Mariz Sintaha - Academia.edu (original) (raw)

Papers by Mariz Sintaha

Lancet (London, England), Jan 28, 2017

The association between intake of fruits, vegetables, and legumes with cardiovascular disease and... more The association between intake of fruits, vegetables, and legumes with cardiovascular disease and deaths has been investigated extensively in Europe, the USA, Japan, and China, but little or no data are available from the Middle East, South America, Africa, or south Asia. We did a prospective cohort study (Prospective Urban Rural Epidemiology [PURE] in 135 335 individuals aged 35 to 70 years without cardiovascular disease from 613 communities in 18 low-income, middle-income, and high-income countries in seven geographical regions: North America and Europe, South America, the Middle East, south Asia, China, southeast Asia, and Africa. We documented their diet using country-specific food frequency questionnaires at baseline. Standardised questionnaires were used to collect information about demographic factors, socioeconomic status (education, income, and employment), lifestyle (smoking, physical activity, and alcohol intake), health history and medication use, and family history of c...

The lancet. Diabetes & endocrinology, Oct 28, 2017

The relation between dietary nutrients and cardiovascular disease risk markers in many regions wo... more The relation between dietary nutrients and cardiovascular disease risk markers in many regions worldwide is unknown. In this study, we investigated the effect of dietary nutrients on blood lipids and blood pressure, two of the most important risk factors for cardiovascular disease, in low-income, middle-income, and high-income countries. We studied 125 287 participants from 18 countries in North America, South America, Europe, Africa, and Asia in the Prospective Urban Rural Epidemiology (PURE) study. Habitual food intake was measured with validated food frequency questionnaires. We assessed the associations between nutrients (total fats, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, carbohydrates, protein, and dietary cholesterol) and cardiovascular disease risk markers using multilevel modelling. The effect of isocaloric replacement of saturated fatty acids with other fats and carbohydrates was determined overall and by levels of intakes by use of...

The Lancet Public Health, 2017

Background Hypertension is considered the most important risk factor for cardiovascular diseases,... more Background Hypertension is considered the most important risk factor for cardiovascular diseases, but its control is poor worldwide. We aimed to assess the availability and affordability of blood pressure-lowering medicines, and the association with use of these medicines and blood pressure control in countries at varying levels of economic development. Methods We analysed the availability, costs, and affordability of blood pressure-lowering medicines with data recorded from 626 communities in 20 countries participating in the Prospective Urban Rural Epidemiological (PURE) study. Medicines were considered available if they were present in the local pharmacy when surveyed, and affordable if their combined cost was less than 20% of the households' capacity to pay. We related information about availability and affordability to use of these medicines and blood pressure control with multilevel mixed-effects logistic regression models, and compared results for high-income, upper-middle-income, lower-middle-income, and low-income countries. Data for India are presented separately because it has a large generic pharmaceutical industry and a higher availability of medicines than other countries at the same economic level. Findings The availability of two or more classes of blood pressure-lowering drugs was lower in low-income and middle-income countries (except for India) than in high-income countries. The proportion of communities with four drug classes available was 94% in high-income countries (108 of 115 communities), 76% in India (68 of 90), 71% in upper-middle-income countries (90 of 126), 47% in lower-middle-income countries (107 of 227), and 13% in low-income countries (nine of 68). The proportion of households unable to afford two blood pressure-lowering medicines was 31% in low-income countries (1069 of 3479 households), 9% in middle-income countries (5602 of 65 471), and less than 1% in high-income countries (44 of 10 880). Participants with known hypertension in communities that had all four drug classes available were more likely to use at least one blood pressure-lowering medicine (adjusted odds ratio [OR] 2•23, 95% CI 1•59-3•12); p<0•0001), combination therapy (1•53, 1•13-2•07; p=0•054), and have their blood pressure controlled (2•06, 1•69-2•50; p<0•0001) than were those in communities where blood pressure-lowering medicines were not available. Participants with known hypertension from households able to afford four blood pressure-lowering drug classes were more likely to use at least one blood pressure-lowering medicine (adjusted OR 1•42, 95% CI 1•25-1•62; p<0•0001), combination therapy (1•26, 1•08-1•47; p=0•0038), and have their blood pressure controlled (1•13, 1•00-1•28; p=0•0562) than were those unable to afford the medicines. Interpretation A large proportion of communities in low-income and middle-income countries do not have access to more than one blood pressure-lowering medicine and, when available, they are often not affordable. These factors are associated with poor blood pressure control. Ensuring access to affordable blood pressure-lowering medicines is essential for control of hypertension in low-income and middle-income countries.

