Manju Mohanty - Academia.edu (original) (raw)

Papers by Manju Mohanty

Stroke, 2016

Introduction: A reliable plasma biomarker in differentiating between Alzheimer’s disease (AD) and... more Introduction: A reliable plasma biomarker in differentiating between Alzheimer’s disease (AD) and Vascular dementia (VaD) is the need of the hour, in most memory clinics. Hypothesis: We assessed the hypothesis that plasma inflammatory [Interleukin 6 (IL 6) and C-Reactive Protein (CRP)] and hemostatic (Fibrinogen and D dimer) biomarkers can aid in differentiating between AD and VaD. Methods: Neuropsychological assessment, MRI brain, FDG-PET brain and CSF biomarkers of AD (Aβ42 and total tau) were used for establishing the diagnosis of Mild Cognitive Impairment (MCI), AD or VaD. ELISA analyses for IL6, Fibrinogen, D dimer and CRP were performed according to the manufacturers’ protocols. Results: During the study period (January 2013-April 2014), 68 diagnosed patients of AD/MCI/VaD were included. FDG PET brain, plasma fibrinogen, D dimer, IL6 and CRP were done in all 68 patients while 48 patients underwent CSF biomarker analysis. Sixteen patients had MCI, of which 11 were MCI-AD and 5 ...

Objectives: Alzheimer's disease (AD) is the most common cause of dementia worldwide in the ol... more Objectives: Alzheimer's disease (AD) is the most common cause of dementia worldwide in the older population. There is no disease-modifying therapy available for AD. The current standard of care drug therapy for AD is cholinesterase inhibitors, including donepezil. Bacopa monnieri or brahmi is used in traditional Indian medicine for memory loss. We conducted a phase 2b randomized controlled trial (RCT) to find out the efficacy of brahmi and donepezil in AD and mild cognitive impairment (MCI). Patients and Methods: The study was planned as a 52 week, randomized, double-blind, parallel-group, phase-2 single-center clinical trial comparing the efficacy and safety of Bacopa monnieri (brahmi) 300 mg OD and donepezil 10 mg OD for 12 months in 48 patients with AD and MCI-AD including cognitive and quality of life outcomes. The primary outcome was differences in the change from baseline of the neuropsychological tests [Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog...

Objective To study the role of hemostatic and inflammatory biomarkers in Alzheimer’s and vascular... more Objective To study the role of hemostatic and inflammatory biomarkers in Alzheimer’s and vascular dementia Background A reliable plasma biomarker in differentiating between Alzheimer’s disease (AD) and Vascular dementia (VaD) is the need of the hour, in most memory clinics. We assessed the hypothesis that plasma inflammatory [Interleukin 6 (IL 6) and C-Reactive Protein (CRP)] and hemostatic (Fibrinogen and D dimer) biomarkers can aid in differentiating between AD and VaD. Methods Neuropsychological assessment, MRI brain, FDG-PET brain and CSF biomarkers of AD (Aβ42 and total tau) were used for establishing the diagnosis of Mild Cognitive Impairment (MCI), AD or VaD. ELISA analyses for IL6, Fibrinogen, D dimer and CRP were performed according to the manufacturers’ protocols. Results During the study period (January 2013-April 2014), 68 diagnosed patients of AD/MCI/VaD were included. FDG PET brain, plasma fibrinogen, D dimer, IL6 and CRP were done in all 68 patients while 48 patients ...

Journal of neurosurgery, Jan 3, 2017

OBJECTIVE Decompressive craniectomy is an established therapy for refractory intracranial hyperte... more OBJECTIVE Decompressive craniectomy is an established therapy for refractory intracranial hypertension. Cranioplasty following decompressive craniectomy not only provides protection to the brain along with cosmetic benefits, but also enhances rehabilitation with meaningful functional recovery of potentially reversible cortical and subcortical damaged areas of the affected as well as the contralateral hemisphere. The aim of the study was to assess neurological and cognitive outcome as well as cerebral blood flow after cranioplasty. METHODS Thirty-four patients admitted for replacement cranioplasty after decompressive craniectomy for head injury were studied prospectively. Clinical, neurological, and cognitive outcomes were assessed by the Glasgow Outcome Scale (GOS), the Glasgow Coma Scale, and a battery of cognitive tests, respectively. Simultaneously, cerebral blood perfusion was assessed by technetium-99m ethyl cysteinate dimer ((99m)Tc-ECD) brain SPECT imaging 7 days prior to and...

