Mariam Salim - Academia.edu (original) (raw)

Papers by Mariam Salim

Research paper thumbnail of Prevalence Of Anemia And The Risk Factors Involved In Pregnant Women Of Quetta Valley

Objective: To find the prevalence of Anemia in pregnant females of Quetta Valley and to identify ... more Objective: To find the prevalence of Anemia in pregnant females of Quetta Valley and to identify the risk factors involved in causing anemia Introduction: Anemia is a major health issue in the developing world, especially in the females of fertile age. Many studies show that the incidence is increasing day by day. Anemia in pregnant women poses a grave danger to the physical and mental health of the growing fetus. Patients and Methods: A sample size of four hundred pregnant females was taken and interviewed. The study was conducted in the public-sector hospital of Quetta. Demographic data was collected on the specially designed Performa and the blood sample was taken for the estimation of hemoglobin levels and ferritin levels. Data was analyzed on SPSS 11. Results: In our study, we found that 96% of pregnant females had anemia of varying severity, the majority being moderately anemic. Analysis of demographics showed that anemia was more prevalent in younger (mean age was 32.5 years)...

Research paper thumbnail of Prognosis of Breast Cancer in Very Young Age (Less Than 30 Years)

Journal of Cancer & Allied Specialties, 2016

Purpose: Breast cancer diagnosed at a younger age has aggressive biology being triple negative an... more Purpose: Breast cancer diagnosed at a younger age has aggressive biology being triple negative and high grade and is associated with poor prognosis.Materials and Methods: Retrospectively data of 121 patients age 30 years or younger registered during the year 2008 were reviewed. Data were extracted from the cancer registry department of the institute. Demographics studied were the age at diagnosis, gender, pregnancy or lactation association, family history of breast cancer, histopathological diagnosis, and stage of the disease, receptors, type of treatment, response, local recurrence, distant relapse, and survival. Results: A total of 121 patients with age 30 years or less were included. An only a single patient was male. The age range was from 20 to 30 years; bilateral involvement was seen in a single patient. Almost half 50.4% (n = 61) patients had locally advanced disease at presentation. Pregnancy/lactation-associated breast cancer was seen in 29.8% (n = 36). The most common stag...

Research paper thumbnail of Mucinous carcinoma of breast: A rare tumour with favorable prognosis - 10 years experience from a single center

Journal of Cancer & Allied Specialties, 2017

Purpose: The purpose of this study was to describe the biological behaviour of mucinous breast ca... more Purpose: The purpose of this study was to describe the biological behaviour of mucinous breast carcinoma (MBC) regarding their clinical presentations, pathological features, prognosis and survival.Methodology: We conducted this retrospective study from 2006 to 2015 (10-year duration) and included all the patients who presented with mucinous carcinoma of the breast at any age. We excluded all the patients who presented with invasive ductal carcinoma or other rare breast tumours. Each patient with mucinous carcinoma breast was categorised in terms of diagnosis, surgery, chemotherapy and outcome. For categorical variables, Chi-square test was used. Kaplan–Meier curves were used to determine estimated overall survival. Data analysis was carried out using the SPSS 20.Results: In total, 8841 patients with breast carcinoma presented during the study period. Of these, 74 patients were diagnosed as cases of MBC, constituting <1%. Family history of breast carcinoma was positive in 20% of p...

Research paper thumbnail of Inflammatory breast cancer. A challenging disease with poor prognosis

Research paper thumbnail of Factors responsible for local recurrence after breast conserving therapy: single center study of population with high percentage of bad prognostic factors

The Breast, 2018

443 Local Recurrence after Breast Conserving Therapy: Single center Study of Population with High... more 443 Local Recurrence after Breast Conserving Therapy: Single center Study of Population with High Percentage of Bad Prognostic Factors Shaukat Khanum Memorial Cancer Hospital & Research Center, Pakistan Mariam Salim, Jamshaid Hameed, Muhammad Taqi Pirzada, Razia Bano, Amina Iqbal Khan, Huma Majeed Khan, Zulqarnain Chaudhry

Research paper thumbnail of Managing the Axilla in Early Breast Cancer. Impact of ACOSOG Z0011 Trial in Changing Practices in a Low Middle Income Country

