Matt Kipper - Academia.edu (original) (raw)
Papers by Matt Kipper
Advanced Functional Materials, Feb 1, 2023
Advances in Chemical Engineering, 2004
... Permissions & Reprints. SURFACE-ERODIBLE BIOMATERIALS FOR DRUG DELIVERY. ... more ... Permissions & Reprints. SURFACE-ERODIBLE BIOMATERIALS FOR DRUG DELIVERY. Balaji Narasimhan a and Matt J Kipper a. a Department of Chemical Engineering, Iowa State University, Ames, IA 50011, USA. Available online 7 June 2004. Article Outline. ...
Materials Letters, Dec 1, 2015
Abstract A new graphene/Ag nanohybrid nanocomposite additive was prepared successfully through so... more Abstract A new graphene/Ag nanohybrid nanocomposite additive was prepared successfully through solvothermal method using ethylene glycol as solvent and reducing agent. The effects of surface modification of amorphous Mg–Ni–La alloy by introduction of graphene/Ag have been systematically investigated. The results showed that the discharge capacity, cycle life, discharge potential characteristics and electrochemical kinetics of the electrodes were all improved significantly. The surface modification enhanced the electrocatalytic activity of the alloy and reduced the contact resistance of the electrodes. The Mg65Ni27La8 with graphene/Ag electrode has the largest discharge capacity of 814.8 mAh g−1, which is 1.33 times that of the electrode without graphene/Ag, and the better electrochemical kinetics.
Carbohydrate Polymers, Oct 1, 2018
Processing stable polysaccharide membranes with suitable mechanical properties has been challengi... more Processing stable polysaccharide membranes with suitable mechanical properties has been challenging for applications in wound healing and tissue engineering. Here we expand the characterization of pectin/chitosan (PT/ CS) membranes (without covalent crosslinking), which we recently reported. Membranes containing pectin (PT) excess were formed, and PT/CS ratio can be tuned to enhance the mechanical strength, and to modulate hydrophilicity and cytocompatibility. The surface wettability and swelling properties of the polyelectrolyte complexes (PECs) played an important role to promote the attachment of stem cells. These PECs membranes have ultimate tensile strength similar to that of human skin, which is on the order of ten times higher than similar previously reported polysaccharide materials. We show for the first time that these new PT/CS membranes may promote anchorage, adhesion and support human stem cell growth, making them candidate materials for tissue engineering purposes.
Mines. This Proceeding contains papers based on most of the oral presentations. The first symposi... more Mines. This Proceeding contains papers based on most of the oral presentations. The first symposium was first held in 1971. It has been held annually since then except for a one year break. The following institutions have hosted the symposium.
Advanced Healthcare Materials, Apr 10, 2023
Owing to significant differences across species in liver functions, in vitro human liver models a... more Owing to significant differences across species in liver functions, in vitro human liver models are used for screening the metabolism and toxicity of compounds, modeling diseases, and cell‐based therapies. However, the extracellular matrix (ECM) scaffold used for such models often does not mimic either the complex composition or the nanofibrous topography of native liver ECM. Thus, here novel methods are developed to electrospin decellularized porcine liver ECM (PLECM) and collagen I into nano‐ and microfibers (≈200–1000 nm) without synthetic polymer blends. Primary human hepatocytes (PHHs) on nanofibers in monoculture or in coculture with nonparenchymal cells (3T3‐J2 embryonic fibroblasts or primary human liver endothelial cells) display higher albumin secretion, urea synthesis, and cytochrome‐P450 1A2, 2A6, 2C9, and 3A4 enzyme activities than on conventionally adsorbed ECM controls. PHH functions are highest on the collagen/PLECM blended nanofibers (up to 34‐fold higher CYP3A4 activity relative to adsorbed ECM) for nearly 7 weeks in the presence of the fibroblasts. In conclusion, it is shown for the first time that ECM composition and topography synergize to enhance and stabilize PHH functions for several weeks in vitro. The nanofiber platform can prove useful for the above applications and to elucidate cell‐ECM interactions in the human liver.
