Matko Marusic - Academia.edu (original) (raw)

Papers by Matko Marusic

JAMA: The Journal of the American Medical Association, 1993

... Edited by Roxanne K. Young, Associate Editor. has retired to the war room) tries to focus on ... more ... Edited by Roxanne K. Young, Associate Editor. has retired to the war room) tries to focus on the Big Picture, tries to formulate a strategy. ... 2. One, two, no, ten thousand regulations from CLIA, from OSHA, from state, local, and fire inspectors. ...

Cellular Immunology, 1984

Lethally irradiated mice reconstituted with syngeneic bone marrow cells were grafted with allogen... more Lethally irradiated mice reconstituted with syngeneic bone marrow cells were grafted with allogeneic skin grafts 6-7 weeks after irradiation and reconstitution. Mice with intact thymuses rejected the grafts whereas the mice thymectomized before irradiation and reconstitution did not. Thymectomized irradiated mice (TIR mice) reconstituted with bone marrow cells from donors immune to the a&rafts rejected the grafts. Bone marrow cells from immunized donors, pretreated with Thy 1.2 antibody and C', did not confer immunity to TIR recipients. To determine the number of T lymphocytes necessary for the transfer of immunity by bone marrow cells from immunized donors, thymectomized irradiated mice were reconstituted with nonimmune bone marrow cells treated with Thy 1.2 antibody and C' and with various numbers of splenic T lymphocytes from nonimmune and immune donors. Allogeneic skin graIt rejection was obtained with lo6 nonimmune or lo4 immune T cells. The effect of immune T cells was specific: i.e., immune T cells accelerated only rejection of the relevant skin grafts whereas against a thirdparty skin grafts acted as normal T lymphocytes.

Anaesthesia, Jul 1, 1991

Immunological changes in anaesthetic personnel exposed to occupational concentrations of holothan... more Immunological changes in anaesthetic personnel exposed to occupational concentrations of holothane and nitrous oxide 1040 times greater than the advised maximum were studied during routine work and after 3-4 weeks holiday. Red cell count, haemoglobin concentration and haematocrit decreased during exposure although not signijicantly, in comparison with a control group, but all had increased significantly after the holidays. Other changes were altered neutrophils and lymphocyte counts. Basophils disappeared from the blood during the exposure. Monocytes were not affected during the exposure, but increased after its cessation. Percentages of CD2 and CD4 lymphocytes increased significantly, but numbers of cells in T lymphocyte subpopulations (total, heber and cytotoxiclsupressor lymphocytes) were not signiJcantly altered. B lymphocytes were most strongly affected: they decreased during working periods and did not recover after holidays. Natural killer (N K) cells, on the other hand, decreased signijicantly during exposure, but fully recovered during holidays. After stimulation with mitogens. phytohaemaglutin, concanavalin A , and pokeweed, lymphocytes from exposed personnel incorporated significantly more 'H-thymidine than those from control subjects, but stimulation indices did not differ. The natural killer-cell activity, serum Ig concentrations and phagocytosis by granulocytes were not altered.

Experientia, 1976

Thymectomized, lethally irradiated rats reconstituted with syngeneic bone marrow were injected wi... more Thymectomized, lethally irradiated rats reconstituted with syngeneic bone marrow were injected with rat brain in complete Freund adjuvant mixture. Both, they and sham-thymectomized, irradiated and bone marrow protected rats displayed a higher incidence of leg paralysis than normal non-irradiated animals. Thymectomy lowered the incidence of the disease.

