Mattia Berselli - Academia.edu (original) (raw)

Papers by Mattia Berselli

Digestive and Liver Disease, 2017

Journal of Radiological Review, 2019

Additional file 1: Table 1S. Complete dataset used for the study. Adenomas evidenced in red were ... more Additional file 1: Table 1S. Complete dataset used for the study. Adenomas evidenced in red were excluded from the statistical analysis since they did not match the selection criteria. Abbreviations : M = male, F = female, CNTRL = control, TB = tubular, TBV = tubulovillous, V = villous, mm= millimeter, SX = left, DX = right.

Additional file 2: Fig. S1. Methylation level in relation to the adenoma histotype. A) LINE-1 met... more Additional file 2: Fig. S1. Methylation level in relation to the adenoma histotype. A) LINE-1 methylation level in tubular and tubulovillous/villous adenomas divided in cases and controls (CNTRL). B) L1-MET methylation level in tubular and tubulovillous/villous adenomas divided in cases and controls (CNTRL). The dotted line indicates the methylation threshold (60%) below which adenomas are considered hypomethylated. The green lines indicate the average level of methylation of the low-risk group, while the red lines indicate the average level of high-risk group.

Copyright © 2012 Lorenzo Livraghi et al. This is an open access article distributed under the Cre... more Copyright © 2012 Lorenzo Livraghi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Introduction. Single-incision laparoscopic surgery (SILS) is a virtually “scarless ” technique. A retrospective analysis is performed to evaluate an initial experience of this surgical approach. Materials and Methods. From January 2010 to October 2011, SILS was considered as a minimally invasive approach to abdominal disease. The access was made by a standard wound protector and a size 6 glove. A series of little accesses were made on the tips of the glove-fingers to induce pneumoperitoneum and to create a working channel for the laparoscopic instruments. An analysis of costs of this technique was made too. Results. SILS was successfully

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques

INTRODUCTION Symptomatic uncomplicated diverticular disease (SUDD) is characterized by abdominal ... more INTRODUCTION Symptomatic uncomplicated diverticular disease (SUDD) is characterized by abdominal pain and altered bowel function and may affect quality of life. When symptoms are severe and conservative therapy is ineffective, surgical intervention becomes an option. OBJECTIVE This study aims to investigate quality of life after elective sigmoidectomy for patients affected by SUDD. MATERIALS AND METHODS Retrospective multicenter review of consecutive patients affected by SUDD that underwent elective laparoscopic sigmoidectomy from January 2015 to March 2018. SUDD was defined as the presence of diverticula with persistent localized pain and diarrhea or constipation without macroscopic inflammation. Quality of life was investigated using the Gastrointestinal Quality of Life Index questionnaire at baseline, and at 6 and 12 months after surgery. Readmissions, unplanned clinical examination, mesalazine resumption, and emergency department visit for abdominal symptoms were recorded. RESULTS Fifty-two patients were included in the analysis. Gastrointestinal Quality of Life Index score at 6 months from surgery did not statistically differ from baseline (96±10.2 vs. 89±11.2; P>0.05), while patients reported a better quality of life at 12 months after surgery (109±8.6; P<0.05). Within the first year of follow-up, 3 patients (5.8%) were readmitted for acute enteritis, 8 patients (15.4%) had emergency room access for abdominal pain, and 8 patients had unplanned outpatients' medical examinations for referred lower abdominal pain and bowel changes. Mesalazine was resumed in 17.3% of patients. CONCLUSION Elective laparoscopic sigmoidectomy for SUDD is safe and effective in improving quality of life, although in some cases symptoms may persist.

Updates in Surgery

Background The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted ... more Background The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted the surgical community. Recommendations have been published to manage patients needing surgery during the COVID-19 pandemic. This survey, under the aegis of the Italian Society of Endoscopic Surgery, aims to analyze how Italian surgeons have changed their practice during the pandemic. Methods The authors designed an online survey that was circulated for completion to the Italian departments of general surgery registered in the Italian Ministry of Health database in December 2020. Questions were divided into three sections: hospital organization, screening policies, and safety profile of the surgical operation. The investigation periods were divided into the Italian pandemic phases I (March–May 2020), II (June–September 2020), and III (October–December 2020). Results Of 447 invited departments, 226 answered the survey. Most hospitals were treating both COVID-19-positive and -negative pati...