Nursing Journal of India

In this study, conducted to assess the in uence of the type-D personality of patients with intrac... more In this study, conducted to assess the in uence of the type-D personality of patients with intracranial tumours on their behavioural changes, a prospective design was undertaken. Patients were enrolled before surgery or any de nitive treatment (pre-treatment) and were followed up for behavioural symptoms at one month and six months after surgery. Using purposive sampling, 150 patients who were treated and followed up in Neurosurgery outpatient department at a tertiary care centre of North India, DS14 questionnaire and Neuropsychiatric inventory were used to measure type-D personality and behavioural symptoms. The type-D personality of the patients was assessed before surgery or initiating any de nitive treatment (pre-treatment), and behavioural symptoms were assessed at pre-treatment, and at one month and six months after surgery or any de nitive treatment. Patients of intracranial tumours with and without type-D personality were comparable regarding demographic and clinical variabl...

Indian Journal of Psychiatry, 2002

The study was aimed at estimating the joint-rater reliability and applicability of Hindi version ... more The study was aimed at estimating the joint-rater reliability and applicability of Hindi version of ICD-10 IPDE that was obtained following a standard translation protocol. The instrument was administered to 22 non-psychotic patients by two raters. The average intraclass correlation for each item (0.89), number of criteria met per disorder (0.92) and dimensional scores (0.98) was high. Kappa for definite (0.65-0.78) and probaole personality disorder (PD) (0.78-1.00) and for presence/absence of any PD (0.78) was acceptable. Overall weighted kappa was 0.81 for definite and 0.91 for probable PD. Findings suggest that ICD-10 IPDE (Hindi version) has acceptable joint- rater reliability and applicability in the North Indian Hindi speaking population.

Background: Learning Disabilities are neurologically based disabilities and are associated with d... more Background: Learning Disabilities are neurologically based disabilities and are associated with deficits in learning basic skills like reading, arithmetic and writing. Problems become evident when the child starts going to school and is unable to match up with other students of his age. With the growing awareness of the problem it is the need of the hour to have a battery on Specific Learning Disabilities (SLD) with normative data based on a regional sample. The batteries which were being used for assessment were reviewed and their merits and limitations were evaluated on the basis of the reported limitations and clinical experience of the experts. Objective: The aim of the paper is to present the preliminary results of the pilot study conducted to try out the battery prepared for the assessment of Specific Learning Disabilities. Sample: 40 regular school children (6years to 16 years) with average intelligence. Design: The schools were selected purposely and students were selected t...

Aim: The study compared the pattern of deficits, intelligence and neuropsychological functioning ... more Aim: The study compared the pattern of deficits, intelligence and neuropsychological functioning in subcategories of learning disorders. Methods: Forty-six children (16 with reading disorders, 11 with writing disorders and 19 with both reading and writing disorders mixed group) in the age range of 7–14 years were assessed using the NIMHANS Index of Specific Learning Disabilities, Malin’s Intelligence Scale for Indian Children, and the PGI Memory Scale. Results: The mixed group had greater dysfunction than the reading and writing groups in alphabet sequencing and graded division, and the mixed group had greater dysfunction than the writing group in capital letters, division and graded subtraction. Also, the mixed and reading groups had greater dysfunction than the writing group in speech and language. Intellectual functions and mental balance (on PGI memory scale) were more affected in the mixed group in comparison to the writing group. Conclusion: Subtypes of learning disorders diff...