Materials, Jul 27, 2022
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
ACS applied polymer materials, Jul 24, 2022
Nano-Structures and Nano-Objects, Apr 1, 2022
APS March Meeting Abstracts, Mar 1, 2003
Polyanhydrides are a class of bioerodible polymers with unique properties that make them ideal fo... more Polyanhydrides are a class of bioerodible polymers with unique properties that make them ideal for drug delivery applications. One of the most interesting properties of these materials is the microphase separation that occurs in copolymers of certain compositions. Microphase separation of copolymers, when coupled with the disparity in degradation rates between two constituent monomers, results in interesting degradation and drug
Nano research & applications, May 10, 2018
2004 AIChE Annual Meeting, Dec 1, 2004
Biomaterials, 2008
We have tested the hypothesis that cell adhesion and spreading on polymer films are influenced by... more We have tested the hypothesis that cell adhesion and spreading on polymer films are influenced by the amount of time that the polymer films are pre-aged in cell culture medium. Cell adhesion and spreading were assessed after a 6-h culture on poly(D,L-lactic acid) (PDLLA) films that had been pre-aged in cell culture medium for 30 min, 1, 3 or 7 d. Cell adhesion and spread area were enhanced as the duration of pre-aging PDLLA films in cell culture medium was increased. Materials characterization showed that the hydrophobicity and surface morphology of the PDLLA films changed with increasing length of preaging time. These results suggest that cell adhesion and spreading are sensitive to the time-dependent changes in PDLLA hydrophobicity and surface morphology that occur during exposure of the polymer to cell medium for different lengths of time. These results demonstrate that cell response to a degradable, biomedical polymer can change as a function of the amount of time that the polymer is exposed to physiological medium.
This work describes the synthesis of polysaccharide-based magnetic hydrogels with the introductio... more This work describes the synthesis of polysaccharide-based magnetic hydrogels with the introduction of magnetite nanoparticles in the polymer network. The magnetic hydrogels were characterized by Fouriertransform infrared spectroscopy (FTIR) and magnetization curves. FTIR analysis confirmed the efficiency of the polysaccharide-modifying process. The amounts of diffused water into or out-of a hydrogel network were measured. The degree of swelling of the polysaccharide-based magnetic hydrogels was less than that found for the regular polysaccharide-based hydrogels and there was no variation in the water diffusion mechanism. The absence of hysteresis loops and coercivity observed through magnetization curves indicated that magnetic hydrogels can be applied in external-controlled solute release. 2 EXPERIMENTAL PROCEDURES 2.1 Materials Chitosan (Aldrich), acetic acid (Merck), acrylic acid (Merck), glycidyl methacrylate (Across Organics), methylenebisacrylamide (Merck), hydrochloric acid (Merck), ammonium persulfate (Aldrich), gum arabic (Sudan), sodium hydroxide (Nuclear), acrylamide (Aldrich), potassium acrylate (Aldrich), maltodextrin (Aldrich), ethanol (TEDIA), magnetite nanoparticles (Fe 3 O 4) purchased from Fisher Scientific and characterized elsewhere (Paulino et al., 2009). All experiments were performed using Milli-Q ® water. 2.2 Hydrogel Synthesis 1% chitosan solution was prepared by diluting the 263
Powder Diffraction, Jun 1, 2004
Procedia Engineering, 2012
Progress in Organic Coatings, Sep 1, 2022
Sensors and Actuators B-chemical, Jun 1, 2021
Abstract Nanoparticle drug delivery systems are designed to be biocompatible and to control the d... more Abstract Nanoparticle drug delivery systems are designed to be biocompatible and to control the distribution of poorly soluble drugs. Fluorescent nanoparticle drug carriers have been designed to enable fluorescence tracking. While such particles enable tracking of the carrier, this tracking does not report the local drug concentration. In this article, we report new nanoparticle drug carriers with stable, high-intensity fluorescence that sensitively reports the loaded drug concentration. The dumbbell-shaped nanoparticles are synthesized by combining europium (Eu3+) complexes with hyaluronic acid. The Eu3+ complexes are superior to organic fluorophores, providing a narrow emission peak, high fluorescence intensity, long fluorescence lifetime, and insensitivity to photobleaching. The hyaluronic acid compatibilizes the nanoparticles with aqueous environments, and provides biocompatibility. We demonstrate that these polysaccharide nano-dumbbell aggregates (PNDAs) can effectively load drugs through structural changes, and sense the amount of drug loaded through changes in fluorescence intensity, enabling precise tracking of drug loading and release.
