul 1, 1989
Ninety two out of one hundred cases of major depressive disorder were followed up for a period of... more Ninety two out of one hundred cases of major depressive disorder were followed up for a period of 5 to 10 years after the index diagnosis. 36.6 per cent of the cases, had no recurrence. Out of the 63.4 per cent of the cases who had recurrences, 37.8 per cent cases turned out to be having bipolar affective disorder and remaining 25.6 per cent had major depressive disorder, recurrent type. The change of polarity from major depressive disorder to bipolar affective illness occurred within three years after the initial depressive episode in 77 per cent of the cases. The number of depressive episodes before I he onset of mania, was one in 63.0 per cent of the cases; two in 33.3 per cent and three in 3.7 per cent. 31 cases of bipolar affective disorder had a total of 152 recurrences, comprising 97 manic and 55 depressive episodes, the average being 4.9. The total number of episodes in 21 cases of major depressive disorder, recurrent type, were 73 yielding an average of 3.4, significantly less than those of bipolar affective illness cases. 2.2 per cent of the cases had successfully committed suicide.
PubMed, 1987
Page 1. Indian Journal of Psychiatry, January 1987 29(1), pp. 15-31 TILAK VENKOBA RAO ORATION PSY... more Page 1. Indian Journal of Psychiatry, January 1987 29(1), pp. 15-31 TILAK VENKOBA RAO ORATION PSYCHOBIOLOGY OF DEPRESSIONH MANILAL GADA** Introduction I am grateful to you all, the Chairman and members ...
Mens Sana Monographs, 2015
Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankar... more Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankaras, 23 having preceded him. The principals of Jaina religion teach us: (1) Self-control, which includes: (a) Control over physiological instinct of hunger and sex; (b) control over desires; (c) control over emotions; (2) meditation; (3) introspection; (4) concentration; and (5) healthy interpersonal relationship. The principles of Jaina Religion can contribute to Positive Mental Health.
PubMed, Apr 1, 1987
The present study was undertaken with the aim of 1) Identifying students with ADDH in a primary s... more The present study was undertaken with the aim of 1) Identifying students with ADDH in a primary school children and 2) to study the phenomenology of ADDH. One English medium school of suburb of Bombay agreed to participate in the study. The clats teachers of primary divisions (Std. I to IV) filled the specially designed proforma for each student. Those students scoring 11 or more points were studied in detail. The parents were asked to fill other special proforma including 10 item Parent Teacher rating scale for ADDH. At least one of the parent and the index child were interviewed separately. Prevalence of ADDH in 321 primary school children between the age of 5-10 years was found to be 8.1 %. The ratio of boys to girls was 7.6:1. ADDH was significantly associated with age group 8 to 10 years in boys and in total sample. First born children were significantly more in ADDH group. All the students had average or above average I. Q. still 8.33 percent students had failed in annual examinations. The complicated deliveries were more common. 87.5% of parents had not considered ADDH as abnormal.
Progress in neuro-psychopharmacology, 1979
Humans have developed specific abilities to interact efficiently with their conspecifics (social ... more Humans have developed specific abilities to interact efficiently with their conspecifics (social cognition). Despite abundant behavioral and neuroscientific research, the influence of cultural factors on these skills remains poorly understood. This issue is of particular importance as most cognitive tasks are developed in highly specific contexts, not representative of what is encountered by the world’s population. Through a large international and multi-site study, we assessed core social cognition aspects using current gold-standard tasks in 587 participants from 12 countries. Age, gender, and education were found to impact emotion recognition as well as the ability to infer mental states. After controlling for these factors, differences between countries accounted for more than 20% of the variance on both abilities. Importantly, it was possible to isolate cultural from linguistic impacts, which classically constitute a major limitation. We suggest important methodological shifts ...
Journal of Affective Disorders, 1986
International Journal of Social Psychiatry, 1982
The symptoms exhibited by 100 depressed patients from Western India were studied. A statistical c... more The symptoms exhibited by 100 depressed patients from Western India were studied. A statistical comparison was made of these symptoms with the symptoms of British depressed patients, reported in two studies from Newcastle-upon-Tyne. The symptoms in this group are similar to what has been reported for the Indian population in general except for paranoid features, which were less common. Compared with depressed patients from North India, somatic symptoms were significantly more common, while late insomnia, reduction in work and activities, and retardation were significant less frequent. Compared to South Indian depressed patients, depressed mood and hypochondriasis were significantly greater, and suicidal tendency and diurnal variation significantly less. Amongst Indian depressed patients generally, somatic symptoms, hypochondriasis, anxiety and agitation are present in a significantly larger percentage of patients, but guilt feelings, obsessional and paranoid symptoms are significantly less frequent, compared with British depressed patients.