Asian Pacific journal of cancer prevention : APJCP, Aug 27, 2017

Objective: To determine the impact of the trial on surgeon practice patterns at our institution. ... more Objective: To determine the impact of the trial on surgeon practice patterns at our institution. Methodology: A comparison of patients undergoing surgery for early breast cancer before and after the implementation of the new guidelines was done. We adopted the new guidelines in April 2015. Patients meeting Z0011 inclusion criteria were identified. For group A (Pre Z0011) patients operated between Jan to Dec 2013 were studied. And for Group B (Post Z0011) patients operated between July 2014 to Jun 2015 were included. Clinicopathologic data were compared between the two groups. Results: There were 318 patients with clinical T1-2 tumors planned for breast conservation. 68% patients had T1 tumor and 32% had T2. 92% of the patients had IDCa. There were 150 patients in the pre-Z0011 group and 168 post-Z0011. 68% of the patients in Group A were ER+ve while 70% in group B. 38 (25.7 %) patients were sentinel lymph node (SLN) positive in the pre-Z0011 group versus 34 (21 %) post-Z0011 (p = 0....

Research paper thumbnail of Emerging trend of breast conserving treatment in a developing country. Single centre study of 2035 patients

European Journal of Surgical Oncology (EJSO), 2016

Research paper thumbnail of Do we need to stage the axilla prior to neo adjuvant chemo? Analysis of clinically and radiologically negative (n0) breast cancer patients from a single centre

Background: Staging the axilla via Sentinel Node biopsy (SLNBx) is a standard technique for cl... more Background: Staging the axilla via Sentinel Node biopsy (SLNBx) is a standard technique for clinically and radiologically negative patients. The timing to do the SLNBx before or after Neo Adj Chemo (NAC) is controversial. The aim of the study is to see the outcomes of SLNBX in our patients who underwent NAC in clinically and radiological negative axilla. Methods: Retrospective analysis of all patients from 2009–2013 were included with clinically and radiologically node negative axilla, requiring NAC to downstage their breast disease. Patient’s data was retrieved via hospital information System. Patient’s record was followed up for three years to see for axillary recurrence Data was analyzed on SPSS V 19. Results: A total of 560 patients were selected for the study and 34 were excluded so a total of 523 patients data was analyzed. All patients underwent SLNBX and 64.4% (334) were found to be negative on staging whereas only 35.5% (187) were found to be negative. All patients w...

Research paper thumbnail of Prevalence Of Anemia And The Risk Factors Involved In Pregnant Women Of Quetta Valley

Objective: To find the prevalence of Anemia in pregnant females of Quetta Valley and to identify ... more Objective: To find the prevalence of Anemia in pregnant females of Quetta Valley and to identify the risk factors involved in causing anemia Introduction: Anemia is a major health issue in the developing world, especially in the females of fertile age. Many studies show that the incidence is increasing day by day. Anemia in pregnant women poses a grave danger to the physical and mental health of the growing fetus. Patients and Methods: A sample size of four hundred pregnant females was taken and interviewed. The study was conducted in the public-sector hospital of Quetta. Demographic data was collected on the specially designed Performa and the blood sample was taken for the estimation of hemoglobin levels and ferritin levels. Data was analyzed on SPSS 11. Results: In our study, we found that 96% of pregnant females had anemia of varying severity, the majority being moderately anemic. Analysis of demographics showed that anemia was more prevalent in younger (mean age was 32.5 years)...

Research paper thumbnail of Prognosis of Breast Cancer in Very Young Age (Less Than 30 Years)

Journal of Cancer & Allied Specialties, 2016

Purpose: Breast cancer diagnosed at a younger age has aggressive biology being triple negative an... more Purpose: Breast cancer diagnosed at a younger age has aggressive biology being triple negative and high grade and is associated with poor prognosis.Materials and Methods: Retrospectively data of 121 patients age 30 years or younger registered during the year 2008 were reviewed. Data were extracted from the cancer registry department of the institute. Demographics studied were the age at diagnosis, gender, pregnancy or lactation association, family history of breast cancer, histopathological diagnosis, and stage of the disease, receptors, type of treatment, response, local recurrence, distant relapse, and survival. Results: A total of 121 patients with age 30 years or less were included. An only a single patient was male. The age range was from 20 to 30 years; bilateral involvement was seen in a single patient. Almost half 50.4% (n = 61) patients had locally advanced disease at presentation. Pregnancy/lactation-associated breast cancer was seen in 29.8% (n = 36). The most common stag...