Journal of Molecular Liquids, May 1, 2021
Abstract We present chitosan (CHT)/heparin (HP) polyelectrolyte complexes (PECs) that quickly ads... more Abstract We present chitosan (CHT)/heparin (HP) polyelectrolyte complexes (PECs) that quickly adsorb citrate-capped silver nanoparticles (AgNPs). CHT/HP blends in ionic liquid ([HMIm][HSO4]) form durable PECs after precipitation in water. CHT/HP PECs have positive Zeta potentials (higher than +20 mV). They adsorb citrate-capped AgNPs (Zeta potential of - 12.25 mV) synthesized from Turkevich's method. PEC/AgNPs composites are characterized by spectroscopic, thermal, and microscopy analyses. AgNPs on the PEC surfaces are confirmed by transmission electron microscopy. PECs adsorb AgNPs from aqueous suspensions, achieving ≈ 95% of removal (17.18 μg of AgNPs per milligram of PEC) after only 10 min. The pseudo-second-order kinetic model adjusted well to the experimental data. The PECs release approximately 11.80 μg/mg Ag+ (66%) compared to the initial adsorbed AgNPs content (17.18 μg/mg) after 7200 min at pH 2.0. The PECs present low swelling degrees (between 130 and 150%), supporting high stability in water. PEC/AgNPs composites promote significant bactericidal activity toward Staphylococcus aureus and Escherichia coli between 0.25 and 0.5 mg/mL. This study shows a new strategy to create hybrid polysaccharide/AgNPs composites. PECs can stabilize the AgNPs and release Ag+ ions, supporting antimicrobial materials.
Advanced Functional Materials, Feb 1, 2023
Advances in Chemical Engineering, 2004
... Permissions & Reprints. SURFACE-ERODIBLE BIOMATERIALS FOR DRUG DELIVERY. ... more ... Permissions & Reprints. SURFACE-ERODIBLE BIOMATERIALS FOR DRUG DELIVERY. Balaji Narasimhan a and Matt J Kipper a. a Department of Chemical Engineering, Iowa State University, Ames, IA 50011, USA. Available online 7 June 2004. Article Outline. ...
Materials Letters, Dec 1, 2015
Abstract A new graphene/Ag nanohybrid nanocomposite additive was prepared successfully through so... more Abstract A new graphene/Ag nanohybrid nanocomposite additive was prepared successfully through solvothermal method using ethylene glycol as solvent and reducing agent. The effects of surface modification of amorphous Mg–Ni–La alloy by introduction of graphene/Ag have been systematically investigated. The results showed that the discharge capacity, cycle life, discharge potential characteristics and electrochemical kinetics of the electrodes were all improved significantly. The surface modification enhanced the electrocatalytic activity of the alloy and reduced the contact resistance of the electrodes. The Mg65Ni27La8 with graphene/Ag electrode has the largest discharge capacity of 814.8 mAh g−1, which is 1.33 times that of the electrode without graphene/Ag, and the better electrochemical kinetics.
Carbohydrate Polymers, Oct 1, 2018
Processing stable polysaccharide membranes with suitable mechanical properties has been challengi... more Processing stable polysaccharide membranes with suitable mechanical properties has been challenging for applications in wound healing and tissue engineering. Here we expand the characterization of pectin/chitosan (PT/ CS) membranes (without covalent crosslinking), which we recently reported. Membranes containing pectin (PT) excess were formed, and PT/CS ratio can be tuned to enhance the mechanical strength, and to modulate hydrophilicity and cytocompatibility. The surface wettability and swelling properties of the polyelectrolyte complexes (PECs) played an important role to promote the attachment of stem cells. These PECs membranes have ultimate tensile strength similar to that of human skin, which is on the order of ten times higher than similar previously reported polysaccharide materials. We show for the first time that these new PT/CS membranes may promote anchorage, adhesion and support human stem cell growth, making them candidate materials for tissue engineering purposes.