Clinical Epigenetics

Background Aberrant DNA hypomethylation of the long interspersed nuclear elements (LINE-1 or L1) ... more Background Aberrant DNA hypomethylation of the long interspersed nuclear elements (LINE-1 or L1) has been recognized as an early event of colorectal transformation. Simultaneous genetic and epigenetic analysis of colorectal adenomas may be an effective and rapid strategy to identify key biological features leading to accelerated colorectal tumorigenesis. In particular, global and/or intragenic LINE-1 hypomethylation of adenomas may represent a helpful tool for improving colorectal cancer (CRC) risk stratification of patients after surgical removal of polyps. To verify this hypothesis, we analyzed a cohort of 102 adenomas derived from 40 high-risk patients (who developed CRC in a post-polypectomy of at least one year) and 43 low-risk patients (who did not develop CRC in a post-polypectomy of at least 5 years) for their main pathological features, the presence of hotspot variants in driver oncogenes (KRAS, NRAS, BRAF and PIK3CA), global (LINE-1) and intragenic (L1-MET) methylation sta...

British Journal of Surgery

Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numb... more Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst ...

Gastric Cancer, 2016

This article reports the guidelines for gastric cancer staging and treatment developed by the GIR... more This article reports the guidelines for gastric cancer staging and treatment developed by the GIRCG, and contains comprehensive indications for clinical management, including radiological, endoscopic, surgical, pathological, and oncological paths.

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy, 2015

Hiatal hernia is a common disorder and a controversial topic. In symptomatic voluminous hernias l... more Hiatal hernia is a common disorder and a controversial topic. In symptomatic voluminous hernias laparoscopic surgery and use of mesh can be considered. An initial experience in voluminous hiatal hernia laparoscopic repair using absorbable glycolic acid/trimethylene carbonate synthetic mesh is reported. Retrospective study from an institutional database was performed to analyze laparoscopic hiatal hernia repair using absorbable synthetic mesh from January 2010 to December 2013. All preoperative symptoms and exams were collected and a standardized procedure was performed. Clinical and radiological follow-up was performed. Eight patients underwent laparoscopic repair of hiatal hernia performed by two highly skilled laparoscopic surgeons. One Toupet and seven Nissen fundoplications were tailored. No conversions into laparotomy, neither intraoperative complications nor mortality occurred. After a median follow-up of 23.5 months (range 14 - 44) no mesh complications occurred and all patie...

Minimally Invasive Surgery, 2012

Introduction. Single-incision laparoscopic surgery (SILS) is a virtually “scarless” technique. A ... more Introduction. Single-incision laparoscopic surgery (SILS) is a virtually “scarless” technique. A retrospective analysis is performed to evaluate an initial experience of this surgical approach.Materials and Methods. From January 2010 to October 2011, SILS was considered as a minimally invasive approach to abdominal disease. The access was made by a standard wound protector and a size 6 glove. A series of little accesses were made on the tips of the glove-fingers to induce pneumoperitoneum and to create a working channel for the laparoscopic instruments. An analysis of costs of this technique was made too.Results. SILS was successfully completed with low cost in 34 patients: 20 appendectomy, 12 cholecystectomy, and 2 right colectomy were performed with a median operative time of 35, 45, and 67.5 minutes, respectively. In no patient any conversion to standard laparoscopy or to open surgery was needed. The postoperative course was uneventful in all patients. In right hemicolectomy, the...

Trials, Jan 27, 2015

BackgroundThe position of arterial ligation during laparoscopic anterior rectal resection with to... more BackgroundThe position of arterial ligation during laparoscopic anterior rectal resection with total mesorectal excision can affect genito-urinary function, bowel function, oncological outcomes, and the incidence of anastomotic leakage. Ligation to the inferior mesenteric artery at the origin or preservation of the left colic artery are both widely performed in rectal surgery. The aim of this study is to compare the incidence of genito-urinary dysfunction, anastomotic leak and oncological outcomes in laparoscopic anterior rectal resection with total mesorectal excision with high or low ligation of the inferior mesenteric artery in a controlled randomized trial.Methods/designThe HIGHLOW study is a multicenter randomized controlled trial in which patients are randomly assigned to high or low inferior mesenteric artery ligation during laparoscopic anterior rectal resection with total mesorectal excision for rectal cancer. Inclusion criteria are middle or low rectal cancer (0 to 12 cm f...