Journal of Medical Internet Research, Aug 31, 2022

Background: Publishing identifiable patient data in scientific journals may jeopardize patient pr... more Background: Publishing identifiable patient data in scientific journals may jeopardize patient privacy and confidentiality if best ethical practices are not followed. Current journal practices show considerable diversity in the publication of identifiable patient photographs, and different stakeholders may have different opinions of and practices in publishing patient photographs. Objective: This scoping review aimed to identify existing evidence and map knowledge gaps in medical research on the policies and practices of publishing identifiable photographs in scientific articles. Methods: We performed a comprehensive search of the Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, CINAHL with Full Text, Database of Abstracts of Reviews of Effects, Ovid MEDLINE, and Scopus. The Open Science Framework, PROSPERO, BASE, Google Scholar, OpenGrey, ClinicalTrials.gov, the Campbell Collaboration Library, and Science.gov were also searched. Results: After screening the initial 15,949 titles and abstracts, 98 (0.61%) publications were assessed for eligibility at the full-text level, and 30 (0.19%) publications were included in this review. The studies were published between 1994 and 2020; most had a cross-sectional design and were published in journals covering different medical disciplines. We identified 3 main topics. The first included ethical aspects of the use of facial photographs in publications. In different clinical settings, the consent process was not conducted properly, and health professionals did not recognize the importance of obtaining written patient consent for taking and using patient medical photographs. They often considered verbal consent sufficient or even used the photographs without consent. The second topic included studies that investigated the practices and use of medical photography in publishing. Both patients and doctors asked for confidential storage and maintenance of medical photographs. Patients preferred to be photographed by their physicians using an institutional camera and preferred nonidentifiable medical photographs not only for publication but also in general. Conventional methods of deidentification of facial photographs concealing the eye area were recognized as unsuccessful in protecting patient privacy. The third topic emerged from studies investigating medical photography in journal articles. These studies showed great diversity in publishing practices regarding consent for publication of medical photographs. Journal policies regarding the consent process and consent forms were insufficient, and existing ethical professional guidelines were not fully implemented in actual practices. Patients' photographs from open-access medical journals were found on public web-based platforms.

PubMed, Dec 1, 2003

During the last few years, the questions of editorial independence and journal governance have co... more During the last few years, the questions of editorial independence and journal governance have come into the focus of scholarly journals. There is little data on the legal regulation of journals outside mainstream science, although they constitute the largest body of biomedical literature. The Croatian Medical Journal functioned for more than 10 years without much legal regulation but with lot of enthusiasm and hard work. This Editorial presents our attempt to make legal provisions for the current status of the Journal and its future work. We defined our owners, main participants in making of the journal, and their responsibilities and benefits. The Agreement will be signed by all four medical schools in Croatia, which will become owners of the Journal. We hope that our experiences and solutions for strengthening the legal status of the Journal will help other editors from small scientific communities to think about their journal and its governance.

Medical Hypotheses, 2004

Immunoglobulin A and G (IgA, IgG) serum concentrations were detected in children with nonallergic... more Immunoglobulin A and G (IgA, IgG) serum concentrations were detected in children with nonallergic/intrinsic (36 children) or allergic/extrinsic asthma (43 children) and in age-matching control children (40 children). Asthmatic children with allergic asthma had lower IgA (1.36+/-0.54 g/L) and higher IgG (10.48+/-2.77 g/L) levels than the age-matching control children group (1.63+/-0.69 vs. 9.01+/-2.32 g/L). Children with nonallergic/intrinsic asthma had lower IgA (1.03+/-0.41 g/L) ( p = 0.004) and IgG (8.38+/-1.93 g/L) (p = 0.001) levels than the allergic/extrinsic asthma group (1.36+/-0.54 vs. 10.48+/-2.77 g/L). Low IgA levels were found in children with nonallergic/intrinsic asthma and high IgG levels were found in those children with allergic/extrinsic childhood asthma. The hypothesis is that the increased incidence of asthma in the population may be caused by a decrease in childhood infections (hygiene hypothesis). Frequent infections in early life boost the immune system, stimulating Th1-type response in young children and reducing the risk of atopic diseases. Our hypothesis is that low IgA (and/or IgG) levels in our patients might be responsible for infection development among those children with nonallergic/intrinsic asthma. These infections stimulate the normal development of immune system in young children, reducing risk of atopy, so that those children do not get allergic/extrinsic childhood asthma. Intrinsic childhood asthma=nonallergic (nonatopic) childhood asthma. Extrinsic childhood asthma=allergic (atopic) childhood asthma.