Plants, Nov 2, 2022

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Lancet (London, England), Jan 28, 2017

The relationship between macronutrients and cardiovascular disease and mortality is controversial... more The relationship between macronutrients and cardiovascular disease and mortality is controversial. Most available data are from European and North American populations where nutrition excess is more likely, so their applicability to other populations is unclear. The Prospective Urban Rural Epidemiology (PURE) study is a large, epidemiological cohort study of individuals aged 35-70 years (enrolled between Jan 1, 2003, and March 31, 2013) in 18 countries with a median follow-up of 7·4 years (IQR 5·3-9·3). Dietary intake of 135 335 individuals was recorded using validated food frequency questionnaires. The primary outcomes were total mortality and major cardiovascular events (fatal cardiovascular disease, non-fatal myocardial infarction, stroke, and heart failure). Secondary outcomes were all myocardial infarctions, stroke, cardiovascular disease mortality, and non-cardiovascular disease mortality. Participants were categorised into quintiles of nutrient intake (carbohydrate, fats, and...

American-Eurasian Journal of Sustainable Agriculture, 2011

... Shejuty Shareen Lithy, Shahnaz Fatema Lisa, FM Safiul Azam, Shahnaz Rahman, Farjana Akter Noo... more ... Shejuty Shareen Lithy, Shahnaz Fatema Lisa, FM Safiul Azam, Shahnaz Rahman, Farjana Akter Noor, Mariz Sintaha, Alok Kumar Paul, Mohammed ... Alam, MA, FMS Azam, MM Karim, F. Rehana, N. Sharmin, MA Kalpana, R. Jahan, M. Rahmatullah and MA Khatun, 2010. ...

Bioremediation refers to the use of organisms to remove environmental pollutants. Besides identif... more Bioremediation refers to the use of organisms to remove environmental pollutants. Besides identifying different new plasmids capable of degrading environmental pollutants, many attempts have been taken by the genetic engineers to enhance the bioremediation potential of different microorganisms. Escherichia coli was engineered to convert chlorinated solvents such as trichloro ethylene and the highly toxic methyl parathion (pesticide), to non-toxic form. Escherichia coli was also engineered to remove radioactive waste (uranium) from environment through precipitation. Pseudomonas fluorescens, Escherichia coli and C. testosterone were engineered to degrade different Polychlorinated Biphenyls. Deinococcus geothermalis, Escherichia coli and Ralstonia eutropha were engineered for bioaccumulation of heavy metals to remove it from environment. Sinorhizobium meliloti and Escherichia coli were engineered for decolorization of azodye. Poly Aromatic Hydrocarbons and 2,4-dichlorophenoxyacetate (p...

Advances in Natural and Applied Sciences, 2011

ABSTRACT The antinociceptive activity of Xanthium indicum leaves and Leucas aspera whole plants w... more ABSTRACT The antinociceptive activity of Xanthium indicum leaves and Leucas aspera whole plants was evaluated in acetic acid-induced gastric pain models in Swiss albino mice. The methanol extract of leaves of Xanthium indicum demonstrated a significant and dose-...

American-Eurasian Journal of Sustainable Agriculture, 2010

Folk medicinal practitioners (Kavirajes) are the primary health-care providers to substantial seg... more Folk medicinal practitioners (Kavirajes) are the primary health-care providers to substantial segments of the rural population as well as the urban population of Bangladesh. Every village of Bangladesh has at least one practicing Kaviraj. The Kavirajes rely primarily on simple formulations of medicinal plants for treatment of ailments. While overall, simple ailments are treated by the Kavirajes, occasionally complicated ailments, which are hard to cure with allopathic medicine, are also treated by them. In previous ethnomedicinal surveys, we have observed considerable variation in the use of medicinal plants by the Kavirajes of different regions of Bangladesh, which extended to Kavirajes of even the same village or adjoining villages. To get a comprehensive picture of the medicinal plants used by the Kavirajes, it is therefore necessary to conduct surveys of individual villages. The objective of the present study was to conduct a survey among Kavirajes of seven villages in Ishwardi ...