“A fellow psychiatrist once told an anecdote. He was at a conference about depression in developi... more “A fellow psychiatrist once told an anecdote. He was at a conference about depression in developing countries. The essence of the lectures was that people in those areas commonly expressed depression as physical symptoms. They ‘somaticize ’ their depression, to use the medical parlance, complaining of malaise, stomach aches, dizziness and other symptoms that are hard to pin down. Young psychiatrist from third world commented “it is not that we in the third world somaticize depression, but rather that you in the developed world psychologise it?’’ [Times of India, 8th Feb. 2004] The relationship between physical symptoms and psychiatric disorders is widely recognized as complex (Mechanic, 1972; Goldberg, 1975). Most standard assessment instruments for evaluating psychiatric disorders inquire into the presence
Indian journal of psychiatry, 1989
Ninety two out of one hundred cases of major depressive disorder were followed up for a period of... more Ninety two out of one hundred cases of major depressive disorder were followed up for a period of 5 to 10 years after the index diagnosis. 36.6 per cent of the cases, had no recurrence. Out of the 63.4 per cent of the cases who had recurrences, 37.8 per cent cases turned out to be having bipolar affective disorder and remaining 25.6 per cent had major depressive disorder, recurrent type. The change of polarity from major depressive disorder to bipolar affective illness occurred within three years after the initial depressive episode in 77 per cent of the cases. The number of depressive episodes before I he onset of mania, was one in 63.0 per cent of the cases; two in 33.3 per cent and three in 3.7 per cent. 31 cases of bipolar affective disorder had a total of 152 recurrences, comprising 97 manic and 55 depressive episodes, the average being 4.9. The total number of episodes in 21 cases of major depressive disorder, recurrent type, were 73 yielding an average of 3.4, significantly l...
The rabbit syndrome, a neuroleptic induced extrapyramidal side effect with Vafe onset, consists o... more The rabbit syndrome, a neuroleptic induced extrapyramidal side effect with Vafe onset, consists of rapid fine rhythmic movements of the lips that mimic the chewing movements of a rabbit. This syndrome was first described by Villeneuve in 1972. Unlike the buccolingual movements of the tardive dyskinesia, the rabbit syndrome improves with antiparkinsonian medication. The condition is reported to be rare. To the best knowledge of the author, no case has been described or reported from India. A case of rabbit syndrome is described with review of the literature.
Despite the availability of several antidepressants, low patient compliance with medication, main... more Despite the availability of several antidepressants, low patient compliance with medication, mainly due to adverse effects remains a major problem. The aim of this study was to evaluate the efficacy and compliance of tianeptine, a selective serotonin reuptake enhancer (SSRE), for the treatment of major depression in primary care setting of India. In a prospective observational multicentric study, 320 outpatients with major depression were treated with tianeptine 12.5 mg thrice daily for 60 days. Outcome measures were change in Hamilton depression rating scale (HDRS) score, frequency of side-effects, and compliance with medication. After treatment, mean HDRS score decreased from 10.9 +/- 3.2 at baseline to 6.9 +/- 2.7 at day 60 (p < 0.01), with more than half the patients showing > 50% improvement in HDRS score. No patient withdrew due to side-effects, which were reported in 23 patients (7.2%). Mean compliance with the medication was 91%. This study demonstrates the efficacy an...
Indian journal of psychiatry, 1985
Indian journal of psychiatry, 1987
Page 1. Indian Journal of Psychiatry, January 1987 29(1), pp. 15-31 TILAK VENKOBA RAO ORATION PSY... more Page 1. Indian Journal of Psychiatry, January 1987 29(1), pp. 15-31 TILAK VENKOBA RAO ORATION PSYCHOBIOLOGY OF DEPRESSIONH MANILAL GADA** Introduction I am grateful to you all, the Chairman and members ...