Neurology India, 2021

Background: Surgical revascularization is the mainstay of treatment in symptomatic patients of mo... more Background: Surgical revascularization is the mainstay of treatment in symptomatic patients of moyamoya disease (MMD). Objective: The present study analyzed the postoperative angio-architecture in pediatric and adult patients of moyamoya disease. Material and Methods: Patients with MMD, both ischemic and hemorrhagic, were subjected to surgery. A superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis was attempted in all. It was augmented by an encephalo-duro-myo-synangiosis), this was labelled as the combined surgical group. In patients where a direct bypass was not possible encephalo-duro-arterio-myo-synangiosis (EDAMS) was performed and these patients were put in the indirect surgery group. In the postoperative period, MRA was performed in all patients to look for (a) graft patency, (b) regression of moyamoya vessels, and (c) degree of surgical neovascularization (as quantified on adapted Matsushima and Inaba grading system). Results: Eighty-two patients underwen...

Neurology, 2015

Objective To evaluate the diagnostic value of plasma clusterin in Alzheimer’s disease (AD) Backgr... more Objective To evaluate the diagnostic value of plasma clusterin in Alzheimer’s disease (AD) Background Plasma clusterin is a promising biomarker in Alzheimer9s disease as various studies have shown it to be associated with entorhinal cortex atrophy, baseline disease severity, and rapid clinical progression. But other studies have shown that plasma clusterin levels were not increased in presymptomatic AD. Hence the diagnostic value of plasma clusterin is still not conclusive. Methods All consecutive patients diagnosed as mild cognitive impairment, Alzheimer’s disease and Vascular dementia in our memory clinic were included for this hospital based cross-sectional study. We used Neuropsychological assessment, MRI brain, FDG-PET brain and CSF markers of Alzheimer’s disease (Aβ₄₂ , total tau) for establishing the diagnosis. The CSF control group included patients who were having knee or hip surgery and plasma control group included the spouses or relatives of patients. Results Of the 70 p...

This book is about examination of functional relation between language structure, internal brain ... more This book is about examination of functional relation between language structure, internal brain regulatory processes and external processes in nature. Book describes the relation of learning, language and cognitive fitness as adaptive biological interrelations of a process called life. Author describes human being's unique advantage of understanding thought process, language and the reality under the shadow of scientific processes. Evolution of language contributes to the search of novelty of thoughts, behaviour, knowledge, problems, solutions, creativity, learning, innovation, trust and belief in the human kind to serve the horizon. Author linked the evolution of human brain with evolution of primitive language which represented primitive information processing and reasoning. Complexity of language is attributed for understanding complexity of nature to reveal its most dynamic aspects enabling the bigger view of perspective. Linkage of Hippocampus and amygdala to segregate and...

Indian Journal of Radiology and Imaging, 2019

Purpose:The association between obstructive sleep apnea (OSA) and cognitive impairment is well-re... more Purpose:The association between obstructive sleep apnea (OSA) and cognitive impairment is well-recognized, but little is known about neural derangements that underlie this phenomenon. The purpose of this study was to evaluate the utility of diffusion kurtosis imaging (DKI) using a whole-brain atlas to comprehensively assess microstructural tissue changes in the brain of patients with OSA.Methods:This prospective study was conducted in 20 patients with moderate-to-severe OSA and 20 age- and gender-matched controls. MRI data acquisition was performed with 3 Tesla and data was analyzed using a whole-brain atlas. DKI data were processed and transformed into a brain template space to obtain various kurtosis parameters including axial kurtosis (AK), radial kurtosis (RK), mean kurtosis (MK), and kurtosis fractional anisotropy (KFA) using a 189-region brain atlas in the same template space. These kurtosis measurements were further analyzed using a student t-test in order to determine kurtosis measurements that present significant differences between the OSA patient set and the control set.Results:Significant differences (P < 0.05) were found in AK (54 regions), RK (10 regions), MK (6 regions) and KFA (41 regions) values in patients with OSA as compared to controls. DKI indices, using an atlas-based whole-brain analysis approach used in our study, showed widespread involvement of the anatomical regions in patients with OSA.Conclusion:The kurtosis parameters are more sensitive in demonstrating abnormalities in brain tissue structural organization at the microstructural level before any detectable changes appear in conventional MRI or other imaging modalities.

Clinical Journal of Oncology Nursing

18th Annual Conference of Indian Society of Neuroanaesthesiology and Critical Care (ISNACC 2017)

Clinical Neurology and Neurosurgery