Mara Antonoff - Academia.edu (original) (raw)
Papers by Mara Antonoff
Principles and Practice, 2015
Imaging the ICU Patient, 2014
Ashcraft's Pediatric Surgery, 2010
Seminars in Thoracic and Cardiovascular Surgery, 2010
Identifying novel drugs for treatment of lung cancer remains of utmost importance, and, in recent... more Identifying novel drugs for treatment of lung cancer remains of utmost importance, and, in recent years, targeted therapies have been acknowledged as particularly attractive. Metformin, a commonly prescribed oral hypoglycemic agent, has known effects on the mammalian target of rapamycin pathway, ultimately resulting in downstream inhibition of cellular growth and proliferation. In a recent article (Memmott RM, Mercado JR, Maier CR, et al: Metformin prevents tobacco carcinogen-induced lung tumorigenesis. Cancer Prev Res (Phila) 3:1066-1076, 2010), Memmott et al assessed the utility of metformin in an in vivo model of tobacco carcinogen-induced lung cancer. The authors show that tumor burden is decreased in animals administered metformin, suggesting that this drug may have promising potential for the treatment and chemoprevention of lung cancer.
The Annals of Thoracic Surgery, 2015
The Journal of Thoracic and Cardiovascular Surgery, 2015
To identify predictors of BNP levels, we evaluated 163 hospitalized acute HF patients. Thoracic f... more To identify predictors of BNP levels, we evaluated 163 hospitalized acute HF patients. Thoracic fluid content (TFC) and hemodynamic parameters were measured by impedance cardiography at discharge. Patients were followed-up for 60 days for the occurrence of death/hospital ...
RESULTS: Oxidative stress (hypoxia or H2O2 treatment) induced the nucleocytoplasmic shuttling and... more RESULTS: Oxidative stress (hypoxia or H2O2 treatment) induced the nucleocytoplasmic shuttling and release of HMGB1 from cultured hepatocytes. Cisplatin abrogated this effect and resulted in the S21
The Journal of thoracic and cardiovascular surgery, Jan 14, 2015
Annals of vascular surgery, 2012
Before the development of the inferior vena cava (IVC) filter, various techniques of IVC interrup... more Before the development of the inferior vena cava (IVC) filter, various techniques of IVC interruption were described for the management of patients at high risk for thromboembolic events, and for whom anticoagulation was either inadequate or contraindicated. In this report, we describe the enteric migration of a Miles IVC clip, occurring 27 years after IVC interruption. This previously undescribed complication and the patient's prolonged follow-up period render this case of significant interest.
Seminars in thoracic and cardiovascular surgery, 2011
In a recent report, authors describe their findings from the Exhale Airway Stents for Emphysema (... more In a recent report, authors describe their findings from the Exhale Airway Stents for Emphysema (EASE) trial. In this study, investigators follow patients with emphysema and severe hyperinflation after a novel bronchoscopic lung-volume reduction procedure utilizing paclitaxel-eluting stents. Despite the merits of this randomized, sham-controlled, multi-institutional study, the authors were unable to demonstrate any sustainable benefit for the treatment group upon follow-up. Nonetheless, important lessons can be learned from this trial, which has set a foundation for future investigations.
Seminars in thoracic and cardiovascular surgery, 2011
In a recent article published in The Lancet, investigators studied the impact of daily aspirin us... more In a recent article published in The Lancet, investigators studied the impact of daily aspirin use on subsequent cancer deaths. Utilizing data from more than 25,000 patients enrolled in 8 large trials, which were originally intended to study the impact of daily aspirin use on the incidence of cardiovascular events, the authors found a substantial decrease in risk of fatal solid organ malignancies. In particular, the risk reduction was specific to adenocarcinomas. The findings from this study are highly relevant to the thoracic surgeon, with adenocarcinomas of the lung and esophagus among those tumors demonstrating the most profound risk reduction.
Seminars in thoracic and cardiovascular surgery, 2011
In a recent publication, investigators examined the ways in which learners most effectively acqui... more In a recent publication, investigators examined the ways in which learners most effectively acquired new knowledge. The authors found that students achieved the most meaningful and long-lasting learning through retrieval practice, a method consisting of taking tests on the curricular material covered as part of the primary learning activity. The findings from this study may be useful in enhancing the ways that we prepare our surgical trainees. Further, these data have important implications as we consider our own processes for lifelong learning.
Seminars in thoracic and cardiovascular surgery, 2010
Identifying novel drugs for treatment of lung cancer remains of utmost importance, and, in recent... more Identifying novel drugs for treatment of lung cancer remains of utmost importance, and, in recent years, targeted therapies have been acknowledged as particularly attractive. Metformin, a commonly prescribed oral hypoglycemic agent, has known effects on the mammalian target of rapamycin pathway, ultimately resulting in downstream inhibition of cellular growth and proliferation. In a recent article (Memmott RM, Mercado JR, Maier CR, et al: Metformin prevents tobacco carcinogen-induced lung tumorigenesis. Cancer Prev Res (Phila) 3:1066-1076, 2010), Memmott et al assessed the utility of metformin in an in vivo model of tobacco carcinogen-induced lung cancer. The authors show that tumor burden is decreased in animals administered metformin, suggesting that this drug may have promising potential for the treatment and chemoprevention of lung cancer.