Research paper thumbnail of Mucinous carcinoma of breast: A rare tumour with favorable prognosis - 10 years experience from a single center

Journal of Cancer & Allied Specialties, 2017

Purpose: The purpose of this study was to describe the biological behaviour of mucinous breast ca... more Purpose: The purpose of this study was to describe the biological behaviour of mucinous breast carcinoma (MBC) regarding their clinical presentations, pathological features, prognosis and survival.Methodology: We conducted this retrospective study from 2006 to 2015 (10-year duration) and included all the patients who presented with mucinous carcinoma of the breast at any age. We excluded all the patients who presented with invasive ductal carcinoma or other rare breast tumours. Each patient with mucinous carcinoma breast was categorised in terms of diagnosis, surgery, chemotherapy and outcome. For categorical variables, Chi-square test was used. Kaplan–Meier curves were used to determine estimated overall survival. Data analysis was carried out using the SPSS 20.Results: In total, 8841 patients with breast carcinoma presented during the study period. Of these, 74 patients were diagnosed as cases of MBC, constituting <1%. Family history of breast carcinoma was positive in 20% of p...

Research paper thumbnail of Inflammatory breast cancer. A challenging disease with poor prognosis

Research paper thumbnail of Factors responsible for local recurrence after breast conserving therapy: single center study of population with high percentage of bad prognostic factors

The Breast, 2018

443 Local Recurrence after Breast Conserving Therapy: Single center Study of Population with High... more 443 Local Recurrence after Breast Conserving Therapy: Single center Study of Population with High Percentage of Bad Prognostic Factors Shaukat Khanum Memorial Cancer Hospital & Research Center, Pakistan Mariam Salim, Jamshaid Hameed, Muhammad Taqi Pirzada, Razia Bano, Amina Iqbal Khan, Huma Majeed Khan, Zulqarnain Chaudhry

Research paper thumbnail of Managing the Axilla in Early Breast Cancer. Impact of ACOSOG Z0011 Trial in Changing Practices in a Low Middle Income Country

Asian Pacific journal of cancer prevention : APJCP, Aug 27, 2017

Objective: To determine the impact of the trial on surgeon practice patterns at our institution. ... more Objective: To determine the impact of the trial on surgeon practice patterns at our institution. Methodology: A comparison of patients undergoing surgery for early breast cancer before and after the implementation of the new guidelines was done. We adopted the new guidelines in April 2015. Patients meeting Z0011 inclusion criteria were identified. For group A (Pre Z0011) patients operated between Jan to Dec 2013 were studied. And for Group B (Post Z0011) patients operated between July 2014 to Jun 2015 were included. Clinicopathologic data were compared between the two groups. Results: There were 318 patients with clinical T1-2 tumors planned for breast conservation. 68% patients had T1 tumor and 32% had T2. 92% of the patients had IDCa. There were 150 patients in the pre-Z0011 group and 168 post-Z0011. 68% of the patients in Group A were ER+ve while 70% in group B. 38 (25.7 %) patients were sentinel lymph node (SLN) positive in the pre-Z0011 group versus 34 (21 %) post-Z0011 (p = 0....

Research paper thumbnail of Emerging trend of breast conserving treatment in a developing country. Single centre study of 2035 patients

European Journal of Surgical Oncology (EJSO), 2016

Research paper thumbnail of Do we need to stage the axilla prior to neo adjuvant chemo? Analysis of clinically and radiologically negative (n0) breast cancer patients from a single centre

Background: Staging the axilla via Sentinel Node biopsy (SLNBx) is a standard technique for cl... more Background: Staging the axilla via Sentinel Node biopsy (SLNBx) is a standard technique for clinically and radiologically negative patients. The timing to do the SLNBx before or after Neo Adj Chemo (NAC) is controversial. The aim of the study is to see the outcomes of SLNBX in our patients who underwent NAC in clinically and radiological negative axilla. Methods: Retrospective analysis of all patients from 2009–2013 were included with clinically and radiologically node negative axilla, requiring NAC to downstage their breast disease. Patient’s data was retrieved via hospital information System. Patient’s record was followed up for three years to see for axillary recurrence Data was analyzed on SPSS V 19. Results: A total of 560 patients were selected for the study and 34 were excluded so a total of 523 patients data was analyzed. All patients underwent SLNBX and 64.4% (334) were found to be negative on staging whereas only 35.5% (187) were found to be negative. All patients w...