Heritiera fomes Buch.-Ham. (Sterculiaceae family, local name: sundari) is a tree which is very co... more Heritiera fomes Buch.-Ham. (Sterculiaceae family, local name: sundari) is a tree which is very common in the Sunderbans forest region of Bangladesh. By nature, it is a mangrove species. Various parts of the plant are used by folk medicinal practitioners for treatment of heart diseases, bloating, stomachache, diabetes, pain, diarrhea, skin disorders, hepatic disorders, and goiter. The objective of the present study was to evaluate the antihyperglycemic activity of methanol extract of barks in oral glucose tolerance tests in glucose-loaded Swiss albino mice, and to evaluate the antinociceptive activity of methanol extract of barks in acetic acid-induced gastric pain writhing in the same mouse model. In antihyperglycemic activity tests, the extract demonstrated a dose-dependent and significant reduction in serum glucose levels, both at 60 as well as 120 minutes after glucose loading. At a dose of 250 mg extract/kg body weight, the level of serum glucose fell by 49.2% in mice following ...

American-Eurasian Journal of Sustainable Agriculture, 2010

Bagerhat district is in the southern portion of Bangladesh and contains a portion of the world&#3... more Bagerhat district is in the southern portion of Bangladesh and contains a portion of the world's largest mangrove forest, the Sunderbans. The Rupsha River flows through the district and falls into the Bay of Bengal after passing through the Sunderbans forest. Because of the coastal position of the district and the presence of the Sunderbans forest, the plants occurring in this estuarine region are considerably different from the plants in other districts of Bangladesh. The occupations of the people of the villages adjoining the Rupsha River are mainly agriculture, agricultural laborer, and extracting timber and other forest products from the Sunderbans forest. In absence of modern medicinal facilities, the people rely on folk medicinal practitioners for treatment of their ailments. It was the objective of the present study to conduct a survey among the folk medicinal practitioners (Kavirajes) in two villages on the banks of the Rupsha River, namely Chanpur and Andabaaz, to learn...

Bangladesh is a predominantly agricultural country containing 86,000 villages. The village popula... more Bangladesh is a predominantly agricultural country containing 86,000 villages. The village population consists of mainly farmers, with the majority of them being resource-poor in the sense of having small land holdings on which they grow various crops, the major crop being paddy. Most farmers maintain one or two cows, buffaloes, or goats in their homesteads. Animals like cows or buffaloes are mainly used for plowing (use of machines like tractors cannot be afforded by the small farmers) the land or as a source for milk production, the latter being both sold as well as consumed at home. Goats are raised for selling or occasional consumption of meat. By tradition, and because of the general poverty prevalent among small farmers, they still depend on traditional medicinal practitioners for treatment of their cattle during occurrence of various cattle ailments. The traditional medicinal practitioners, known as Kavirajes or cattle Kavirajes, rely on dispensation of various medicinal plan...

International Journal of Molecular Sciences

In the natural environment, plants are often bombarded by a combination of abiotic (such as droug... more In the natural environment, plants are often bombarded by a combination of abiotic (such as drought, salt, heat or cold) and biotic (necrotrophic and biotrophic pathogens) stresses simultaneously. It is critical to understand how the various response pathways to these stresses interact with one another within the plants, and where the points of crosstalk occur which switch the responses from one pathway to another. Calcium sensors are often regarded as the first line of response to external stimuli to trigger downstream signaling. Abscisic acid (ABA) is a major phytohormone regulating stress responses, and it interacts with the jasmonic acid (JA) and salicylic acid (SA) signaling pathways to channel resources into mitigating the effects of abiotic stresses versus defending against pathogens. The signal transduction in these pathways are often carried out via GTP-binding proteins (G-proteins) which comprise of a large group of proteins that are varied in structures and functions. Dec...