Food and Chemical Toxicology, 2001

Zeolites are natural or synthetic crystalline alumosilicates with ion exchanging properties. Supp... more Zeolites are natural or synthetic crystalline alumosilicates with ion exchanging properties. Supplied in fodder, they promote biomass production and animal health. Our aim was to asses the effects of the natural zeolite, clinoptilolite on hematopoiesis, serum electrolytes, and essential biochemical indicators of kidney and liver function in mice. Two preparations differing in particle size were tested: a powderized form obtained by countercurrent mechanical treatment of the clinoptilolite (MTCp) and normally ground clinoptilolite (NGCp). Young adult mice were supplied with food containing 12.5%, 25% or 50% clinoptilolite powder. Control animals received the same food ration without the clinoptilolite. After 10, 20, 30 and 40 days, six animals from each group were exsanguinated as to obtain blood for hematological and serum for biochemical measurements as well as to collect femoral bone marrow for determination of hematopoietic activity. Clinoptilolite ingestion was well tolerated, as judged by comparable body masses of treated and control animals. A 20% increase of the potassium level was detected in mice receiving the zeolite-rich diet, without other changes in serum chemistry. Erythrocyte, hemoglobin and platelet levels in peripheral blood were not materially affected. NGCp caused leukocytosis, with concomitant decline of the GM-CFU content in the bone marrow. That was attributed to intestinal irritation by rough zeolite particles. The mechanically treated clinoptilolite preparation caused similar, albeit less pronounced changes. In a limited experiment mice having transplanted mammary carcinoma in the terminal stage showed increased potassium and decreased sodium and chloride levels, severe anemia and leukocytosis, decreased bone marrow cellularity and diminished content of hematopoietic progenitor cells in the marrow. The clinoptilolite preparations ameliorated the sodium and chloride decline, whereas the effects on hematopoiesis were erratic.

Gazzetta medica italiana. Archivio per le scienze mediche, Feb 1, 2022

Nurse Education Today, Apr 1, 2022

BACKGROUND There is conflicting evidence on predictors of nursing degree completion. Identificati... more BACKGROUND There is conflicting evidence on predictors of nursing degree completion. Identification of predictors of student desire to continue their education could be important in developing strategies for encouraging and supporting students to complete their university-level nursing education. AIM To explore the factors associated with the enrollment in the first graduate year of nursing studies, progression from the first to the third year of university undergraduate nursing study, and the desire of third-year undergraduate students to continue nursing education at the graduate level. PARTICIPANTS AND METHODS A cross-sectional study involving 351 first- and third-year undergraduate and first-year graduate nursing students from three cohorts of the University of Split Department of Health Studies and one generation of first- and third-year undergraduate nursing students from the Catholic University of Croatia, Zagreb. We collected sociodemographic data on the participants, their opinions about their education, and scores on nine psychological questionnaires: performance self-efficacy, academic self-efficacy, perseverance, attitudes towards science, self-respect, motivation, dispositional hope, future time perspective, and perceived personal incompetence. RESULTS More than half of third-year undergraduate students wanted to continue their nursing studies at the graduate level, but they did not progress to the graduate degree studies immediately after finishing their undergraduate studies. None of the assessed characteristics predicted the desire of the final undergraduate year students to continue nursing education at the graduate level. In a nested follow-up study of a cohort of undergraduate students, we observed an increase in student attitudes towards science, extrinsic and intrinsic motivation, future orientation, and a decrease in perceived personal incompetence. CONCLUSION Our results demonstrate that immediate progression to graduate level of nursing education, although perceived as desired, is not achieved by undergraduate nursing students. Interventions focusing on motivation, future orientation, and personal competence need to be explored as a way to promote academic progression in nursing.

