Mbajiorgu Felix - Academia.edu (original) (raw)
Papers by Mbajiorgu Felix
Veterinary Integrative Sciences, Oct 19, 2024
Globally, the use of antibiotic in animal industry was well known in the 20th century. Antibiotic... more Globally, the use of antibiotic in animal industry was well known in the 20th century. Antibiotics usage as therapeutic and subtherapeutic means of improving growth and feed efficiency in livestock was well documented in literature. However, continuous use of antibiotics in food animals for increased growth and disease prevention has resulted in the development of antibiotic resistant bacteria in animals. This has led to disease treatment failure in the affected animals. The problem of transmission of antibiotic resistant bacteria to human through food chain and contamination of environment is another challenge of antibiotic usage in poultry production. Hence, the ban was placed on antibiotic usage in animal production. The restriction to the use of animal growth promoting antibiotic has gained high compliance in the developed countries. However, in the third world countries, this is still a battle that is ongoing. To achieve the 2023 Global Action Plan on Antimicrobial Resistance goal, a lot is still left to be done. This review synthesized information on implications of antibiotics uses on broiler chickens' production cost efficiency and profitability; impact of antibiotics mode of action, diseases prevention and treatments of infection in broiler chickens' production; challenges of antibiotics residual effect on meat quality and safety and alternatives to synthetic antibiotic for broiler chickens' production.
Applied Sciences
Atrazine (ATZ) is an herbicide commonly detected in groundwater. Several studies have focused on ... more Atrazine (ATZ) is an herbicide commonly detected in groundwater. Several studies have focused on its immunological and endocrine effects on adult Xenopus laevis species. However, we investigated the impact of atrazine on the renal and hepatic biochemistry and histomorphology in adult male frogs. Forty adult male frogs were allocated to four treatment groups (control, one ATZ (0.01 µg/L), two ATZ (200 µg/L) and three ATZ (500 µg/L), 10 animals per group, for 90 days. Alanine aminotransferase (ALT) and creatinine levels increased significantly (p < 0.05) in the 200 and 500 μg/L groups but malondialdehyde only in the 500 μg/L group (p < 0.05). Histopathological observations of derangement, hypertrophy, vascular congestion and dilation, infiltration of inflammatory cells incursion, apoptosis and hepatocytes cell death were observed with atrazine exposure, mostly in the 500 μg/L group. Additionally, histochemical labelling of caspase-3 in the sinusoidal endothelium was observed in ...
Applied Sciences, 2021
Atrazine (ATZ) is an herbicide commonly detected in groundwater. Several studies have focused on ... more Atrazine (ATZ) is an herbicide commonly detected in groundwater. Several studies have focused on its immunological and endocrine effects on adult Xenopus laevis species. However, we investigated the impact of atrazine on the renal and hepatic biochemistry and histomorphology in adult male frogs. Forty adult male frogs were allocated to four treatment groups (control, one ATZ (0.01 µg/L), two ATZ (200 µg/L) and three ATZ (500 µg/L), 10 animals per group, for 90 days. Alanine aminotransferase (ALT) and creatinine levels increased significantly (p < 0.05) in the 200 and 500 μg/L groups but malondialdehyde only in the 500 μg/L group (p < 0.05). Histopathological observations of derangement, hypertrophy, vascular congestion and dilation, infiltration of inflammatory cells incursion, apoptosis and hepatocytes cell death were observed with atrazine exposure, mostly in the 500 μg/L group. Additionally, histochemical labelling of caspase-3 in the sinusoidal endothelium was observed in ...
DECLARATION In fulfillment of the requirements for the degree of Doctor of Philosophy (PhD) in th... more DECLARATION In fulfillment of the requirements for the degree of Doctor of Philosophy (PhD) in the Department of Health
Veterinary Integrative Sciences, Oct 19, 2024
Globally, the use of antibiotic in animal industry was well known in the 20th century. Antibiotic... more Globally, the use of antibiotic in animal industry was well known in the 20th century. Antibiotics usage as therapeutic and subtherapeutic means of improving growth and feed efficiency in livestock was well documented in literature. However, continuous use of antibiotics in food animals for increased growth and disease prevention has resulted in the development of antibiotic resistant bacteria in animals. This has led to disease treatment failure in the affected animals. The problem of transmission of antibiotic resistant bacteria to human through food chain and contamination of environment is another challenge of antibiotic usage in poultry production. Hence, the ban was placed on antibiotic usage in animal production. The restriction to the use of animal growth promoting antibiotic has gained high compliance in the developed countries. However, in the third world countries, this is still a battle that is ongoing. To achieve the 2023 Global Action Plan on Antimicrobial Resistance goal, a lot is still left to be done. This review synthesized information on implications of antibiotics uses on broiler chickens' production cost efficiency and profitability; impact of antibiotics mode of action, diseases prevention and treatments of infection in broiler chickens' production; challenges of antibiotics residual effect on meat quality and safety and alternatives to synthetic antibiotic for broiler chickens' production.
Applied Sciences
Atrazine (ATZ) is an herbicide commonly detected in groundwater. Several studies have focused on ... more Atrazine (ATZ) is an herbicide commonly detected in groundwater. Several studies have focused on its immunological and endocrine effects on adult Xenopus laevis species. However, we investigated the impact of atrazine on the renal and hepatic biochemistry and histomorphology in adult male frogs. Forty adult male frogs were allocated to four treatment groups (control, one ATZ (0.01 µg/L), two ATZ (200 µg/L) and three ATZ (500 µg/L), 10 animals per group, for 90 days. Alanine aminotransferase (ALT) and creatinine levels increased significantly (p < 0.05) in the 200 and 500 μg/L groups but malondialdehyde only in the 500 μg/L group (p < 0.05). Histopathological observations of derangement, hypertrophy, vascular congestion and dilation, infiltration of inflammatory cells incursion, apoptosis and hepatocytes cell death were observed with atrazine exposure, mostly in the 500 μg/L group. Additionally, histochemical labelling of caspase-3 in the sinusoidal endothelium was observed in ...
Applied Sciences, 2021
Atrazine (ATZ) is an herbicide commonly detected in groundwater. Several studies have focused on ... more Atrazine (ATZ) is an herbicide commonly detected in groundwater. Several studies have focused on its immunological and endocrine effects on adult Xenopus laevis species. However, we investigated the impact of atrazine on the renal and hepatic biochemistry and histomorphology in adult male frogs. Forty adult male frogs were allocated to four treatment groups (control, one ATZ (0.01 µg/L), two ATZ (200 µg/L) and three ATZ (500 µg/L), 10 animals per group, for 90 days. Alanine aminotransferase (ALT) and creatinine levels increased significantly (p < 0.05) in the 200 and 500 μg/L groups but malondialdehyde only in the 500 μg/L group (p < 0.05). Histopathological observations of derangement, hypertrophy, vascular congestion and dilation, infiltration of inflammatory cells incursion, apoptosis and hepatocytes cell death were observed with atrazine exposure, mostly in the 500 μg/L group. Additionally, histochemical labelling of caspase-3 in the sinusoidal endothelium was observed in ...
DECLARATION In fulfillment of the requirements for the degree of Doctor of Philosophy (PhD) in th... more DECLARATION In fulfillment of the requirements for the degree of Doctor of Philosophy (PhD) in the Department of Health