The Lancet. Global health, Mar 1, 2018

There is little evidence on the use of secondary prevention medicines for cardiovascular disease ... more There is little evidence on the use of secondary prevention medicines for cardiovascular disease by socioeconomic groups in countries at different levels of economic development. We assessed use of antiplatelet, cholesterol, and blood-pressure-lowering drugs in 8492 individuals with self-reported cardiovascular disease from 21 countries enrolled in the Prospective Urban Rural Epidemiology (PURE) study. Defining one or more drugs as a minimal level of secondary prevention, wealth-related inequality was measured using the Wagstaff concentration index, scaled from -1 (pro-poor) to 1 (pro-rich), standardised by age and sex. Correlations between inequalities and national health-related indicators were estimated. The proportion of patients with cardiovascular disease on three medications ranged from 0% in South Africa (95% CI 0-1·7), Tanzania (0-3·6), and Zimbabwe (0-5·1), to 49·3% in Canada (44·4-54·3). Proportions receiving at least one drug varied from 2·0% (95% CI 0·5-6·9) in Tanzania...

Bagerhat district is in the southern portion of Bangladesh and contains a portion of the world's ... more Bagerhat district is in the southern portion of Bangladesh and contains a portion of the world's largest mangrove forest, the Sunderbans. The Rupsha River flows through the district and falls into the Bay of Bengal after passing through the Sunderbans forest. Because of the coastal position of the district and the presence of the Sunderbans forest, the plants occurring in this estuarine region are considerably different from the plants in other districts of Bangladesh. The occupations of the people of the villages adjoining the Rupsha River are mainly agriculture, agricultural laborer, and extracting timber and other forest products from the Sunderbans forest. In absence of modern medicinal facilities, the people rely on folk medicinal practitioners for treatment of their ailments. It was the objective of the present study to conduct a survey among the folk medicinal practitioners (Kavirajes) in two villages on the banks of the Rupsha River, namely Chanpur and Andabaaz, to learn about the medicinal plants used. The Kavirajes rely almost exclusively on medicinal plants for treatment of diverse ailments. Since the plant species of the Sunderbans forest are unique to the region, it was expected that the medicinal plants used by the Kavirajes of the two villages surveyed would be distinct from plant species used by Kavirajes in other regions of Bangladesh. Our survey revealed that 50 plant species and one mushroom species distributed into 32 families were used by the Kavirajes of the two villages. The Euphorbiaceae family provided 5 species, followed by the Araceae family with 4 species, and the Asteraceae, Combretaceae and Fabaceae families with 3 species, each. Even though the number of plant species used was small, a wide variety of ailments were treated by the Kavirajes. The highest number of plant species, twenty five, was used for treatment of gastrointestinal disorders. Skin disorders were treated with 22 plant species; respiratory tract disorders with 14 plant species, and sexual disorders treated with 11 plant species. Because the inhabitants of the two villages work often in the Sunderbans forest, they are exposed to snake and tiger bites. Ten plant species were used for treatment of snake bites, and six for treatment of tiger bites. Other ailments treated included heart disorders, typhus. Three plants were used as astringents, four plants as tonic, one plant for treatment of vitamin C deficiency, three plants as antidote to poisoning, five plants as stimulants of the central nervous system, and

Zebrafish ovarian follicle is developed in five stages. The best method of isolationg follicle fr... more Zebrafish ovarian follicle is developed in five stages. The best method of isolationg follicle from ovary is enzymatic
treatment with collagenase and hyaluronidase. 90% L-15 media (pH 9.0, temperature 28o) supplemented with
hCG (for stage I and II follicle) for 24 hour or 60% L-15 media (pH 9.0, temperature 26o) supplemented with DHP
(for stage III follicle) for 8-24 hour for can be used to mature ovarian follicle in vitro. But follicles cultured this way
cannot be fertilized. Follicle of third stage cultured in 90% L-15 media supplemented with DHP or BSA for 270
minute can be fertilized successfully. The follicle can be cryopreserved by slow-cooling method in cryoprotectant
solution of DMSO and methanol prepared in KCl buffer. The viability of cryopreserved follicle can be tested by TB,
FDA+PI and GVBD assay and by calculating ADP/ATP ratio.