Learned Publishing, Aug 11, 2022

The rising importance of preprints and the growing number of journals accepting them necessitate ... more The rising importance of preprints and the growing number of journals accepting them necessitate a (re)definition of an overlay journal and its place in today's publishing context. Using a snowball search strategy, we searched Web of Science and Scopus databases for articles on overlay journals. From these articles, we identified 28 overlay journals that fit the traditional overlay journal definition (they did not host articles but provided links to final versions on repositories or they searched repositories for viable preprints to publish) or that defined themselves as overlay journals. Most journals were not indexed in bibliographic databases, and crucial information such as journal ownership was not publicly available. Likewise, most journals both self‐hosted articles and provided links to final versions on repositories, which might mean repositories are more valuable in their ‘open access’ functionality than in the capacity for hosting articles. Editorial policies and practices of these overlay journals were often undeveloped or non‐existent. It seems overlay journals remain a niche publishing model in 2021, especially due to the increased number of journals accepting preprints and using preprint servers in their core functionality. However, overlay journals can take an ‘active’ approach in finding, reviewing, and publishing preprints, replacing other inefficient publishing models.

PubMed, 2001

In order to describe the real biological behavior of the small-cell lung cancer we have analyzed ... more In order to describe the real biological behavior of the small-cell lung cancer we have analyzed survival rates of 66 patients with small-cell lung cancer who did not receive any specific anti cancer therapy. Also, objective of this study was to evaluate the staging system of the small-cell lung cancer. Untreated small-cell lung cancer patients with limited stage disease had statistically significant (p < 0.05) better survival rates in comparison to patients with extensive stage disease. T and N factor of the TNM classification did not influence the survival in untreated small-cell lung cancer patients. It appears that the TNM staging system is not predicting survival probabilities of untreated patients with small-cell lung cancer, while the two-stage system appeared very well based on survival probabilities of these patients.

Detaljno je opisana kronologija, razlozi i mehanizmi napada na urednike casopisa Croatian Medical... more Detaljno je opisana kronologija, razlozi i mehanizmi napada na urednike casopisa Croatian Medical Journal, koji su 2011. zavrsili ostavkom cijelog Urednickog odbora (35/37 clanova) i prjelaskom casopisa u ruke napadaca.

Periodicum Biologorum, 1986

We studied the incidence and growth dynamics of chemically induced tumors in mice depleted of T l... more We studied the incidence and growth dynamics of chemically induced tumors in mice depleted of T lymphocytes and mice with either depressed or stimulated NK-cell/macrophages functions in nine experimental groups (30 mice per group): untreated mice, TIR mice, IR mice, mice received silica particles with or without MCA, mice received injections of Corynebacterium parvum. We concluded that immulnological status does not influence the incidence of chemically induced tulmors in mice but strongly influence the time of tumor appearance, the resistance of mice to tumors and the dynamics of tumor growth.

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PubMed, Nov 1, 1991

With respect to the recent discoveries related to activation and effects of oncogenes, it should ... more With respect to the recent discoveries related to activation and effects of oncogenes, it should be postulated that malignant transformation is due to their inappropriate activation. The postulate must be taken into account when analyzing any other question concerning malignant tumors, e.g. the role of genetic and environmental factors, defence mechanisms, strategy of prevention and treatment, etc. It is argued in this paper that a) in principle, tumors are caused by the events occurring within the body (oxidative radicals that damage DNA), whereas the environmental factors influence the incidence of certain tumors only superficially, eliciting no effect upon the overall tumor incidence; b) malignant transformation (tumors) is one of the consequences of biological deterioration of the body which, like aging, is caused by mutation accumulation; the death due to a malignant tumor is "one of the mechanisms of dying due to the aging process", c) congenital resistance to tumors mostly concerns the quality of DNA, less the influence of classical defence mechanisms, like immune system; d) malignant tumors are relatively more frequent today, which should not be ascribed to (increased) environmental pollution but is due to the increased longevity of contemporary man, and possibly to negative selection materialized through extremely effective modern medicine. Future research will bring about detailed understanding of the mechanisms of action and interaction of oncogenes in the process of cell malignant transformation for numerous types of tumors, elucidation of the role of oncogenic viruses and, much later, use of drugs providing protection against oncogenic viruses and selectively killing the transformed cells, at least in some (early) phases of the disease.(ABSTRACT TRUNCATED AT 250 WORDS)