Journal of the Indian Medical Association, 2005
Despite the availability of several antidepressants, low patient compliance with medication, main... more Despite the availability of several antidepressants, low patient compliance with medication, mainly due to adverse effects remains a major problem. The aim of this study was to evaluate the efficacy and compliance of tianeptine, a selective serotonin reuptake enhancer (SSRE), for the treatment of major depression in primary care setting of India. In a prospective observational multicentric study, 320 outpatients with major depression were treated with tianeptine 12.5 mg thrice daily for 60 days. Outcome measures were change in Hamilton depression rating scale (HDRS) score, frequency of side-effects, and compliance with medication. After treatment, mean HDRS score decreased from 10.9 +/- 3.2 at baseline to 6.9 +/- 2.7 at day 60 (p < 0.01), with more than half the patients showing > 50% improvement in HDRS score. No patient withdrew due to side-effects, which were reported in 23 patients (7.2%). Mean compliance with the medication was 91%. This study demonstrates the efficacy an...
Mens Sana Monographs, 2015
Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankar... more Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankaras, 23 having preceded him. The principals of Jaina religion teach us: (1) Self-control, which includes: (a) Control over physiological instinct of hunger and sex; (b) control over desires; (c) control over emotions; (2) meditation; (3) introspection; (4) concentration; and (5) healthy interpersonal relationship. The principles of Jaina Religion can contribute to Positive Mental Health.
Mens Sana Monographs, 2015
Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankar... more Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankaras, 23 having preceded him. The principals of Jaina religion teach us: (1) Self-control, which includes: (a) Control over physiological instinct of hunger and sex; (b) control over desires; (c) control over emotions; (2) meditation; (3) introspection; (4) concentration; and (5) healthy interpersonal relationship. The principles of Jaina Religion can contribute to Positive Mental Health.
Indian journal of psychiatry, 2004
PubMed, Feb 1, 2005
Despite the availability of several antidepressants, low patient compliance with medication, main... more Despite the availability of several antidepressants, low patient compliance with medication, mainly due to adverse effects remains a major problem. The aim of this study was to evaluate the efficacy and compliance of tianeptine, a selective serotonin reuptake enhancer (SSRE), for the treatment of major depression in primary care setting of India. In a prospective observational multicentric study, 320 outpatients with major depression were treated with tianeptine 12.5 mg thrice daily for 60 days. Outcome measures were change in Hamilton depression rating scale (HDRS) score, frequency of side-effects, and compliance with medication. After treatment, mean HDRS score decreased from 10.9 +/- 3.2 at baseline to 6.9 +/- 2.7 at day 60 (p < 0.01), with more than half the patients showing > 50% improvement in HDRS score. No patient withdrew due to side-effects, which were reported in 23 patients (7.2%). Mean compliance with the medication was 91%. This study demonstrates the efficacy and acceptability of tianeptine in the management of major depression in Indian clinical practice.
PubMed, Jul 1, 1989
Ninety two out of one hundred cases of major depressive disorder were followed up for a period of... more Ninety two out of one hundred cases of major depressive disorder were followed up for a period of 5 to 10 years after the index diagnosis. 36.6 per cent of the cases, had no recurrence. Out of the 63.4 per cent of the cases who had recurrences, 37.8 per cent cases turned out to be having bipolar affective disorder and remaining 25.6 per cent had major depressive disorder, recurrent type. The change of polarity from major depressive disorder to bipolar affective illness occurred within three years after the initial depressive episode in 77 per cent of the cases. The number of depressive episodes before I he onset of mania, was one in 63.0 per cent of the cases; two in 33.3 per cent and three in 3.7 per cent. 31 cases of bipolar affective disorder had a total of 152 recurrences, comprising 97 manic and 55 depressive episodes, the average being 4.9. The total number of episodes in 21 cases of major depressive disorder, recurrent type, were 73 yielding an average of 3.4, significantly less than those of bipolar affective illness cases. 2.2 per cent of the cases had successfully committed suicide.
PubMed, 1987
Page 1. Indian Journal of Psychiatry, January 1987 29(1), pp. 15-31 TILAK VENKOBA RAO ORATION PSY... more Page 1. Indian Journal of Psychiatry, January 1987 29(1), pp. 15-31 TILAK VENKOBA RAO ORATION PSYCHOBIOLOGY OF DEPRESSIONH MANILAL GADA** Introduction I am grateful to you all, the Chairman and members ...