Mines. This Proceeding contains papers based on most of the oral presentations. The first symposi... more Mines. This Proceeding contains papers based on most of the oral presentations. The first symposium was first held in 1971. It has been held annually since then except for a one year break. The following institutions have hosted the symposium.
Advanced Healthcare Materials, Apr 10, 2023
Owing to significant differences across species in liver functions, in vitro human liver models a... more Owing to significant differences across species in liver functions, in vitro human liver models are used for screening the metabolism and toxicity of compounds, modeling diseases, and cell‐based therapies. However, the extracellular matrix (ECM) scaffold used for such models often does not mimic either the complex composition or the nanofibrous topography of native liver ECM. Thus, here novel methods are developed to electrospin decellularized porcine liver ECM (PLECM) and collagen I into nano‐ and microfibers (≈200–1000 nm) without synthetic polymer blends. Primary human hepatocytes (PHHs) on nanofibers in monoculture or in coculture with nonparenchymal cells (3T3‐J2 embryonic fibroblasts or primary human liver endothelial cells) display higher albumin secretion, urea synthesis, and cytochrome‐P450 1A2, 2A6, 2C9, and 3A4 enzyme activities than on conventionally adsorbed ECM controls. PHH functions are highest on the collagen/PLECM blended nanofibers (up to 34‐fold higher CYP3A4 activity relative to adsorbed ECM) for nearly 7 weeks in the presence of the fibroblasts. In conclusion, it is shown for the first time that ECM composition and topography synergize to enhance and stabilize PHH functions for several weeks in vitro. The nanofiber platform can prove useful for the above applications and to elucidate cell‐ECM interactions in the human liver.
Materials, Jul 27, 2022
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
ACS applied polymer materials, Jul 24, 2022
Nano-Structures and Nano-Objects, Apr 1, 2022
APS March Meeting Abstracts, Mar 1, 2003
Polyanhydrides are a class of bioerodible polymers with unique properties that make them ideal fo... more Polyanhydrides are a class of bioerodible polymers with unique properties that make them ideal for drug delivery applications. One of the most interesting properties of these materials is the microphase separation that occurs in copolymers of certain compositions. Microphase separation of copolymers, when coupled with the disparity in degradation rates between two constituent monomers, results in interesting degradation and drug
Nano research & applications, May 10, 2018
2004 AIChE Annual Meeting, Dec 1, 2004
Biomaterials, 2008
We have tested the hypothesis that cell adhesion and spreading on polymer films are influenced by... more We have tested the hypothesis that cell adhesion and spreading on polymer films are influenced by the amount of time that the polymer films are pre-aged in cell culture medium. Cell adhesion and spreading were assessed after a 6-h culture on poly(D,L-lactic acid) (PDLLA) films that had been pre-aged in cell culture medium for 30 min, 1, 3 or 7 d. Cell adhesion and spread area were enhanced as the duration of pre-aging PDLLA films in cell culture medium was increased. Materials characterization showed that the hydrophobicity and surface morphology of the PDLLA films changed with increasing length of preaging time. These results suggest that cell adhesion and spreading are sensitive to the time-dependent changes in PDLLA hydrophobicity and surface morphology that occur during exposure of the polymer to cell medium for different lengths of time. These results demonstrate that cell response to a degradable, biomedical polymer can change as a function of the amount of time that the polymer is exposed to physiological medium.