According to an online survey among literate women of Bangladesh, 53% of them avoided raw papaya,... more According to an online survey among literate women of Bangladesh, 53% of them avoided raw papaya, 46% avoided ripe papaya, 77% avoided pineapple and 40% avoided coffee consumption during pregnancy. Tea is frequently consumed and caffeinated beverage was few times consumed by most women (47% & 54% respectively). Ripe papaya blend/juice neither has any effect on pregnant rat/fetus nor affects the pregnancy any way. Crude papaya latex or latex extract induces contraction in pregnant or non-pregnant rat uterus in vitro. Unripe papaya can even induce abortion in rat in vivo. The isolated papaya proteinase I has no effect on pregnancy moreover it prevents pre-implantation loss in rat. Papaya seed extract has toxic effect on rat uterine tissue in vitro and prevents pregnancy in rat even in as low dose as 100mg/kg body weight. Nor the unripe pineapple or extract of pineapple leaf affect pregnancy even in high dose (1000 mg/kg and 2000 mg/kg body weight respectively), though pure constituent of some chemical isolated from extract of pineapple leaf showed pre-and post-implantation abortifacient activity even in low dose (30 mg/kg) in one study. Caffeine consumption does not increase the risk of reduced fecundibility, subfecundity, failure of assisted reproductive technology, low birth weight of newborn, pre-term delivery, gestational diabetes and behavior problem of child by maternal consumption in recommended dose of 300 mg/kg body weight. Daily 2 cups of coffee is not found to be associated with neural tube defect and 4 cups of coffee (400mg/day) is associated with Sudden Infant Death Syndrome (SIDS) in human.In rat, high dose maternal caffeine consumption is associated with increased risk of seizure and impaired cognitive ab ility of child; moderate dose (120 mg/kg body weight) caffeine consumption is associated with increased risk of fatty liver, reduced femur length and neuroendocrine disease in child; and low dose caffeine consumption is associated with increased risk of deformation of bone

The antinociceptive activity of Xanthium indicum leaves and Leucas aspera whole plants was evalua... more The antinociceptive activity of Xanthium indicum leaves and Leucas aspera whole plants was evaluated in acetic acid-induced gastric pain models in Swiss albino mice. The methanol extract of leaves of Xanthium indicum demonstrated a significant and dose-dependent inhibition in the number of writhings (constrictions) induced by intraperitoneal administration of acetic acid. The numbers of writhings were inhibited, respectively, by 31.8, 36.6, 41.2 and 42.9% when mice were administered methanolic leaf extract of Xanthium indicum at doses of 50, 100, 200 and 400 mg per kg body weight. The standard antinociceptive drug, aspirin, when administered at a dose of 200 mg per kg body weight reduced the number of constrictions (induced by acetic acid) by 50.8%. Methanolic extract of whole plants of Leucas aspera showed higher antinociceptive activity compared to methanolic extract of leaves of Xanthium indicum. At doses of 50, 100, 200 and 400 mg whole plant methanolic extract, the number of constrictions were reduced, respectively, by 50.1, 51.9, 55.8 and 57.7%. Thus even at the lowest dose of the Leucas aspera extract, the antinociceptive activity obtained was comparable to that of aspirin. The results indicate that both plants merit further studies towards discovery of novel compounds in them that can prove to be efficacious pain killers and with possible lesser side-effects than the currently used pain killer drugs.

Lancet (London, England), Jan 28, 2017

The lancet. Diabetes & endocrinology, Oct 28, 2017

The Lancet Public Health, 2017

Plants, Nov 2, 2022

Lancet (London, England), Jan 28, 2017

American-Eurasian Journal of Sustainable Agriculture, 2011

Advances in Natural and Applied Sciences, 2011

American-Eurasian Journal of Sustainable Agriculture, 2010

International Journal of Molecular Sciences

The Lancet. Global health, Mar 1, 2018