Mens Sana Monographs, 2015
Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankar... more Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankaras, 23 having preceded him. The principals of Jaina religion teach us: (1) Self-control, which includes: (a) Control over physiological instinct of hunger and sex; (b) control over desires; (c) control over emotions; (2) meditation; (3) introspection; (4) concentration; and (5) healthy interpersonal relationship. The principles of Jaina Religion can contribute to Positive Mental Health.
PubMed, Apr 1, 1987
The present study was undertaken with the aim of 1) Identifying students with ADDH in a primary s... more The present study was undertaken with the aim of 1) Identifying students with ADDH in a primary school children and 2) to study the phenomenology of ADDH. One English medium school of suburb of Bombay agreed to participate in the study. The clats teachers of primary divisions (Std. I to IV) filled the specially designed proforma for each student. Those students scoring 11 or more points were studied in detail. The parents were asked to fill other special proforma including 10 item Parent Teacher rating scale for ADDH. At least one of the parent and the index child were interviewed separately. Prevalence of ADDH in 321 primary school children between the age of 5-10 years was found to be 8.1 %. The ratio of boys to girls was 7.6:1. ADDH was significantly associated with age group 8 to 10 years in boys and in total sample. First born children were significantly more in ADDH group. All the students had average or above average I. Q. still 8.33 percent students had failed in annual examinations. The complicated deliveries were more common. 87.5% of parents had not considered ADDH as abnormal.
Progress in neuro-psychopharmacology, 1979
Humans have developed specific abilities to interact efficiently with their conspecifics (social ... more Humans have developed specific abilities to interact efficiently with their conspecifics (social cognition). Despite abundant behavioral and neuroscientific research, the influence of cultural factors on these skills remains poorly understood. This issue is of particular importance as most cognitive tasks are developed in highly specific contexts, not representative of what is encountered by the world’s population. Through a large international and multi-site study, we assessed core social cognition aspects using current gold-standard tasks in 587 participants from 12 countries. Age, gender, and education were found to impact emotion recognition as well as the ability to infer mental states. After controlling for these factors, differences between countries accounted for more than 20% of the variance on both abilities. Importantly, it was possible to isolate cultural from linguistic impacts, which classically constitute a major limitation. We suggest important methodological shifts ...
Journal of Affective Disorders, 1986
International Journal of Social Psychiatry, 1982
The symptoms exhibited by 100 depressed patients from Western India were studied. A statistical c... more The symptoms exhibited by 100 depressed patients from Western India were studied. A statistical comparison was made of these symptoms with the symptoms of British depressed patients, reported in two studies from Newcastle-upon-Tyne. The symptoms in this group are similar to what has been reported for the Indian population in general except for paranoid features, which were less common. Compared with depressed patients from North India, somatic symptoms were significantly more common, while late insomnia, reduction in work and activities, and retardation were significant less frequent. Compared to South Indian depressed patients, depressed mood and hypochondriasis were significantly greater, and suicidal tendency and diurnal variation significantly less. Amongst Indian depressed patients generally, somatic symptoms, hypochondriasis, anxiety and agitation are present in a significantly larger percentage of patients, but guilt feelings, obsessional and paranoid symptoms are significantly less frequent, compared with British depressed patients.
“A fellow psychiatrist once told an anecdote. He was at a conference about depression in developi... more “A fellow psychiatrist once told an anecdote. He was at a conference about depression in developing countries. The essence of the lectures was that people in those areas commonly expressed depression as physical symptoms. They ‘somaticize ’ their depression, to use the medical parlance, complaining of malaise, stomach aches, dizziness and other symptoms that are hard to pin down. Young psychiatrist from third world commented “it is not that we in the third world somaticize depression, but rather that you in the developed world psychologise it?’’ [Times of India, 8th Feb. 2004] The relationship between physical symptoms and psychiatric disorders is widely recognized as complex (Mechanic, 1972; Goldberg, 1975). Most standard assessment instruments for evaluating psychiatric disorders inquire into the presence
Indian journal of psychiatry, 1989
Ninety two out of one hundred cases of major depressive disorder were followed up for a period of... more Ninety two out of one hundred cases of major depressive disorder were followed up for a period of 5 to 10 years after the index diagnosis. 36.6 per cent of the cases, had no recurrence. Out of the 63.4 per cent of the cases who had recurrences, 37.8 per cent cases turned out to be having bipolar affective disorder and remaining 25.6 per cent had major depressive disorder, recurrent type. The change of polarity from major depressive disorder to bipolar affective illness occurred within three years after the initial depressive episode in 77 per cent of the cases. The number of depressive episodes before I he onset of mania, was one in 63.0 per cent of the cases; two in 33.3 per cent and three in 3.7 per cent. 31 cases of bipolar affective disorder had a total of 152 recurrences, comprising 97 manic and 55 depressive episodes, the average being 4.9. The total number of episodes in 21 cases of major depressive disorder, recurrent type, were 73 yielding an average of 3.4, significantly l...