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, 2014

Recurrence rate and the perioperative outcome evaluation through laparoscopic approach for ventra... more Recurrence rate and the perioperative outcome evaluation through laparoscopic approach for ventral (primary and incisional) hernia repair. A retrospective evaluation of a series of patients treated through a minimally invasive approach for ventral hernia was performed. A standardized surgical technique was adopted. All the patients were evaluated through a clinical follow-up. From July 2004 to June 2011, 150 videolaparoscopic ventral hernia repairs were performed. The median follow-up was 40 months. One hernia recurrence (0.7%) was detected after 55 months. The intraoperative and postoperative complication rate was 2.6% (1 conversion to open surgery) and 5.3%, respectively. Chronic pain nonresponsive to drug was registered in 2 patients (1.3%). The videolaparoscopic approach to ventral hernia repair is a safe technique that can guarantee a low recurrence rate; moreover, if it is performed in an experienced laparoscopic surgical center, it can be a valid alternative to the traditional open approach.

European Journal of Gastroenterology & Hepatology, 2008

Tangier disease is a rare genetic disorder of lipid metabolism, characterized by severe deficienc... more Tangier disease is a rare genetic disorder of lipid metabolism, characterized by severe deficiency of plasma high-density lipoprotein cholesterol, low-plasma total cholesterol, and accumulation of cholesteryl ester in macrophages. Abdominal manifestation of Tangier disease is extremely rare, being reported only once in the English literature. We describe a 55-year-old patient with this condition, who underwent splenectomy 37 years before, because of splenomegaly with thrombocytopenia, and subsequently presented with abdominal pain and pancreatic mass, simulating a pancreatic tumor. The preoperative diagnosis of endocrine or solid-cystic neoplasm was made, and the tumor was successfully resected with distal pancreatectomy. Histological examination showed that the mass was composed of histiocytic cells containing lipids; some aggregates of giant polynucleated histiocytes with intracytoplasmic cholesterol crystals. To our knowledge, this is the first report of pancreatic manifestation of Tangier disease. As suggested earlier, splenectomy in these patients seems to predispose to deposition of lipids and infiltration of the abdomen by inflammatory cells.

CardioVascular and Interventional Radiology, 2016

We describe a man who presented with a traumatic portal vein pseudoaneurysm, which was subsequent... more We describe a man who presented with a traumatic portal vein pseudoaneurysm, which was subsequently managed with a percutaneous transhepatic stent graft. This case demonstrates a rarely seen condition in the traumatic population and a novel management strategy, which should be considered in the management of this challenging injury.

Chirurgia

Imagistica prin rezonanţă magnetică (IRM) este utilizată în mod obişnuit în stadializarea preoper... more Imagistica prin rezonanţă magnetică (IRM) este utilizată în mod obişnuit în stadializarea preoperatorie a cancerului rectal. Concordanţa stadializării IRM cu examenul histopatologic final, deşi îmbunătăţită, nu a ajuns încă la perfecţiune. Scopul acestui studiu este de a analiza gradul de concordanţă dintre IRM şi examenul histopatologic la pacienţii operaţi de cancer de rect mediu/inferior. Au fost incluşi în studiu pacienţii la care s-a practicat intervenţia chirurgicală pentru cancer rectal cu sau fără chimio-radioterapiei neoadjuvante (nCRT). În perioada ianuarie 2019-decembrie 2019, au fost analizaţi 140 de pacienţi înscrişi în registrul de cancer rectal al AIMS Academy. Dintre aceştia, 62 pacienţi au primit nCRT. În general, concordanţa dintre IRM şi examenul histopatologic în ceea ce priveşte stadiul T şi stadiul N a fost de 64,7%, respectiv, 69,2%. Concordanţa dintre IRM şi examenul histopatologic în ceea ce priveşte stadiul T a fost de 62,7% pentru