Principles and Practice, 2015
Imaging the ICU Patient, 2014
Ashcraft's Pediatric Surgery, 2010
Seminars in Thoracic and Cardiovascular Surgery, 2010
Identifying novel drugs for treatment of lung cancer remains of utmost importance, and, in recent... more Identifying novel drugs for treatment of lung cancer remains of utmost importance, and, in recent years, targeted therapies have been acknowledged as particularly attractive. Metformin, a commonly prescribed oral hypoglycemic agent, has known effects on the mammalian target of rapamycin pathway, ultimately resulting in downstream inhibition of cellular growth and proliferation. In a recent article (Memmott RM, Mercado JR, Maier CR, et al: Metformin prevents tobacco carcinogen-induced lung tumorigenesis. Cancer Prev Res (Phila) 3:1066-1076, 2010), Memmott et al assessed the utility of metformin in an in vivo model of tobacco carcinogen-induced lung cancer. The authors show that tumor burden is decreased in animals administered metformin, suggesting that this drug may have promising potential for the treatment and chemoprevention of lung cancer.
The Annals of Thoracic Surgery, 2015
The Journal of Thoracic and Cardiovascular Surgery, 2015
To identify predictors of BNP levels, we evaluated 163 hospitalized acute HF patients. Thoracic f... more To identify predictors of BNP levels, we evaluated 163 hospitalized acute HF patients. Thoracic fluid content (TFC) and hemodynamic parameters were measured by impedance cardiography at discharge. Patients were followed-up for 60 days for the occurrence of death/hospital ...
RESULTS: Oxidative stress (hypoxia or H2O2 treatment) induced the nucleocytoplasmic shuttling and... more RESULTS: Oxidative stress (hypoxia or H2O2 treatment) induced the nucleocytoplasmic shuttling and release of HMGB1 from cultured hepatocytes. Cisplatin abrogated this effect and resulted in the S21
The Journal of thoracic and cardiovascular surgery, Jan 14, 2015
Annals of vascular surgery, 2012
Before the development of the inferior vena cava (IVC) filter, various techniques of IVC interrup... more Before the development of the inferior vena cava (IVC) filter, various techniques of IVC interruption were described for the management of patients at high risk for thromboembolic events, and for whom anticoagulation was either inadequate or contraindicated. In this report, we describe the enteric migration of a Miles IVC clip, occurring 27 years after IVC interruption. This previously undescribed complication and the patient's prolonged follow-up period render this case of significant interest.
Seminars in thoracic and cardiovascular surgery, 2011
In a recent report, authors describe their findings from the Exhale Airway Stents for Emphysema (... more In a recent report, authors describe their findings from the Exhale Airway Stents for Emphysema (EASE) trial. In this study, investigators follow patients with emphysema and severe hyperinflation after a novel bronchoscopic lung-volume reduction procedure utilizing paclitaxel-eluting stents. Despite the merits of this randomized, sham-controlled, multi-institutional study, the authors were unable to demonstrate any sustainable benefit for the treatment group upon follow-up. Nonetheless, important lessons can be learned from this trial, which has set a foundation for future investigations.
Seminars in thoracic and cardiovascular surgery, 2011
In a recent article published in The Lancet, investigators studied the impact of daily aspirin us... more In a recent article published in The Lancet, investigators studied the impact of daily aspirin use on subsequent cancer deaths. Utilizing data from more than 25,000 patients enrolled in 8 large trials, which were originally intended to study the impact of daily aspirin use on the incidence of cardiovascular events, the authors found a substantial decrease in risk of fatal solid organ malignancies. In particular, the risk reduction was specific to adenocarcinomas. The findings from this study are highly relevant to the thoracic surgeon, with adenocarcinomas of the lung and esophagus among those tumors demonstrating the most profound risk reduction.
Seminars in thoracic and cardiovascular surgery, 2011
In a recent publication, investigators examined the ways in which learners most effectively acqui... more In a recent publication, investigators examined the ways in which learners most effectively acquired new knowledge. The authors found that students achieved the most meaningful and long-lasting learning through retrieval practice, a method consisting of taking tests on the curricular material covered as part of the primary learning activity. The findings from this study may be useful in enhancing the ways that we prepare our surgical trainees. Further, these data have important implications as we consider our own processes for lifelong learning.
Seminars in thoracic and cardiovascular surgery, 2010
Identifying novel drugs for treatment of lung cancer remains of utmost importance, and, in recent... more Identifying novel drugs for treatment of lung cancer remains of utmost importance, and, in recent years, targeted therapies have been acknowledged as particularly attractive. Metformin, a commonly prescribed oral hypoglycemic agent, has known effects on the mammalian target of rapamycin pathway, ultimately resulting in downstream inhibition of cellular growth and proliferation. In a recent article (Memmott RM, Mercado JR, Maier CR, et al: Metformin prevents tobacco carcinogen-induced lung tumorigenesis. Cancer Prev Res (Phila) 3:1066-1076, 2010), Memmott et al assessed the utility of metformin in an in vivo model of tobacco carcinogen-induced lung cancer. The authors show that tumor burden is decreased in animals administered metformin, suggesting that this drug may have promising potential for the treatment and chemoprevention of lung cancer.