The rabbit syndrome, a neuroleptic induced extrapyramidal side effect with Vafe onset, consists o... more The rabbit syndrome, a neuroleptic induced extrapyramidal side effect with Vafe onset, consists of rapid fine rhythmic movements of the lips that mimic the chewing movements of a rabbit. This syndrome was first described by Villeneuve in 1972. Unlike the buccolingual movements of the tardive dyskinesia, the rabbit syndrome improves with antiparkinsonian medication. The condition is reported to be rare. To the best knowledge of the author, no case has been described or reported from India. A case of rabbit syndrome is described with review of the literature.
Despite the availability of several antidepressants, low patient compliance with medication, main... more Despite the availability of several antidepressants, low patient compliance with medication, mainly due to adverse effects remains a major problem. The aim of this study was to evaluate the efficacy and compliance of tianeptine, a selective serotonin reuptake enhancer (SSRE), for the treatment of major depression in primary care setting of India. In a prospective observational multicentric study, 320 outpatients with major depression were treated with tianeptine 12.5 mg thrice daily for 60 days. Outcome measures were change in Hamilton depression rating scale (HDRS) score, frequency of side-effects, and compliance with medication. After treatment, mean HDRS score decreased from 10.9 +/- 3.2 at baseline to 6.9 +/- 2.7 at day 60 (p < 0.01), with more than half the patients showing > 50% improvement in HDRS score. No patient withdrew due to side-effects, which were reported in 23 patients (7.2%). Mean compliance with the medication was 91%. This study demonstrates the efficacy an...
Indian journal of psychiatry, 1985
Indian journal of psychiatry, 1987
Page 1. Indian Journal of Psychiatry, January 1987 29(1), pp. 15-31 TILAK VENKOBA RAO ORATION PSY... more Page 1. Indian Journal of Psychiatry, January 1987 29(1), pp. 15-31 TILAK VENKOBA RAO ORATION PSYCHOBIOLOGY OF DEPRESSIONH MANILAL GADA** Introduction I am grateful to you all, the Chairman and members ...
Journal of the Indian Medical Association, 2005
Despite the availability of several antidepressants, low patient compliance with medication, main... more Despite the availability of several antidepressants, low patient compliance with medication, mainly due to adverse effects remains a major problem. The aim of this study was to evaluate the efficacy and compliance of tianeptine, a selective serotonin reuptake enhancer (SSRE), for the treatment of major depression in primary care setting of India. In a prospective observational multicentric study, 320 outpatients with major depression were treated with tianeptine 12.5 mg thrice daily for 60 days. Outcome measures were change in Hamilton depression rating scale (HDRS) score, frequency of side-effects, and compliance with medication. After treatment, mean HDRS score decreased from 10.9 +/- 3.2 at baseline to 6.9 +/- 2.7 at day 60 (p < 0.01), with more than half the patients showing > 50% improvement in HDRS score. No patient withdrew due to side-effects, which were reported in 23 patients (7.2%). Mean compliance with the medication was 91%. This study demonstrates the efficacy an...
Mens Sana Monographs, 2015
Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankar... more Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankaras, 23 having preceded him. The principals of Jaina religion teach us: (1) Self-control, which includes: (a) Control over physiological instinct of hunger and sex; (b) control over desires; (c) control over emotions; (2) meditation; (3) introspection; (4) concentration; and (5) healthy interpersonal relationship. The principles of Jaina Religion can contribute to Positive Mental Health.
Mens Sana Monographs, 2015
Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankar... more Jaina religion has existed for thousands of years. Lord Mahavir was the last of the 24 Tirthankaras, 23 having preceded him. The principals of Jaina religion teach us: (1) Self-control, which includes: (a) Control over physiological instinct of hunger and sex; (b) control over desires; (c) control over emotions; (2) meditation; (3) introspection; (4) concentration; and (5) healthy interpersonal relationship. The principles of Jaina Religion can contribute to Positive Mental Health.
Indian journal of psychiatry, 2004