This work describes the synthesis of polysaccharide-based magnetic hydrogels with the introductio... more This work describes the synthesis of polysaccharide-based magnetic hydrogels with the introduction of magnetite nanoparticles in the polymer network. The magnetic hydrogels were characterized by Fouriertransform infrared spectroscopy (FTIR) and magnetization curves. FTIR analysis confirmed the efficiency of the polysaccharide-modifying process. The amounts of diffused water into or out-of a hydrogel network were measured. The degree of swelling of the polysaccharide-based magnetic hydrogels was less than that found for the regular polysaccharide-based hydrogels and there was no variation in the water diffusion mechanism. The absence of hysteresis loops and coercivity observed through magnetization curves indicated that magnetic hydrogels can be applied in external-controlled solute release. 2 EXPERIMENTAL PROCEDURES 2.1 Materials Chitosan (Aldrich), acetic acid (Merck), acrylic acid (Merck), glycidyl methacrylate (Across Organics), methylenebisacrylamide (Merck), hydrochloric acid (Merck), ammonium persulfate (Aldrich), gum arabic (Sudan), sodium hydroxide (Nuclear), acrylamide (Aldrich), potassium acrylate (Aldrich), maltodextrin (Aldrich), ethanol (TEDIA), magnetite nanoparticles (Fe 3 O 4) purchased from Fisher Scientific and characterized elsewhere (Paulino et al., 2009). All experiments were performed using Milli-Q ® water. 2.2 Hydrogel Synthesis 1% chitosan solution was prepared by diluting the 263
Powder Diffraction, Jun 1, 2004
Procedia Engineering, 2012
Progress in Organic Coatings, Sep 1, 2022
Sensors and Actuators B-chemical, Jun 1, 2021
Abstract Nanoparticle drug delivery systems are designed to be biocompatible and to control the d... more Abstract Nanoparticle drug delivery systems are designed to be biocompatible and to control the distribution of poorly soluble drugs. Fluorescent nanoparticle drug carriers have been designed to enable fluorescence tracking. While such particles enable tracking of the carrier, this tracking does not report the local drug concentration. In this article, we report new nanoparticle drug carriers with stable, high-intensity fluorescence that sensitively reports the loaded drug concentration. The dumbbell-shaped nanoparticles are synthesized by combining europium (Eu3+) complexes with hyaluronic acid. The Eu3+ complexes are superior to organic fluorophores, providing a narrow emission peak, high fluorescence intensity, long fluorescence lifetime, and insensitivity to photobleaching. The hyaluronic acid compatibilizes the nanoparticles with aqueous environments, and provides biocompatibility. We demonstrate that these polysaccharide nano-dumbbell aggregates (PNDAs) can effectively load drugs through structural changes, and sense the amount of drug loaded through changes in fluorescence intensity, enabling precise tracking of drug loading and release.
Journal of Molecular Liquids, May 1, 2021
Abstract We present chitosan (CHT)/heparin (HP) polyelectrolyte complexes (PECs) that quickly ads... more Abstract We present chitosan (CHT)/heparin (HP) polyelectrolyte complexes (PECs) that quickly adsorb citrate-capped silver nanoparticles (AgNPs). CHT/HP blends in ionic liquid ([HMIm][HSO4]) form durable PECs after precipitation in water. CHT/HP PECs have positive Zeta potentials (higher than +20 mV). They adsorb citrate-capped AgNPs (Zeta potential of - 12.25 mV) synthesized from Turkevich's method. PEC/AgNPs composites are characterized by spectroscopic, thermal, and microscopy analyses. AgNPs on the PEC surfaces are confirmed by transmission electron microscopy. PECs adsorb AgNPs from aqueous suspensions, achieving ≈ 95% of removal (17.18 μg of AgNPs per milligram of PEC) after only 10 min. The pseudo-second-order kinetic model adjusted well to the experimental data. The PECs release approximately 11.80 μg/mg Ag+ (66%) compared to the initial adsorbed AgNPs content (17.18 μg/mg) after 7200 min at pH 2.0. The PECs present low swelling degrees (between 130 and 150%), supporting high stability in water. PEC/AgNPs composites promote significant bactericidal activity toward Staphylococcus aureus and Escherichia coli between 0.25 and 0.5 mg/mL. This study shows a new strategy to create hybrid polysaccharide/AgNPs composites. PECs can stabilize the AgNPs and release Ag+ ions, supporting antimicrobial materials.